573,255 results match your criteria patient developed


An efficient design for real-time obstructive sleep apnea OSA detection through esophageal pressure Pes signal.

Biomed Tech (Berl) 2021 May 5. Epub 2021 May 5.

Tunisian Society of Sleep Medicine TSSM, Tunis, Tunisia.

Obstructive Sleep Apnea (OSA) is a potentially common sleep disorder in which the upper airways are collapsed either partially or completely. The golden standard method for treating OSA, is the full night Continuous Positive Airway Pressure (CPAP). Yet, due to the ensuing discomfort, it incurs on patients, researchers have been motivated to investigate other alternatives, whereby, OSA can be effectively treated. Read More

View Article and Full-Text PDF

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models.

CPT Pharmacometrics Syst Pharmacol 2021 Apr;10(4):309-317

Department of Pharmacy, Uppsala University, Uppsala, Sweden.

This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progression. Two historical studies of the dopaminergic drug ropinirole were analyzed: a cross-over formulation comparison trial in 161 patients with early-stage Parkinson's disease, and a 24-week, parallel-group, placebo-controlled efficacy trial in 393 patients with advanced-stage Parkinson's disease. We applied item response theory to estimate the patients' symptom severity and developed a longitudinal model using the symptom severity to describe the time course of the placebo response and the drug effect on the time course. Read More

View Article and Full-Text PDF

Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

Authors:
Vita Boyar

J Wound Ostomy Continence Nurs 2021 May-Jun 01;48(3):256-261

Vita Boyar, MD, Steven & Alexandra Cohen Children's Medical Center, New Hyde Park, New York; and Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Background: Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has been used for pediatric patients over the last decade. In addition, bevacizumab is used for neonatal intravitreal administration for retinopathy of prematurity, a major complication of preterm birth, characterized by incomplete and abnormal vascularization of the retina that can lead to retinal detachment and blindness without treatment. Read More

View Article and Full-Text PDF

Topical Management of Peristomal Pyoderma Gangrenosum: A Report of 3 Case Studies.

J Wound Ostomy Continence Nurs 2021 May 3. Epub 2021 May 3.

Tomohiro Toyoda, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Shinji Mitsuyama, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Eri Nagao, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Fumihito Abe, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Masaaki Kimura, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Yurie Seido, RN, WOC Nurse, Department of Nursing Care, Toho University Sakura Medical Center, Sakura, Japan. Tetsuya Higuchi, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan.

Background: Peristomal pyoderma gangrenosum (PPG) presents multiple challenges for healthcare providers. The diagnosis of PPG may be delayed, and it may be mistaken for an irritant dermatitis or an infection. Patients with ostomies secondary to inflammatory bowel disease (IBD) may experience PPG. Read More

View Article and Full-Text PDF

Lessons From Learners: Adapting Medical Student Education During and Post-COVID-19.

Acad Med 2021 May 4. Epub 2021 May 4.

M.R.H. Castro is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-2085-4893. L.M. Calthorpe is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-0496-9471. S.E. Fogh is associate professor, Department of Radiation Oncology, University of California San Francisco School of Medicine, San Francisco, California. S. McAllister is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. C.L Johnson is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. E.D. Isaacs is professor of emergency medicine, Department of Emergency Medicine, University of California San Francisco, San Francisco, California. A. Ishizaki is manager, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. A. Kozas is curriculum coordinator, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. D. Lo is assistant professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco School of Medicine; and Department of Geriatrics and Extended Care, San Francisco Veterans Affairs Health Care System, San Francisco, California. S. Rennke is professor of medicine, Division of Hospital Medicine, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California. J. Davis is professor of medicine and associate dean for curriculum, University of California San Francisco School of Medicine, San Francisco, California. A. Chang is professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California.

In response to the COVID-19 pandemic, many medical schools suspended clinical clerkships and implemented newly adapted curricula to facilitate continued educational progress. While the implementation of these new curricula has been described, an understanding of the impact on student learning outcomes is lacking. In 2020, the authors followed Kern's 6-step approach to curricular development to create and evaluate a novel COVID-19 curriculum for medical students at the University of California San Francisco School of Medicine and evaluate its learning outcomes. Read More

View Article and Full-Text PDF

Preoperative Parameters to Predict the Development of Symptomatic Lymphoceles after Radical Prostatectomy.

