210 results match your criteria passing decades

Going Backwards to Fill in the Missing Processes for Training and Evaluation of Clinical Bioethicists: What Has Been Needed for Decades to Move Real Professionalism Forward.

Evan G DeRenzo

J Clin Ethics 2021 ;32(2):149-154

John J. Lynch Center for Ethics, MedStar Washington Hospital Center, Washington, District of Columbia 20020 USA.

As the field of clinical bioethics has moved from its pioneers, who turned their attention to ethics problems in clinical medicine and clinical and animal research, to today's ubiquity of university degrees and fellowships in bioethics, there has been a steady drumbeat to professionalize the field. The problem has been that the necessary next steps-to specify the skills, knowledge, and personal and professional attributes of a clinical bioethicist, and to have a method to train and evaluate mastery of these standards-are lacking. Ordinarily, the path to professionalism in medicine starts with the intellectual pioneers. Read More

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How We Got Where We Are in Blood Pressure Targets.

Curr Hypertens Rep 2021 Jun 10;23(6):33. Epub 2021 Jun 10.

Medicine Services, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.

Purpose Of Review: While we started clinical trials evaluating the benefit of lowering systolic BP's >160 mm Hg and diastolic BPs of <130 mm Hg, the latest guideline suggests a target of <130/80 mm Hg in those with hypertension. This article summarizes exactly how we got to where we are looking over the last half-century.

Recent Findings: Our understanding of systolic and diastolic blood pressure targets to improve cardiovascular outcomes has changed substantially over the past 5 decades. Read More

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Ultra-trace interference-free analysis of palladium in natural waters by ICP-MS after on-line matrix separation and pre-concentration.

Talanta 2021 Sep 17;232:122289. Epub 2021 Mar 17.

University of Bordeaux, UMR CNRS 5805 EPOC, 33615, Pessac, France.

The determination of palladium (Pd) in environmental samples by ICP-MS is challenging as all its isotopes are extensively interfered due to isobaric (e.g. Cd on Pd, Cd on Pd), polyatomic (e. Read More

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September 2021

Harnessing Natural Mosaics: Antibody-Instructed, Multi-Envelope HIV-1 Vaccine Design.

Viruses 2021 May 11;13(5). Epub 2021 May 11.

Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

The year 2021 marks the 40th anniversary since physicians recognized symptoms of the acquired immunodeficiency syndrome (AIDS), a disease that has since caused more than 30 million deaths worldwide. Despite the passing of four decades, there remains no licensed vaccine for the human immunodeficiency virus type 1 (HIV-1), the etiologic agent of AIDS. Despite the development of outstanding anti-retroviral drugs, there are currently more than one-half million deaths each year due to AIDS. Read More

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Offshore Online Measurements of Total Suspended Solids Using Microscopy Analyzers.

Sensors (Basel) 2021 May 4;21(9). Epub 2021 May 4.

Department of Energy Technology, Aalborg University, Niels Bohrs Vej 8, 6700 Esbjerg, Denmark.

Accurate online water quality measurements have gained attention during the last decades in the oil and gas industry for improving operational performance and protecting the surrounding environment. One potential solution to extend the reservoirs' economic life and put less strain on the environment is by re-injecting the produced water, but the injected water quality must be high and consistent to prevent injectivity reduction. This paper evaluates two different online microscopy analyzers that utilize a high-resolution video camera for capturing images of the particles passing their view cell. Read More

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Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.

Bioconjug Chem 2021 Jun 25;32(6):1067-1077. Epub 2021 May 25.

Department of Experimental and Health Sciences, Pompeu Fabra University, 08003 Barcelona, Spain.

Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive permeability. In particular, this includes drugs such as antiviral porphyrins, with the ability to fight brain-resident viruses causing diseases such as HIV-associated neurocognitive disorders (HAND). Read More

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[The impact of territorial care in the treatment of people diagnosed with schizophrenia and delusional disorders in a Rio de Janeiro community].

Salud Colect 2021 Mar 17;17:e3020. Epub 2021 Mar 17.

