7,722 results match your criteria pathogens opportunistic

Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites.

Food Chem 2021 Sep 9;371:131106. Epub 2021 Sep 9.

State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China. Electronic address:

Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia. Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S rRNA gene sequencing were employed to investigate the effects of arabinoxylan on gut microbiota and their metabolites in type 2 diabetic rats. Read More

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September 2021

Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation.

Anaerobe 2021 Sep 17:102449. Epub 2021 Sep 17.

Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway. Electronic address:

Background: The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. nucleatum and P. Read More

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September 2021

Thymus Degeneration and Regeneration.

Front Immunol 2021 1;12:706244. Epub 2021 Sep 1.

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.

The immune system's ability to resist the invasion of foreign pathogens and the tolerance to self-antigens are primarily centered on the efficient functions of the various subsets of T lymphocytes. As the primary organ of thymopoiesis, the thymus performs a crucial role in generating a self-tolerant but diverse repertoire of T cell receptors and peripheral T cell pool, with the capacity to recognize a wide variety of antigens and for the surveillance of malignancies. However, cells in the thymus are fragile and sensitive to changes in the external environment and acute insults such as infections, chemo- and radiation-therapy, resulting in thymic injury and degeneration. Read More

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September 2021

Dual-site recognition of Pseudomonas aeruginosa using polymyxin B and bacteriophage tail fiber protein.

Anal Chim Acta 2021 Oct 15;1180:338855. Epub 2021 Jul 15.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address:

As one of the top three opportunistic pathogens, Pseudomonas aeruginosa (P. aeruginosa) has long accounted for hospital-acquired infections with high risk of death. In this work, a fluorescent method based on a dual-site recognition mode was developed for rapid assay of P. Read More

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October 2021

Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens.

Anim Microbiome 2021 Sep 19;3(1):62. Epub 2021 Sep 19.

Vaccine & Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, Canada.

Background: The bovine upper respiratory tract (URT) microbiome includes opportunistic pathogens that cause respiratory disease and stress associated with maternal separation and transportation contributes to the severity of this respiratory disease. Stress is known to alter the gut microbiome but little is known regarding the effect of stress on the URT microbiota. This study used six-month old suckling beef calves to investigate whether maternal separation (weaned), by itself or combined with transportation (weaned + transport), altered the URT microbiome and host immune responses to resident opportunistic pathogens. Read More

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September 2021

Evaluation of renal effects of liposomal amphotericin B in children with malignancies with KDIGO and RIFLE criteria.

Nephrol Ther 2021 Sep 14. Epub 2021 Sep 14.

Department of pediatric infectious diseases, Dr Behçet Uz children's diseases and surgery training and research hospital, İzmir, Turkey.

Background: Amphotericin B is a broad-spectrum antifungal agent and is the backbone of the treatment for medically important opportunistic fungal pathogens in children. This study aimed to compare the nephrotoxicity associated with L-AmB in children with acute lymphoblastic leukemia and acute myeloid leukemia.

Materials And Methods: A total of 112 pediatric acute lymphoblastic leukemia or acute myeloid leukemia patients who received treatment with L-AmB (Ambisome®) at the University of Health Sciences Dr Behcet Uz Children's Hospital over 7 years were included. Read More

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September 2021

From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance.

Nat Rev Microbiol 2021 Sep 16. Epub 2021 Sep 16.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Secondary metabolites profoundly affect microbial physiology, metabolism and stress responses. Increasing evidence suggests that these molecules can modulate microbial susceptibility to commonly used antibiotics; however, secondary metabolites are typically excluded from standard antimicrobial susceptibility assays. This may in part account for why infections by diverse opportunistic bacteria that produce secondary metabolites often exhibit discrepancies between clinical antimicrobial susceptibility testing results and clinical treatment outcomes. Read More

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September 2021

Surveillance of Wisconsin Organisms for Trends in Antimicrobial Resistance and Epidemiology (SWOTARE): 2018-2019 Report on Clinical Isolates.

Clin Med Res 2021 Sep;19(3):123-131

College of Health Sciences, Marquette University, Milwaukee, Wisconsin USA

Both and have been regarded as important opportunistic pathogens for humans. Recent data have described the spread of multi-resistant strains of these organisms. Development of novel resistance phenotypes may result in a reduction in anti-infective efficacy, therefore making patient treatment decisions challenging. Read More

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September 2021

Draft Genome Sequences of Staphylococcus sp. Strain CWZ226, of Unknown Origin, and Pseudomonas sp. Strain CVAP#3, Antagonistic to Strain CWZ226.

