756,402 results match your criteria pathway

Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

Background: Elevated plasma homocysteine has been found to be associated with an increased risk of osteoporosis, especially hip and vertebral fractures. The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine β-synthase (CBS).

Objectives: We investigated whether genetic variants in some of the genes involved in 1 carbon metabolism modify the association of B vitamin-related measures with bone mineral density (BMD) and strength. Read More

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APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma.

Int Immunopharmacol 2021 May 5;97:107675. Epub 2021 May 5.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) seriously affect the life quality of patients. Nowadays, immunotherapy is widely used in the treatment of cancer. Tumor-infiltrating lymphocytes (TILs), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) play key roles in the immunotherapy of cancer. Read More

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Prediction of human-Streptococcus pneumoniae protein-protein interactions using logistic regression.

Comput Biol Chem 2021 Apr 24;92:107492. Epub 2021 Apr 24.

Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia. Electronic address:

Streptococcus pneumoniae is a major cause of mortality in children under five years old. In recent years, the emergence of antibiotic-resistant strains of S. pneumoniae increases the threat level of this pathogen. Read More

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Outdoor dissolution and photodegradation of insensitive munitions formulations IMX-101 and IMX-104: Photolytic transformation pathway and mechanism study.

Chemosphere 2021 Apr 27;280:130672. Epub 2021 Apr 27.

Biosphere 2, University of Arizona, Oracle, AZ, 85721-0158, United States; Department of Environmental Science, University of Arizona, Tucson, AZ, 85721-0038, United States. Electronic address:

New munition compounds have been developed to replace traditional explosives to prevent unintended detonations. However, insensitive munitions (IM) can leave large proportion of unexploded charge in the field, where it is subjected to photodegradation and dissolution in precipitation. The photolytic reactions occurring on the surfaces of IMX-101 and IMX-104 formulations and the subsequent fate of photolytic products in the environment were thoroughly investigated. Read More

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Ischiorectal fossa metastasis from colon cancer: Case report of a rare entity and review of literature.

Int J Surg Case Rep 2021 Apr 27;82:105912. Epub 2021 Apr 27.

Department of Surgery, King Fahad Specialist Hospital-Dammam, Saudi Arabia.

Introduction And Importance: Colorectal cancer is one of the most common cancers both nationally and internationally. It commonly metastases to local lymph nodes, liver and lungs, with few reported cases of rare sites of metastasis such as adrenal glands, breast and skin.

Case Presentation: We report a 55-year-old-female admitted as case of large bowel obstruction and unintentional weight loss. Read More

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Nanocellulose-derived carbon/g-CN heterojunction with a hybrid electron transfer pathway for highly photocatalytic hydrogen peroxide production.

J Colloid Interface Sci 2021 Apr 24;599:507-518. Epub 2021 Apr 24.

College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350108, China.

Using oxygen reduction for the photocatalytic production of hydrogen peroxide (HO) has been considered a green and sustainable route. In the present study, to achieve high efficiency, graphitic carbon nitride (g-CN) was obtained using thermal polymerization from a bi-component precursor and was then assembled with cellulose nanofibers. It was found that a small quantity of cellulose nanofibers that generates carbon fibers upon pyrolysis greatly improves the photocatalytic activity compared with that of g-CN alone. Read More

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Grapevine TPS (trehalose-6-phosphate synthase) family genes are differentially regulated during development, upon sugar treatment and drought stress.

Plant Physiol Biochem 2021 Apr 30;164:54-62. Epub 2021 Apr 30.

Department of Agriculture, Forest and Food Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, Italy.

Trehalose-6-phosphate synthase (TPS) performs the first step in the biosynthetic pathway of trehalose-6-phosphate and trehalose. These two molecules play key roles in the control of carbon allocation and of stress responses in plants. We investigated the organization of the TPS gene family and its developmental and environmental expression regulation in grapevine, a major horticultural crop. Read More

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Multi-omics analyses on the response mechanisms of 'Shine Muscat' grapevine to low degree of excess copper stress (Low-ECS).

Environ Pollut 2021 Apr 30;286:117278. Epub 2021 Apr 30.

Department of Horticulture, Nanjing Agricultural University, Nanjing, Jiangsu Province, 210095, China; Fruit Crop Genetic Improvement and Seedling Propagation Engineering Center of Jiangsu Province, Nanjing, 210095, China.