Doctora en Psiquiatría, Posdoctora en Epidemiología Psiquiátrica. Profesora Titular, Departamento de Psiquiatria, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Care for people diagnosed with schizophrenia and delusional disorders involves many challenges, especially in territorial contexts of pronounced social vulnerability. In Rio de Janeiro, the two decades after the passing of Federal Law 10,216 on Psychiatric Reform in 2001 have been characterized by the transition from a hospital-centered model to one based on community services. Taking the case of a community in Rio de Janeiro, data was extracted from the medical records of 94 patients diagnosed with schizophrenia, schizotypal disorders, and delusional disorders (ICD-10 codes F20 to F29) in five public health services. Read More

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The evolution in the surgical management of Peyronie's disease.

Urologia 2021 May 30;88(2):79-89. Epub 2021 Mar 30.

Department of Urology, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still remains uncertain. Read More

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A Personal Tribute to a Highly Inspiring Mentor, Professor Sir Peter J. Lachmann, 1931-2020.

Viruses 2021 01 29;13(2). Epub 2021 Jan 29.

Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.

With great sadness and sympathy for his family, especially for his wife and companion for many decades, Sylvia, I convey the news of the peaceful passing of Professor Sir Peter Lachmann on 26 December 2020, three days after his 89th birthday and after a Christmas celebration-as far as this was possible these days-in the heart of his family [... Read More

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January 2021

Stereocilia Bundle Imaging with Nanoscale Resolution in Live Mammalian Auditory Hair Cells.

J Vis Exp 2021 01 21(167). Epub 2021 Jan 21.

Department of Physiology, College of Medicine, University of Kentucky;

Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that consists of stereocilia that are arranged in rows of increasing height. When stereocilia are deflected, they tug on tiny (~5 nm in diameter) extracellular tip links interconnecting stereocilia, which convey forces to the mechanosensitive transduction channels. Although mechanotransduction has been studied in live hair cells for decades, the functionally important ultrastructural details of the mechanotransduction machinery at the tips of stereocilia (such as tip link dynamics or transduction-dependent stereocilia remodeling) can still be studied only in dead cells with electron microscopy. Read More

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January 2021

The Prevalence and Clinical Profile of Hirschsprung's Disease at a Tertiary Hospital in Bahrain.

Cureus 2021 Jan 4;13(1):e12480. Epub 2021 Jan 4.

Pediatric Surgery, Salmaniya Medical Complex, Manama, BHR.

Background Hirschsprung's disease (HD) is a rare but important congenital pediatric disease of the colon, and its incidence varies widely between ethnic groups. Its incidence was first studied in Bahrain in 1980 using hospital-based data. Over a 16-month period, 10 cases were reported, representing a relatively high incidence rate: 1 per 4000 births. Read More

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January 2021

Generation of Neurosphere-Derived Organoid-Like-Aggregates (NEDAS) from Neural Stem Cells.

Curr Protoc 2021 Feb;1(2):e15

Laboratory of Neural Stem cells and Functional Neurogenetics, Division of Multiple Sclerosis and Translational Neuroimmunology, UConn Health Comprehensive Multiple Sclerosis Center, Department of Neurology and Neuroscience UConn School of Medicine, Farmington, Connecticut.

Neurosphere cultures have been used to propagate and study the intrinsic properties of neural stem cells (NSCs) for more than two decades but this method has many limitations. It is well known that neurospheres fuse in culture, but the long-term biological consequences of this phenomena are not well characterized. We leveraged the fusion behavior of human neurospheres to improve upon this technique with our Neurosphere-derived organoid-like aggregates (NEDAS) culture method, allowing the fusion of human NSCs at high density, which were maintained in orbital shaker conditions for 8-12 weeks without passing leading to the formation of 3D organoid-like aggregates without the use of Matrigel. Read More

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February 2021

Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China.

Environ Sci Pollut Res Int 2021 Jun 2;28(22):28207-28221. Epub 2021 Feb 2.

Shanxi Research Academy of Environmental Science, Taiyuan, 030027, China.

