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[Translation, Adaptation, Reliability and Validity of the German Version of the Prosthesis Mobility Questionnaire 2.0 (PMQ) on Patients with Major Lower Limb Amputation].

Rehabilitation (Stuttg) 2021 Jul 22. Epub 2021 Jul 22.

Klinik für Rehabilitationsmedizin, Medizinische Hochschule Hannover.

Purpose: The aim of this prospective validation study was to translate the Prosthesis Mobility Questionnaire 2.0 (PMQ) into German based on a guideline, following by psychometric testing for its validity and reliability using classical test theory.

Methods: The PMQ was translated into German according to ISPOR guidelines using double forward and double backward translations, finalized by pilot testing (N=10). Read More

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The Impact of Incorporating Evidence-based Guidelines for Lumbar Fusion Surgery in Neurosurgical Resident Education.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania.

Background: Instrumented fusion procedures are essential in the treatment of degenerative lumbar spine disease to alleviate pain and improve neurologic function, but are being performed with increasing incidence and variability.

Objective: We implemented a training module for neurosurgery residents that is based on evidence-based criteria for lumbar fusion surgery and measured its effectiveness in the residents' decision making regarding whether patients should or should not undergo instrumented fusion.

Methods: The study design is a pretest versus posttest experiment conducted from September 2019 until July 2020 to measure improvement after formalized instruction on evidence-based guidelines. Read More

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Validating the Michigan Hand Outcomes Questionnaire in patients with rheumatoid arthritis using Rasch analysis.

PLoS One 2021 22;16(7):e0254984. Epub 2021 Jul 22.

Section of Plastic Surgery, Michigan Medicine, Ann Arbor, Michigan, United States of America.

Introduction: The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a more rigorous method of questionnaire validation that has not been used to test the psychometric properties of the MHQ in patients with RA. The objective of this study is to evaluate the validity and reliability of the MHQ for measuring outcomes in patients with RA with metacarpophalangeal joint deformities. Read More

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Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.

PLoS One 2021 22;16(7):e0254939. Epub 2021 Jul 22.

Hepato-Gastroenterology Department, Hôpital Saint-Joseph, Marseille, France.

Background & Aim: Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study was to evaluate the interest of liver fibrosis screening using systematic calculation of FIB-4 in routine blood analysis. Read More

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Maternal and neonatal canine cortisol measurement in multiple matrices during the perinatal period: A pilot study.

PLoS One 2021 22;16(7):e0254842. Epub 2021 Jul 22.

Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.

Stress exposure during perinatal period may lead to maternal cortisol increase that negatively affects the offspring development. In recent years, the interest on non-invasive sampling methods to measure cortisol as a marker of stress is increasing in both humans and animals. Indeed, discomfort due to blood collection may compromise the diagnostic outcome, mainly in uncooperative patients. Read More

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ENDOCRINOLOGY IN THE TIME OF COVID-19 - 2021 updates: The Management of Diabetes insipidus and Hyponatraemia.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

M Sherlock, Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Tallaght, Dublin 24 , Dublin, Ireland.

COVID-19 has changed the nature of medical consultations, emphasizing virtual patient counseling, with relevance for patients with diabetes insipidus (DI) or hyponatremia. The main complication of desmopressin treatment in DI is dilutional hyponatraemia. Since plasma sodium monitoring is not always possible in times of COVID-19, we recommend to delay the desmopressin dose once a week until aquaresis occurs allowing excess retained water to be excreted. Read More

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Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty: A Randomized, Controlled Trial.

Orthopedics 2021 Jul-Aug;44(4):249-255. Epub 2021 Jul 1.

Peripheral nerve blocks are commonly used in total knee arthroplasty (TKA). Liposomal bupivacaine is an extended-release anesthetic medication that maintains efficacy upwards of 72 hours. This study compared single-shot liposomal bupivacaine (LB) with the standard single-shot bupivacaine (SB) in a preoperative adductor canal block in TKA patients. Read More

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Clinical accuracy of non-contact forehead infrared thermometer and infrared tympanic thermometer in postoperative adult patients: A comparative study.