Copper stress is one of the most severe heavy metal stresses in plants. Grapevine has a relatively higher copper tolerance than other fruit crops. However, there are no reports regarding the tolerance mechanisms of the 'Shine Muscat' ('SM') grape to a low degree of excess copper stress (Low-ECS). Read More

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Prenatal environmental tobacco smoke exposure alters children's cognitive control circuitry: A preliminary study.

Environ Int 2021 May 5;155:106516. Epub 2021 May 5.

The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

Background And Objectives: Prenatal exposure to environmental tobacco smoke (ETS) is associated with increased attention problems in children, however, the effects of such exposure on children's brain structure and function have not been studied. Herein, we probed effects of prenatal ETS on children's cognitive control circuitry and behavior.

Methods: Forty-one children (7-9 years) recruited from a prospective longitudinal birth cohort of non-smoking mothers completed structural and task-functional magnetic resonance imaging to evaluate effects of maternal ETS exposure, measured by maternal prenatal urinary cotinine. Read More

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Distribution, behaviour, bioavailability and remediation of poly- and per-fluoroalkyl substances (PFAS) in solid biowastes and biowaste-treated soil.

Environ Int 2021 May 5;155:106600. Epub 2021 May 5.

Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA; Department of Agronomy, Kansas State University, Manhattan, KS 66506, USA.

Aqueous film-forming foam, used in firefighting, and biowastes, including biosolids, animal and poultry manures, and composts, provide a major source of poly- and perfluoroalkyl substances (PFAS) input to soil. Large amounts of biowastes are added to soil as a source of nutrients and carbon. They also are added as soil amendments to improve soil health and crop productivity. Read More

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RIPK1 regulates cell function and death mediated by UVB radiation and TNF-α.

Mol Immunol 2021 May 5;135:304-311. Epub 2021 May 5.

College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. Electronic address:

The RIP family plays a key role in mediating cell inflammation, oxidative stress and death. Among them, RIPK1, as an important regulatory factor in the upstream of the NF-κB pathway, is involved in multiple pathways of cell inflammation and death. Epidermal cells constitute the outermost barrier of the human body. Read More

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Plumbagin Inhibits Proliferation, Migration, and Invasion of Retinal Pigment Epithelial Cells Induced by FGF-2.

Tissue Cell 2021 Apr 28;72:101547. Epub 2021 Apr 28.

Department of Ophthalmology, The second Hospital of Hebei Medical University, Shijiazhuang, 05000, China. Electronic address:

Proliferative vitreoretinopathy (PVR) is a serious ophthalmic disease and characterized by the formation of proliferative membranes by retinal pigment epithelial (RPE) cells. In PVR, the contraction and traction of the fibrocellular membranes cause retinal detachment, which can cause reduction surgery for retinal detachment to fail. Fibroblast growth factor-2 (FGF-2) causes RPE cells to form extracellular matrix (ECM), promotes chemotaxis, mitosis, and positively promotes the disease process of PVR. Read More

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Delinquency as a consequence of parental warmth and self-efficacy: Total sample and individual male and female mediation analyses.

Glenn D Walters

J Adolesc 2021 May 5;89:137-148. Epub 2021 May 5.

Kutztown University, United States. Electronic address:

Introduction: This study's purpose was to investigate the mediating effect of parental control self-efficacy on the parental warmth → child delinquency relationship in the mothers and fathers of early to mid-adolescent youth in a test of performance accomplishments as a prelude to parental self-efficacy.

Methods: Parental warmth and control self-efficacy estimates, representing parental support and control, respectively, were provided by the mothers and fathers of 3934 (2010 boys, 1924 girls) youth from the Longitudinal Study of Australian Children (LSAC) and self-reported delinquency was obtained from the child.

Results: As predicted, parental control self-efficacy mediated the relationship between parental warmth and child delinquency, whereas parental warmth did not mediate the relationship between parental self-efficacy and child delinquency. Read More

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Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.

Redox Biol 2021 Apr 30;43:101994. Epub 2021 Apr 30.

Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China; Laboratory of Anesthesia and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain to be elucidated. Read More

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The enantioselective study of the toxicity effects of chiral acetochlor in HepG2 cells.

