3,014 results match your criteria passed quality

Machine Learning-Aided Causal Inference Framework for Environmental Data Analysis: A COVID-19 Case Study.

Environ Sci Technol 2021 Sep 24. Epub 2021 Sep 24.

Northern Region Persistent Organic Pollution Control (NRPOP) Laboratory, Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's A1B 3X5, Newfoundland and Labrador, Canada.

Links between environmental conditions (e.g., meteorological factors and air quality) and COVID-19 severity have been reported worldwide. Read More

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September 2021

The Persistence of Slowed Time Experience During the COVID-19 Pandemic: Two Longitudinal Studies in France.

Front Psychol 2021 1;12:721716. Epub 2021 Sep 1.

Université Clermont Auvergne, CNRS, LAPSCO, Clermont-Ferrand, France.

The home confinement imposed on people to fight the COVID-19 pandemic interrupted the flow of time by disrupting daily life, making them feel that time was passing slowly. The aim of this longitudinal study was to evaluate the evolution over time of this subjective experience of time and its significant predictors (boredom, decreased happiness, life rhythm, and sleep quality). Twso samples of French participants were followed up: the first for several weeks during the first lockdown (April 2020) and then 1year later (April 2021; Study 1), and the second during the first lockdown (April 2020) and then 6months (November 2020) and 1year later (April 2021; Study 2). Read More

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September 2021

Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson's Disease.

Aging Dis 2021 Sep 1;12(6):1494-1515. Epub 2021 Sep 1.

1Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Torre Biologica, 95125 Catania, Italy.

The elderly population will significantly increase in the next decade and, with it, the proportion of people affected by age-related diseases. Among them, one of the most invalidating is Parkinson's disease (PD), characterized by motor- and non-motor dysfunctions which strongly impair the quality of life of affected individuals. PD is characterized by the progressive degeneration of dopaminergic neurons, with consequent dopamine depletion, and the accumulation of misfolded α-synuclein aggregates. Read More

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September 2021

Dose rate correction for a silicon diode detector array.

J Appl Clin Med Phys 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, University of Wuerzburg, Wuerzburg, Germany.

Purpose: A signal dependence on dose rate was reported for the ArcCHECK array due to recombination processes within the diodes. The purpose of our work was to quantify the necessary correction and apply them to quality assurance measurements.

Methods: Static 10 × 10 cm 6-MV fields delivered by a linear accelerator were applied to the detector array while decreasing the average dose rate, that is, the pulse frequency, from 500 to 30 MU/min. Read More

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September 2021

Sociodemographic and lifestyle predictors of mental health adaptability during COVID-19 compulsory confinement: A longitudinal study in the Portuguese population.

J Affect Disord 2021 Sep 3;295:797-803. Epub 2021 Sep 3.

Life and Health Sciences Research Institute (ICVS), University of Minho, Campus de Gualtar, Braga 4710-057, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga, Guimarães, Portugal; Clinical Academic Center - Braga, Braga, Portugal.

Background: The outbreak of COVID-19 and the physical isolation measures taken by the governments to reduce its propagation might have negative psychological consequences on the population. In this study, we aimed to explore, for the first time, how mental health status fluctuated along the weeks of the emergency state in Portugal, and to identify which factors may shape these changes in mental health outcomes.

Methods: To this end, we conducted an online survey to evaluate demographic, lifestyle and mental health variables (DASS-21 and quality of life) in the Portuguese population at three different time-points. Read More

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September 2021

Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank.

Malar J 2021 Sep 8;20(1):365. Epub 2021 Sep 8.

Centre for Emerging Zoonotic and Parasitic Infections, National Institute for Communicable Diseases, Johannesburg, South Africa.

Background: A malaria slide bank (MSB) is a useful asset for any malaria microscopy testing laboratory to have access to. However, it is not feasible for every country to have its own MSB. If countries are able to pool their resources, a regional MSB is a viable solution. Read More

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September 2021

Summit: Automated Analysis of Arrayed Single-Cell Gel Electrophoresis.

SLAS Technol 2021 Sep 2:24726303211036869. Epub 2021 Sep 2.

Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.

