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Surveillance imaging during first remission in follicular lymphoma does not impact overall survival.

Cancer 2021 Jun 22. Epub 2021 Jun 22.

Department of Hematology and Medical Oncology, Emory University-Winship Cancer Institute, Atlanta, Georgia.

Background: Although many patients with follicular lymphoma (FL) undergo routine radiographic surveillance during their first remission, no consensus exists on the modality, duration, frequency, or need for routine imaging studies. The authors retrospectively examined the effect of surveillance imaging on relapse detection and overall survival (OS) in patients with FL.

Methods: Patients with newly diagnosed FL who had a response to induction therapy were identified from the Lymphoid Malignancies Enterprise Architecture Database (LEAD) at Emory University and from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic. Read More

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[Hypothyroidism in dogs: an overview].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):195-205. Epub 2021 Jun 22.

Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover.

Hypothyroidism is one of the most common endocrinopathies in dogs. In rare cases, it may be associated with further endocrinopathies. The most common combination is the con-currence of hypothyroidism and hypoadrenocorticism. Read More

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Prevalence and risk factors of undiagnosed diabetes mellitus among gastroenterological patients: a HbA1c-based single center experience.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Diabetes mellitus is a major risk factor for microvascular disease, leading to chronic kidney injury or cardiovascular disease, but there is a tremendous proportion of patients worldwide who suffer from undiagnosed diabetes. Until now, little is known about the prevalence of undiagnosed diabetes in gastroenterology inpatients.

Objective: To improve detection of undiagnosed diabetes, a routine screening procedure for gastroenterology inpatients, based on hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measurement, was established. Read More

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Hyperbaric oxygen treatment for toxic epidermal necrolysis: A case report.

Diving Hyperb Med 2021 Jun;51(2):216-219

University of Health Sciences, Kartal Dr Lütfi Kirdar City Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

Toxic epidermal necrolysis (TEN) is a potentially life-threatening muco-cutaneous disease, largely caused by an idiosyncratic reaction to medication or infectious disease, and is characterised by acute necrosis of the epidermis. No definitive consensus regarding the treatment of TEN has been agreed. A 60-year-old woman, diagnosed with multiple myeloma three months prior, was admitted with signs of TEN to the intensive care burns unit. Read More

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Statin associated lower cancer risk and related mortality in patients with heart failure.

Eur Heart J 2021 Jun 22. Epub 2021 Jun 22.

Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, No. 1 Haiyuan 1st Rd, Futian district, Shenzhen city, Guangdong province, 518009, China.

Aims: Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association of statin use with cancer risk and cancer-related mortality among patients with HF are sparse.

Methods And Results: Using a previously validated territory-wide clinical information registry, statin use was ascertained among all eligible patients with HF (n = 87 102) from 2003 to 2015. Read More

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Ultrasonographic 3D Evaluation in the Diagnosis of Bladder Endometriosis: A Prospective Comparative Diagnostic Accuracy Study.

Gynecol Obstet Invest 2021 Jun 22:1-8. Epub 2021 Jun 22.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy.

Objective: The use of three-dimensional (3D) transvaginal ultrasonography (TVS) has been investigated for the diagnosis of deep endometriosis (DE). This study aimed to evaluate if 3D reconstructions improve the performance of TVS) in assessing the presence and characteristics of bladder endometriosis (BE).

Design: This was a single-center comparative diagnostic accuracy study. Read More

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A deep learning framework with multi-perspective fusion for interictal epileptiform discharges detection in scalp electroencephalogram.

J Neural Eng 2021 Jun 22. Epub 2021 Jun 22.

BeiHang University School of Biological Science and Medical Engineering, No. 37 Xueyuan Road, Haidian District, Beijing, Beijing, 100191, CHINA.

Objective: Interictal epileptiform discharges (IEDs) are an important and widely accepted biomarker used in the diagnosis of epilepsy based on scalp electroencephalography (EEG). Because the visual detection of IEDs has various limitations, including high time consumption and high subjectivity, a faster, more robust, and automated IED detector is strongly in demand.

Approach: Based on deep learning, we proposed an end-to-end framework with multi-scale morphologic features in the time domain and correlation in sensor space to recognize IEDs from raw scalp EEG. Read More

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The risk of depression and anxiety in patients with familial mediterranean fever - a cross-sectional study.

