24,602 results match your criteria pathologic features

An Incidental Finding of Congenital Pulmonary Airway Malformation Type 3 During a Forensic Autopsy for a Sudden Infant Death: A Case Report With a Brief Literature Review.

Am J Forensic Med Pathol 2021 Apr 7. Epub 2021 Apr 7.

From the Departments of Forensic Pathology Radiology Clinical Pathology, Antwerp University Hospital, Edegem Department of Pathology, Antwerp University, Wilrijk, Belgium.

Abstract: Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic airway malformation, is a developmental disorder of the lower respiratory tract. It is subdivided into 5 types based on clinical and pathologic features. Type 3, an adenomatoid type of CPAM, is the second rarest form of CPAM, occurring in approximately 5% of all CPAM cases. Read More

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A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases.

HPB (Oxford) 2021 Mar 18. Epub 2021 Mar 18.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Background: Intraductal papillary neoplasm of the bile-duct (IPNB) has recently been further subclassified into "so-called IPNBs" (Type-1) and "narrow-sense papillary cholangiocarcinomas" (Type-2), but their differential diagnosis is challenging. This study aimed to reevaluate Type-1 and Type-2 IPNBs.

Methods: Consecutive patients who underwent papillary bile-duct tumor resection were included. Read More

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Rupture of a huge infectious abdominal chronic expanding hematoma.

Clin J Gastroenterol 2021 Apr 8. Epub 2021 Apr 8.

Department of Surgery, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Minami-ku, Kumamoto, 861-4193, Japan.

A 72-year-old woman was referred to our hospital with the diagnosis of peritonitis due to the rupture of a huge abdominal cystic tumor, 27 cm in diameter. Abdominal computed tomography 14 years before revealed the tumor, which was 18 cm in diameter. She had undergone no examinations or treatment in the interim. Read More

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Comparison of Conventional Gadoxetate Disodium-Enhanced MRI Features and Radiomics Signatures With Machine Learning for Diagnosing Microvascular Invasion.

AJR Am J Roentgenol 2021 Apr 7:1-11. Epub 2021 Apr 7.

Department of Radiology, Guangxi Medical University First Affiliated Hospital, No. 6 Shuangyong Rd, Nanning, Guangxi 530021, China.

This study aimed to determine the best model for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) using conventional gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadoxetate disodium)-enhanced MRI features and radiomics signatures with machine learning. This retrospective study included 269 patients with a postoperative pathologic diagnosis of HCC. Gadoxetate disodium-enhanced MRI features were assessed, including T1 relaxation time, tumor margin, tumor size, peritumoral enhancement, peritumoral hypointensity, and ADC. Read More

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A Review of Clinical and Imaging Features of Diffuse Pulmonary Hemorrhage.

AJR Am J Roentgenol 2021 Apr 7:1-10. Epub 2021 Apr 7.

Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY.

The purpose of this article is to review the clinical and imaging features of diffuse pulmonary hemorrhage. Diffuse pulmonary hemorrhage is a life-threatening syndrome associated with a wide variety of underlying pathologic categories. Nonspecific clinical and imaging features pose challenges to promptly diagnosing this condition. Read More

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Diagnostic and Prognostic Utility of F-FDG PET/CT in Recurrent Salivary Gland Cancers.

AJR Am J Roentgenol 2021 Apr 7:1-13. Epub 2021 Apr 7.

Department of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065.

The role of F-FDG PET/CT in the evaluation of recurrent salivary gland tumors remains poorly defined. We investigated the diagnostic and prognostic utility of PET in this setting. A total of 146 patients with recurrent salivary gland cancer were treated at our institution between January 2002 and December 2015. Read More

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MRI-based radiomics signature for pretreatment prediction of pathological response to neoadjuvant chemotherapy in osteosarcoma: a multicenter study.

Eur Radiol 2021 Mar 30. Epub 2021 Mar 30.

Department of Radiology, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics. Guangdong Province), 183 Zhongshan Da Dao Xi, Guangzhou, 510630, Guangdong, China.

Objective: To develop and validate a radiomics signature based on magnetic resonance imaging (MRI) from multicenter datasets for preoperative prediction of pathologic response to neoadjuvant chemotherapy (NAC) in patients with osteosarcoma.

Methods: We retrospectively enrolled 102 patients with histologically confirmed osteosarcoma who received chemotherapy before treatment from 4 hospitals (68 in the primary cohort and 34 in the external validation cohort). Quantitative imaging features were extracted from contrast-enhanced fat-suppressed T1-weighted images (CE FS T1WI). Read More

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Morphologic subtypes of lobular carcinoma in situ diagnosed on core needle biopsy: clinicopathologic features and findings at follow-up excision.