New pipelines are required to automate the quantitation of emerging high-throughput electrophoretic (EP) assessment of DNA damage, or proteoform expression in single cells. EP cytometry consists of thousands of Western blots performed on a microscope slide-sized gel microwell array for single cells. Thus, EP cytometry images pose an analysis challenge that blends requirements for accurate and reproducible analysis encountered for both standard Western blots and protein microarrays. Read More

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September 2021

[Systematic review and sequential analysis of Xuebijing Injection in treatment of systemic inflammatory response syndrome].

Zhongguo Zhong Yao Za Zhi 2021 Aug;46(15):3980-3989

Henan University of Chinese Medicine Zhengzhou 450008, China.

To systematically review the efficacy of Xuebijing Injection combined with western medicine in the treatment of systemic inflammatory response syndrome(SIRS). In this study, CBM, CNKI, Wanfang, VIP, PubMed and EMbase databases were retrieved for clinical randomized controlled trials on the effect of Xuebijing Injection combined with western medicine in the treatment of SIRS from the establishment of the database to July 31, 2020. After screening, Meta-analysis was conducted by RevMan 5. Read More

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Vaccine preferences driving vaccine-decision making of different target groups: a systematic review of choice-based experiments.

BMC Infect Dis 2021 Aug 28;21(1):879. Epub 2021 Aug 28.

Department of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Duboisdomein 30, 6229, Maastricht, Netherlands.

Background: Choice-based experiments have been increasingly used to elicit preferences for vaccines and vaccination programs. This study aims to systematically identify and examine choice-based experiments assessing (differences in) vaccine preferences of vaccinees, representatives and health advisors.

Methods: Five electronic databases were searched on choice-based conjoint analysis studies or discrete choice experiments capturing vaccine preferences of children, adolescents, parents, adults and healthcare professionals for attributes of vaccines or vaccine settings up to September 2020. Read More

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An Advanced Noise Reduction and Edge Enhancement Algorithm.

Sensors (Basel) 2021 Aug 10;21(16). Epub 2021 Aug 10.

Department of Computer Science, National Chengchi University, Taipei 11605, Taiwan.

Complementary metal-oxide-semiconductor (CMOS) image sensors can cause noise in images collected or transmitted in unfavorable environments, especially low-illumination scenarios. Numerous approaches have been developed to solve the problem of image noise removal. However, producing natural and high-quality denoised images remains a crucial challenge. Read More

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Partitioning of Proteins and Anti-Nutrients in Cassava ( Crantz) Leaf Processing Fractions after Mechanical Extraction and Ultrafiltration.

Foods 2021 Jul 23;10(8). Epub 2021 Jul 23.

Tropics and Subtropics Group, Institute of Agricultural Engineering, University of Hohenheim, 70599 Stuttgart, Germany.

Cassava plays a major role in improving food security and reducing malnutrition. The purpose of this study was to evaluate the influence of mechanical pressing coupled with ultrafiltration (UF) on the quality of different fractions of cassava leaves. Cassava leaves harvested from the greenhouse at the University of Hohenheim were passed through a mechanical screw press to extract the juice and separate the press cake. Read More

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US Medical Licensing Exam Performance and American Board of Surgery Qualifying and Certifying Examinations.

J Am Coll Surg 2021 Aug 23. Epub 2021 Aug 23.

Superior Value in Program Accreditation, Chicago, IL.

Background: Program directors use United States Medical Licensing Exam (USMLE) scores as criteria for ranking applicants. First-time pass rates of the American Board of Surgery (ABS) Qualifying (QE) and Certifying (CE) Examinations have become important measures of residency program quality. USMLE Step 1 will become pass/fail in 2022. Read More

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A data independent acquisition all ion fragmentation mode tool for the suspect screening of natural toxins in surface water.

MethodsX 2021 22;8:101286. Epub 2021 Feb 22.

Water and Soil Quality Research Group, IDAEA-CSIC, c/Jordi Girona 18-26, Barcelona 08034, Spain.

