6,208 results match your criteria parts skeletons


Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists.

Bioorg Chem 2021 Mar 2;110:104782. Epub 2021 Mar 2.

School of Pharmacy, Fudan University, Shanghai 201203, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China. Electronic address:

Relaxin family peptide receptors (RXFPs) are the potential therapeutic targets for neurological, cardiovascular, and metabolic indications. Among them, RXFP3 and RXFP4 (formerly known as GPR100 or GPCR142) are homologous class A G protein-coupled receptors with short N-terminal domain. Ligands of RXFP3 or RXFP4 are only limited to endogenous peptides and their analogues, and no natural product or synthetic agonists have been reported to date except for a scaffold of indole-containing derivatives as dual agonists of RXFP3 and RXFP4. Read More

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[Extensor tendon injuries of fingers in the region of the metacarpophalangeal joint (zone V)].

Unfallchirurg 2021 Apr 16;124(4):275-286. Epub 2021 Mar 16.

Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Münster, Waldeyerstr. 1, 48129, Münster, Deutschland.

Due to the exposed situation of the extension side of the metacarpophalangeal joint when the fingers are bent, injuries in this region are not uncommon. The extensor apparatus lies directly below the skin and the various parts can be easily injured. Due to the complex anatomical structure, the different clinical appearances and the various forms of treatment, injuries of the extensor tendons in the region of the metacarpophalangeal joint must be examined in a very differentiated manner. Read More

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Accuracy of Model Estimation versus Tanaka and Johnston Arch Length Analysis.

J Clin Pediatr Dent 2021 Jan;45(1):54-57

Objectives: This study examines how accurate pediatric dentists are at estimating dental arch lengths by comparing their model estimations (guesstimating the arch length without measuring) to the Tanaka and Johnston mixed dentition arch length analysis.

Study Design: This study consisted of two parts, a survey of practitioners and a model estimating and measuring component. The survey was designed and given to 44 pediatric dentists to determine how many were practicing orthodontics and using arch length analyses routinely. Read More

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January 2021

Toxicity of Somadril Compound on Fetal Ileum Tissues of Albino Rats.

Pak J Biol Sci 2021 Jan;24(1):72-79

Background And Objective: Carisoprodol is a relaxant muscular-skeleton associated with sore muscles and appropriate studies have not been performed on carisoprodol effects on fetuses and mothers. This study has been conducted to clarify the treatment with a high and low dosage of carisoprodol (Somadril) on the histopathological, histochemical changes in the fetal ileum of the Albino rats.

Materials And Methods: In the present research 30 adult pregnant rats have been used and divided into three classes (10 pregnant rats in each group), the first group was the group of Control (C). Read More

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January 2021

[Three dimensional finite element analysis of optimal distribution model of fillers in vertebroplasty].

Zhongguo Gu Shang 2021 Jan;34(1):26-33

Songjiang District Central Hospital, Shanghai 201600, China.

Objective: To establish a three-dimensional finite element model of osteoporosis and to study the stiffness recovery of injured vertebrae and stress analysis of adjacent vertebrae after percutaneous vertebroplasty under different perfusion and distribution conditions by simulating fluid flow into the vertebral body.

Methods: A male healthy volunteer was selected. CT scans were performed from T to L. Read More

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January 2021

FOS Rearrangement and Expression in Cementoblastoma.

Am J Surg Pathol 2021 May;45(5):690-693

Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). Read More

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Phytochemical and anti-inflammatory properties of Senegalese propolis and isolated compounds.

Fitoterapia 2021 Feb 22;151:104861. Epub 2021 Feb 22.

Department of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

Propolis is a chemically complex resinous product collected from various plant sources by honeybees that has been used historically a traditional folk medicine in many parts of the world. The main constituents of propolis are beeswax and plant resins. We recently obtained Senegalese propolis, which, to our knowledge, has not been previously reported. Read More

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February 2021

(-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis.

Angew Chem Int Ed Engl 2021 Feb 23. Epub 2021 Feb 23.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

(-)-Isoscopariusin A was isolated from the aerial parts of Isodon scoparius. Chemical synthesis and spectroscopic analysis established its structure as an unsymmetrical meroditerpenoid bearing a sterically congested 6/6/4 tricyclic carbon skeleton with seven continuous stereocenters. A gram-scale synthesis was achieved in 12 steps from commercially available (+)-sclareolide. Read More

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February 2021

Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances.

Front Chem 2020 14;8:594717. Epub 2021 Jan 14.

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.

