452,987 results match your criteria patient presented

Periocular Presentation of Solitary Plasmacytomas and Multiple Myeloma.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital Service, Moorfields Eye Hospital, London, United Kingdon.

Aims: To describe patients with periocular solitary extramedullary plasmacytoma (SEMP) and multiple myeloma (MM), together with an estimate of the risk of progression from SEMP to MM.

Patients And Methods: A retrospective case-note review for patients seen between 1978 and 2020, examining demographics, presentation, imaging, pathology, management, and outcome.

Results: Twenty patients (10 male; 50%) presented at a mean age of 60. Read More

View Article and Full-Text PDF

Corrective Proximal Humerus Osteotomy with Blade Plate Osteosynthesis in Adolescents: A Report of 2 Cases.

JBJS Case Connect 2021 07 22;11(3). Epub 2021 Jul 22.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Case: Two cases are presented to highlight the indications, surgical technique, and early clinical outcomes associated with proximal humerus corrective osteotomy using a 90° cannulated blade plate in adolescent patients.

Conclusion: A complex deformity of the proximal humerus in the adolescent patient poses an uncommon yet debilitating clinical condition that is challenging to manage. We report a unique method for surgical correction and fixation using an infant hip osteotomy 90° blade plate that restores native shoulder anatomy, improves function, and has led to early clinical success. Read More

View Article and Full-Text PDF

Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

View Article and Full-Text PDF
September 2021

Multiple-Session Subthreshold Micropulse Laser Therapy for Exudative Perifoveal Vascular Anomalous Complex: a case report.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea.

Purpose: To report a case of exudative perifoveal vascular anomalous complex treated with a 532 nm subthreshold micropulse laser unresponsive to intravitreal injections.

Methods: A case report.

Results: A 65-year-old woman presented with blurred vision in left eye for 1 month. Read More

View Article and Full-Text PDF

Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Weill Cornell Medical College, New York, United States.

Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein).

Methods: Case report and review of the relevant literature.

Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services. Read More

View Article and Full-Text PDF

Blunt Abdominopelvic Trauma Complicated by Traumatic Testicular Dislocation in a 19-Year-Old Male Patient: A Case Report.

JBJS Case Connect 2021 07 22;11(3). Epub 2021 Jul 22.

Department of Urology Surgery, Puerto Rico Medical Center, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

Case: A 19 year-old male patient presented with testicular dislocation after abdominopelvic trauma. During open reduction and internal fixation, consult to urology was placed after discovering the presence of the intra-abdominal testicle. The testicle was repositioned into the scrotum with orchiopexy, and pelvic fixation was completed with 1 sacroiliac percutaneous screw and pubic symphysis fixation. Read More

View Article and Full-Text PDF

Mini-invasive Osteotomy for Pediatric Distal Radius Malunion.

Tech Hand Up Extrem Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Hand Surgery, Turku University Hospital, University of Turku and CoE TYKS ORTO, Turku, Finland.

Although most malunions after pediatric distal radius fractures will remodel as the child grows, adolescent patients with severe malunion and limited growth require reduction to restore alignment. The authors technique for a mini-invasive osteotomy is presented. The apex of the malunion is approached from a single 2 cm volar incision through the flexor carpi radialis sheath. Read More

View Article and Full-Text PDF

A Case of Hypophosphatemia due to Oncogenic Osteomalacia in a Patient with Natural Killer T-Cell Lymphoma.

Kidney Blood Press Res 2021 Jul 22:1-5. Epub 2021 Jul 22.

Ochsner Clinical School/The University of Queensland, Brisbane, Queensland, Australia.

Introduction: Oncogenic osteomalacia (Onc-Ost) is a paraneoplastic phenomenon characterized by hypophosphatemia due to elevated fibroblast growth factor-23 (FGF-23). Onc-Ost has been previously reported in patients with germ line mesenchymal tumors and solid organ malignancies. This is the first report of aggressive natural killer (NK) T-cell lymphoma presenting as Onc-Ost. Read More

View Article and Full-Text PDF

A patient with concurrent multiple sclerosis and moyamoya disease.

Mult Scler Relat Disord 2021 Jul 16;54:103151. Epub 2021 Jul 16.

Division of Neuro-Immunology, Department of Neurology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY. Electronic address:

Background: Moyamoya disease (MMD) is a rare vasculopathy and Multiple Sclerosis (MS) is an autoimmune disease which causes CNS demyelination. While most literature has focused on misdiagnosis of MMD as an "MS-mimic", we present a patient in which both co-existed.