Mod Pathol 2021 Apr 6. Epub 2021 Apr 6.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lobular carcinoma in situ (LCIS) is currently classified as classic (CLCIS), florid (FLCIS), and pleomorphic (PLCIS). Given the rarity of FLCIS and PLCIS, information on their clinico-pathologic features and biologic potential remains limited. We evaluated the upgrade rates at excision of FLCIS and PLCIS diagnosed on inhouse core needle biopsy (CNB) and their clinical presentation and follow-up. Read More

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Histological growth patterns and molecular analysis of resected colorectal lung metastases.

Pathol Res Pract 2021 Mar 24;222:153414. Epub 2021 Mar 24.

Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Unit of Thoracic Surgery Sant'Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy.

Lung is the site of metastasis in about 15-25 % of colorectal cancer (CRC) patients. Lung metastasectomy of CRC represents a standard therapy in patients with resectable metastases. In this study we investigated both histological patterns of metastases and mutations in MAPkinase pathway genes and their relationship to prognosis. Read More

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Maternal and perinatal outcomes and placental pathologic examination of 29 SARS-CoV-2 infected patients in the third trimester of gestation.

J Obstet Gynaecol Res 2021 Apr 5. Epub 2021 Apr 5.

Department of Pathology, University Hospital La Paz, Madrid, Spain.

Aim: On December 31, 2019, an unknown outbreak of pulmonary disease was reported in China. The novel coronavirus SARS-CoV-2 was the etiologic agent of this disease, and responsible of the current pandemic of COVID-19. Accumulated evidence on placental features is based most on case-reports and small case-series, with differing results. Read More

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The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren's Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution.

Front Immunol 2021 19;12:639975. Epub 2021 Mar 19.

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Since B-cell hyperactivity and pathologic antibody response are key features in the immunopathogenesis of primary Sjögren's syndrome (pSS), the role of follicular T helper (T) cells as efficient helpers in the survival and differentiation of B cells has emerged. Our aim was to investigate whether a change in the balance of circulating (c)T subsets and follicular regulatory T (T) cells could affect the distribution of B cells in pSS. Peripheral blood of 38 pSS patients and 27 healthy controls was assessed for the frequencies of cT cell subsets, T cells, and certain B cell subpopulations by multicolor flow cytometry. Read More

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How to Classify and Define Pituitary Tumors: Recent Advances and Current Controversies.

Front Endocrinol (Lausanne) 2021 17;12:604644. Epub 2021 Mar 17.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Pituitary tumors are very complex and heterogeneous and have a very wide range of proliferative and aggressive behaviors, and how to define and classify these tumors remains controversial. This review summarizes the epidemiology and progress in the classification and definition of pituitary tumors, as well as controversial issues. Based on the results of radiologic and autopsy studies, the prevalence of pituitary tumors has recently increased significantly. Read More

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Nerve Sheath Myxoma in the Lower Extremity: A Rare Case with Description of Magnetic Resonance Imaging and Sonographic Findings.

Am J Case Rep 2021 Apr 5;22:e927922. Epub 2021 Apr 5.

Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, TX, USA.

BACKGROUND This report is of a nerve sheath myxoma presenting as a slow-growing mass in the back of the left ankle of a 36-year-old man that was investigated by ultrasound and magnetic resonance imaging (MRI) before the diagnosis was confirmed by histopathology. CASE REPORT We report a nerve sheath myxoma of the ankle in a 36-year-old man. The palpable abnormality was falsely assumed to be a ganglion cyst prior to advanced imaging. Read More

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Biphenotypic Sinonasal Sarcoma: A Case Report and Review of Literature.

Ear Nose Throat J 2021 Apr 5:145561321999196. Epub 2021 Apr 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, NY, USA.

Objectives: Biphenotypic sinonasal sarcoma (BSNS), previously low-grade sinonasal sarcoma with neural and myogenic features, is a rare tumor of the sinonasal tract first described in 2012. Due to its rarity, limited literature is available in providing clinicians with a standardized treatment regimen, . This article aims to provide a clinical review of the currently available reported cases of BSNS, as well as presenting clinical, radiologic, and pathologic details of 2 novel cases. Read More

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Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia.

Int J Mol Sci 2021 Mar 24;22(7). Epub 2021 Mar 24.

Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including amyloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Read More

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The Biochemical Diagnosis of Acromegaly.

