1,693,944 results match your criteria patient cancer

Germline mutations and age at onset of lung adenocarcinoma.

Cancer 2021 Apr 15. Epub 2021 Apr 15.

City of Hope Comprehensive Cancer Center, Duarte, California.

Background: To identify additional at-risk groups for lung cancer screening, which targets persons with a long history of smoking and thereby misses younger or nonsmoking cases, the authors evaluated germline pathogenic variants (PVs) in patients with lung adenocarcinoma for an association with an accelerated onset.

Methods: The authors assembled a retrospective cohort (1999-2018) of oncogenetic clinic patients with lung adenocarcinoma. Eligibility required a family history of cancer, data on smoking, and a germline biospecimen to screen via a multigene panel. Read More

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[Oncological Rehabilitation and Development of Strategies in Crisis Situations Using the Example of the Covid 19 Pandemic in 2020 by Using a Patient and Staff Survey Results of Pandemic Care].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):142-151. Epub 2021 Apr 15.

Klinik Sonnenblick der Deutschen Rentenversicherung Hessen, Marburg.

Introduction: Cancer is a life-threatening disease often with curative therapy approaches, high risk of relapse and distressing symptoms, which require immediate, quality-assured care throughout the entire therapy process including rehabilitation, even in a pandemie.

Methods: We started to develop a pandemic plan to maintain oncological rehabilitation in February 2020. With the involvement of the whole clinic staff we developed protection scenarios with the aim of achieving Covid-19-free clinics. Read More

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[Development of a Psychosocial Online Self-Help Program for Cancer Patients: A Patient-Oriented Approach].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):132-141. Epub 2021 Apr 15.

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz.

Aim Of The Study: Involving potential end users in the development process of digital interventions makes it possible to ensure that these programs meet the needs, requirements and expectations of future users, which in turn has a positive impact on acceptance and adherence. This contribution presents a participatory development approach for the patient-centered design of the psycho-oncological online self-help , which aims to provide support in coping with cancer.

Methods: Patients were involved in the developmental process at two points. Read More

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[Childhood Cancer Patients in a Family-Oriented Rehabilitation Program: Goals and Change in Physical Functioning].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):124-131. Epub 2021 Apr 15.

Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Deutschland.

Purpose: Childhood cancer often leads to physical and psychosocial burdens that can persist beyond the end of treatment. Family-oriented rehabilitation programs (FOR) focus on long-term consequences and support families in returning to daily life. The objectives of this study were to describe rehabilitation goals and goal attainment, to analyze the relationship between physical functioning and physical well-being and to examine predictors of changes in physical functioning during the FOR. Read More

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[A Motivational-Volitional Program for Women after Breast Cancer Increases Physical Activity 12 Months Post Rehabilitation - Results of a Prospective Controlled Trial].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):110-123. Epub 2021 Apr 15.

Pädagogische Hochschule Freiburg.

Purpose: To assess the effectiveness of a motivational-volitional program for women after breast cancer (MoVo-BnB) who engage less than 60 minutes per week in physical activity.

Methods: This is a non-randomised, prospective bi-centered controlled trial in 2 in-patient medical rehabilitation centers. Data are assessed at 4 measurement points: at admission, discharge, 6 and 12 months post discharge. Read More

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[The Impact of Health literacy on Health Outcomes in Cancer Patients Attending Inpatient Rehabilitation].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):102-109. Epub 2021 Apr 15.

Institut für Klinische Epidemiologie und Biometrie (IKE-B), Universität Würzburg.

Purpose: Health literacy (HL) entails people's knowledge, motivation, and competences to access, understand, appraise, and apply health information. Lower HL is associated with poorer psychosocial health. However, there are no studies so far evaluating the impact of HL within oncological rehabilitation in Germany. Read More

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[Predictors of the Utilization and Waiting Period Before Starting an Oncological Rehabilitation after Breast Cancer].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):86-94. Epub 2021 Apr 15.

Forschungs- und Lehreinheit Medizinische Soziologie, Med. Hochschule Hannover.

Purpose: This study explores the sociodemographic, medical and work-related factors leading to a participation in an in-house rehabilitation measure after primary treatment for breast cancer.

Methods: The prospective multi-center study is based on a written survey with employed breast cancer patients who were recruited at 11 breast cancer centers in Lower Saxony, Germany. Predictors of participation were examined by logistic regression, predictors of the time period before starting the rehabilitation by linear regression. Read More

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[Early and Late Toxicities and Socio-Medical Relevant Disorders after Oncological Treatment for Breast Cancer-Implications and Assessment of Rehabilitation Requirement].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):77-85. Epub 2021 Apr 15.

Frauenklinik, Universitätsklinikum, Würzburg.