Norihiro Kameda

J Perioper Pract 2021 Jul 22:17504589211022314. Epub 2021 Jul 22.

Graduate school of Nursing Sciences, St. Luke's International University, Tokyo, Japan.

Core temperature monitoring is important for the assessment and prevention of possible postoperative complications. The aim of the present study was to examine the agreement between the core temperature values and the forehead, tympanic membrane and axillary values in postoperative adult patients in clinical practice. The study measured the core temperature of 65 patients undergoing scheduled abdominal surgery using SpotOn™ and compared these with those obtained using non-contact forehead infrared, infrared tympanic and axillary thermometers. Read More

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Newborn Screening in the Diagnosis of Primary Immunodeficiency.

Lisa J Kobrynski

Clin Rev Allergy Immunol 2021 Jul 22. Epub 2021 Jul 22.

Pediatrics Institute, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Newborn screening for severe combined immune deficiency (SCID) is the first inborn error of immunity (IEI) to be detected through population screening. It also represents the first newborn screening test to utilize molecular testing on DNA from newborn dried blood spots. Newborn screening for SCID has provided opportunities to measure the population prevalence of this disorder and evaluate the effect of early interventions on the overall outcomes in affected infants. Read More

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Prostate heterogeneity correlates with clinical features on multiparametric MRI.

Abdom Radiol (NY) 2021 Jul 22. Epub 2021 Jul 22.

Department of Radiology, Weill Cornell Medicine, 525 East 68th Street, New York, NY, 10065, USA.

Background: Prostate heterogeneity on multi-parametric MRI (mpMRI) may confound image interpretation by obscuring lesions; systematic biopsy may have a role in this context.

Purpose: To determine if prostate heterogeneity (1) correlates with clinical risk factors for prostate cancer and (2) associates with higher-grade tumor in systematic biopsy (SB), compared with MRI-directed target biopsy (MDTB), i.e. Read More

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Effect of Implant Surface Modification on Bone Mineral Density and Survival Rate in the Maxilla After a Short Period Using Cone Beam Computed Tomography.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Chairman of Iraqi scientific council of maxillofacial surgery-Iraqi Board for medical specializations, Baghdad University Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Al Mustansyria University, Baghdad, Iraq.

Abstract: This study was aimed to objectively measure the changes in bone density amount obtained through cone-beam computed tomography around dental implants after a short period of time in the maxilla. Thirty-two SLActive Straumann implants were inserted into 12 healthy patients. Changes in bone density were measured at the surgery time (Bone mineral density (BMD)0) and 60 days after investment (Bone mineral density (BMD)60). Read More

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Antigen-based rapid diagnostic testing or alternatives for diagnosis of symptomatic COVID-19: A simulation-based net benefit analysis.

Epidemiology 2021 Jul 13. Epub 2021 Jul 13.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA MRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK Foundation for Innovative New Diagnostics, Geneva, Switzerland.

Background: SARS-CoV-2 antigen-detection rapid diagnostic tests can diagnose COVID-19 rapidly and at low cost, but lower sensitivity compared with reverse-transcriptase polymerase chain reaction (PCR) has limited clinical adoption.

Methods: We compared antigen testing, PCR testing, and clinical judgment alone for diagnosing symptomatic COVID-19 in an outpatient setting (10% COVID-19 prevalence among the patients tested, 3-day PCR turnaround) and a hospital setting (40% prevalence, 24-hour PCR turnaround). We simulated transmission from cases and contacts, and relationships between time, viral burden, transmission, and case detection. Read More

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A Novel Luminescent "Nanochip" as a Tandem Catalytic System for Chemiluminescent Detection of Sweat Glucose.

Anal Chem 2021 Jul 22. Epub 2021 Jul 22.

National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Chemistry and Biomedicine Innovation Center, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, China.