Urol Int 2021 May 5:1-8. Epub 2021 May 5.

Department of Urology, Uro-Oncology, Robot-assisted and Specialized Urologic Surgery, Cologne University Hospital, Cologne, Germany.

Introduction: Symptomatic lymphoceles (SLs) represent the most common complication after radical prostatectomy (RP) and pelvic lymph node dissection (PLND). To date, preoperative risk factors are missing.

Methods: Clinical and pathological data of 592 patients who underwent RP and PLND were evaluated. Read More

View Article and Full-Text PDF

Development of a Multivariable Prediction Model for Citrate Accumulation in Liver Transplant Patients Undergoing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation.

Blood Purif 2021 May 5:1-11. Epub 2021 May 5.

Surgical Intensive Care Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Introduction: Patients with impaired citrate metabolism may experience citrate accumulation (CA), which causes life-threatening metabolic acidosis and hypocalcemia. CA poses a challenge for clinicians when deciding on the use of regional citrate anticoagulation (RCA) for patients with liver dysfunction. This study aimed to develop a prediction model integrating multiple clinical variables to assess the risk of CA in liver transplant patients. Read More

View Article and Full-Text PDF

Popliteal Artery Thrombosis in a Young Patient Secondary to Proximal Tibial Osteochondroma.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Division of Interventional Radiology, Department of Radiology, Mayo Clinic Health System Northwest Wisconsin, 1400 Bellinger St, Eau Claire WI 54701. Electronic address:

Popliteal artery occlusion is mainly seen in elderly patients with late stage atherosclerotic occlusive disease. In young, nonsmoking patients, popliteal artery occlusion can be caused by a variety of other etiologies. The diagnosis is suspected clinically and confirmed with ultrasound, computed tomography angiogram(CTA) or angiography, which can also aid in understanding the underlying cause. Read More

View Article and Full-Text PDF

Post-operative Recurrent Ascending Aortic Pseudoaneurysm with Aorto-cutaneous Fistula- Endovascular management with an In-situ stent-graft fenestration for the Innominate Artery.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Professor, Department of Cardiothoracic Surgery, Nizam's Institute of Medical Sciences, Hyderabad, India.

Ascending aortic pseudoaneurysm is a known complication of previous cardiac surgery that needs surgical or endovascular intervention. The presence of arch branches complicates the later approach necessitating additional procedures, either hybrid surgical or endovascular modification of the grafts. We describe a patient who developed an ascending aortic pseudoaneurysm after mitral valve replacement, which recurred after surgical patch closure with the formation of a cutaneous fistula. Read More

View Article and Full-Text PDF

TB-QUICK: CRISPR-Cas12b-assisted rapid and sensitive detection of Mycobacterium tuberculosis.

J Infect 2021 May 2. Epub 2021 May 2.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025,China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China. Electronic address:

Objectives: Tuberculosis (TB) remains one of the public health problems worldwide. Rapid, sensitive and cost-effective diagnosis of Mycobacterium tuberculosis (M.tb) is critical for TB control. Read More

View Article and Full-Text PDF

Interictal spike networks predict surgical outcome in patients with drug-resistant focal epilepsy.

Ann Clin Transl Neurol 2021 May 5. Epub 2021 May 5.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.

Objective: To determine if properties of epileptic networks could be delineated using interictal spike propagation seen on stereo-electroencephalography (SEEG) and if these properties could predict surgical outcome in patients with drug-resistant epilepsy.

Methods: We studied the SEEG of 45 consecutive drug-resistant epilepsy patients who underwent subsequent epilepsy surgery: 18 patients with good post-surgical outcome (Engel I) and 27 with poor outcome (Engel II-IV). Epileptic networks were derived from interictal spike propagation; these networks described the generation and propagation of interictal epileptic activity. Read More

View Article and Full-Text PDF

Multicenter clinical evaluation of a piezoresistive-MEMS-sensor rapid-exchange pressure microcatheter system for fractional flow reserve measurement.