Methods: Case Report RESULTS: A 57-year-old woman presented with gait dysfunction and paresthesias in both feet. Read More

View Article and Full-Text PDF

Differences in SCN1A intronic variants result in diverse aberrant splicing patterns and are related to the phenotypes of epilepsy with febrile seizures.

Epilepsy Res 2021 Jul 7;176:106711. Epub 2021 Jul 7.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, GX, China. Electronic address:

Objective: Intronic variants of the SCN1A gene are detected in patients with epilepsy with febrile seizures (EFS), which includes a series of phenotypes with different severities. However, the pathogenicity of intronic variants and their genotype-phenotype correlation remain under characterized. The purpose of this study was to determine the changes in mRNA splicing caused by SCN1A intronic variants associated with EFS and their association with phenotypes. Read More

View Article and Full-Text PDF

Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer.

Eur J Cancer 2021 Jul 19;154:217-226. Epub 2021 Jul 19.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350007, China. Electronic address:

Purpose: We investigate the prognostic value of tumour-infiltrating lymphocytes (TILs) based on the evaluation of the present frequency in patients with breast cancer rather than that of the density proposed in previous research.

Methods: Multiphoton microscopy (MPM) was introduced to label-freely obtain TIL images from a total of 564 patients, and then TILs were redefined as TILs-1 to TILs-3 from MPM images according to the relative positions between TILs, tumour cells and collagen fibres. More seminally, a new method, which was based on the present frequency of TILs-1 to TILs-3, was presented for assessing the predictive ability of TILs, and then a tumour-infiltrating lymphocytes score (TILs-score) for each patient was obtained by ridge regression analysis. Read More

View Article and Full-Text PDF

Endovascular treatment of vertebro-vertebral arteriovenous fistula in neurofibromatosis type I: A report of two cases and literature review with a focus on endovascular treatment.

Clin Neurol Neurosurg 2021 Jul 14;207:106806. Epub 2021 Jul 14.

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Vertebro-Vertebral arteriovenous fistula (VV-AVF) associated with neurofibromatosis Type I (NF-1) is rare. We presented two female NF-1 patients with a diagnosis of VV-AVF treated with endovascular approach. The fistula was completely obliterated with balloon assisted embolization and covered stent separately and VA patency was preserved in both cases. Read More

View Article and Full-Text PDF

Legg-Calvé-Perthes disease following Ender nail fixation of a pediatric femoral fracture.

Int J Surg Case Rep 2021 Jul 17;85:106209. Epub 2021 Jul 17.

Department of Orthopaedic Surgery, Jichi Medical University, Tochigi, Japan.

Introduction And Importance: Legg-Calvé-Perthes disease (LCPD) sometimes occur in children, however it is difficult to diagnose it at the early stage especially in the cases there are no complaints of symptoms. Femoral shaft fractures in children cause various complications such as leg-length discrepancy, nonunion and malunion, refracture, and osteonecrosis of the femoral head. We presented a rare case in which a pediatric patient developed LCPD after femoral shaft fracture. Read More

View Article and Full-Text PDF

Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report.

Int J Surg Case Rep 2021 Jul 9;85:106194. Epub 2021 Jul 9.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia. Electronic address:

Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Read More

View Article and Full-Text PDF

Endoscopic Endonasal Approach for Giant Pituitary Adenoma Occupying The Entire Third Ventricle: Surgical Results and A Review of Literature.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery , Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India - 695011. Electronic address:

Background: Pituitary macroadenomas, occasionally, disrupt the sellar diaphragm and extend directly to the third ventricle causing hydrocephalus.

Objective: We present the results of a single stage extended endoscopic approach for managing giant pituitary adenomas occupying the entire third ventricle.

Methods: A retrospective study of all giant pituitary adenomas, occupying the entire third ventricle, operated via the endoscopic endonasal approach between January 2016 and December 2020 was performed. Read More

View Article and Full-Text PDF

Complementary and Alternative Medicine Use in First-time and Recurrent Kidney Stone Formers.

Urology 2021 Jul 19. Epub 2021 Jul 19.

Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.

Objective: To describe the patterns of complementary and alternative medicine (CAM) among patients with kidney stones and analyze the alkali content of commonly used CAM therapies.