J Clin Med 2021 Mar 9;10(5). Epub 2021 Mar 9.

Institute of Endocrinology, Beilinson Hospital, 49100 Petach Tikva, Israel.

Background: The diagnosis of acromegaly still poses a clinical challenge, and prolonged diagnostic delay is common. The most important assays for the biochemical diagnosis and management of acromegaly are growth hormone (GH) and insulin-like growth factor-1 (IGF-1).

Objective: Discuss the role of IGF-1, basal serum GH, and nadir GH after oral glucose tolerance test (OGTT) for the diagnosis, management, and treatment of patients with acromegaly. Read More

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Histologic and Molecular Features in Pathologic Human Menisci from Knees with and without Osteoarthritis.

J Orthop Res 2021 Apr 1. Epub 2021 Apr 1.

Hospital for Special Surgery, Lab. for Soft Tissue Research, New York, New York, United States.

The objective of this study was to evaluate histologic and molecular features of meniscus degeneration in cohorts of patients with and without osteoarthritis (OA) of the knee. Menisci were obtained from patients undergoing total knee arthroplasty for OA (TKA) or arthroscopic partial meniscectomy (APM) for a torn knee meniscus. Degenerative meniscal tears were among the most common tear type in the APM group based on pattern. Read More

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Unusual Tissue - Unusual Issue: Pancreatic Heterotopia Presenting as Gastric Outlet Obstruction.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):338-343. Epub 2021 Mar 11.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Gundersen Health System, La Crosse, Wisconsin, USA.

Pancreatic heterotopia (PH) is a common, but typically small (<1 cm), incidental and asymptomatic finding; however, PH should be considered even for large and symptomatic upper gastrointestinal masses. A 27-year-old white woman presented with a 3-week history of burning epigastric pain, nausea, early satiety, and constipation. Physical examination revealed epigastric and right upper quadrant tenderness with normal laboratory workup, but imaging revealed a 5-cm, partly cystic mass arising from the gastric antrum with resulting pyloric stenosis and partial gastric outlet obstruction. Read More

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CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria.

Sci Rep 2021 Mar 31;11(1):7254. Epub 2021 Mar 31.

Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.

Phenylketonuria (PKU) is an autosomal recessive inborn error of L-phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the enzyme phenylalanine hydroxylase (PAH), which is necessary for conversion of Phe to tyrosine (Tyr). This metabolic error results in buildup of Phe and reduction of Tyr concentration in blood and in the brain, leading to neurological disease and intellectual deficits. Read More

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Solid Components in the Mediastinal Window of Computed Tomography Define a Distinct Subtype of Subsolid Nodules in Clinical Stage I Lung Cancers.

Clin Lung Cancer 2021 Feb 27. Epub 2021 Feb 27.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: We aimed to validate the clinicopathologic characteristics and prognostic value of the presence of solid components in the mediastinal window of computed tomography scan in clinical stage I pulmonary subsolid nodules (SSNs).

Methods: We retrospectively evaluated patients with pulmonary SSNs resected between 2011 and 2016. We classified SSNs into heterogeneous ground-glass nodules (HGGNs) (solid component detected only in lung window) and part-solid nodules (PSNs) (solid component detected both in lung/mediastinal windows). Read More

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February 2021

Sporadic multiple renal angiomyolipoma with lymph node involvement: a case report and literature review.

J Int Med Res 2021 Mar;49(3):3000605211001710

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.

Angiomyolipoma (AML) is a benign tumor that mainly occurs in the kidneys. Simultaneous involvement of the kidney and local regional lymph nodes is very rare and might be misdiagnosed as a metastasizing malignant cancer. In the present study, a 50-year-old woman was referred to our hospital after a routine health screening ultrasound. Read More

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A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.

Life Sci 2021 Mar 27;276:119403. Epub 2021 Mar 27.

Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. Electronic address:

Aims: Many dietary NASH models require a long duration to establish (4-6 months). Chronic intermittent hypoxia (CIH), a cardinal hallmark of obstructive sleep apnea (OSA), may accelerate the progression of pediatric nonalcoholic fatty liver disease (NAFLD). However, diet-induced obese (DIO) mice exposed to CIH have not been perceived as a fast or reliable tool in NASH research. Read More

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Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy.

Eur Urol 2021 Mar 27. Epub 2021 Mar 27.

Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA. Electronic address:

Background: Patients diagnosed with high risk localized prostate cancer have variable outcomes following surgery. Trials of intense neoadjuvant androgen deprivation therapy (NADT) have shown lower rates of recurrence among patients with minimal residual disease after treatment. The molecular features that distinguish exceptional responders from poor responders are not known. Read More

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Meibum lipid composition in type 2 diabetics with dry eye.