Ecotoxicol Environ Saf 2021 May 5;218:112261. Epub 2021 May 5.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Acetochlor is one of the most widely used chiral herbicides in the world, and it is usually produced and used as racemic form (Rac). The potential effects of acetochlor in human body are mainly induced by its residue in agriculture food. The direct target exposed is the liver in human body. Read More

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EMS blood collection from patients with acute chest pain reduces emergency department length of stay.

Am J Emerg Med 2021 Apr 26;47:248-252. Epub 2021 Apr 26.

Department of Emergency Medicine, Wake Forest School of Medicine, USA.

Background: Expediting the measurement of serum troponin by leveraging EMS blood collection could reduce the diagnostic time for patients with acute chest pain and help address Emergency Department (ED) overcrowding. However, this practice has not been examined among an ED chest pain patient population in the United States.

Methods: A prospective observational cohort study of adults with non-traumatic chest pain without ST-segment elevation myocardial infarction was conducted in three EMS agencies between 12/2016-4/2018. Read More

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Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8 cells.

Pharmacol Res 2021 May 5:105656. Epub 2021 May 5.

Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research. Electronic address:

Non-small cell lung cancer (NSCLC) is one of the most frequently diagnosed cancers and the leading causes of cancer death worldwide. Therefore, new therapeutic agents are urgently needed to improve patient outcomes. Plumbagin (PLB), a natural sesquiterpene present in many Chinese herbal medicines, has been reported for its anti-cancer activity in various cancer cells. Read More

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Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.

Pharmacol Res 2021 May 5:105650. Epub 2021 May 5.

College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 280 Waihuan East Road, Panyu District, Guangdong 510006, P.R. China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P.R. China. Electronic address:

Stroke is one of the leading causes of death worldwide. Hemorrhagic transformation (HT) is a common serious complication of ischemic stroke (IS) and is related to poor prognosis. Hyperglycemia after stroke is associated with the occurrence of HT and seriously affects the clinical treatment of stroke. Read More

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Hypoxia-induced retinal pigment epithelium cell-derived bFGF promotes the migration and angiogenesis of HUVECs through regulating TGF-β1/smad2/3 pathway.

Gene 2021 May 5:145695. Epub 2021 May 5.

Department of Pediatric Ophthalmology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University. Electronic address:

Hypoxia promotes the secretion of basic fibroblast growth factor (bFGF) in retinal pigment epithelium (RPE), which plays an important part in retinopathy of prematurity (ROP). This study preliminarily explored the effect of hypoxia-induced RPE-derived bFGF on the biological functions of human umbilical vein endothelial cells (HUVECs). After cell culture in hypoxia conditions, the cell viability, apoptosis, and the expressions of bFGF and vascular endothelial growth factor A (VEGFA) in human RPEs were detected by 3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), flow cytometry, Western blot, RT-qPCR, or ELISA. Read More

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Effect of gamma rays and colchicine on silymarin production in cell suspension cultures of Silybum marianum: a transcriptomic study of key genes involved in the biosynthetic pathway.

Gene 2021 May 5:145700. Epub 2021 May 5.

Department of Biology, Health, and Environment, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.

The aim of this study was to investigate secondary metabolite production in Silybum marianum L. cell suspension cultures obtained from seeds treated with gamma rays (200 and 600Gy) and 0.05% colchicine. Read More

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Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

J Ethnopharmacol 2021 May 5:114190. Epub 2021 May 5.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear. Read More

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Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.

J Ethnopharmacol 2021 May 5:114189. Epub 2021 May 5.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming 650500, China. Electronic address:

Ethnopharmacological Relevance: Ophiocordyceps lanpingensis (O. lanpingensis) is a traditional ethno-medicine distributed in Eastern Himalayas, which has been used by local minorities to prevent and treat urinary diseases for hundreds of years. However, the corresponding active components and related pharmacological mechanism of such medication are not clear yet. Read More

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Central and peripheral pain intervention by Ophiorrhizarugosaleaves: potential underlying mechanismsandinsight into the role of pain modulators.

J Ethnopharmacol 2021 May 5:114182. Epub 2021 May 5.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy. Electronic address:

Ethnopharmacological Relevance: Ophiorrhiza rugosa var.prostratais a traditional medicinal plant used by the indigenous and local tribes (Chakma, Marma and Tanchangya) of Bangladesh for the management of chest pain, body ache, and earache. However, the knowledge of anti-nociceptive and anti-inflammatory potentials of this plant is scarce. Read More

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A Literature Overview on Epilepsy and Inflammasome Activation.