Among natural freshwater pollutants, cyanotoxins, mycotoxins, and phytotoxins are the most important and less studied. Their identification in surface water is challenging especially cause of the lack of standards and established analytical parameters. Most target methods focus one or a single group of compounds with similar characteristics. Read More

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February 2021

Minimally Invasive Approach for Dorsal Arachnoid Web: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Aug 25. Epub 2021 Aug 25.

Service de Neurochirurgie, Hôpital Roger Salengro, CHU de Lille, Lille, France.

A 67-yr-old patient presented with severe paraparesis and lower limb spasticity. The spinal cord magnetic resonance imaging (MRI) revealed the "scalpel sign" 1,2 at the T7 level, suggesting a diagnosis of a dorsal arachnoid web. This video demonstrates a microsurgical technique for the excision of a dorsal arachnoid web with a minimally invasive approach. Read More

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Examining the reach and exposure of a mobile phone-based training programme for frontline health workers (ASHAs) in 13 states across India.

BMJ Glob Health 2021 Aug;6(Suppl 5)

International Health, Baltimore, Maryland, USA.

Mobile phones are increasingly used to facilitate in-service training for frontline health workers (FLHWs). Mobile learning (mLearning) programmes have the potential to provide FLHWs with high quality, inexpensive, standardised learning at scale, and at the time and location of their choosing. However, further research is needed into FLHW engagement with mLearning content at scale, a factor which could influence knowledge and service delivery. Read More

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Efficacy and Quality Attributes of Antimicrobial Agents Application via a Commercial Electrostatic Spray Cabinet to Inactivate Salmonella on Chicken Thigh Meat.

J Food Prot 2021 Aug 19. Epub 2021 Aug 19.

Perdue Farms, Inc.

Salmonella is a foodborne pathogen associated with poultry meat. This study aimed to determine the efficiency and quality attributes of two antimicrobial agents to reduce Salmonella on raw chicken meat when applied individually and in combination using an electrostatic spray cabinet. Five logs CFU/g of non-pathogenic, rifampicin-resistant Salmonella Typhimurium were inoculated on skin less, bone less, raw chicken thigh meat and passed through an electrostatic spray cabinet while being sprayed with 5% lauric arginate (LAE), and 100, 1000, 1500, 1750 ppm of peracetic acid (PAA). Read More

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Emerging Indoor Air Laws for Onsite Cannabis Consumption Businesses in the U.S.

Am J Prev Med 2021 Aug 13. Epub 2021 Aug 13.

Center for Tobacco Control Research and Education, University of California San Francisco, San Francisco, California; Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California. Electronic address:

Introduction: Secondhand cannabis smoke, like secondhand tobacco smoke, creates unhealthy indoor air quality. Ventilation and engineering techniques cannot reduce this pollution to healthy levels, and complete smoke-free policies are the only way to provide healthy indoor environments. Even so, multiple state and local governments have begun to allow indoor smoking of cannabis in businesses. Read More

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Is there an optimal timing for surgical treatment of pediatric supracondylar humerus fractures in the first 24 hours?

J Orthop Surg Res 2021 Aug 10;16(1):484. Epub 2021 Aug 10.

Department of Orthopedics and Traumatology, University of Health Sciences, Ankara Kecioren Training and Research Hospital, Pınarbaşı District, Sanatoryum Street, D:25, 06280, Keçiören, Ankara, Turkey.

Background: We aimed to determine the ideal surgical timing in the first 24 hours after admission to the hospital of pediatric supracondylar humerus fractures (SHF) that do not require emergent intervention.

Materials And Methods: Patients who underwent surgery in our institution between January 2011 and January 2019 due to pediatric Gartland type 3 SHFs were evaluated retrospectively. Open fractures, fractures associated with vascular injury and compartment syndrome, flexion type fractures were excluded. Read More

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Quantum generators of random numbers.

Sci Rep 2021 Aug 9;11(1):16108. Epub 2021 Aug 9.

Department of Quantum Technologies, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370, Wrocław, Poland.

Generation of random numbers is a central problem for many applications in the field of information processing, including, e.g., cryptography, in classical and quantum regime, but also mathematical modeling, Monte Carlo methods, gambling and many others. Read More

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Assessment of Global Health Education: The Role of Multiple-Choice Questions.

