30,319 results match your criteria participating patients


Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: What is the optimal time frame?

PLoS One 2021 12;16(5):e0251372. Epub 2021 May 12.

Research Unit EA7285, Risk and Safety in Clinical Medicine for Women and Perinatal Health, Versailles St-Quentin University, Montigny-le-Bretonneux, Versailles, France.

Introduction: The Endometriosis Fertility Index (EFI) is a validated score for predicting the postoperative spontaneous pregnancy rate in patients undergoing endometriosis surgery. However, the practical use of the EFI to advise patients about postoperative fertility management is unclear.

Materials And Methods: All patients participating in the ENDOQUAL study-a prospective observational bi-center cohort study conducted between 01/2012 and 06/2018-who underwent surgery for infertility were asked to complete a questionnaire collecting time and mode of conception. Read More

View Article and Full-Text PDF

Stereotactic Radiosurgery for Differentiated Thyroid Cancer Brain Metastases: An International, Multicenter Study.

Thyroid 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.

Brain metastases (BM) from differentiated thyroid cancer are rare. Stereotactic radiosurgery (SRS) is commonly used for the treatment of BMs; however, the experience with SRS for thyroid cancer BMs remains limited. The goal of this international, multi-centered study was to evaluate the efficacy and safety of SRS for thyroid cancer BMs. Read More

View Article and Full-Text PDF

Perceptions and experiences of older patients and healthcare professionals regarding shared decision-making in pulmonary rehabilitation: A qualitative study.

Clin Rehabil 2021 May 12:2692155211010279. Epub 2021 May 12.

Rongjun Hospital of Jiangsu Province, Wuxi, China.

Objective: To understand the perceptions and experiences of older patients with chronic obstructive pulmonary disease (COPD) and healthcare professionals (HCPs) regarding shared decision-making in pulmonary rehabilitation (PR).

Design: A qualitative study using single, semi-structured interviews, and thematic analysis.

Setting: Face-to-face interviews were conducted in the Jiangnan University, in hospital and in patients' homes. Read More

View Article and Full-Text PDF

[Anatomometric characteristics and pleural cavity changes after pneumonectomy].

Khirurgiia (Mosk) 2021 (5):32-41

Orenburg State Medical University, Orenburg, Russia.

Objective: To analyze the anatomometric characteristics of post-pneumonectomy cavity and their changes at various times after surgery.

Material And Methods: The study included 47 patients aged 39-75 years after pneumonectomy (right-sided - 23 cases, left-sided - 24 cases). Computed tomography was performed prior to surgery, in 10-12 days, 6 and 12 months after intervention. Read More

View Article and Full-Text PDF
January 2021

Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up.

Qual Life Res 2021 May 12. Epub 2021 May 12.

Anaesthesia and Intensive Care Unit, M.Bufalini Hospital, Cesena, Italy.

Purpose: The onset of the coronavirus disease 19 (COVID-19) pandemic in Italy induced a dramatic increase in the need for intensive care unit (ICU) beds for a large proportion of patients affected by COVID-19-related acute respiratory distress syndrome (ARDS). The aim of the present study was to describe the health-related quality of life (HRQoL) at 90 days after ICU discharge in a cohort of COVID-19 patients undergoing invasive mechanical ventilation and to compare it with an age and sex-matched sample from the general Italian and Finnish populations. Moreover, the possible associations between clinical, demographic, social factors, and HRQoL were investigated. Read More

View Article and Full-Text PDF

Variations in the mineral content of bottled 'carbonated or sparkling' water across Europe: a comparison of 126 brands across 10 countries.

Cent European J Urol 2021 19;74(1):71-75. Epub 2021 Feb 19.

University Hospital Southampton NHS Trust, Department of Urology, Southampton, United Kingdom.

Introduction: Kidney stone disease is a common disease with high recurrence rates. Sufficient intake of water is the cornerstone in primary prevention of stone disease. However, the mineral composition of water can affect urinary minerals and influence stone formation. Read More

View Article and Full-Text PDF
February 2021

Treatment of COPD with Long-Acting Bronchodilators: Association Between Early and Longer-Term Clinically Important Improvement.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1215-1226. Epub 2021 May 3.

Global Specialty & Primary Care, GSK, Brentford, Middlesex, UK.

Introduction: This post hoc analysis of the "Early MAXimization of bronchodilation for improving COPD stability" (EMAX) trial investigated whether patients achieving early clinically important improvement (CII) sustained longer-term improvements and lower risk of clinically important deterioration (CID).

