Neurochem Int 2021 May 4:105054. Epub 2021 May 4.
Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854; Department of Neurosurgery, New Jersey Medical School, Rutgers University, Newark, NJ 07102; Brain Health Institute, Rutgers University, Piscataway, NJ 08854. Electronic address:
Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5'-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). The two isoforms are developmentally regulated and are differentially expressed in distinct subcellular compartments with ADK-L localized in the nucleus and ADK-S localized in the cytoplasm. Read More