Microbiol Resour Announc 2021 Sep 16;10(37):e0068821. Epub 2021 Sep 16.

Smith College, Department of Biological Sciences, Northampton, Massachusetts, USA.

Many Staphylococcus and Pseudomonas species, such as Staphylococcus aureus and Pseudomonas aeruginosa, are opportunistic human pathogens. However, Pseudomonas species are also known to produce bioactive compounds. Here, we report on the genome sequences of a Pseudomonas isolate and a Staphylococcus species of unknown origin that it inhibits. Read More

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September 2021

COVID-19 and oral diseases: Assessing manifestations of a new pathogen in oral infections.

Int Rev Immunol 2021 Sep 16:1-15. Epub 2021 Sep 16.

Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA.

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a recently identified virus responsible for life-threatening coronavirus disease 19 (COVID-19). The SARS-CoV-2 infected subjects can be asymptomatic or symptomatic; the later may present a wide spectrum of clinical manifestations. However, the impact of SARS-CoV-2 on oral diseases remain poorly studied. Read More

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September 2021

The Gut Microbiota Protects Bees from Invasion by a Bacterial Pathogen.

Microbiol Spectr 2021 Sep 15:e0039421. Epub 2021 Sep 15.

Department of Integrative Biology, University of Texas at Austin, Austin, Texas, USA.

Commensal microbes in animal guts often help to exclude bacterial pathogens. In honey bees, perturbing or depleting the gut microbiota increases host mortality rates upon challenge with the opportunistic pathogen Serratia marcescens, suggesting antagonism between S. marcescens and one or more members of the bee gut microbiota. Read More

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September 2021

Multiplex Real-Time Polymerase Chain Reaction on Sputum for the Diagnosis of Pneumonia in Children: A Retrospective Study.

Infect Drug Resist 2021 7;14:3627-3635. Epub 2021 Sep 7.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Background: pneumonia (PCP) is a serious opportunistic infection in immunocompromised children. Real-time polymerase chain reaction (PCR) is widely used for the diagnosis of PCP due to its good accuracy. However, the diagnostic performance of multiplex real-time PCR on sputum in children with PCP has never been explored. Read More

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September 2021

Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study.

Genome Med 2021 Sep 13;13(1):150. Epub 2021 Sep 13.

Applied Microbiology Research, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.

Background: Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently been described, yet their clinical impact and antibiotic resistance profiles are largely unknown. Read More

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September 2021

The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation.

Bioengineered 2021 Dec;12(1):6484-6498

Department of Gastrointestinal Surgery, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu Province, China.

To explore mechanism of intestinal flora dysregulation promoting constipation, 60 specific pathogen-free (SPF) mice were used as research objects and were treated with constipation population fecal fluid gavage and distilled water gavage. Then, relationship between intestinal dysregulation and constipation in mice with biofilm-mediated intestinal flora was investigated in vitro. The results showed that recombinant serotonin transporter (SERT) messenger ribonucleic acid (mRNA) level of the constipation population fecal fluid gavage group and the relative expression level of SERT mRNA were 1. Read More

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December 2021

Single-Cell Imaging Reveals That Is Highly Competitive Against on Surfaces.

Front Cell Infect Microbiol 2021 26;11:733991. Epub 2021 Aug 26.

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

and frequently occur together in polymicrobial infections, and their interactions can complicate disease progression and treatment options. While interactions between and have been extensively described using planktonic batch cultures, little is known about whether and how individual cells interact with each other on solid substrates. This is important because both species frequently colonize surfaces to form aggregates and biofilms in infections. Read More

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Characterization, enzymatic activity and biofilm formation of Candida species isolated from goat milk.

Rev Iberoam Micol 2021 Sep 9. Epub 2021 Sep 9.

Laboratorio de Micología Veterinaria, Unidad de Servicios de Diagnóstico y Constatación, Centro de Enseñanza, Investigación y Extensión en Producción Animal en Altiplano, Facultad de Medicina Veterinaria y Zootecnia, UNAM, Mexico.

Background: Data regarding yeast microbiota in goat milk is scarce.