The antibiotic distributions, partitioning, and migration pathways in river basins have withdrawn great attention in the past decades. This study investigates 26 antibiotics of five classifications in surface water and sediment samples at 23 sites in Fenhe River, a typical tributary of Yellow River. There are 21 antibiotics found in the water samples at the concentration from 113. Read More

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[The Development of General Practices in Ambulatory Care in the Last Decades - An Analysis of the Physicians' Registry of Bavaria].

Gesundheitswesen 2021 Jan 28. Epub 2021 Jan 28.

Institut für Allgemeinmedizin und Versorgungsforschung, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.

Aim Of The Study: There is an increasing shortage of general practitioners (GPs) in Germany. An in-depth understanding of the variation regarding the characteristics of the GPs in the last decades might help to optimize primary health care. The aim of the analysis of the characteristic features of GPs as preserved by the registry of the Bavarian Association of Statutory Health Insurance of Physicians (KVB) was to delineate the time interval between passing the medical state examination and establishment of one's own private practice, the development of group practices and employments, and the number of additional qualifications. Read More

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January 2021

What Do People Know About the Heritability of Sleep?

Behav Genet 2021 03 23;51(2):144-153. Epub 2021 Jan 23.

Department of Psychology, Goldsmiths, University of London, London, UK.

Study Objectives: Twin studies have provided data about the relative weight of genetic and environmental factors on sleep variables over the last few decades. However, heritability is a non-intuitive concept and it is often misunderstood even amongst the scientific community. This study aimed to analyze: (1) understanding of the meaning of heritability of insomnia; (2) the accuracy of estimations of heritability in the general population regarding three sleep traits (sleep duration, sleep quality and insomnia); (3) perceptions of the effectiveness of different treatments for insomnia depending on how the disorder is presented (i. Read More

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An Emphasis on Screening to Detect Liver Cirrhosis and Hepatocellular Carcinoma in Patients Having Undergone the Fontan Procedure in Early Childhood.

Case Rep Gastroenterol 2020 Sep-Dec;14(3):615-623. Epub 2020 Nov 23.

Department of Pathology, Staten Island University Hospital, New York, New York, USA.

The Fontan procedure is a surgical procedure for patients with single-ventricle anatomy that results in the flow of systemic venous blood to the lungs without passing through a ventricle. Before the 1970s, most children with single-ventricle anatomy failed to survive into adulthood. With the introduction of the Fontan procedure, and its many modifications, the survival rate of these patients improved exponentially. Read More

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November 2020

Integrating high resolution drone imagery and forest inventory to distinguish canopy and understory trees and quantify their contributions to forest structure and dynamics.

PLoS One 2020 10;15(12):e0243079. Epub 2020 Dec 10.

Laboratório de Manejo Florestal, Instituto Nacional de Pesquisas da Amazônia, Manaus, Amazonas, Brazil.

Tree growth and survival differ strongly between canopy trees (those directly exposed to overhead light), and understory trees. However, the structural complexity of many tropical forests makes it difficult to determine canopy positions. The integration of remote sensing and ground-based data enables this determination and measurements of how canopy and understory trees differ in structure and dynamics. Read More

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January 2021

Extracellular Vesicles, the Road toward the Improvement of ART Outcomes.

Animals (Basel) 2020 Nov 21;10(11). Epub 2020 Nov 21.

Research Group of Intracellular Signalling and Technology of Reproduction (Research Institute INBIO G+C), University of Extremadura, 10003 Cáceres, Spain.

Nowadays, farm animal industries use assisted reproductive technologies (ART) as a tool to manage herds' reproductive outcomes, for a fast dissemination of genetic improvement as well as to bypass subfertility issues. ART comprise at least one of the following procedures: collection and handling of oocytes, sperm, and embryos in in vitro conditions. Therefore, in these conditions, the interaction with the oviductal environment of gametes and early embryos during fertilization and the first stages of embryo development is lost. Read More

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November 2020

Spectral Verification of the Mechanisms behind FBG-Based Ultrasonic Guided Wave Detection.