Introduction: Reasonable to the improved prognosis of breast cancer (BC) long-term toxicities and side effects of oncological therapy gain more importance for work ability and social life of BC patients. Aim of this study was the analysis of occurence and differences of treatment-related side effects in relation to type of rehabilitation (so-called AHB vs. later rehabilitation) after therapy for BC. Read More

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Fully Automated Segmentation of Pulmonary Fibrosis Using Different Software Tools.

Respiration 2021 Apr 15:1-8. Epub 2021 Apr 15.

Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany.

Objective: Evaluation of software tools for segmentation, quantification, and characterization of fibrotic pulmonary parenchyma changes will strengthen the role of CT as biomarkers of disease extent, evolution, and response to therapy in idiopathic pulmonary fibrosis (IPF) patients.

Methods: 418 nonenhanced thin-section MDCTs of 127 IPF patients and 78 MDCTs of 78 healthy individuals were analyzed through 3 fully automated, completely different software tools: YACTA, LUFIT, and IMBIO. The agreement between YACTA and LUFIT on segmented lung volume and 80th (reflecting fibrosis) and 40th (reflecting ground-glass opacity) percentile of the lung density histogram was analyzed using Bland-Altman plots. Read More

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Characteristics Associated With Functional Changes During Systemic Cancer Treatments: A Systematic Review Focused on Older Adults.

J Natl Compr Canc Netw 2021 Apr 15:1-8. Epub 2021 Apr 15.

2Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

Background: Maintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125). Read More

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Early ctDNA response to chemotherapy. A potential surrogate marker for overall survival.

Eur J Cancer 2021 Apr 12;149:128-133. Epub 2021 Apr 12.

Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark.

Aim: The aim of the study was to compare ctDNA response rate and objective response rate as surrogate markers for overall survival (OS) in patients with metastatic cancer treated with chemotherapy.

Methods: The study included 420 patients distributed in five cohorts with colorectal, ovarian, and non-small cell lung cancer. It represents a retrospective analysis of patients enrolled in prospective biomarker studies and clinical trials. Read More

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LncRNA signature in colorectal cancer.

Pathol Res Pract 2021 Apr 7;222:153432. Epub 2021 Apr 7.

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Colorectal cancer (CRC) is among the most frequent cancers and is associated with high mortality particularly when being diagnosed in advanced stages. Although several environmental and intrinsic risk factors have been identified, the underlying cause of CRC is not clear in the majority of cases. Several studies especially in the recent decade have pointed to the role of epigenetic factors in this kind of cancer. Read More

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Exploring the association between metastatic sites and androgen receptor splice variant 7 (AR-V7) in castration-resistant prostate cancer patients: A meta-analysis of prospective clinical trials.

Pathol Res Pract 2021 Apr 9;222:153440. Epub 2021 Apr 9.

Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy.

Background: The Androgen Receptor Splice Variant 7 (AR-V7) has been associated with poor clinical outcomes in patients with castration-resistant prostate cancer (CRPC). Herein, we performed a meta-analysis aimed at systematically exploring the association between metastatic sites and AR-V7 expression in CRPC patients across prospective clinical trials.

Methods: We retrieved all the relevant prospective clinical trials through PubMed/Medline, Cochrane library, and EMBASE; additionally, proceedings of the main international oncological meetings were also searched for relevant abstracts. Read More

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Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study.

Pathol Res Pract 2021 Apr 5;222:153434. Epub 2021 Apr 5.

Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, 14068, Republic of Korea.

Local recurrences in early gastric cancers (EGCs) after complete endoscopic submucosal dissection (ESD) remain problematic. Here, we investigated the spatially sequential molecular changes in various cancer-related proteins along the axis of the histologically clear but recurrent resection margins (TRM) to determine the appropriate tumor-free margin distance and potential molecular risk markers related to local recurrence. Five eligible patients with recurrent EGCs after complete ESD were selected from 548 EGC patients. Read More

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Postoperative extremity compartment syndrome in a cancer center: Incidence and risk factors.

Surg Oncol 2021 Apr 3;38:101563. Epub 2021 Apr 3.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Objective: Postoperative compartment syndrome is a reported complication with known patient- and treatment-specific risk factors. Cancer patients carry unique risk factors associated with their underlying disease and long, complex procedures. While elevated serum lactate in traumatic and intensive care settings portends higher risk, no laboratory parameter has demonstrated utility in postoperative risk stratification. Read More

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Postoperative morbidity following pancreatic cancer surgery is significantly associated with worse overall patient survival; systematic review and meta-analysis.

Surg Oncol 2021 Apr 6;38:101573. Epub 2021 Apr 6.

Department of Visceral, Thoracic- and Vascular Surgery, Philipps-University Marburg, Germany.

Backround: The influence of postoperative morbidity on survival after potentially curative resection for pancreatic ductal adenocarcinoma (PDAC) remains unclear.