Methods: We prospectively conducted structured interviews with patients who presented to a specialty stone clinic for the management of kidney stones. Open-ended questions were used to elicit information regarding CAM knowledge, formulation/dosing, and patterns of use. Read More

View Article and Full-Text PDF

Transcondylar Odontoid Resection and Stabilization for Craniovertebral Degenerative Compression: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Non-neoplastic craniovertebral junction lesions are well known with various etiologies.1,2 They are frequently associated with craniovertebral junction instability. Many require only stabilization for their management. Read More

View Article and Full-Text PDF

Tracheal window resection and reconstruction via sternocleidomastoid flap for invasive thyroid carcinoma.

Interact Cardiovasc Thorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objectives: The aim of this study was to present surgical techniques and evaluate outcomes of a sternocleidomastoid muscle (SCM) myoperiosteal flap used for the reconstruction of tracheal or laryngotracheal defects after the radical resection of invasive thyroid carcinoma.

Methods: A retrospective study was performed for patients at Peking Union Medical College Hospital from January 2008 to December 2018 of papillary thyroid carcinoma with tracheal or laryngotracheal invasion. Patients were enrolled only when they received window resection and reconstruction via an SCM myoperiosteal flap. Read More

View Article and Full-Text PDF

Persistent negative dysphotopsia and small eyes August consultation #1.

Nicole R Fram

J Cataract Refract Surg 2021 Aug;47(8):1096

A 56-year-old man with an ocular history of strabismus surgery at age 3 years, anatomically narrow angles, and patent laser peripheral iridotomies in both eyes underwent refractive lens exchange in which a SA60AT (Alcon Laboratories, Inc.) 38 diopter (D) intraocular lens (IOL) was implanted in the right eye and a SA60AT 36 D IOL was implanted in the left eye. He presented with symptoms consistent with negative dysphotopsia (ND) in both eyes immediately after surgery, describing temporal dark arcs that were constantly present and did not improve over the past 2 years. Read More

View Article and Full-Text PDF

COVID-19 Shelter-In-Place Orders Associated With Delayed Presentation and Deep Venous Thrombosis in Geriatric Hip Fractures.

Orthopedics 2021 Jul-Aug;44(4):223-228. Epub 2021 Jul 1.

Geriatric hip fractures benefit from timely surgery. At the onset of the corona-virus disease 2019 (COVID-19) pandemic, shelter-in-place (SIP) orders were mandated in high-risk cities. The authors hypothesized that geriatric patients with hip fractures were more likely to present to the hospital greater than 24 hours after injury during SIP orders. Read More

View Article and Full-Text PDF

Spectrum of BCR-ABL Mutations and Treatment Outcomes in Ethiopian Imatinib-Resistant Patients With Chronic Myeloid Leukemia.

JCO Glob Oncol 2021 Jul;7:1187-1193

Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: Despite the successes achieved in chronic myeloid leukemia (CML) with tyrosine kinase inhibitor (TKI) therapy, resistance remains an obstacle. The most common mechanism of resistance is the acquisition of a point mutation in the BCR-ABL kinase domain. Few studies have reported African patients with CML in regard to such mutations. Read More

View Article and Full-Text PDF

Intratumoural Budding is Associated with Poor Clinical Outcome in Early-Stage Clear Cell Carcinoma of Ovary.

Histopathology 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, NYU Langone Health.

Aims: Clear cell carcinoma of ovary (CCC) is considered a high-grade malignancy by default and the role of histological grading for assessing clinical outcome is not established. We aimed to evaluate histopathological features associated with clinical outcome in CCC patients. Seventy-six cases of CCC with available clinical follow-up information were studied. Read More

View Article and Full-Text PDF

Clinicopathologic Findings in COVID-19-Associated Ischemic Enterocolitis.

Histopathology 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Aims: Coronavirus disease 2019 (COVID-19) has been recognized as a predominantly respiratory tract infection, but some patients manifest severe systemic symptoms/coagulation abnormalities. We evaluated the impact of severe COVID-19 infection on the gastrointestinal tract.

Methods And Results: We examined clinicopathologic findings in 28 resected ischemic bowels from 22 patients with severe COVID-19. Read More

View Article and Full-Text PDF

Preserving nurses' professional dignity: Six evidence-based strategies.

Int Nurs Rev 2021 Jul 22. Epub 2021 Jul 22.