Sensors (Basel) 2020 Nov 17;20(22). Epub 2020 Nov 17.

Brussels Photonics (B-PHOT), Department of Applied Physics and Photonics, Vrije Universiteit Brussel and Flanders Make, Pleinlaan 2, B-1050 Brussels, Belgium.

Ultrasonic guided wave (UGW) detection with fiber Bragg grating (FBG)-based sensors has received increasing attention in the last decades due to the ability to perform non-destructive inspection (NDI) of large plate-like surfaces with a network of lightweight and multiplexed sensors. For accurate UGW measurements, several studies concluded that the ratio between the wavelength of the UGW and the length of the FBG should be above 7. However, shorter FBGs suffer from a lower FBG reflectivity and less steep slopes in the reflection spectrum. Read More

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November 2020

Lasers in Glaucoma: an Overview.

Int Ophthalmol 2021 Mar 19;41(3):1111-1128. Epub 2020 Nov 19.

Department of Ophthalmology , SKMCH, Muzaffarpur, India.

Lasers have been in use as a treatment modality of glaucoma for more than last four decades. Each passing year has added newer dimensions to the existing laser technologies enhancing their safety and efficacy profile. This has become possible due to continuous research and innovations with proper understanding of the mechanism of action of different variety of lasers as treatment options. Read More

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Novel Neuromodulation Approach to Improve Left Ventricular Contractility in Heart Failure: A First-in-Human Proof-of-Concept Study.

Circ Arrhythm Electrophysiol 2020 11 29;13(11):e008407. Epub 2020 Sep 29.

Na Homolce Hospital, Prague, Czech Republic (V.Y.R., J.P., F.M., P.N.).

Background: Morbidity and mortality outcomes for patients admitted for acute decompensated heart failure are poor and have not significantly changed in decades. Current therapies are focused on symptom relief by addressing signs and symptoms of congestion. The objective of this study was to test a novel neuromodulation therapy of stimulation of epicardial cardiac nerves passing along the posterior surface of the right pulmonary artery. Read More

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November 2020

Convalescent plasma therapy: a promising coronavirus disease 2019 treatment strategy.

Open Biol 2020 09 9;10(9):200174. Epub 2020 Sep 9.

Department of Biotechnology, Mahatma Gandhi Central University, Motihari 845401, India.

The world is passing through a very difficult phase due to the coronavirus disease 2019 (COVID-19) pandemic, which has disrupted almost all spheres of life. Globally, according to the latest World Health Organization report (10 August 2020), COVID-19 has affected nearly 20 million lives, causing 728 013 deaths. Due to the lack of specific therapeutic drugs and vaccines, the outbreak of disease has spawned a corpus of contagious infection all over the world, day by day, without control. Read More

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September 2020

The CECAM electronic structure library and the modular software development paradigm.

J Chem Phys 2020 Jul;153(2):024117

Institute of Materials Chemistry, TU Wien, 1060 Vienna, Austria.

First-principles electronic structure calculations are now accessible to a very large community of users across many disciplines, thanks to many successful software packages, some of which are described in this special issue. The traditional coding paradigm for such packages is monolithic, i.e. Read More

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Processes of chromium (VI) migration and transformation in chromate production site: A case study from the middle of China.

Chemosphere 2020 Oct 4;257:127282. Epub 2020 Jun 4.

College of Resources and Environment, Southwest University, Chongqing, 400715, PR China; Chongqing Engineering Research Center of Rural Cleaning, Chongqing, 400716, PR China.

The migration and redox transformation processes of toxic Cr(VI) in the upper and deep soil of chromate-polluted site are of great importance for the environmental risk control and soil remediation. In this study, soils from surface to deep (around 30-60 m) and the groundwater in a typical abandoned chromate production plant site which has experienced decades of contamination were both sampled and analyzed. The results show that the soil in the leaching workshop of Cr(VI), dichromate transformation workshop and chromium slag dumping ground exhibits severe contamination of chromium and the pollution has extended to the groundwater, causing serious pollution in groundwater too. Read More

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October 2020

2020: A Time for Contemplation and Action.