Brain Res Bull 2021 May 5. Epub 2021 May 5.

CNR Neuroscience Institute, Milan, Italy.

Epilepsy is one of the most prevalent serious brain disorders worldwide. Accumulating evidence has suggested that inflammation participates in the progression and pathogenesis of epilepsy. During inflammation, a cytosolic multimolecular complex called the "inflammasome" is activated, driving the innate immune response. Read More

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Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 5:110344. Epub 2021 May 5.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Adult neurogenesis in the hippocampal dentate gyrus plays a critical role in learning and memory. Projections originating from entorhinal cortex, known as the perforant pathway, provide the main input to the dentate gyrus and promote neurogenesis. However, neuromodulators and molecular changes mediating neurogenic effects of this pathway are not yet fully understood. Read More

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Cryo-EM: a new dawn in thyroid biology.

Mol Cell Endocrinol 2021 May 5:111309. Epub 2021 May 5.

University of Ljubljana, Faculty of Medicine, Institute of Biochemistry and Molecular Genetics, Vrazov trg 2, 1000, Ljubljana, Slovenia.

The thyroid gland accumulates the rare dietary element iodine and incorporates it into iodinated thyroid hormones, utilising several tightly regulated reactions and molecular mechanisms. Thyroid hormones are essential in vertebrates and play a central role in many biological processes, such as development, thermogenesis and growth. The control of these functions is exerted through the binding of hormones to nuclear thyroid hormone receptors that rule the transcription of numerous metabolic genes. Read More

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Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation.

Mol Cell Endocrinol 2021 May 5:111297. Epub 2021 May 5.

Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, J2S 7C6, QC, Canada. Electronic address:

Growth factors regulate ovarian follicle development and they signal through intracellular pathways including mitogen-activated protein kinase (MAPK) phosphorylation, which is negatively regulated by a subfamily of 23 dual-specificity phosphatases (DUSP). Using sheep granulosa cells as a model, we detected mRNA encoding 16 DUSPs in vivo and in vitro. Stimulation of cells in vitro with FGF2 increased (p < 0. Read More

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Systematic evaluation of activated carbon-FeO composites for removing and degrading emerging organic pollutants.

Environ Res 2021 May 5:111187. Epub 2021 May 5.

Civil and Environmental Engineering Faculty, Technion, Haifa, 32000 Israel. Electronic address:

In this study, a comparative activity assessment of several activated carbon (AC) and AC-FeO composites was performed to evaluate their efficiency and versatility as Fenton-like catalysts. Although many studies have demonstrated the advantages of AC-based materials as Fenton-like catalysts, most have been developed using only one oxidant and/or one pollutant. Here, untreated (AC) and acid-treated AC (AC) iron-oxide composites were synthesized, characterized, and compared in terms of activity to bare ACs using several oxidants and pollutants, the activation efficiency of hydrogen peroxide (HO) and ammonium persulfate ((NH)SO), and the subsequent oxidation extent and kinetics of bisphenol-A, atrazine, and carbamazepine by the AC-based materials were studied in depth. Read More

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Exosomal lncRNA TCONS_00064356 derived from injured alveolar epithelial type II cells affects the biological characteristics of mesenchymal stem cells.

Life Sci 2021 May 5:119568. Epub 2021 May 5.

Department of Respiratory Medicine, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200090, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease, and a leading cause of morbidity and mortality worldwide. There is still a lack of effective treatment to improve pulmonary structural abnormality and reverse the progression of COPD. Mesenchymal stem cell (MSC)-based therapies have attracted much attention and show promising clinical application prospects in COPD treatment. Read More

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Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma.

Biochem Pharmacol 2021 May 5:114593. Epub 2021 May 5.

Institute of Clinical Pharmacology, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Research Center of Chinese Herbal Resources Science and Engineering, School of Pharmaceutical Sciences, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:

Aberrant activation of the Hedgehog (Hh) pathway is implicated in the pathogenesis and development of multiple cancers, especially Hh-driven medulloblastoma (MB). Smoothened (SMO) is a promising therapeutic target of the Hh pathway in clinical cancer treatment. However, SMO mutations frequently occur, which leads to drug resistance and tumor relapse. Read More

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