Exp Eye Res 2021 Mar 26;206:108522. Epub 2021 Mar 26.

Department of Ophthalmology,Yangpu Hospital, Tongji University School of Medicine, Shanghai, 20090, China. Electronic address:

Purpose: The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).

Methods: 90 subjects were divided into the following 4 groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); naive control group: normal subjects (n = 16). The lipid composition of meibum samples collected from these subjects was analyzed by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) system. Read More

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Morphologic and Molecular Aspects of Glioblastomas.

Neurosurg Clin N Am 2021 Apr;32(2):149-158

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Building 10, Room 2S235 Bethesda, MD 20892, USA. Electronic address:

The definition of glioblastomas has continually evolved from a reliance on strict morphologic features to a combination of histologic and molecular criteria, as the understanding of the genetic basis of these tumors expands. Modern pathologic workup of glioblastomas includes intraoperative evaluations with tissue-sparing techniques, histologic assessment with immunohistochemical markers, and comprehensive molecular characterization aiming at personalized targeting of genetic abnormalities. Machine learning analysis of DNA methylation profiles is a breakthrough technology that has bolstered central nervous system tumor classification and discovery and is particularly beneficial for the diagnosis and subtyping of glioblastomas. Read More

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Typical CT Features of Intrapulmonary Lymph Nodes: A Review.

Radiol Cardiothorac Imaging 2020 Aug 27;2(4):e190159. Epub 2020 Aug 27.

Diagnostic Image Analysis Group, Department of Radiology, Nuclear Medicine, and Anatomy, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands (A.S., C.J., E.T.S., B.v.G., C.M.S.P., M.P.); Fraunhofer MEVIS, Bremen, Germany (C.J., B.v.G.); and Department of Radiology, Meander Medisch Centrum, Amersfoort, the Netherlands (C.M.S.P.).

Several studies investigated the appearance of intrapulmonary lymph nodes (IPLNs) at CT with pathologic correlation. IPLNs are benign lesions and do not require follow-up after initial detection. There are indications that IPLNs represent a considerable portion of incidentally found pulmonary nodules seen at high-resolution CT. Read More

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Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.

Front Endocrinol (Lausanne) 2021 10;12:565981. Epub 2021 Mar 10.

Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.

A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans, pancreata from T1D deceased donors exhibit significant neutrophil accumulation. We present a time course of previously unknown inflammatory changes that accompany neutrophil and neutrophil elastase accumulation in the pancreas of the non-obese diabetic (NOD) mouse strain as early as 2 weeks of age. Read More

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Postmortem radiologic and pathologic findings in COVID-19: The Toronto experience with pre-hospitalization deaths in the community.

Forensic Sci Int 2021 Mar 17;322:110755. Epub 2021 Mar 17.

Provincial Forensic Pathology Unit, Ontario Forensic Pathology Service, Forensic Services and Coroners Complex, 25 Morton Shulman Avenue, Toronto, Ontario M3M 0B1, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, 6th Floor, Toronto, Ontario M5S 1A8, Canada. Electronic address:

Over a year after the initial emergence of the disease, the COVID-19 pandemic continues to strain healthcare systems worldwide. The value of feedback and connection between clinical care, public health, and death investigation systems has never been more clear. To this end, knowledge of the radiologic and histopathologic features of fatal COVID-19 is critical for those working with the living and the dead. Read More

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Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer.

Breast Cancer Res Treat 2021 Mar 26. Epub 2021 Mar 26.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.

Purpose: The SP142 PD-L1 assay is a companion diagnostic for atezolizumab in metastatic triple-negative breast cancer (TNBC). We strove to understand the biological, genomic, and clinical characteristics associated with SP142 PD-L1 positivity in TNBC patients.

Methods: Using 149 TNBC formalin-fixed paraffin-embedded tumor samples, tissue microarray (TMA) and gene expression microarrays were performed in parallel. Read More

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Adenomyosis in Pregnancy: Diagnostic Pearls and Pitfalls.

Radiographics 2021 Mar 26:200120. Epub 2021 Mar 26.

From the Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L-340, Portland, OR 97239.

Adenomyosis is a common benign uterine disorder in which ectopic endometrial glands extend into the myometrium. Adenomyosis is increasingly diagnosed in young women, affecting 20%-35% of women of reproductive age. Features of adenomyosis can be seen with either US or MRI, especially with newer imaging technology. Read More

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