J Affect Disord 2021 Jun 6;292:695-699. Epub 2021 Jun 6.

Division of Psychiatry, Barzilai Medical Center, Ashkelon, Israel.

Background: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease associated with various systemic comorbidities. Recent research regarding the association with depression and anxiety has yielded conflicting results. The current study aims were to examine whether such an association exists using big data analysis methodology. Read More

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[Health consequences (mortality and institutionalization) of hip fracture among the elderly people: Population cohort study in Segovia].

Aten Primaria 2021 Jun 19;53(9):102129. Epub 2021 Jun 19.

Medicina de Familia y Comunitaria, Centro de Salud Segovia 1 y Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.

Objective: In order to know the social and health consequences of hip fractures (HF).

Design: A retrospective cohort study of an entire health area was carried out in patients aged 75 or more, over a period of 5 years. SITE: Segovia Health Area. Read More

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Characteristics and oncologic outcomes of patients with Ewing Sarcoma of the scapula.

Surg Oncol 2021 Jun 16;38:101619. Epub 2021 Jun 16.

Department of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. Electronic address:

Background And Objectives: Ewing sarcoma is the second most common bone sarcoma of childhood. Ewing sarcomas of the scapula are rare, with little known about their characteristics and outcomes. In this study, we describe the demographic characteristics, tumor characteristics, and oncologic outcomes of patients with Ewing sarcoma of the scapula. Read More

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Mammographic density and prognosis in primary breast cancer patients.

Breast 2021 Jun 17;59:51-57. Epub 2021 Jun 17.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Purpose: Mammographic density (MD) is one of the strongest risk factors for breast cancer (BC). However, the influence of MD on the BC prognosis is unclear. The objective of this study was therefore to investigate whether percentage MD (PMD) is associated with a difference in disease-free or overall survival in primary BC patients. Read More

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Feasibility of using an automated analysis of formulation effort in patients' spoken seizure descriptions in the differential diagnosis of epileptic and nonepileptic seizures.

Seizure 2021 Jun 13;91:141-145. Epub 2021 Jun 13.

Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objective: There are three common causes of Transient Loss of Consciousness (TLOC), syncope, epileptic and psychogenic nonepileptic seizures (PNES). Many individuals who have experienced TLOC initially receive an incorrect diagnosis and inappropriate treatment. Whereas syncope can be distinguished relatively easily with a small number of "yes"/"no" questions, the differentiation of the other two causes of TLOC is more challenging. Read More

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Guideline interval: A new time interval in the diagnostic pathway for symptomatic cancer.

Cancer Epidemiol 2021 Jun 19;73:101969. Epub 2021 Jun 19.

College House, University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK. Electronic address:

Background: A standard measure of the cancer diagnostic pathway, diagnostic interval, is the time from "first presentation of cancer" to diagnosis. Cancer presentation may be unclear in patients with multimorbidity or non-specific symptoms, signs or test results ("features"). We propose an alternative, guideline interval, with a more certain start date; namely, when the patient first meets suspected-cancer criteria for investigation or referral. Read More

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Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.

Oral Oncol 2021 Jun 19;119:105370. Epub 2021 Jun 19.

Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China. Electronic address:

Secretory carcinoma (SC) and acinic cell carcinoma (AciCC) are two rare tumors originating in the salivary gland of the head and neck. Before the World Health Organization (WHO) classified SC as a new entity in 2017, the majority of SC cases were incorrectly diagnosed as AciCC. Indeed, they are similar in biological behaviors, clinical manifestations and histomorphological features. Read More

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Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience.

Leuk Res 2021 Jun 11;109:106642. Epub 2021 Jun 11.

Haematology and Bone Marrow Transplant Unit, IRCSS San Raffaele Scientific Institute, Italy. Electronic address:

Background: Chronic Graft versus Host Disease (GvHD) is a serious complication of allogeneic hematopoietic stem cell transplant that severely impacts quality of life and long-term survival. About 50-to-60 % of patients treated with steroids require a further line of therapy due to lack of sustained response. Ruxolitinib, a JAK1/2 inhibitor, has recently been approved for the treatment of acute GvHD. Read More

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DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations.

EBioMedicine 2021 Jun 19;69:103446. Epub 2021 Jun 19.