Accurate sweat glucose detection is a promising alternative to invasive finger-prick blood tests, allowing for self-monitoring of blood glucose with good patient compliance. In this study, we have developed a tandem catalytic system, termed as a luminescent "nanochip" (LAON), which was composed of gold nanoparticles (AuNPs) and -(aminobutyl)--(ethylisoluminol) (ABEI)-engineered oxygen-doped carbon nitride (O-g-CN), for chemiluminescent detection of sweat glucose. The LAON exhibits dual catalytic activity of glucose oxidase and peroxidase and can not only oxidize glucose to generate HO but catalyze HO-mediated luminol chemiluminescence, resulting in sensitive detection of glucose. Read More

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Mode of delivery of Cognitive Behaviour Therapy for Insomnia: A randomized controlled non-inferiority trial of digital and face- to-face therapy.

Sleep 2021 Jul 22. Epub 2021 Jul 22.

Division of Mental Health Care, St Olavs University Hospital, Trondheim, Norway.

Study Objectives: Digital CBT-I (dCBT-I) has demonstrated efficacy in reducing insomnia severity in self-referred and community samples. It is unknown, however, how dCBT-I compares to individual face-to-face (FtF) CBT-I for individuals referred to clinical secondary services. We undertook a randomized controlled trial to test whether fully automated dCBT-I is non-inferior to individual FtF CBT-I in reducing insomnia severity. Read More

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Genetic risk for bipolar disorder and schizophrenia predicts structure and function of the ventromedial prefrontal cortex.

J Psychiatry Neurosci 2021 Jul 22;46(4):E441-E450. Epub 2021 Jul 22.

From the Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (Abé, Petrovic, Ossler, Thompson, Liberg, Fransson, Ingvar, Landén); the Department of Psychology, Stanford University, Stanford, California, USA (Thompson); the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (Song, Bergen); the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (Sellgren); Karolinska University Hospital, Department of Neuroradiology, Stockholm, Sweden (Ingvar); and the Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Sweden (Landén).

Background: Bipolar disorder is highly heritable and polygenic. The polygenic risk for bipolar disorder overlaps with that of schizophrenia, and polygenic scores are normally distributed in the population. Bipolar disorder has been associated with structural brain abnormalities, but it is unknown how these are linked to genetic risk factors for psychotic disorders. Read More

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Decision fatigue among clinical nurses during the COVID-19 pandemic.

J Clin Nurs 2021 Jul 21. Epub 2021 Jul 21.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

Aims And Objectives: The purpose of this study was to report the psychometric properties, including validity and reliability, of the decision fatigue scale (DFS).

Background: Decision fatigue may impair nurses' ability to make sound clinical decisions and negatively impact patient care. Given the negative impact of the COVID-19 pandemic on psychological well-being and the workplace environment, decision fatigue may be even more apparent among clinical nurses. Read More

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Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.

NMR Biomed 2021 Jul 21:e4589. Epub 2021 Jul 21.

Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.

Abnormal coronary endothelial function (CEF), manifesting as depressed vasoreactive responses to endothelial-specific stressors, occurs early in atherosclerosis, independently predicts cardiovascular events, and responds to cardioprotective interventions. CEF is spatially heterogeneous along a coronary artery in patients with atherosclerosis, and thus recently developed and tested non-invasive 2D MRI techniques to measure CEF may not capture the extent of changes in CEF in a given coronary artery. The purpose of this study was to develop and test the first volumetric coronary 3D MRI cine method for assessing CEF along the proximal and mid-coronary arteries with isotropic spatial resolution and in free-breathing. Read More

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Prediction of quadriceps tendon-patellar bone autograft diameter in adolescents with 2-dimensional magnetic resonance imaging and anthropometric measures.

Skeletal Radiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Orthopedics, Children's Hospital Colorado, 13123 E. 16th Avenue, Box 060, Aurora, CO, 80045, USA.

Objectives: This study evaluates the correlation between the bone end and soft tissue end of the quadriceps tendon-patellar bone autograft (QPA) size and pre-operative MRI measurements of the quadriceps tendon along sections to be included in the graft harvest in adolescents. We also assessed association between graft diameter and anthropometric measures (height, weight, and BMI), age, and sex.