Methods: Patients were randomized to umeclidinium/vilanterol, umeclidinium, or salmeterol for 24 weeks. The patient-reported outcomes (PROs) Transition Dyspnea Index (TDI), Evaluating Respiratory Symptoms, St George's Respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT) were assessed. Read More

View Article and Full-Text PDF

Improving Holistic Care Skills for Advanced Practice Registered Nurses: Integration of a Complementary and Alternative Medicine Course into a Doctor of Nursing Practice Curriculum.

J Dr Nurs Pract 2021 May 11. Epub 2021 May 11.

Uniformed Services University, Inouye Graduate School of Nursing, Bethesda, MD.

Background: Complementary alternative medicine (CAM) is an expanding domain of healing practices harmonized with Western medicine to provide comprehensive treatment of individuals as holistic beings. Patients and healthcare providers worldwide are increasingly inviting and employing CAM practices into healthcare delivery routines. Implementation of courses to introduce CAM into Advanced Practice Registered Nurse (APRN) programs exposes future practitioners to current best practices for integrative treatment strategies and encourages consideration when developing a holistic patient-centered care plan. Read More

View Article and Full-Text PDF

Monoclonal Antibodies vs COVID-19: Eduardo Ojito-Magaz MS General Director, Molecular Immunology Center.

MEDICC Rev 2021 Apr 30;23(2):12. Epub 2021 Apr 30.

Cuba has five COVID-19 vaccines in clinical trials and is on track to receive emergency use authorization from the country's regulatory agency to begin mass vaccination with two of those candidates: Abdala and SOBERANA 02. Results from phase 1 and 2 trials of these vaccines, the first developed and produced in Latin America, have been encouraging, both in terms of safety and immunogenicity. The ongoing phase 3 trials will continue to look at safety, together with efficacy; parallel intervention studies involving over a million people in Havana will begin generating data on effectiveness. Read More

View Article and Full-Text PDF

Descriptive Regional Subanalysis of a Real-World Study in Patients with Type 2 Diabetes Treated with Gliclazide MR During Fasting: DIA-RAMADAN.

Diabetes Ther 2021 May 11. Epub 2021 May 11.

Dasman Diabetes Institute, Kuwait City, Kuwait.

Introduction: To analyse the safety and effectiveness of gliclazide modified release (MR) in adults with type 2 diabetes mellitus participating in Ramadan from three geographically and culturally different regions of the world included in the DIA-RAMADAN study.

Methods: DIA-RAMADAN was a real-world, observational, international, non-comparative study. The global study population was divided into three regional subgroups, with data gathered at inclusion 6-8 weeks prior to Ramadan (V0), during Ramadan (4. Read More

View Article and Full-Text PDF

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis.

Invest Ophthalmol Vis Sci 2021 May;62(6):11

Center of Neuroimmunology, Institut d'Investigacions Biomediques August Pi Sunyer, Barcelona, Spain.

Purpose: Raman spectroscopy allows molecular changes to be quantified in vivo from the tissues like the retina. Here we aimed to assess the metabolic changes in the retina of patients with multiple sclerosis (MS).

Methods: We built a Raman spectroscopy prototype by connecting a scanning laser ophthalmoscope to a spectrophotometer. Read More

View Article and Full-Text PDF

Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study.

Fertil Steril 2021 Apr 12. Epub 2021 Apr 12.

Maternal-Fetal Medicine Unit, Department Obstetrics and Gynecology, Hospital Universitario Puerta de Hierro.Majadahonda, Madrid, Spain. Electronic address:

Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes).

Design: Multicenter, prospective, observational study.

Setting: 78 centers participating in the Spanish COVID19 Registry. Read More

View Article and Full-Text PDF

Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome - Report from the German LGG Studies.

Klin Padiatr 2021 May 10;233(3):107-122. Epub 2021 May 10.

Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.

Methods And Results: Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996-2018), rising from 109 to 278/year. Read More

View Article and Full-Text PDF

Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution.

Stereotact Funct Neurosurg 2021 May 10:1-9. Epub 2021 May 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Deep brain stimulation (DBS) has been an established surgical procedure in the field of functional neurosurgery for many years. The experimental electrophysiological method of local field potential (LFP) recordings in postsurgically externalized patients has made substantial contributions to the better understanding of pathophysiologies underlying movement disorders. As interest in LFP recordings for the development of improved stimulation strategies increases, this study's aim was to provide evidence concerning safety of this research method, in a major DBS center. Read More

View Article and Full-Text PDF

Psychometric evaluation of the Swedish self-rated 36-item version of WHODAS 2.0 for use in psychiatric populations - using classical test theory.