Phil Rivers Technology, Beijing, China; Western Institute of Advanced Technology, Chinese Academy of Science, Chongqing, China. Electronic address:

Background: Breast cancers can be divided into HER2-negative and HER2-positive subtypes according to different status of HER2 gene. Despite extensive studies connecting germline mutations with possible risk of HER2-negative breast cancer, the main category of breast cancer, it remains challenging to obtain accurate risk assessment and to understand the potential underlying mechanisms.

Methods: We developed a novel framework named Damage Assessment of Genomic Mutations (DAGM), which projects rare coding mutations and gene expressions into Activity Profiles of Signalling Pathways (APSPs). Read More

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Management of vascular complications following facial hyaluronic acid injection: high-dose hyaluronidase protocol: a technical note.

J Stomatol Oral Maxillofac Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of ENT and Maxillofacial surgery, Head and Neck Institute, University Hospital of Nice, France.. Electronic address:

Aesthetic medicine has experienced major developments in recent years, which is illustrated by the increasing number of hyaluronic acid injected in the area of facial rejuvenation. Although considered low risk, it can rarely result in arterial embolization with potentially major aesthetic and functional consequences. These vascular complications range from livedo to skin necrosis to permanent blindness. Read More

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Severe Maternal Morbidity and Mortality During Delivery Hospitalization of Class I, II, III, and Super Obese Women.

Am J Obstet Gynecol MFM 2021 Jun 19:100420. Epub 2021 Jun 19.

Yale School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut.

Background: Previous studies show that obesity predisposes patients to higher risks of adverse pregnancy outcomes. Data on the relationship between increasing degrees of obesity and risks of severe maternal morbidity (SMM), including mortality, are limited.

Objective: We examined the association of increasing classes of obesity, especially super obesity, with the risk of SMM and mortality at the time of delivery hospitalization. Read More

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SARS Cov2 Outbreak Management On A Landing Helicopter Dock : An Observational Retrospective Study.

Infect Dis Now 2021 Jun 19. Epub 2021 Jun 19.

Medical Unit, Land Helicopter Dock Dixmude, Toulon, France.

Objectives: Even though SARS Cov2 outbreak management has been well-described, scant information is available in military settings. We aimed to describe a SARS Cov2 outbreak and its management on the Dixmude, a French landing helicopter dock.

Patients And Methods: We performed an observational retrospective and monocentric study in a ship. Read More

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Endosonography-Guided Biopsy as a First Test in the Diagnosis of Lymphoma.

Semin Thorac Cardiovasc Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of Surgery, Division of Thoracic Surgery, CHUM Endoscopic Tracheobronchial and Oesophageal Center (CETOC), University of Montreal, Montreal, Quebec, Canada. Electronic address:

To evaluate the diagnostic accuracy of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) and Endoscopic Ultrasound-guided Fine Needle Aspiration (EUS-FNA) in the diagnosis of lymphoma. A retrospective analysis of patients with suspected mediastinal lymphoproliferative disorders who underwent EBUS-TBNA, EUS-FNA or combined procedures from 2009 to 2019 was conducted using a prospectively maintained interventional thoracic endoscopy database. Demographic data, imaging, needle size, surgical biopsy, complications rate and pathology reports were reviewed. Read More

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Using a stepwise approach to simultaneously develop and validate Machine Learning based prediction models: Stepwise model development and validation.

J Clin Epidemiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Epidemiology, Medisch Spectrum Twente, Enschede, the Netherlands.

Accurate diagnosis of a disease is essential in healthcare. Prediction models, based on classical regression techniques, are widely used in clinical practice. Machine Learning (ML) techniques might be preferred in case of a large amount of data per patient and relatively limited numbers of subjects. Read More

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Effect of the mediterranean diet on histological indicators and imaging tests in non-alcoholic fatty liver disease.

Gastroenterol Hepatol 2021 Jun 19. Epub 2021 Jun 19.

Escuela de Nutrición y Dietética. Facultad de Farmacia Universidad de Valparaíso, Chile. Electronic address:

Aim: To analyze the scientific evidence regarding to the effect of the Mediterranean diet on the imaging tests and biopsy characteristics in subjects with non-alcoholic fatty liver disease.

Methods: A bibliographic search was carried out in this narrative review in Pubmed and Web of Science databases, considering studies published between 2011-2020, in english or spanish, randomized clinical trials and observational studies in patients with a diagnosis of non-alcoholic fatty liver disease, in subjects over 18 years of age of both sexes.