Front Public Health 2021 22;9:640204. Epub 2021 Jul 22.

BMJ Case Reports, London, United Kingdom.

The standardization of global health education and assessment remains a significant issue among global health educators. This paper explores the role of multiple choice questions (MCQs) in global health education: whether MCQs are appropriate in written assessment of what may be perceived to be a broad curriculum packed with fewer facts than biomedical science curricula; what form the MCQs might take; what we want to test; how to select the most appropriate question format; the challenge of quality item-writing; and, which aspects of the curriculum MCQs may be used to assess. The Medical School for International Health (MSIH) global health curriculum was blue-printed by content experts and course teachers. Read More

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Air quality evaluation during COVID-19 in Southern Italy: the case study of Avellino city.

Environ Res 2021 Aug 5;203:111803. Epub 2021 Aug 5.

Department of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.

The present study relies on the air quality evaluation during COVID-19 pandemic in Avellino, described in the last years and for several consecutive years, among the worst Italian cities in this context. The main purpose of this manuscript was to investigate the effects of quarantine and lockdown measures on air pollution. The concentrations of the main atmospheric pollutants (Carbon monoxide (CO), Ozone (O), Fine Particulate (PM and PM), Benzene (CH) and Nitrogen dioxide (NO) were recorded during the period January-December 2020 using two stationary monitoring stations (AV1 and AV2) of the Regional Environmental Protection Agency (ARPAC). Read More

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Virtual Patient-Specific Quality Assurance of IMRT Using UNet++: Classification, Gamma Passing Rates Prediction, and Dose Difference Prediction.

Front Oncol 2021 20;11:700343. Epub 2021 Jul 20.

Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.

The dose verification in radiotherapy quality assurance (QA) is time-consuming and places a heavy workload on medical physicists. To provide a clinical tool to perform patient specific QA accurately, the UNet++ is investigated to classify failed or pass fields (the GPR lower than 85% is considered "failed" while the GPR higher than 85% is considered "pass"), predict gamma passing rates (GPR) for different gamma criteria, and predict dose difference from virtual patient-specific quality assurance in radiotherapy. UNet++ was trained and validated with 473 fields and tested with 95 fields. Read More

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Measure Partial Liver Volumetric Variations from Paired Inspiratory-expiratory Chest CT Scans.

Proc SPIE Int Soc Opt Eng 2021 15;11596. Epub 2021 Feb 15.

Data Science Institute, Vanderbilt University, Nashville, TN, 37235 USA.

Liver stiffness is an essential clinical biomarker for diagnosing liver fibrosis and cirrhosis. In current clinical practice, elastography techniques are standard non-invasive diagnosis tools to assess stiffness of liver, using either Ultrasound (US) or magnetic resonance imaging (MRI). However, the US elastography yields ≈ 10 % failure rate and degraded performance on obese patients, while the MR elastography is costlier and less available. Read More

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February 2021

Approaches to Measure Efficiency in Primary Care: A Systematic Literature Review.

Appl Health Econ Health Policy 2021 Aug 5. Epub 2021 Aug 5.

Office of Health Economics, Southside 7th floor, 105 Victoria Street, London, SW1E 6QT, UK.

Background: Primary care in England is facing increasing pressure due to the increasing number and complexity of consultations and the declining number of doctors per head of population. The improvement of primary care efficiency and productivity should be a priority, to ensure that future investments in the medical workforce can cope with the increasingly large and complex demand for care.

Objectives: This paper presents a systematic literature review of studies that define or measure efficiency in primary care in high-income settings. Read More

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Determinants and perception of health insurance participation among healthcare providers in Nigeria: A mixed-methods study.

PLoS One 2021 4;16(8):e0255206. Epub 2021 Aug 4.

PharmAccess Group and Joep Lange Institute, Amsterdam, Netherlands.

Background: To accelerate universal health coverage, Nigeria's National Health Insurance Scheme (NHIS) decentralized the implementation of government health insurance to the individual states in 2014. Lagos is one of the states that passed a State Health Insurance Scheme into law, in order to expand the benefits of health insurance beyond the few residents enrolled in community-based health insurance programs, commercial private health insurance plans or the NHIS. Public and private healthcare providers are a critical component of the Lagos State Health Scheme (LSHS) rollout. Read More

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SNP-based assessment of genetic purity and diversity in maize hybrid breeding.