Catheter Cardiovasc Interv 2021 May 5. Epub 2021 May 5.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: This multicenter, prospective clinical study investigates whether the microelectromechanical-systems-(MEMS)-sensor pressure microcatheter (MEMS-PMC) is comparable to a conventional pressure wire in fractional flow reserve (FFR) measurement.

Background: As a conventional tool for FFR measurement, pressure wires (PWs) still have some limitations such as suboptimal handling characteristics and unable to maintain the wire position during pullback assessment. Recently, a MEMS-PMC compatible with any 0. Read More

View Article and Full-Text PDF

From the (skin) doctor's office to the lecture hall: An innovative, practice-oriented, media-supported teaching project with supra-regional interdisciplinary usage options.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Medical Faculty of CAU Kiel, Kiel, Germany.

Background: The transfer of practical knowledge and skills is the focus of modern medical teaching (master plan medical studies 2020). The aim of the teaching project is to provide medical students with important dermatological learning goals and contents by using innovative methods.

Methods: As part of a teaching project funded by the Federal Ministry of Education and Research (BMBF) at the Department of Dermatology, University Hospital Schleswig-Holstein in Kiel, various new, partly media-supported teaching modules were developed in addition to curricular teaching and optimized by regular acceptance evaluations during the development process. Read More

View Article and Full-Text PDF

Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo.

J Dermatol 2021 May 5. Epub 2021 May 5.

Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Nagoya, Japan.

A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol-induced leukoderma based on data from original or review articles published in the literature to provide a wide range of information regarding the pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments. We compile and discuss the latest information, including data related to the cytotoxicity of rhododendrol, cytoprotective functions, and involvement of the immune system, and consider the possibility of novel treatments based on the differences between individual patients and on the mechanism underlying the onset of the condition. Read More

View Article and Full-Text PDF

Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathies patients.

J Med Virol 2021 May 5. Epub 2021 May 5.

Rehabilitation Unit, Maggiore City Hospital Department of Medicine, Surgery and Health Sciences, ASUGI, 34149, Trieste, Italy.

This case series describes three patients affected by SARS-CoV-2 who developed polyradiculoneuritis as a probable neurological complication of COVID-19. A diagnosis of Guillain Barré syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis and electroneurography (ENG). In all of them therapeutic approach included the administration of intravenous immunoglobulin (0. Read More

View Article and Full-Text PDF

Dysphagia due to necrotizing otitis externa.

Age Ageing 2021 May;50(3):1004-1005

University of Nottingham School of Health Sciences, Nottingham, UK.

An 88-year-old man presented with delirium, and subsequently developed hoarseness and oropharyngeal dysphagia. This was due to skull-based osteomyelitis from necrotizing otitis externa (NOE), causing lower cranial nerve (X, XII) palsies and venous sinus thrombosis. Diagnosis was delayed as the patient reported no otalgia, had an almost normal looking external auditory canal and was not diabetic. Read More

View Article and Full-Text PDF

Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial.

Anesthesiology 2021 May 5. Epub 2021 May 5.

Background: Individualized hemodynamic management during surgery relies on accurate titration of vasopressors and fluids. In this context, computer systems have been developed to assist anesthesia providers in delivering these interventions. This study tested the hypothesis that computer-assisted individualized hemodynamic management could reduce intraoperative hypotension in patients undergoing intermediate- to high-risk surgery. Read More

View Article and Full-Text PDF

Azathioprine-induced toxoplasma gondii infection in a patient with Crohn's disease with NUDT15 variation: A case report.

Medicine (Baltimore) 2021 May;100(18):e25781

Department of Gastroenterology, The Second Xiangya Hospital.