Methods: Patients (10-18 years) who underwent QPA ACL reconstruction and had a pre-operative MRI were considered for inclusion. Read More

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Mechanical alignment for primary TKA may change both knee phenotype and joint line obliquity without influencing clinical outcomes: a study comparing restored and unrestored joint line obliquity.

Knee Surg Sports Traumatol Arthrosc 2021 Jul 22. Epub 2021 Jul 22.

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Lyon University Hospital, 103 grande rue de la croix rousse, Hopital de La Croix Rousse, 69004, Lyon, France.

Purpose: In total knee arthroplasty (TKA), knee phenotypes including joint line obliquity are of interest regarding surgical realignment strategies. The hypothesis of this study is that better clinical results, including decreased postoperative knee pain, will be observed for patients with a restored knee phenotype.

Methods: A retrospective analysis was performed on prospective data, including 1078 primary osteoarthritic knees in 936 patients. Read More

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One Room Schoolhouse: A Novel Intervention for Inspired Academic Half-Day Learning in Distributed Campus Settings.

J Med Educ Curric Dev 2021 Jan-Dec;8:23821205211029462. Epub 2021 Jul 8.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Introduction: Some studies on academic half days (AHDs) suggest that learning in this context is associated with a lack of educational engagement. This challenge may be amplified in distributed campus settings, where geographical disadvantages demand reliance on videoconferencing or considerable time spent travelling to in-person learning events. Concerns about the educational effectiveness of AHDs by learners within our distributed campus setting led to the development and evaluation of the One Room Schoolhouse (ORS), a unique, evidence-informed, community-based curriculum that partially replaced the AHD sessions delivered at the main campus. Read More

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Independent Versus Transtibial Drilling in Anterior Cruciate Ligament Reconstruction: A Meta-analysis With Meta-regression.

Orthop J Sports Med 2021 Jul 12;9(7):23259671211015616. Epub 2021 Jul 12.

Clinica Ortopedica e Traumatologica II, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: Anterior cruciate ligament (ACL) reconstruction can be performed with different techniques for independent and transtibial (TT) drilling of femoral tunnels, but there is still no consensus on which approach leads to the best outcome.

Purpose: To assess whether the independent or TT drilling approach for ACL reconstruction leads to the best functional outcomes.

Study Design: Systematic review; Level of evidence, 2. Read More

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Role of Threat and Coping Appraisal in Protection Motivation for Adoption of Preventive Behavior During COVID-19 Pandemic.

Front Public Health 2021;9:678566. Epub 2021 Jul 5.

World Health Organization RNTCP Technical Support Network, Swasthya Bhawan, Kolkata, India.

With more than 100 million cases and over 2 million deaths globally, the COVID-19 pandemic continues to remain a major threat. Identifying the behavioral factors influencing preventive behaviors for COVID-19 are crucial in devising public health policies to promote essential strategies to combat the pandemic in an efficient manner. The current study was therefore conducted to estimate the prevalence of COVID-19 preventive behaviors and measure their association with behavioral constructs like threat perception, response efficacy, and self-efficacy, as per socio-demographic background. Read More

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Diagnostic sensitivity of impulse oscillometry in early detection of patients exposed to risk factors chronic obstructive pulmonary diseases.

Med J Islam Repub Iran 2021 12;35:89. Epub 2021 Jul 12.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Impulse oscillometry (IOS) is a method that does not depend on the cooperation of the patient and can detect small airway diseases with higher sensitivity than spirometry. However, the clinical application value of IOS in the screening of patients exposed to risk factors COPD and early diagnosis remains unclear. The aim of this study is to evaluate diagnostic sensitivity of IOS in the early detection of patients exposed to risk factors COPD. Read More

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Therapeutic Hypothermia With Progesterone Improves Neurologic Outcomes in Ventricular Fibrillation Cardiac Arrest After Electric Shock.

Cureus 2021 Jun 18;13(6):e15749. Epub 2021 Jun 18.

Surgery, St. Mary's Medical Center, West Palm Beach, USA.

