15,342 results match your criteria pathways terms


The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis.

Toxicol Appl Pharmacol 2021 Jun 21:115633. Epub 2021 Jun 21.

Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address:

Chronic exposure to environmental arsenic promotes lung cancer. Emerging evidence indicates that compromised host immunity, particularly T cell anti-tumor immunity, may play a critical role in cancer development. However, there is a knowledge gap in terms of the effects of arsenic exposure on T cell anti-tumor immunity and how that may contribute to arsenic lung carcinogenicity. Read More

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Preventive and therapeutic effects of SHA113 and its culture supernatant on alcoholic gastric ulcers.

Food Funct 2021 Jun 24. Epub 2021 Jun 24.

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi'an, Shanxi Province 710072, China.

Background: Alcoholic gastric ulcers are currently a common upper gastrointestinal disease with a high recurrence rate, causing gastric perforation or even gastric cancer in severe cases. Lactobacillus rhamnosus was previously found to prevent alcoholic gastric ulcers, but its therapeutic effects were not illustrated.

Aims: This study aims to illustrate the preventive and therapeutic effects of L. Read More

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Using Multilayer Heterogeneous Networks to Infer Functions of Phosphorylated Sites.

J Proteome Res 2021 Jun 24. Epub 2021 Jun 24.

Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9PT, U.K.

Mass spectrometry-based quantitative phosphoproteomics has become an essential approach in the study of cellular processes such as signaling. Commonly used methods to analyze phosphoproteomics datasets depend on generic, gene-centric annotations such as Gene Ontology terms, which do not account for the function of a protein in a particular phosphorylation state. Analysis of phosphoproteomics data is hampered by a lack of phosphorylated site-specific annotations. Read More

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Arts engagement supports social connectedness in adulthood: findings from the HEartS Survey.

BMC Public Health 2021 Jun 24;21(1):1208. Epub 2021 Jun 24.

Centre for Performance Science, Royal College of Music, London, UK.

Background: Loneliness is a public health challenge, associated with premature mortality and poorer health outcomes. Social connections can mitigate against loneliness, and there is evidence that the arts can support social connectedness. However, existing research on the arts and social connectedness is limited by focus on particular age groups and arts activities, as well as a reliance on typically small-scale studies. Read More

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Prognostic Value of Immune-Related lncRNA SBF2-AS1 in Diffuse Lower-Grade Glioma.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211011966

Department of Hepatopancreatobiliary Surgery, The People's Hospital of Lishui, Lishui, Zhejiang, China.

LncRNA SET-binding factor 2 (SBF2) antisense RNA1 (SBF2-AS1) has been proven to play an oncogenic role in various types of tumors, but the prognostic role of SBF2-AS1 in tumors, especially in diffuse lower-grade glioma (LGG), is still unclear. Here, we aimed to investigate the prognostic value of SBF2-AS1 in LGG. The LGG expression profiles from The Cancer Genome Atlas (TCGA, = 524) and Chinese Glioma Genome Atlas (CGGA, = 431) were mined by Kaplan-Meier analysis, Cox regression analysis, Chi-square test and GSEA analysis. Read More

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Understanding loneliness: a systematic review of the impact of social prescribing initiatives on loneliness.

Perspect Public Health 2021 Jun 23:1757913920967040. Epub 2021 Jun 23.

University of Essex, Colchester, UK.

Aims: The aim of this systematic literature review is to assess the impact of social prescribing (SP) programmes on loneliness among participants and the population.

Methods: We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to search EBSCOHost (CINAHL Complete, eBook Collection, E-Journals, MEDLINE with Full Text, Open Dissertations, PsycARTICLES, and PsycINFO), UK National Institute for Health and Care Excellence (NICE), Web of Science Core Collection, and grey literature. We included studies measuring the effectiveness and impact of SP programmes in terms of loneliness. Read More

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Toward Nonbinary Nuance in Research and Care: Mapping Differences in Gender Affirmation and Transgender Congruence in an Online National U.S. Survey.

Transgend Health 2021 Jun 2;6(3):156-163. Epub 2021 Jun 2.

Department of Counseling & Clinical Psychology, Teachers College, Columbia University, New York, New York, USA.

To close gaps in transgender health research, we mapped trends in gender affirmation processes (i.e., social, legal, and psychological transitions) that are unique among nonbinary (NB) transgender adults when compared with transgender women (TW) and transgender men (TM). Read More

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Robustification of GWAS to explore effective SNPs addressing the challenges of hidden population stratification and polygenic effects.

Sci Rep 2021 Jun 22;11(1):13060. Epub 2021 Jun 22.

Bioinformatics Lab, Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh.