Department of Nursing Science, University of Pretoria, Pretoria, South Africa.

Aim: This study aimed to develop and refine strategies for preserving nurses' professional dignity.

Background: Professional dignity is a non-negotiable nursing professional value. It should at all times be respected because of the worthiness of nurses as professional human beings. Read More

View Article and Full-Text PDF

Efficacy of nintedanib plus docetaxel in patients with refractory advanced epidermal growth factor receptor mutant lung adenocarcinoma.

Clin Transl Oncol 2021 Jul 22. Epub 2021 Jul 22.

Medical Oncology Department, Hospital de La Santa Creu I Sant Pau, Sant Quintí, 89, 08041, Barcelona, Spain.

Background: Anti-angiogenic agents are reported to exert clinical activity in patients with epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). We evaluated the outcomes of the combination of docetaxel plus nintedanib in refractory NSCLC patients harboring EGFR mutations.

Methods: We retrospectively analyzed 19 patients with advanced EGFR-mutant NSCLC who had progressed to EGFR tyrosine kinase inhibitors (TKI) and platinum-based chemotherapy receiving docetaxel and nintedanib at 14 Spanish institutions from January 2013 to December 2019. Read More

View Article and Full-Text PDF

Urgent surgery for COVID-19-positive pediatric patient.

JA Clin Rep 2021 Jul 22;7(1):57. Epub 2021 Jul 22.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.

Background: We present a case of COVID-19-positive pediatric patient for urgent urological surgery by spinal anesthesia to avoid aerosolizing procedure.

Case Presentation: A 12-year-old, COVID-19-positive boy presented for urgent wound incision and drainage at the circumcision site. Our anesthetic plan consisted of spinal anesthesia with sedation. Read More

View Article and Full-Text PDF

De novo lupus-like glomerulonephritis after pediatric non-kidney organ transplantation.

Pediatr Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatrics, Division of Nephrology, University of California Los Angeles Medical Center, Los Angeles, CA, USA.

Background: We propose a novel clinically significant finding, de novo lupus-like glomerulonephritis (DNLLGN), in patients with autoantibodies and kidney abnormalities in pediatric liver transplant (LT) and intestinal inclusive transplants (ITx).

Methods: We describe the clinical, serologic, and histopathologic presentation and kidney outcomes in eight patients from our center found to have DNLLGN on kidney biopsy.

Results: Pediatric recipients of non-kidney solid organ transplants developed an unusual de novo immune complex glomerulonephritis with morphologic similarity to lupus nephritis. Read More

View Article and Full-Text PDF

Three near fatal or fatal complications during implantation of tunnelled hemodialysis catheters : Learning from experts.

Anaesthesist 2021 Jul 22. Epub 2021 Jul 22.

Department of Anaesthesiology, Luzerner Kantonsspital, 6000, Lucerne, Switzerland.

Tunnelled hemodialysis catheters are well accepted and widely used devices to provide vascular access for dialysis in patients when an arteriovenous shunt is not feasible or dysfunctional. In the literature complications after implantation are well documented but fatal or near-fatal events during implantation are seldom reported. In this article 3 such cases from a single tertiary center over a period of more than 10 years are presented and discussed. Read More

View Article and Full-Text PDF

Pelvic floor architectural defects in female patients with urge fecal incontinence versus passive fecal leakage: a dynamic ultrasound study.

Int Urogynecol J 2021 Jul 22. Epub 2021 Jul 22.

Division of Urogynecology, University of Chicago Pritzker School of Medicine, NorthShore University HealthSystem, Skokie, IL, USA.

Introduction And Hypothesis: Fecal incontinence (FI) has two primary subtypes: urgency fecal incontinence (UFI) and passive fecal leakage (PFL). The pathophysiology underlying the subtypes is incompletely understood.

Objectives: To compare the bowel habits, physical examinations and pelvic floor anatomical defects in patients with UFI-dominant FI versus patients with PFL-dominant FI. Read More

View Article and Full-Text PDF

Dengue and the heart.

Cardiovasc J Afr 2021 Jul 20;32:1-6. Epub 2021 Jul 20.

Department of Anaesthesiology, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Email:

Background: Peri-operative morbidity and mortality are increased in patients with rheumatic heart disease. Pre-operative risk stratification is imperative for optimisation and a better outcome.

Methods: This was a descriptive, retrospective, contextual study. Read More

View Article and Full-Text PDF