Results: In the observational studies found, an inverse association between adherence to a Mediterranean diet and liver damage stands out, while in the intervention studies with measurement of liver biopsy a 4. Read More

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Prevalence and characteristics of myocardial injury during COVID-19 pandemic: A new role for high-sensitive troponin.

Int J Cardiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Cardiovascular and Pulmonary Sciences, Università Cattolica Sacro Cuore, Rome, Italy.

Background: Coronavirus disease 2019 (COVID-19) is a pandemic disease that is causing a public health emergency. Characteristics and clinical significance of myocardial injury remain unclear.

Methods: This retrospective single-center study analyzed analyzed 189 patients who received a COVID-19 diagnosis out of all 758 subjects with a high sensitive troponin I (Hs-TnI) measurement within the first 24 h of admission at the Policlinico A. Read More

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Vaginal Free Graft Dorsal Onlay Urethroplasty.

Urology 2021 Jun 19. Epub 2021 Jun 19.

Henry Ford Hospital, K-9, Vattikuti Urology Institute, Detroit, MI, 48202, United States of America. Electronic address:

Objective: Female urethral stricture is a rare, but often underrecognized, cause of voiding dysfunction in females. Vaginal free graft urethroplasty has been shown to have good efficacy and durability in treating urethral stricture, though accessible descriptions of technique are not widely available. Accordingly, we set out to describe and demonstrate our technique for vaginal mucosal free graft dorsal onlay urethroplasty. Read More

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Spinal and cranio-cervical mycetoma: a difficult surgery, with poor prognosis.

Neurochirurgie 2021 Jun 19. Epub 2021 Jun 19.

Department of Neurosurgery, Hôpital de Bretonneau, Tours, France.

Background: Few central nervous systems (CNS) cases of actinomycetoma have been recorded in the literature, and most were reported in tropical and subtropical regions. The management of this invasive infection is difficult, especially when it affects the spine and the cranio-cervical regions.

Case: We report an unusual case of a cranio-cervical junction actinomycetoma, in a patient presenting a cerebellar syndrome from brainstem compression. Read More

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Neurochirurgie 2021 Jun 19. Epub 2021 Jun 19.

Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Background: The jugular foramen (JF) can be the site of several tumours. Paragangliomas, schwannomas and meningiomas are the most commonly reported. We describe a case of melanocytoma originating from the JF and presenting with an accessory nerve palsy. Read More

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Priapism in lymphoproliferative disorders: A systematic review.

Hematol Oncol Stem Cell Ther 2021 Jun 10. Epub 2021 Jun 10.

Department of Hematology and Oncology, Hamad Medical Corporation, Doha, Qatar.

Priapism is defined as a persistent penile erection lasting more than 4 h. We searched the literature for reviews, case reports, and series for patients with lymphoproliferative disorders who developed priapism. The search involved all the lymphoproliferative disorders included in the revised 2016 World Health Organization classification of lymphoid neoplasms including chronic lymphocytic leukemia, multiple myeloma, Waldenström macroglobulinemia, and lymphomas. Read More

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Infective Endocarditis and Solid Organ Transplantation: Only worse outcomes during initial transplantation hospitalization.

Am Heart J 2021 Jun 19. Epub 2021 Jun 19.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA; Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: The epidemiology, and outcome of infective endocarditis (IE) among solid organ transplant (SOT) recipients is unknown.

Methods: We used data from the 2013-2018 Nationwide Readmissions Database (NRD). IE- and SOT-associated hospitalizations were identified using diagnosis and procedure codes. Read More

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Accuracy of Magnetic Resonance Imaging in Evaluating the Depth and Level of Invasion of Buccal Carcinoma: A Prospective Cohort Study.

J Oral Maxillofac Surg 2021 May 18. Epub 2021 May 18.

Department Head, Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China. Electronic address:

Purpose: This study evaluated the accuracy of magnetic resonance imaging (MRI) in determining the depth and level of invasion of buccal carcinoma.

Methods: Patients with buccal squamous cell carcinoma diagnosed pathologically from July 2016 to December 2019 were included. The depth of invasion (DOI) and level of invasion (LOI) were evaluated by MRI, intraoperative specimens and pathological sections. Read More

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