Trauma by electricity imposes mechanical, electrical, and thermal forces on the human body. Often, the delicate cardiac electrophysiology is disrupted causing dysrhythmia and subsequent cardiac arrest. Anoxic brain injury (ABI) is the most severe consequence and the main cause of mortality following cardiac arrest. Read More

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The Validation of Clinical Examination and MRI as a Diagnostic Tool for Cruciate Ligaments and Meniscus Injuries of the Knee Against Diagnostic Arthroscopy.

Cureus 2021 Jun 17;13(6):e15727. Epub 2021 Jun 17.

Department of Orthopedic Surgery, King George's Medical University, Lucknow, IND.

Background: This study was conducted to compare the accuracy of MRI findings and clinical examination of ligamentous and meniscal injuries of the knee, taking arthroscopy as a standard diagnostic tool in knee injuries.  Methods: All patients with knee injuries attending the outpatient department or emergency of our hospital underwent clinical examination. Out of them, 60 patients with knee injuries were subjected to clinical examination, MRI, and then arthroscopy. Read More

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Comparison of clinical characteristics and outcomes between alcohol-induced and gallstone-induced acute pancreatitis: An Australian retrospective observational study.

SAGE Open Med 2021 10;9:20503121211030837. Epub 2021 Jul 10.

Department of Intensive Care Medicine, Frankston Hospital, Frankston, VIC, Australia.

Objectives: To compare the characteristics and outcomes of patients presenting to hospital with alcohol-induced and gallstone-induced acute pancreatitis.

Methods: Retrospective study of all patients with alcohol-induced or gallstone-induced pancreatitis during the period 1 June 2012 to 31 May 2016. The primary outcome measure was hospital mortality. Read More

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An unusual case of Adrenocortical Adenocarcinoma with Biochemical Masquerade of Pheochromocytoma.

Pak J Med Sci 2021 Jul-Aug;37(4):1241-1243

Lubna Mirza Norman Regional Hospital, Norman, United State.

Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and often presents as adrenal incidentaloma on abdominal scans with rise in the use of imaging modalities. ACC often presents as Cushing's syndrome or virilization. On the other hand, pheochromocytoma is an adrenal medullary tumor. Read More

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November 2020

Sensory Stimulation of the Foot and Ankle Early Post-stroke: A Pilot and Feasibility Study.

Front Neurol 2021 5;12:675106. Epub 2021 Jul 5.

School of Allied Health Professions, Faculty of Medicine and Health Sciences, Keele University, Keele, United Kingdom.

Somatosensory stimulation of the lower extremity could improve motor recovery and walking post-stroke. This pilot study investigated the feasibility of a subsequent randomized controlled trial (RCT) to determine whether task-specific gait training is more effective following either (a) intensive hands-on somatosensory stimulation or (b) wearing textured insoles. Determine recruitment and attrition rates, adherence to intervention, acceptability and viability of interventions and outcome measures, and estimate variance of outcome data to inform sample size for a subsequent RCT. Read More

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Acta Ortop Bras 2021 May-Jun;29(3):127-131

Universidade de São Paulo, Faculty of Medicine, Hospital das Clínicas, Institute of Orthopedics and Traumatology, HC-FMUSP, São Paulo, SP, Brazil.

Objective: To compare the long-term effects of a brace designed to stabilize the patellofemoral (PF) joint in comparison to a standard neoprene sleeve for the knee with patellar hole in patients with patellofemoral osteoarthritis (PFOA).

Methods: 38 patients with PFOA and comorbidities received either a functional PF brace (Study Group, SG) or a neoprene sleeve for the knee (Control Group, CG). Both groups received clinical treatment to OA and comorbidities according to a program from the institution. Read More

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September 2020

MicroRNA-151a-3p Functions in the Regulation of Osteoclast Differentiation: Significance to Postmenopausal Osteoporosis.

Clin Interv Aging 2021 14;16:1357-1366. Epub 2021 Jul 14.

Community Medicine Department, Beijing Jishuitan Hospital, Beijing City, 100096, People's Republic of China.

Background: Studies have found the pivotal role of miRNAs in the progression of postmenopausal osteoporosis (OP). However, the function of miRNAs in OP is unclear. This study aimed to explore the biological functions of microRNA-151a-3p in OP. Read More

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