In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies. Owing to its numerous potential applications, in the past two decades, there is an increase in the importance of designing novel quinazolines, exploring promising routes to synthesize quinazolines, investigating different properties of quinazolines, and seeking for potential applications of quinazolines. The present review article describes synthesis of quinazolines eco-friendly, mild, atom-efficient, multi-component synthetic strategies reported in the literature. Read More

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January 2021

Brownian dynamics simulation of protofilament relaxation during rapid freezing.

PLoS One 2021 12;16(2):e0247022. Epub 2021 Feb 12.

Department of Physics, Lomonosov Moscow State University, Moscow, Russia.

Electron cryo-microscopy (Cryo-EM) is a powerful method for visualizing biological objects with up to near-angstrom resolution. Instead of chemical fixation, the method relies on very rapid freezing to immobilize the sample. Under these conditions, crystalline ice does not have time to form and distort structure. Read More

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February 2021

FACEts of mechanical regulation in the morphogenesis of craniofacial structures.

Int J Oral Sci 2021 02 5;13(1). Epub 2021 Feb 5.

School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.

During embryonic development, organs undergo distinct and programmed morphological changes as they develop into their functional forms. While genetics and biochemical signals are well recognized regulators of morphogenesis, mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as well. These physical factors drive coordinated cell movements and reorganizations, shape and size changes, proliferation and differentiation, as well as gene expression changes, and ultimately sculpt any developing structure by guiding correct cellular architectures and compositions. Read More

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February 2021

Clinical, radiological and computational studies on two novel GNPTG variants causing mucolipidosis III gamma phenotypes with varying severity.

Mol Biol Rep 2021 Feb 28;48(2):1465-1474. Epub 2021 Jan 28.

Department of Pediatric Endocrinology, Adıyaman Training and Research Hospital, Adıyaman, Turkey.

Mucolipidosis III gamma (ML III γ) is a slowly progressive disorder that affects multiple parts of the body such as the skeleton, joints, and connective tissue structures. It is caused by pathogenic variants in the GNPTG gene that provides instructions for producing the γ subunit of GlcNAc-1-phosphotransferase. In this study we aim to characterize clinical findings and biological insights on two novel GNPTG variants causing ML III γ phenotypes with varying severity. Read More

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February 2021

Curcumin regulates EZH2/Wnt/β-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.

Kaohsiung J Med Sci 2021 Jan 26. Epub 2021 Jan 26.

Department of Prosthodontics, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.

Osteoporosis (OP) behaves in different manners in different parts of the skeleton. This study aims to investigate the effects of curcumin on bone mass of the mandibular and femur from ovariectomized OP rats and to validate whether enhancer of zeste homolog 2 (EZH2)/Wnt/β-Catenin pathway is involved in this process. Curcumin was administered intragastrically into ovariectomized rats for 12 weeks. Read More

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January 2021

Analysis of temporal bone thickness outside of the petrous temporal bone between superior semicircular canal dehiscence and normal patients.

J Clin Neurosci 2021 Feb 28;84:23-28. Epub 2020 Dec 28.

Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States; UCLA Jonsson Comprehensive Cancer Center, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States; Office of the Patient Experience, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States; Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, United States.

Background: SSCD is a rare inner ear disorder. This study aims to compare the thickness of the temporal bone beyond the petrous portion between healthy subjects and those with SSCD to determine whether the etiopathology of SSCD is localized to the petrous temporal bone or generalized to other parts of the temporal bone.

Methods: A retrospective chart review of electronic medical records from September 2011 to February 2018 was conducted at a single-institution study at the University of California, Los Angeles. Read More

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February 2021

Symbiotic Graph Neural Networks for 3D Skeleton-based Human Action Recognition and Motion Prediction.

IEEE Trans Pattern Anal Mach Intell 2021 Jan 22;PP. Epub 2021 Jan 22.

3D skeleton-based action recognition and motion prediction are two essential problems of human activity understanding. In many previous works: 1) they studied two tasks separately, neglecting internal correlations; 2) they did not capture sufficient relations inside the body. To address these issues, we propose a symbiotic model to handle two tasks jointly; and we propose two scales of graphs to explicitly capture relations among body-joints and body-parts. Read More

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January 2021

Ultrastructural and molecular analysis of the origin and differentiation of cells mediating brittle star skeletal regeneration.

BMC Biol 2021 Jan 18;19(1). Epub 2021 Jan 18.

Department of Genetics, Evolution and Environment, University College London, London, UK.

Background: Regeneration is the ability to re-grow body parts or tissues after trauma, and it is widespread across metazoans. Cells involved in regeneration can arise from a pool of undifferentiated proliferative cells or be recruited from pre-existing differentiated tissues. Both mechanisms have been described in different phyla; however, the cellular and molecular mechanisms employed by different animals to restore lost tissues as well as the source of cells involved in regeneration remain largely unknown. Read More

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January 2021

In Pursuit of Synthetic Efficiency: Convergent Approaches.

