mSphere 2021 Sep 8:e0069121. Epub 2021 Sep 8.
Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bolognagrid.6292.f, Bologna, Italy.
Antibiotic resistance (AR) is indisputably a major health threat which has drawn much attention in recent years. In particular, the gut microbiome has been shown to act as a pool of AR genes, potentially available to be transferred to opportunistic pathogens. Herein, we investigated for the first time changes in the human gut resistome during aging, up to extreme longevity, by analyzing shotgun metagenomics data of fecal samples from a geographically defined cohort of 62 urban individuals, stratified into four age groups: young adults, elderly, centenarians, and semisupercentenarians, i. Read More