Aims: To isolate and identify species of the genus Candida in milk samples from clinically healthy goats, and evaluate their enzymatic activity and biofilm formation.

Methods: 1092 milk samples from clinically healthy goats were collected and processed. Read More

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September 2021

Contamination of Hospital Surfaces with Bacterial Pathogens under the Current COVID-19 Outbreak.

Int J Environ Res Public Health 2021 08 27;18(17). Epub 2021 Aug 27.

Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.

The SARS-CoV-2 pandemic remains a global health issue for several reasons, such as the low vaccination rates and a lack of developed herd immunity to the evolution of SARS-CoV-2, as well as its potential inclination to elude neutralizing antibodies. It should be noted that the severity of the COVID-19 disease is significantly affected by the presence of co-infections. Comorbid conditions are caused not only by pathogenic and opportunistic microorganisms but also by some representatives of the environmental microbiome. Read More

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Extensive horizontal gene transfer within and between species of coagulase-negative Staphylococcus.

Genome Biol Evol 2021 Sep 8. Epub 2021 Sep 8.

Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA 12222.

Members of the gram-positive bacterial genus Staphylococcus have historically been classified into coagulase-positive Staphylococcus (CoPS) and coagulase-negative Staphylococcus (CoNS) based on the diagnostic presentation of the coagulase protein. Previous studies have noted the importance of horizontal gene transfer (HGT) and recombination in the more well-known CoPS species Staphylococcus aureus, yet little is known of the contributions of these processes in CoNS evolution. In this study, we aimed to elucidate the phylogenetic relationships, genomic characteristics and frequencies of HGT in CoNS, which are now being recognized as major opportunistic pathogens of humans. Read More

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September 2021

The Human Gut Resistome up to Extreme Longevity.

mSphere 2021 Sep 8:e0069121. Epub 2021 Sep 8.

Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bolognagrid.6292.f, Bologna, Italy.

Antibiotic resistance (AR) is indisputably a major health threat which has drawn much attention in recent years. In particular, the gut microbiome has been shown to act as a pool of AR genes, potentially available to be transferred to opportunistic pathogens. Herein, we investigated for the first time changes in the human gut resistome during aging, up to extreme longevity, by analyzing shotgun metagenomics data of fecal samples from a geographically defined cohort of 62 urban individuals, stratified into four age groups: young adults, elderly, centenarians, and semisupercentenarians, i. Read More

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September 2021

Carbohydrate Metabolism Affects Macrophage-Mediated Killing of Enterococcus faecalis.

mSystems 2021 Sep 7:e0043421. Epub 2021 Sep 7.

Department of Endodontics and Operative Dentistry, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Enterococcus faecalis, an opportunistic pathogen that causes severe community-acquired and nosocomial infections, has been reported to resist phagocyte-mediated killing, which enables its long-term survival in the host. Metabolism, especially carbohydrate metabolism, plays a key role in the battle between pathogens and hosts. However, the function of carbohydrate metabolism in the long-term survival of E. Read More

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September 2021

LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense.

mBio 2021 Sep 7:e0212721. Epub 2021 Sep 7.

Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.

Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully understood. We report here that a long noncoding RNA (lncRNA), GenBank accession no. XR_001779380, was increased in abundance in murine intestinal epithelial cells following infection by , an important opportunistic pathogen in AIDS patients and a common cause of diarrhea in young children. Read More

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September 2021

Whole genome sequencing data of isolated from agricultural soil of Haryana, India.

Data Brief 2021 Oct 24;38:107311. Epub 2021 Aug 24.

Department of Biotechnology, Deenbandhu Chottu Ram University of Science and Technology, Murthal, Sonipat, Haryana 131039, India.

, is a Gram-negative bacterium, which was previously known as . It is present in all environments such as water, soil, air and hospitals; and is an opportunistic pathogen that causes several types of infections. As compared to other clinically important pathogens included in the ESKAPE category (), the pangenome and population structure of is still poorly understood. Read More

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October 2021

Clinical Application of Metagenomic Next-Generation Sequencing for Suspected Infections in Patients With Primary Immunodeficiency Disease.

Front Immunol 2021 13;12:696403. Epub 2021 Aug 13.

Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.

Background: Infections are the major cause of morbidity and mortality in patients with primary immunodeficiency disease (PID). Timely and accurate microbiological diagnosis is particularly important in these patients. Metagenomic next-generation sequencing (mNGS) has been used for pathogen detection recently. Read More

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An Ohio State Scenic River Shows Elevated Antibiotic Resistance Genes, Including Acinetobacter Tetracycline and Macrolide Resistance, Downstream of Wastewater Treatment Plant Effluent.