Authors:
Yang Gao Dawei Ma

Acc Chem Res 2021 02 15;54(3):569-582. Epub 2021 Jan 15.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.

The field of total synthesis has reached a stage in which emphasis has been increasingly focused on synthetic efficiency rather than merely achieving the synthesis of a target molecule. The pursuit of synthetic efficiency, typically represented by step count and overall yield, is a rich source of inspiration and motivation for synthetic chemists to invent innovative strategies and methods. Among them, convergent strategy has been well recognized as an effective approach to improve efficiency. Read More

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February 2021

Unusual derivatives from Hypericum scabrum.

Sci Rep 2021 Jan 14;10(1):22181. Epub 2021 Jan 14.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran.

Three new compounds (1-3) with unusual skeletons were isolated from the n-hexane extract of the air-dried aerial parts of Hypericum scabrum. Compound 1 represents the first example of an esterified polycyclic polyprenylated acylphloroglucinol that features a unique tricyclo-[4.3. Read More

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January 2021

Genomic Steppe ancestry in skeletons from the Neolithic Single Grave Culture in Denmark.

PLoS One 2021 14;16(1):e0244872. Epub 2021 Jan 14.

Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.

The Gjerrild burial provides the largest and best-preserved assemblage of human skeletal material presently known from the Single Grave Culture (SGC) in Denmark. For generations it has been debated among archaeologists if the appearance of this archaeological complex represents a continuation of the previous Neolithic communities, or was facilitated by incoming migrants. We sampled and analysed five skeletons from the Gjerrild cist, buried over a period of c. Read More

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January 2021

Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant (MRSA).

ACS Sens 2021 03 13;6(3):742-751. Epub 2021 Jan 13.

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Loop-mediated isothermal amplification (LAMP) has been widely used to detect many infectious diseases. However, minor inconveniences during the steps of adding reaction ingredients and lack of simple color results hinder point-of-care detection. We therefore invented a fluorometric paper-based LAMP by incorporating LAMP reagents, including a biotinylated primer, onto a cellulose membrane paper, with a simple DNA fluorescent dye incubation that demonstrated rapid and accurate results parallel to quantitative polymerase chain reaction (qPCR) methods. Read More

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Mapping coral calcification strategies from in situ boron isotope and trace element measurements of the tropical coral Siderastrea siderea.

Sci Rep 2021 Jan 12;11(1):472. Epub 2021 Jan 12.

School of Ocean and Earth Science, University of Southampton, National Oceanography Centre Southampton, Southampton, UK.

Boron isotopic and elemental analysis of coral aragonite can give important insights into the calcification strategies employed in coral skeletal construction. Traditional methods of analysis have limited spatial (and thus temporal) resolution, hindering attempts to unravel skeletal heterogeneity. Laser ablation mass spectrometry allows a much more refined view, and here we employ these techniques to explore boron isotope and co-varying elemental ratios in the tropical coral Siderastrea siderea. Read More

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January 2021

Response of Novel Functionally-Graded Prepacked Aggregate Fibrous Concrete against Low Velocity Repeated Projectile Impacts.

Materials (Basel) 2021 Jan 7;14(2). Epub 2021 Jan 7.

Department of Machinery Parts and Theory of Mechanisms, Moscow Automobile and Road Construction University, 125319 Moscow, Russia.

Preplaced Aggregate Fibrous Concrete (PAFC) is a newly minted composite that has recently become more popular. The production of PAFC involves two essential processes; first, the fibres and coarse aggregate were filled into the empty framework to form the first layer of a natural skeleton, followed by grout injecting. A cement grout fills the voids in the first layer skeleton with slight compaction. Read More

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January 2021

Incidence and clinical impact of vertebral endplate changes after limited lumbar microdiscectomy and implantation of a bone-anchored annular closure device.

BMC Surg 2021 Jan 6;21(1):19. Epub 2021 Jan 6.

Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, 5001, Aarau, Switzerland.

Background: An annular closure device (ACD) could potentially prevent recurrent herniation by blocking larger annular defects after limited microdiscectomy (LMD). The purpose of this study was to analyze the incidence of endplate changes (EPC) and outcome after LMD with additional implantation of an ACD to prevent reherniation.

Methods: This analysis includes data from a) RCT study-arm of patients undergoing LMD with ACD implantation and b) additional patients undergoing ACD implantation at our institution. Read More

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January 2021

Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase.