Genome-wide association studies (GWAS) play a vital role in identifying important genes those is associated with the phenotypic variations of living organisms. There are several statistical methods for GWAS including the linear mixed model (LMM) which is popular for addressing the challenges of hidden population stratification and polygenic effects. However, most of these methods including LMM are sensitive to phenotypic outliers that may lead the misleading results. Read More

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Network topology analysis of essential genes interactome of Helicobacter pylori to explore novel therapeutic targets.

Microb Pathog 2021 Jun 19;158:105059. Epub 2021 Jun 19.

Central Research Laboratory, K. S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, 575018, Karnataka, India.

The Helicobacter pylori chronic colonization produces a wide range of gastric diseases in the gastric mucosa by abetting inflammation. Amidst coevolution and reorganization of its metabolism with humans, it has become difficult still imperative to understand and prevent its growth. This study focus to explore functional insights into identification of hub proteins/genes by aggregating the behavior of genes connected in a protein-protein interaction (PPI) network. Read More

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Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence.

mSystems 2021 Jun 22:e0050021. Epub 2021 Jun 22.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

The complex cell wall and biofilm matrix (ECM) act as key barriers to antibiotics in mycobacteria. Here, the ECM and envelope proteins of Mycobacterium marinum ATCC 927, a nontuberculous mycobacterial model, were monitored over 3 months by label-free proteomics and compared with cell surface proteins on planktonic cells to uncover pathways leading to virulence, tolerance, and persistence. We show that ATCC 927 forms pellicle-type and submerged-type biofilms (PBFs and SBFs, respectively) after 2 weeks and 2 days of growth, respectively, and that the increased CelA1 synthesis in this strain prevents biofilm formation and leads to reduced rifampicin tolerance. Read More

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Strategies to improve viability of a circular carbon bioeconomy-A techno-economic review of microbial electrosynthesis and gas fermentation.

Water Res 2021 May 27;201:117306. Epub 2021 May 27.

Advanced Water Management Centre, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

A circular carbon bioeconomy has potential to halt atmospheric accumulation of greenhouse gases causing climate change and sustainably produce chemical, agricultural and fuel products. Here, we report application of a simplified technoeconomic assessment to critically review two approaches in this space - microbial electrosynthesis and gas fermentation. For microbial electrosynthesis, decoupling of surface-dependant abiotic process for electron delivery from volume-dependant biotic carbon fixation, is shown as the only economically viable strategy to scale-up due to comparatively low biofilm electron consumption rate. Read More

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Changes in floodplain regimes over Canada due to climate change impacts: Observations from CMIP6 models.

Sci Total Environ 2021 Jun 8;792:148323. Epub 2021 Jun 8.

Department of Civil and Environmental Engineering, Western University, London, Ontario N6A3K7, Canada.

With the recent Coupled Model Intercomparison Project Phase 6 (CMIP6), water experts and flood modellers are curious to explore the efficacy of the new and upgraded climate models in representing flood inundation dynamics and how they will be impacted in the future by climate change. In this study, for the first time, we consider the latest group of General Circulation Models (GCMs) from CMIP6 to examine the probable changes in floodplain regimes over Canada. A set of 17 GCMs from Shared Socioeconomic Pathways (SSPs) 4. Read More

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Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent.

J Med Chem 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Chengdu 610041, China.

Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Read More

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Biological Mechanisms Induced by Soybean Agglutinin Using an Intestinal Cell Model of Monogastric Animals.

Front Vet Sci 2021 2;8:639792. Epub 2021 Jun 2.

Animal Production Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.

Soybean agglutinin (SBA) has a toxic effect on most animals. The anti-nutritional mechanisms of SBA are not fully understood, in terms of cell survival activity and metabolism of intestinal cells. This study aims to investigate the effects of SBA on the cell cycle, apoptosis, and to verify the mechanism of SBA anti-nutritional characters based on proteomic-based analysis. Read More

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An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure.

Front Oncol 2021 3;11:688919. Epub 2021 Jun 3.

Laboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, Pavia, Italy.

Colorectal cancer is among the three top cancer types for incidence and the second in terms of mortality, usually managed with surgery, chemotherapy and radiotherapy. In particular, radiotherapeutic concepts are crucial for the management of advanced rectal cancer, but patients' survival remains poor, despite advances in treatment modalities. The use of well-characterized cell culture systems offers an important preclinical strategy to study mechanisms at the basis of cell response to therapeutic agents, including ionizing radiation, possibly leading to a better understanding of the response to the treatment. Read More

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Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis.

Front Oncol 2021 3;11:636093. Epub 2021 Jun 3.