PLoS One 2021 3;16(8):e0249505. Epub 2021 Aug 3.

School of Agriculture, Earth and Environmental Sciences, University of KwaZulu-Natal, Scottsville, Pietermaritzburg, South Africa.

Assessment of genetic purity of parental inbred lines and their resultant F1 hybrids is an essential quality control check in maize hybrid breeding, variety release and seed production. In this study, genetic purity, parent-offspring relationship and diversity among the inbred lines were assessed using 92 single-nucleotide polymorphism (SNP) markers. A total of 188 maize genotypes, comprising of 26 inbred lines, four doubled haploid (DH) lines and 158 single-cross maize hybrids were investigated in this study using Kompetitive Allele Specific Polymerase Chain Reaction (KASP) genotyping assays. Read More

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The use of real-world data/evidence in regulatory submissions.

Contemp Clin Trials 2021 Jul 31;109:106521. Epub 2021 Jul 31.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. Electronic address:

The 21st Century Cures Act passed by the United States (US) Congress in December 2016 requires the US Food and Drug Administration (FDA) shall establish a program to evaluate the potential use of real-world evidence (RWE) which is generated from real-world data (RWD) to (i) support approval of new indication for a drug approved under section 505 (c) and (ii) satisfy post-approval study requirements. RWE offers the opportunities to develop robust evidence using high-quality data and sophisticated methods for producing causal-effect estimates regardless randomization is feasible. In this article, we have demonstrated that the assessment of treatment effect (RWE) based on RWD could be biased due to the potential selection and information biases of RWD. Read More

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Neural Network Optimal Routing Algorithm Based on Genetic Ant Colony in IPv6 Environment.

Comput Intell Neurosci 2021 13;2021:3115704. Epub 2021 Jul 13.

Guangzhou Xinhua University, Guangzhou, China.

The traditional IPv6 routing algorithm has problems such as network congestion, excessive energy consumption of nodes, and shortening the life cycle of the network. In response to this phenomenon, we proposed a routing optimization algorithm based on genetic ant colony in IPv6 environment. The algorithm analyzes and studies the genetic algorithm and the ant colony algorithm systematically. Read More

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The design and application of a 50 K SNP chip for a threatened Aotearoa New Zealand passerine, the hihi.

Mol Ecol Resour 2021 Jul 29. Epub 2021 Jul 29.

School of Biological Sciences, University of Auckland, Auckland, New Zealand.

Next-generation sequencing has transformed the fields of ecological and evolutionary genetics by allowing for cost-effective identification of genome-wide variation. Single nucleotide polymorphism (SNP) arrays, or "SNP chips", enable very large numbers of individuals to be consistently genotyped at a selected set of these identified markers, and also offer the advantage of being able to analyse samples of variable DNA quality. We used reduced representation restriction-aided digest sequencing (RAD-seq) of 31 birds of the threatened hihi (Notiomystis cincta; stitchbird) and low-coverage whole genome sequencing (WGS) of 10 of these birds to develop an Affymetrix 50 K SNP chip. Read More

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Automated treatment planning of prostate stereotactic body radiotherapy with focal boosting on a fast-rotating O-ring linac: Plan quality comparison with C-arm linacs.

J Appl Clin Med Phys 2021 Sep 28;22(9):59-72. Epub 2021 Jul 28.

Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.

Purpose: The integration of auto-segmentation and automated treatment planning methods on a fast-rotating O-ring linac may improve the time efficiency of online adaptive radiotherapy workflows. This study investigates whether automated treatment planning of prostate SBRT with focal boosting on the O-ring linac could generate plans that are of similar quality as those obtained through manual planning on clinical C-arm linacs.

Methods: For 20 men with prostate cancer, reference treatment plans were generated on a TrueBeam STx C-arm linac with HD120 MLC and a TrueBeam C-arm linac with Millennium 120 MLC using 6 MV flattened dual arc VMAT. Read More

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September 2021