Nord J Psychiatry 2021 May 9:1-8. Epub 2021 May 9.

Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.

Aim: The aim of this study was to evaluate the reliability and validity of the Swedish version of the self-rated 36-item WHODAS 2.0 in patients from Swedish psychiatric outpatient settings, using classical test theory.

Methods: The 36-item WHODAS 2. Read More

View Article and Full-Text PDF

Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease.

Front Med (Lausanne) 2021 21;8:657956. Epub 2021 Apr 21.

Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one of the crucial mechanisms participating in the pathogenesis of DKD. However, the mechanisms of cell communication were not fully elucidated in previous studies. In this study, we performed cell cross-talk analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) and revealed the associations between cell communication-related genes and renal function, providing overall insight into cell communication in DKD. Read More

View Article and Full-Text PDF

Cardiovascular Pharmacological Support Among Preterm Infants in Chinese Referral Center Neonatal Intensive Care Units.

Front Pediatr 2021 22;9:638540. Epub 2021 Apr 22.

Children's Hospital of Fudan University, Shanghai, China.

To describe cardiovascular pharmacological support in infants born at <34 weeks' gestation within the first postnatal week in Chinese neonatal intensive care units (NICUs). A secondary analysis of data from a multicenter randomized controlled study (REIN-EPIQ). A questionnaire regarding cardiovascular support practices was also completed by all participating NICUs. Read More

View Article and Full-Text PDF

Temporal and Spatial Dynamics of Inflammasome Activation After Ischemic Stroke.

Front Neurol 2021 22;12:621555. Epub 2021 Apr 22.

Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

The inflammasome represents a highly pro-inflammatory mechanism. It has been identified that inflammasome was activated after ischemic stroke. However, the impact of inflammasomes on stroke outcomes remains contradictory. Read More

View Article and Full-Text PDF

A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection.

Diabetologia 2021 May 8. Epub 2021 May 8.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims/hypothesis: The aim of this work was to describe the clinical characteristics of adults with type 1 diabetes admitted to hospital and the risk factors associated with severe coronavirus disease-2019 (COVID-19) in the UK.

Methods: A retrospective cohort study was performed using data collected through a nationwide audit of people admitted to hospital with diabetes and COVID-19, conducted by the Association of British Clinical Diabetologists from March to October 2020. Prespecified demographic, clinical, medication and laboratory data were collected from the electronic and paper medical record systems of the participating hospitals by local clinicians. Read More

View Article and Full-Text PDF

[COMPLEX TREATMENT OF PATIENTS WITH VENOUS TROPHIC ULCER IN THE CONDITIONS OF COVID-19 HOSPITAL].

Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

View Article and Full-Text PDF

[ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):555-561

Southern Medical University of Nanfang Hospital, Obstetrics and Gynecology Department, Guangzhou 510515, China.

Objective: To investigate the expression of ENTPD5 in epithelial ovarian cancer and explore its clinical implications.

Objective: The expression level of ENTPD5 in epithelial ovarian cancer was analyzed based on data from Oncomine and TCGA databases. The relationship between the expression level of ENTPD5 and clinical characteristics of the patients was analyzed using UALCAN database. Read More

View Article and Full-Text PDF

The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort.

J Public Health (Oxf) 2021 May 8. Epub 2021 May 8.

Instituto de Virología Dr. J. M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina.

Background: To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control.

Methods: We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Read More

View Article and Full-Text PDF

"Why would you not listen? It is like being given the winning lottery numbers and deciding not to take them": semi-structured interviews with post-acute myocardial infarction patients and their significant others exploring factors that influence participation in cardiac rehabilitation and long-term exercise training.

Disabil Rehabil 2021 May 7:1-11. Epub 2021 May 7.

Institute of Nursing and Health Research, Ulster University, Newtownabbey, UK.

Purpose: Despite the clinical benefits, coronary artery disease patient participation rates in cardiac rehabilitation (CR) and long-term exercise are poor. This study explored the factors related to participation in these interventions from the perspectives of post-acute myocardial infarction (AMI) patients and their significant others.