Department of Internal Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Background: In recent years, DNA methylation modification has been shown to be a critical mechanism in the field of epigenetics.

Methods: Hepatocellular carcinoma (HCC) data were obtained from The Cancer Genome Atlas project, including RNA expression profiles, Illumina Human Methylation 450K BeadChip data, clinical information, and pathological features. Then, differentially expressed genes (DEGs) and differentially methylated genes were identified using R software. Read More

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Transcriptomic Analysis of the Effect of GAT-2 Deficiency on Differentiation of Mice Naïve T Cells Into Th1 Cells .

Front Immunol 2021 2;12:667136. Epub 2021 Jun 2.

College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

The neurotransmitter γ-aminobutyric acid (GABA) is known to affect the activation and function of immune cells. This study investigated the role of GABA transporter (GAT)-2 in the differentiation of type 1 helper T (Th1) cells. Naïve CD4 T cells isolated from splenocytes of GAT-2 knockout (KO) and wild-type (WT) mice were cultured; Th1 cell differentiation was induced and transcriptome and bioinformatics analyses were carried out. Read More

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Enhanced Immune Response Improves Resistance to Cadmium Stress in Triploid Crucian Carp.

Front Physiol 2021 4;12:666363. Epub 2021 Jun 4.

State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, China.

Previous research has indicated that triploid crucian carp (3n fish) have preferential resistance to cadmium (Cd) compared to . (2n fish). In this article, comparative research is further conducted between the 2n and 3n fish in terms of the immune response to Cd-induced stress. Read More

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Engineering triangular bimetallic metal-organic-frameworks derived hierarchical zinc-nickel-cobalt oxide nanosheet [email protected] graphene oxide-Ni foam as a binder-free electrode for ultra-high rate performance supercapacitors and methanol electro-oxidation.

J Colloid Interface Sci 2021 Jun 10;602:573-589. Epub 2021 Jun 10.

Carbon Composite Energy Nanomaterials Research Center, Woosuk University, Wanju, Chonbuk 55338, Republic of Korea; Department of Fire Disaster Prevention, Woosuk University, Wanju, Chonbuk 55338, Republic of Korea; Woosuk Institute of Smart Convergence Life Care (WSCLC), Woosuk University, Wanju, Chonbuk 55338, Republic of Korea. Electronic address:

The rigorous fabrication of electrode materials using upper-ranked porous precursor especially metal organic frameworks (MOFs) are challenging but appealing task to procure electrochemical energy storage and conversion system with altitudinous performance. Herein, we replenish the rational construction of atypical electrode of hollow Zn-Ni-Co-oxide (ZNCO) nanosheet arrays onto rGO garnished Ni foam (rGO/NF) via two step solution based method. Firstly, 2D Zn-Co-MOFs derived nanoleave arrays are prepared by co-precipitation method. Read More

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Jointly Modelling Economics and Epidemiology to Support Public Policy Decisions for the COVID-19 Response: A Review of UK Studies.

Pharmacoeconomics 2021 Jun 19. Epub 2021 Jun 19.

Centre for Health Economics, University of York, York, UK.

COVID-19 in the UK has had a profound impact on population health and other socially important outcomes, including on education and the economy. Although a range of evidence has guided policy, epidemiological models have been central. It is less clear whether models to support decision making have sought to integrate COVID-19 epidemiology with a consideration of broader health, wellbeing and economic implications. Read More

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Comprehensive transcriptome and metabolome profiling reveal metabolic mechanisms of Nitraria sibirica Pall. to salt stress.

Sci Rep 2021 Jun 18;11(1):12878. Epub 2021 Jun 18.

Research Center of Saline and Alkali Land of National of Forestry and Grassland Administration, CAF, Beijing, China.

Nitraria sibirica Pall., a typical halophyte that can survive under extreme drought conditions and in saline-alkali environments, exhibits strong salt tolerance and environmental adaptability. Understanding the mechanism of molecular and physiological metabolic response to salt stress of plant will better promote the cultivation and use of halophytes. Read More

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Comparative transcriptomic and physiological analyses of weedy rice and cultivated rice to identify vital differentially expressed genes and pathways regulating the ABA response.

Sci Rep 2021 Jun 18;11(1):12881. Epub 2021 Jun 18.

Key Laboratory of Northern Japonica Rice Genetics and Breeding, Ministry of Education and Liaoning Province, Key Laboratory of Northeast Rice Biology and Genetics and Breeding, Ministry of Agriculture, Rice Research Institute of Shenyang Agricultural University, Shenyang, 110866, China.