Phytochemistry 2021 Mar 22;183:112614. Epub 2020 Dec 22.

School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China. Electronic address:

Six undescribed clerodane diterpenoids, dodovisins A-F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD calculation. Read More

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Frontal bone virtual reconstruction and geometric morphometric analysis of the mid-Pleistocene hominin KNM-OG 45500 (Olorgesailie, Kenya).

J Anthropol Sci 2020 12;98:49-72

Paleoanthropology, Department of Geosciences, Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tübingen, Tübingen 72070, Germany; DFG Center for Advanced Studies "Words, Bones, Genes, Tools", University of Tübingen, Rümelinstrasse 23, D-72070 Tübingen, Germany.

KNM-OG 45500 is a hominin fossil composed of parts of a frontal bone, left temporal bone, and cranial vault pieces. Since its discovery along the Olorgesailie Formation (Kenya) in 2003, it has been associated with the Homo erectus hypodigm. The specimen, derived from a geological context dated to ca. Read More

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December 2020

Chuanxiongdiolides R4 and R5, phthalide dimers with a complex polycyclic skeleton from the aerial parts of Ligusticum chuanxiong and their vasodilator activity.

Bioorg Chem 2021 Feb 30;107:104523. Epub 2020 Nov 30.

State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China. Electronic address:

Chuanxiongdiolides R4-R6 (1-3), three novel phthalide dimers featuring two classes of unreported monomeric units (ligustilide/senkyunolide A and ligustilide/neocnidilide) with an unprecedented linkage style (3a,7'/7a,7'a), were isolated from the aerial parts of Ligusticum chuanxiong, together with three pairs of enantiomeric phthalide dimers [(-)/(+)-4a/4b, 5a/5b, and 6a/6b]. The bioassays revealed that compounds 1, 3, 4, 5, and 6 showed significant vasodilation effects, and the mechanism may be attributed to Ca1.2 activation blockade. Read More

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February 2021

Nine prenylated acylphloroglucinols with potential anti-depressive and hepatoprotective activities from Hypericum scabrum.

Bioorg Chem 2021 Feb 3;107:104529. Epub 2020 Dec 3.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

In our screening program for new biologically active secondary metabolites, nine new polycyclic polyprenyled acylphloroglucinols, hyperscabins D-L, together with three known compounds, were obtained from the aerial parts of Hypericum scabrum. The chemical structures of 1-9 were characterized by extensive spectroscopic analyses, nuclear magnetic resonance calculation with DP4+ probability analysis, and the electronic circular dichroism spectra were calculated. Compound 1 was an unusual prenylated acylphloroglucinol decorated with a 5-oxaspiro [4,5] deca-1,9-dione skeleton. Read More

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February 2021

[Application of mixed reality technique for the surgery of oral and maxillofacial tumors].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;52(6):1124-1129

Objective: To explore the application of mixed reality technique for the surgery of oral and maxillofacial tumors.

Methods: In this study, patients with a diagnosis of an oral and maxillofacial tumor who were referred to Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from December 2018 to January 2020 were selected. The preoperative contrast-enhanced computed tomography data of the patients were imported into StarAtlas Holographic Medical Imaging System (Visual 3D Corp. Read More

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December 2020

Whole and Part Adaptive Fusion Graph Convolutional Networks for Skeleton-Based Action Recognition.

Sensors (Basel) 2020 Dec 13;20(24). Epub 2020 Dec 13.

National Engineering Laboratory for Risk Perception and Prevention (NEL-RPP), Beijing 100041, China.

Spatiotemporal graph convolution has made significant progress in skeleton-based action recognition in recent years. Most of the existing graph convolution methods take all the joints of the human skeleton as the overall modeling graph, ignoring the differences in the movement patterns of various parts of the human, and cannot well connect the relationship between the different parts of the human skeleton. To capture the unique features of different parts of human skeleton data and the correlation of different parts, we propose two new graph convolution methods: the whole graph convolution network (WGCN) and the part graph convolution network (PGCN). Read More

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December 2020

[Implant arthroplasty in the metacarpophalangeal and proximal interphalangeal finger joints].

Handchir Mikrochir Plast Chir 2021 Feb 14;53(1):40-46. Epub 2020 Dec 14.

Handchirurgie, Kantonsspital Baselland, Liestal, Schweiz.

Background:  Osteoarthritic changes in the finger joints are common, especially in the elderly population. Without adequate treatment, these changes can lead to pain, joint deformity, instability or impaired motion. Operative treatment options can be divided into prosthetic joint replacement, joint fusion and denervation. Read More

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February 2021