Methods: Semi-structured interviews were performed with post-AMI patients (number () = 10) and their significant others ( = 10) following phase-III and phase-IV CR. Read More

View Article and Full-Text PDF

Economic Analysis on Adoption of Biosimilar Granulocyte Colony-Stimulating Factors in Patients With Nonmyeloid Cancer at Risk of Febrile Neutropenia Within the Oncology Care Model Framework.

JCO Oncol Pract 2021 May 7:OP2000994. Epub 2021 May 7.

Scientia Pharmacy Advisors, Boston, MA.

Purpose: Value-based programs, such as the Oncology Care Model (OCM), seek to improve care for patients undergoing chemotherapy, while reducing total costs. The purpose of this study is to quantify the impact of adopting biosimilar granulocyte colony-stimulating factors (G-CSFs) for febrile neutropenia (FN) primary prophylaxis (PP) from a US practice perspective.

Methods: A 1-year economic analysis on real-world direct drug costs and health care resource utilization was conducted in a hypothetical cohort of 500 patients with nonmyeloid cancer receiving chemotherapy. Read More

View Article and Full-Text PDF

Challenges in co-designing an intervention to increase mobility in older patients: a qualitative study.

J Health Organ Manag 2021 Apr;35(9):140-162

Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark.

Purpose: The aim of this study is to explore and discuss key challenges associated with having stakeholders take part in co-designing a health care intervention to increase mobility in older medical patients admitted to two medical departments at two hospitals in Denmark.

Design/methodology/approach: The study used a qualitative design to investigate the challenges of co-designing an intervention in five workshops involving health professionals, patients and relatives. "Challenges" are understood as "situations of being faced with something that needs great mental or physical effort in order to be done successfully and therefore tests a person's ability" (Cambridge Dictionary). Read More

View Article and Full-Text PDF

Outcomes of post-chemotherapy robot-assisted retroperitoneal lymph node dissection in testicular cancer: multi-institutional study.

World J Urol 2021 May 7. Epub 2021 May 7.

Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

Objective: To evaluate the perioperative and oncological outcomes after post-chemotherapy robot-assisted retroperitoneal lymph node dissection (PC-RARPLND).

Materials And Methods: We retrospectively reported the perioperative and oncological outcomes of all the patients with testicular cancer who underwent PC-RARPLND at three tertiary teaching centers. Descriptive statistical measures were used to report demographic, clinical, intraoperative, postoperative and oncological outcomes. Read More

View Article and Full-Text PDF

Oncogenic driver mutations in non-small cell lung cancer: Past, present and future.

World J Clin Oncol 2021 Apr;12(4):217-237

Department of Oncology, University Hospital Geneva, Geneva 1205, Switzerland.

Lung cancer, of which non-small lung cancer is the most common subtype, represents the leading cause of cancer related-death worldwide. It is now recognized that a significant proportion of these patients present alterations in certain genes that drive oncogenesis. In recent years, more of these so-called oncogenic drivers have been identified, and a better understanding of their biology has allowed the development new targeted agents. Read More

View Article and Full-Text PDF

Impact of the COVID-19 Pandemic on Oncology Clinical Research in Latin America (LACOG 0420).

JCO Glob Oncol 2021 04;7:649-658

Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.

Purpose: COVID-19 has affected cancer care worldwide. Clinical trials are an important alternative for the treatment of oncologic patients, especially in Latin America, where trials can be the only opportunity for some of them to access novel and, sometimes, standard treatments.

Methods: This was a cross-sectional study, in which a 22-question survey regarding the impact of the COVID-19 pandemic on oncology clinical trials was sent to 350 representatives of research programs in selected Latin American institutions, members of the Latin American Cooperative Oncology Group. Read More

View Article and Full-Text PDF

Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study.

Transfusion 2021 May 6. Epub 2021 May 6.

Department of Medicine, Kuopio University Hospital, Kuopio, Finland.

Background: Autologous stem cell transplantation (auto-SCT) is a widely used treatment option in multiple myeloma (MM) patients. The optimal graft cellular composition is not known.

Study Design And Methods: Autograft cellular composition was analyzed after freezing by flow cytometry in 127 MM patients participating in a prospective multicenter study. Read More

View Article and Full-Text PDF

Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study: RANTES was associated with periodontitis.

J Periodontal Res 2021 May 5. Epub 2021 May 5.

Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.

Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis.

Background Data: Earlier studies on cytokines in GCF in RA patients have not given clear results.

Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. Read More

View Article and Full-Text PDF