Microbiol Spectr 2021 Sep 1:e0094121. Epub 2021 Sep 1.

Department of Biology, Kenyon Collegegrid.258533.a, Gambier, Ohio, USA.

The entry of antibiotic resistance genes (ARGs) into aquatic systems has been documented for large municipal wastewater treatment plants (WWTPs), but there is less study of the impact of smaller plants that are situated on small rural rivers. We sampled water metagenomes for ARGs and taxa composition from the Kokosing River, a small rural river in Knox County, Ohio, which has been designated an Ohio State Scenic River for retention of natural character. Samples were obtained 1. Read More

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September 2021

Demonstration of ,-Dimethyldithiocarbamate as a Copper-Dependent Antibiotic against Multiple Upper Respiratory Tract Pathogens.

Microbiol Spectr 2021 Sep 1:e0077821. Epub 2021 Sep 1.

Department of Immunobiology, University of Arizonagrid.134563.6, Tucson, Arizona, USA.

Transition metals are necessary cofactors and structural elements in living systems. Exposure to high concentrations of biologically important transition metals, such as zinc and copper, results in cell toxicity. At the infection site, the immune system deploys metal sorbent proteins (e. Read More

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September 2021

Genomic attributes differ between Vibrio parahaemolyticus environmental and clinical isolates including pathotypes.

Environ Microbiol Rep 2021 Aug 30. Epub 2021 Aug 30.

Cholera and Biofilm Research Lab, Department of Pathogen Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

Vibrio parahaemolyticus is a marine bacterium and causes opportunistic gastroenteritis in humans. Clinical strains of V. parahaemolyticus contain haemolysin and type III secretion systems (T3SS) that define their pathotype. Read More

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Gut Microbiota Development: Influence of Diet from Infancy to Toddlerhood.

Ann Nutr Metab 2021 Aug 30:1-14. Epub 2021 Aug 30.

National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Early life is a critical period as our gut microbiota establishes here and may impact both current and future health. Thus, it is of importance to understand how different factors govern the complex microbial colonization patterns in this period. The gut microbiota changes substantially during infancy and toddlerhood in terms of both taxonomic composition and diversity. Read More

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Opportunistic pathogens exhibit distinct growth dynamics in rainwater and tap water storage systems.

Water Res 2021 Aug 19;204:117581. Epub 2021 Aug 19.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address:

Opportunistic pathogens (OPs) are emerging microbial contaminants in engineered water systems, yet their growth potential in rainwater systems has not been evaluated. The purpose of this study was to compare the growth dynamics of bacterial OPs and related genera (Pseudomonas aeruginosa, Legionella spp., L. Read More

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Generation of glucosylated -1-glycerolphosphate teichoic acids: glycerol stereochemistry affects synthesis and antibody interaction.

RSC Chem Biol 2021 Feb 23;2(1):187-191. Epub 2020 Dec 23.

Leiden Institute of Chemistry, Leiden University Einsteinweg 55 2333 CC Leiden The Netherlands

Lipoteichoic acids (LTAs) have been addressed as possible antigen candidates for vaccine development against several opportunistic Gram-positive pathogens. The study of structure-immunogenicity relationship represents a challenge due to the heterogenicity of LTA extracted from native sources. LTAs are built up from glycerol phosphate (GroP) repeating units and they can be substituted at the C-2-OH with carbohydrate appendages or d-alanine residues. Read More

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February 2021

The microbiota-related coinfections in COVID-19 patients: a real challenge.

Beni Suef Univ J Basic Appl Sci 2021 21;10(1):47. Epub 2021 Aug 21.

Department of Synthesis of Bioactive Substances and Pharmaceutical Technologies, National Institute for Chemical and Pharmaceutical Research and Development, Bucharest, Romania.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of ongoing global pandemic of coronavirus disease 2019 (COVID-19), has infected millions of people around the world, especially the elderly and immunocompromised individuals. The infection transmission rate is considered more rapid than other deadly pandemics and severe epidemics encountered earlier, such as Ebola, Zika, Influenza, Marburg, SARS, and MERS. The public health situation therefore is really at a challenging crossroads. Read More

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