Weedy rice is a valuable germplasm resource characterized by its high tolerance to both abiotic and biotic stresses. Abscisic acid (ABA) serves as a regulatory signal in plant cells as part of their adaptive response to stress. However, a global understanding of the response of weedy rice to ABA remains to be elucidated. Read More

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Signposts for Aquatic Toxicity Evaluation in China: Text Mining using Event-Driven Taxonomy within and among Regions.

Environ Sci Technol 2021 Jun 18. Epub 2021 Jun 18.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China.

Selection of toxicity endpoints affects outcomes of risk assessment. Scientific decisions based on more holistic evidence is preferable for designing bioassay batteries rather than subjective selections, particularly when systems are poorly understood. Here, we propose a novel event-driven taxonomy (EDT)-based text mining tool to prioritize stressors likely to elicit water quality deterioration. Read More

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Physical and mechanical cues affecting biomaterial-mediated plasmid DNA delivery: insights into non-viral delivery systems.

Authors:
Valeria Graceffa

J Genet Eng Biotechnol 2021 Jun 17;19(1):90. Epub 2021 Jun 17.

Cellular Health and Toxicology Research Group (CHAT), Institute of Technology Sligo, Ash Ln, Bellanode, Sligo, Ireland.

Background: Whilst traditional strategies to increase transfection efficiency of non-viral systems aimed at modifying the vector or the polyplexes/lipoplexes, biomaterial-mediated gene delivery has recently sparked increased interest. This review aims at discussing biomaterial properties and unravelling underlying mechanisms of action, for biomaterial-mediated gene delivery. DNA internalisation and cytoplasmic transport are initially discussed. Read More

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Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.

BMC Genomics 2021 Jun 18;22(1):451. Epub 2021 Jun 18.

Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.

Background: A number of studies have examined mRNA expression profiles of bovine endometrium at estrus and around the peri-implantation period of pregnancy. However, to date, these studies have been performed on the whole endometrium which is a complex tissue. Consequently, the knowledge of cell-specific gene expression, when analysis performed with whole endometrium, is still weak and obviously limits the relevance of the results of gene expression studies. Read More

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Therapeutic targeting of STAT3 pathways in pancreatic adenocarcinoma: A systematic review of clinical and preclinical literature.

PLoS One 2021 17;16(6):e0252397. Epub 2021 Jun 17.

Department of Surgery, HFR Fribourg, Fribourg, Switzerland.

Background/objectives: Pancreatic ductal adenocarcinoma is a highly lethal disease with increasing incidence. Due to high resistance, chemo/radiotherapy has limited success in pancreatic cancer and only marginally prolongs patient survival. Therefore, novel biomarkers and therapeutic targets are needed. Read More

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Improved Sampling and Free Energy Estimates for Antibiotic Permeation through Bacterial Porins.

J Chem Theory Comput 2021 Jun 17. Epub 2021 Jun 17.

Department of Physics and Earth Sciences, Jacobs University Bremen, 28759 Bremen, Germany.

Antibiotics enter into bacterial cells via protein channels that serve as low-energy pathways through the outer membrane, which is otherwise impenetrable. Insights into the molecular mechanisms underlying the transport processes are vital for the development of effective antibacterials. A much-desired prerequisite is an accurate and reproducible determination of free energy surfaces for antibiotic translocation, enabling quantitative and meaningful comparisons of permeation mechanisms for different classes of antibiotics. Read More

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Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges.

Front Pharmacol 2021 31;12:675675. Epub 2021 May 31.

Immunotherapy Laboratory, College of Pharmacology, Southwest Minzu University, Chengdu, China.

Malignant tumors remain the health problem of highest concern among people worldwide due to its high mortality and recurrence. Lung, gastric, liver, colon, and breast cancers are among the top five malignant tumors in terms of morbidity and mortality. In cancer biology, aberrant signaling pathway regulation is a prevalent theme that drives the generation, metastasis, invasion, and other processes of all malignant tumors. Read More

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Reducing unscheduled hospital care for adults with diabetes following a hypoglycaemic event: which community-based interventions are most effective? A systematic review.

J Diabetes Metab Disord 2021 Jun 10:1-18. Epub 2021 Jun 10.

Faculty of Life and Health Sciences, School of Nursing, Ulster University, Magee, Northland Road, Derry, BT48 7JL UK.

Aim: To determine which community-based interventions are most effective at reducing unscheduled hospital care for hypoglycaemic events in adults with diabetes.

Methods: Medline Ovid, CINAHL Plus and ProQuest Health and Medical Collection were searched using both key search terms and medical subject heading terms (MeSH) to identify potentially relevant studies. Eligible studies were those that involved a community-based intervention to reduce unscheduled admissions in adults with diabetes. Read More

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