Am J Dermatopathol 2021 May 11. Epub 2021 May 11.
Department of Dermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Consultant Dermatologist, HCA UK, London, United Kingdom; Department of Dermatology, The Princess Margaret Hospital, Windsor, Berkshire, United Kingdom; Consultant Dermatopathologist, LD Path, London, United Kingdom; and Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Abstract: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-LPD), recently downgraded from a T-cell lymphoma, is a poorly characterized histopathological entity. Presenting as a solitary lesion that often grows rapidly, it may raise suspicion for a cutaneous B-cell lymphoma. However, classically, the dermal lymphoid proliferation is predominantly CD4+ with a follicular T-helper profile and a smaller B-cell fraction. Read More