Methods: Medline, Web of Science and Cochrane Library were searched for studies reporting survival in patients with and without complications, defined according to the Clavien-Dindo classification, after primary, potentially curative resection for pancreatic cancer followed by adjuvant treatment. Meta-analysis was performed using a random-effects model. Read More

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Stage of ovarian cancer at diagnosis. Does presentation as an emergency make a difference?

Eur J Obstet Gynecol Reprod Biol 2021 Apr 5;261:7-11. Epub 2021 Apr 5.

Study Conducted in Sheffield Teaching Hospitals Obstetrics and Gynaecology Unit, Sheffield, South Yorkshire, United Kingdom.

Objectives: The purpose of this study is to evaluate whether presentation of ovarian cancer as an emergency compared to presentation via referral to diagnostic clinic has an impact on stage of disease at diagnosis. Secondary outcomes include the relationship between stage of diagnosis and age as well as socioeconomic status and type of presentation (emergency or clinic referral).

Study Design: Data were obtained from the central database for all new diagnoses of ovarian, fallopian tube or primary peritoneal malignancy at a tertiary teaching hospital for 2016-2018 (n = 147). Read More

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Tumor Biology Impacts Survival in Surgically Managed Primary Hepatic Vascular Malignancies.

J Surg Res 2021 Apr 12;264:481-489. Epub 2021 Apr 12.

Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas; North Texas Veterans Affairs Medical Center, Dallas, Texas. Electronic address:

Background: Hepatic angiosarcoma (AS) and hepatic epithelioid hemangioendothelioma (HEHE) are rare primary hepatic vascular malignancies (PHVM) that remain poorly understood. To guide management, we sought to identify factors and trends predicting survival after surgical intervention using a national database.

Materials And Methods: In a retrospective analysis of the National Cancer Database patients with a diagnosis of PHVM were identified. Read More

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Efficacy and safety of apixaban for primary prevention in gastrointestinal cancers: A post-hoc analysis of the AVERT trial.

Thromb Res 2021 Mar 21;202:151-154. Epub 2021 Mar 21.

Department of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada. Electronic address:

Background: Recent trials have demonstrated that thromboprophylaxis using direct oral anticoagulants is effective but associated with a higher rate of major bleeding in intermediate-to-high risk (Khorana score ≥ 2) patients with cancer initiating systemic chemotherapy. Patients with gastrointestinal cancer may be at higher risk of major bleeding complications. We sought to assess the efficacy and safety of using thromboprophylaxis with apixaban in this patient population. Read More

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The effect of reconstruction on positive margin rates in oral cancer: Using length of stay as a proxy measure for flap reconstruction in a national database.

Am J Otolaryngol 2021 Mar 29;42(5):103012. Epub 2021 Mar 29.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

Purpose: Planned flap reconstruction, allowing aggressive resections of oral cavity squamous cell carcinoma (OCSCC), may decrease positive surgical margins. The purpose of this study was to determine if length of stay (LOS), as a proxy measure for flap reconstruction, is associated with positive margin rates in OCSCC.

Materials And Methods: Data from the National Cancer Database was retrospectively collected for patients undergoing surgery for previously untreated clinical T1-3 OCSCC. Read More

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Cost and clinical outcomes of postoperative intensive care unit versus general floor management in head and neck free flap reconstructive surgery patients.

Am J Otolaryngol 2021 Apr 12;42(5):103029. Epub 2021 Apr 12.

Department of Otolaryngology- Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address:

Purpose: To compare clinical, surgical, and cost outcomes in patients undergoing head and neck free-flap reconstructive surgery in the setting of postoperative intensive care unit (ICU) against general floor management.

Methods: Retrospective analysis of head and neck free-flap reconstructive surgery patients at a single tertiary academic medical center. Clinical data was obtained from medical records. Read More

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p16 immunohistochemistry for primary tumor detection in HPV-positive squamous cell carcinoma of unknown primary.

Am J Otolaryngol 2021 Apr 5;42(5):103015. Epub 2021 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: To examine the potential benefit of reevaluation of original slides and p16 immunohistochemistry (IHC) of tonsillectomy specimens for primary tumor identification in cases of human papillomavirus (HPV) positive squamous cell carcinoma (SCC) of the head and neck of unknown primary.

Materials And Methods: Through a retrospective review, we identified all patients 18 or older who presented at our institution from 2003 to 2015 with histologically confirmed HPV-positive SCC in a cervical lymph node with unidentified primary tumor after initial workup. For patients for whom specimens were available, an expert head and neck pathologist re-reviewed original hematoxylin and eosin (H&E) slides to confirm absence of tumor and performed p16 IHC and deep sectioning of tissue blocks to identify potential tumor foci. Read More

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TaTME approach as a rescue during a laparoscopic TME for high rectal cancer. A case report.

Int J Surg Case Rep 2021 Apr 7;82:105870. Epub 2021 Apr 7.