Debra Lyon

Oncol Nurs Forum 2020 Mar;47(2):123-124

University of Florida.

Depending on which interpretation of the Gregorian and other calendars that you may believe to be the most accurate, the new decade either began on January 1, 2020, or will begin January 1, 2021. In any case, the contemplation of decades and time passing offers a time for appraisal and reflection, a chance to step outside of the day-to-day routines to consider less urgent, and perhaps more important issues that we will face in the near future. Read More

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Oral administration of porcine epidemic diarrhea virus spike protein expressing in silkworm pupae failed to elicit immune responses in pigs.

AMB Express 2020 Jan 28;10(1):20. Epub 2020 Jan 28.

School of Veterinary Medicine, National Taiwan University, Taipei, 106, Taiwan.

The silkworm (Bombyx mori) and its pupae have been used for decades as nutritional additives and applied on the production of high-quality recombinant proteins via the baculovirus expression vector (BEV) system. The bio-capsule, the fat-rich body, and some body components of the silkworm pupae, which deliver antigens passing through the harsh environment of digestive tract and reaching the intestine, have been used as a vehicle for oral vaccines. In the present study, to develop a novel oral vaccine against porcine epidemic diarrhea virus (PEDV), the PEDV spike (S) protein was expressed in silkworm pupae and BmN cells using the BEV system. Read More

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January 2020

Antimicrobial Resistance: Implications and Costs.

Infect Drug Resist 2019 20;12:3903-3910. Epub 2019 Dec 20.

Milken Institute of Public Health, George Washington University, Washington, DC, USA.

Antimicrobial resistance (AMR) has developed as one of the major urgent threats to public health causing serious issues to successful prevention and treatment of persistent diseases. In spite of different actions taken in recent decades to tackle this issue, the trends of global AMR demonstrate no signs of slowing down. Misusing and overusing different antibacterial agents in the health care setting as well as in the agricultural industry are considered the major reasons behind the emergence of antimicrobial resistance. Read More

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December 2019

Fe-doped mayenite electride composite with 2D reduced Graphene Oxide: As a non-platinum based, highly durable electrocatalyst for Oxygen Reduction Reaction.

Sci Rep 2019 Dec 24;9(1):19809. Epub 2019 Dec 24.

Advanced electromagnetic function laboratory, Dongguan university of Technology, Dongguan, Guangdong, China.

Since the last decades, non-precious metal catalysts (NPMC), especially iron based electrocatalysts show sufficient activity, potentially applicant in oxygen reduction reaction (ORR), however they only withstand considerable current densities at low operating potentials. On the other hand iron based electrocatalysts are not stable at elevated cathode potentials, which is essential for high energy competence, and its remains difficult to deal. Therefore, via this research a simple approach is demonstrated that allows synthesis of nanosize Fe-doped mayenite electride, [CaAlO]·(e) (can also write as, CAFe:e, where doping level, x = 1) (thereafter, Fe-doped C12A7:e), consist of abundantly available elements with gram level powder material production, based on simple citrate sol-gel method. Read More

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December 2019

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications.

Micromachines (Basel) 2019 Nov 29;10(12). Epub 2019 Nov 29.

Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD 4111, Australia.

Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Read More

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November 2019

Prevalence of HIV/Hepatitis C Virus Co-Infection and Injection Risk Correlations in People Who Inject Drugs in Colombia: A Cross-Sectional Study Using Respondent Driven Sampling.

Subst Use Misuse 2020 6;55(3):414-423. Epub 2019 Nov 6.

Epidemiology and Biostatistics Research Group, CES University, Medellin, Colombia.

In Colombia, an exponential growth of people who inject drugs (PWID) has been reported over the past decades. The main burden of disease in PWID is attributed to human immunodeficiency virus (HIV) and hepatitis C virus (HCV) and their co-infection is associated with poor prognosis, high morbidity and treatment related implications. Nevertheless, the prevalence of HIV/HCV co-infection in Colombian PWIDs is unknown. Read More

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