Introduction: Azathioprine (AZA) has been widely used for the treatment of various immune-related diseases and has become a mainstay in the treatment of inflammatory bowel disease. However, patients with genetic mutations may experience severe adverse events when treated with azathioprine. Most of the previous literature focused on the TPMP gene-related adverse reactions, herein, we report a case of Crohn's disease patient with nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) variation and wild-type TPMP gene who developed toxoplasma gondii infection after azathioprine treatment. Read More

View Article and Full-Text PDF

A breastfeeding woman with spontaneous coronary artery dissection and possible takotsubo syndrome: A case report.

Medicine (Baltimore) 2021 May;100(18):e25775

Department of Cardiology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan.

Rationale: The relationship between spontaneous coronary artery dissection (SCAD) and takotsubo syndrome (TTS) remains unclear. Coexistence of SCAD and TTS has been reported in the literature. However, the relationship between these two diseases has not yet been elucidated. Read More

View Article and Full-Text PDF

Sarcomatoid carcinoma associated with chronic empyema and early lung and pleural metastases: A case report.

Medicine (Baltimore) 2021 May;100(18):e25692

Department of Pathology, Inha University Hospital, Inha University College of Medicine, Jung-gu, Incheon, South Korea.

Introduction: The relationship between chronic empyema and malignant tumors, most of which are lymphoma, has been recognized for many decades. Sarcomatoid carcinoma associated with chronic empyema is extremely rare, may metastasize to other organs in the early stage, and rapidly progresses to death. As far as we know, this was the first case report on sarcomatoid carcinoma associated chronic empyema. Read More

View Article and Full-Text PDF

Mycoplasma hominis Lumbar Wound Infection After Posterior Decompression and Instrumented Fusion: A Case Report.

JBJS Case Connect 2021 05 5;11(2). Epub 2021 May 5.

Singhealth Orthopaedic Residency, Department of Orthopedic Surgery, Changi General Hospital, Singapore, Singapore.

Case: A 63-year-old man underwent L2-S1 decompression and fusion for spinal stenosis. He developed urinary retention postoperatively requiring catheterization. He developed fever, purulence, and foot-drop 8 days postoperatively and underwent debridement with implant retention. Read More

View Article and Full-Text PDF

Rasch Analysis of the Listening Effort Questionnaire-Cochlear Implant.

Ear Hear 2021 May 4. Epub 2021 May 4.

Patient and Population Health and Informatics, Swansea University Medical School, Singleton Park, Swansea, United Kingdom Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia Faculty of Medicine and Health, School of Health Sciences, University of Sydney, Sydney, NSW, Australia HEAR Centre, Macquarie University, Sydney, NSW, Australia.

Objectives: Listening effort may be defined as the attentional and cognitive resources needed to understand an auditory message, modulated by motivation. Despite the use of hearing devices such as hearing aids or cochlear implants (CIs), the requirement for high listening effort remains a challenge for individuals with hearing loss. The Listening Effort Questionnaire-Cochlear Implant (LEQ-CI) is a hearing-specific patient-reported outcome measure (PROM), which has been designed for use in the CI candidacy and rehabilitation process to assess perceived listening effort in everyday life in adults with severe-profound hearing loss. Read More

View Article and Full-Text PDF

Focused Ultrasound Biofilm Ablation: Investigation of Histotripsy for the Treatment of Catheter-Associated Urinary Tract Infections (CAUTIs).

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 5;PP. Epub 2021 May 5.

Urinary catheters often become contaminated with biofilms, resulting in catheter-associated urinary tract infections (CAUTIs) that adversely affect patient outcomes. Histotripsy is a non-invasive focused ultrasound therapy previously developed for the non-invasive ablation of cancerous tumors and soft tissues. Histotripsy has also previously shown the ability to treat biofilms on glass slides and surgical meshes. Read More

View Article and Full-Text PDF

Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy.

ACS Chem Neurosci 2021 May 5. Epub 2021 May 5.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.

Neuromuscular diseases result in muscle weakness, disability, and, in many instances, death. Preclinical models form the bedrock of research into these disorders, and the development of and potentially translational biomarkers for the accurate identification of disease is crucial. Spontaneous Raman spectroscopy can provide a rapid, label-free, and highly specific molecular fingerprint of tissue, making it an attractive potential biomarker. Read More

View Article and Full-Text PDF

En kvinne i 50-årene med magesmerter og alvorlig laktacidose.