Colorectal Surgery Unit, Università Campus Bio-Medico, Via Alvaro del Portillo 21, 00128, Rome, Italy.

Introduction And Importance: In the last years, transanal total mesorectal excision (TaTME) has been described in rectal cancer treatment, especially in challenging patients, difficulties in pelvic exposure and limitations of instrumentation improving not only dissection but also the preservation of autonomic pelvic nerves and the achievement of a restorative procedure. Here we report a case report of anterior laparoscopic rectal resection for adenocarcinoma of the high-mid rectum converted to transanal approach.

Case Presentation: A 69-year-old male presented hepatic nodules during radiological follow-up for prostate cancer treated with radical prostatectomy and adjuvant radiotherapy (70 Gy). Read More

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Gastric remnant reconstruction with left gastroepiploic artery supercharge after esophagectomy in a patient with an occluded right gastroepiploic artery: A technical and case report.

Int J Surg Case Rep 2021 Apr 8;82:105876. Epub 2021 Apr 8.

Department of Surgery, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan. Electronic address:

Introduction: Gastric remnant reconstruction is commonly used for esophagectomy reconstruction. However, standard reconstruction cannot be performed in some patients with a specific medical history. We report a case of esophagectomy and gastric remnant reconstruction with left gastroepiploic artery (LGEA) supercharge to treat esophageal cancer in a patient in whom the right gastroepiploic artery (RGEA) had previously been occluded. Read More

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Arsenic trioxide therapy predisposes to herpes zoster reactivation despite minimally myelosuppressive therapy.

Leuk Res 2021 Mar 31;106:106569. Epub 2021 Mar 31.

Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, United States. Electronic address:

Acute Promyelocytic Leukemia (APL) is a unique subtype of acute myeloid leukemia that is highly responsive to minimally myelosuppressive therapy with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). We and others have observed a higher than expected incidence of herpes zoster reactivation in APL patients treated with ATO. Memorial Sloan Kettering Cancer Center (MSKCC) has been using ATO since 1997 in all relapsed APL patients, and more recently has included it in our front-line APL regimens. Read More

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Loss of tumor suppressive properties of lipid metabolism enzyme CPT2 in ovarian carcinoma: Comment on "CPT2 down-regulation promotes tumor growth and metastasis through inducing ROS/NFκB pathway in ovarian cancer" by Zhang et al.

Transl Oncol 2021 Apr 12;14(7):101067. Epub 2021 Apr 12.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, 520 East 70th street, New York, NY 10021, USA. Electronic address:

Lipid metabolism is an essential process in cancer growth and progression. It is highly relevant in tumors with an adipocyte-rich microenvironment, such as ovarian carcinoma (OC). Carnitine palmitoyltransferase 2 (CPT2) is a key enzyme in fatty acid oxidation (FAO) that functions as a tumor suppressor in OC. Read More

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COVID-19 and cancer: Sailing through the tides.

Pathol Res Pract 2021 Mar 26;221:153417. Epub 2021 Mar 26.

Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.

The COVID-19 (coronavirus disease) pandemic caused by SARS-CoV-2 with its rapid expansion has led to extraordinary implications in our understanding of viral infections and their management globally. In this current scenario of unusual circumstances and public health emergency, the cancer care per se is facing unprecedented challenges. The peculiarity of the SARS-CoV-2 infections is still being uncovered as the pandemic spreads across the populations than showing signs of its curtailment. Read More

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[Questionnaire made to understand the opioid analgesics prescription habits in the community of Madrid (Spain)].

Aten Primaria 2021 Apr 12;53(6):102040. Epub 2021 Apr 12.

Unidad de Cuidados Paliativos, Hospital Universitario de La Paz, Servicio Madrileño de Salud, Madrid, España.

Objective: Pain is the fearest and disabling symptom for cancer patients. The cornerstone of treatment is opioid analgesics. The objective of this research was to relate the opioid consumption existing in the Community of Madrid (CM) with the prescription habits expressed by the Primary Care (PrC) and Palliative Care (PalC) physicians. Read More

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Evaluation of Pathologic Response in Lymph Nodes of Lung Cancer Patients Receiving Neoadjuvant Chemotherapy.

J Thorac Oncol 2021 Apr 12. Epub 2021 Apr 12.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Introduction: Major pathologic response (MPR), defined as ≤10% residual viable tumor, currently serves as a surrogate endpoint for survival for patients with resectable non-small cell lung cancer (NSCLC) after neoadjuvant chemotherapy. However, the significance of pathologic response in lymph nodes harboring metastatic tumor in such patients remains uncertain. Therefore, we studied the effect of neoadjuvant chemotherapy on resected positive lymph nodes and determined if the degree of pathologic response in the lymph nodes alone (LN-MPR) or in combination with that of the primary tumor (PT-MPR) was able to predict outcome. Read More

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