Tidsskr Nor Laegeforen 2021 Apr 27. Epub 2021 Apr 27.

Background: Pheochromocytoma is referred to as 'the great mimic' with a broad spectrum of presenting symptoms. In the following case, the diagnosis had an unusual presentation as a medical emergency - pheochromocytoma crisis.

Case Presentation: A previously healthy woman in her fifties was admitted due to abdominal pain and dyspnoea. Read More

View Article and Full-Text PDF

Electroencephalography of mechanically ventilated patients at high risk of delirium.

Acta Neurol Scand 2021 May 5. Epub 2021 May 5.

Department of Intensive Care Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Objective: Neurophysiological exploration of ICU delirium is limited. Here, we examined EEG characteristics of medical-surgical critically ill patients with new-onset altered consciousness state at high risk for ICU delirium.

Materials And Methods: Pre-planned analysis of non-neurological mechanically ventilated medical-surgical ICU subjects, who underwent a prospective multicenter randomized, controlled EEG study (NCT03129438, April 2017-November 2018). Read More

View Article and Full-Text PDF

Return to work of breast cancer survivors: toward an integrative and transactional conceptual model.

J Cancer Surviv 2021 May 5. Epub 2021 May 5.

Univ Angers, Univ Rennes, Inserm, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, SFR ICAT, F-49000, Angers, France.

Purpose: To propose a conceptual framework of the return to work (RTW) of breast cancer survivors (BCS) according to the transactional perspective.

Methods: The Technique for Research of Information by Animation of a Group of Experts was implemented. For each determinant in an initial list established from the literature, experts selected for the consensus exercise were firstly asked to indicate their agreement level individually, via an online questionnaire. Read More

View Article and Full-Text PDF

Patient-caregiver agreement and test-retest reliability of the EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients with haematological malignancies.

Eur J Health Econ 2021 May 5. Epub 2021 May 5.

Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, Singapore.

Background: In 2019, the EuroQol Group developed a 'beta' 5-level version of EQ-5D-Y (Y-5L) by increasing the number of descriptive levels to five for each health dimension, as compared to the standard 3-level EQ-5D-Y (Y-3L).

Objective: To assess patient-caregiver agreement and test-retest reliability of the Y-5L and Y-3L in paediatric patients with haematological malignancies.

Methods: Paediatric inpatients aged 8-17 years were interviewed with the Y-5L and Y-3L questionnaires twice, while their caregivers were interviewed at the same time using the proxy versions of the questionnaires. Read More

View Article and Full-Text PDF

Convolutional neural networks for the diagnosis and prognosis of the coronavirus disease pandemic.

Vis Comput Ind Biomed Art 2021 May 5;4(1):12. Epub 2021 May 5.

Department of Computer Science, Kuvempu University, Shimoga, Karnataka, 577451, India.

A neural network is one of the current trends in deep learning, which is increasingly gaining attention owing to its contribution in transforming the different facets of human life. It also paves a way to approach the current crisis caused by the coronavirus disease (COVID-19) from all scientific directions. Convolutional neural network (CNN), a type of neural network, is extensively applied in the medical field, and is particularly useful in the current COVID-19 pandemic. Read More

View Article and Full-Text PDF

Transvaginal primary layered repair of postsurgical urethrovaginal fistula.

Int Urogynecol J 2021 May 5. Epub 2021 May 5.

ASST Monza, Ospedale San Gerardo, via G.B. Pergolesi, 33 20900, Monza, Italy.

Introduction And Hypothesis: Urethrovaginal fistula (UVF) is a rare disorder, which implies the presence of an abnormal communication between the urethra and the vagina.

Methods: Surgical repair options include transurethral, transabdominal and transvaginal procedures, either with or without tissue interposition. The vaginal route is considered a safe and effective option to correct UVF. Read More

View Article and Full-Text PDF