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Perceived protectiveness of research safeguards and influences on willingness to participate in research: A novel MTurk pilot study.

J Psychiatr Res 2021 Apr 6;138:200-206. Epub 2021 Apr 6.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA, 94305-5717, USA.

Little is known about how individuals with mood disorders view the protectiveness of research safeguards, and whether their views affect their willingness to participate in psychiatric research. We conducted an online survey with 80 individuals (self-reported mood disorder [n = 25], self-reported good health [n = 55]) recruited via MTurk. We assessed respondents' perceptions of the protectiveness of five common research safeguards, as well as their willingness to participate in research that incorporates each safeguard. Read More

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Physical activity status and quality of life in patients with epilepsy - Survey from level four epilepsy monitoring units.

Epilepsy Res 2021 Apr 9;173:106639. Epub 2021 Apr 9.

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA. Electronic address:

Purpose: People with epilepsy (PWE) tend to have sedentary lifestyles which may predispose them to a lower perceived quality of life (QOL). Moreover, the relationship between physical activity (PA) and QOL in populations of PWE with high disease burden has been under-studied. The goal of this study was to evaluate PA level and its impact on health-related QOL in PWE who were admitted to Level-4 epilepsy monitoring units (EMU). Read More

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How Do Adults with Autism Spectrum Disorder Participate in the Labor Market? A German Multi-center Survey.

J Autism Dev Disord 2021 Apr 17. Epub 2021 Apr 17.

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Charité - Medical Faculty Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

International studies show disadvantages for adults with autism spectrum disorder (ASD) in the labor market. Data about their participation in the German labor market are scarce. The aim of this study was to examine the integration of adults with ASD in the German labor market in terms of education, employment and type of occupation by means of a cross-sectional-study, using a postal questionnaire. Read More

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Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis.

Eur J Immunol 2021 Apr 17. Epub 2021 Apr 17.

Institute of Molecular and Translational Medicine (IMTM), and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, West Yanta Road No.76, Xi'an, Shaanxi, 710061, PR China.

MicroRNA-147 (miR-147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells in experimental arthritis. This study was designed to verify whether loss of its function might alleviate inflammatory events in joints of experimental and rheumatoid arthritis (RA). DA rats were injected intradermally with pristane to induce arthritis, and rno-miR-147 antagomir was locally administrated into individual ankle compared with negative control or rno-miR-155-5p antagomir (potential positive control). Read More

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Professional development training preferences of occupational therapists working with older adults in Australia: A discrete choice experiment.

Aust Occup Ther J 2021 Apr 16. Epub 2021 Apr 16.

College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Introduction: Members of the public expect occupational therapists to provide evidence-based practice. Participation in professional development activities is essential to update knowledge and acquire skills to enable delivery of evidence-based assessment and intervention. Therapists commonly choose to participate in professional development through attending training workshops. Read More

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Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study).

BMJ Open 2021 Apr 16;11(4):e046622. Epub 2021 Apr 16.

Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.

Introduction: Approximately 40% of the 55 000 women diagnosed with breast cancer each year in the UK undergo mastectomy because they are considered unsuitable for standard breast-conserving surgery (BCS) due to tumour size or multiple tumour foci. Mastectomy can significantly impact women's quality of life, and only one in four women currently undergo immediate breast reconstruction (IBR).Level 2 oncoplastic breast-conserving surgery (OPBCS) combines removing the cancer with a range of plastic surgical volume replacement (eg, local perforator flaps) and volume displacement techniques (eg, therapeutic mammaplasty) that can extend the role of BCS and may allow some women not suitable for standard BCS to avoid mastectomy. Read More

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Incidence and factors associated with delirium in children in a single pediatric intensive care unit in Brazil.

J Pediatr Nurs 2021 Apr 13. Epub 2021 Apr 13.

Pediatric Nursing Department, Escola Paulista de Enfermagem, Universidade Federal de São Paulo, Brazil. Electronic address:

Purpose: To identify the incidence of delirium in a Pediatric Intensive Care Unit (PICU); to determine the factors associated with the occurrence of delirium and the agreement between two scales used for detection of pediatric delirium in critically ill children.

Designs And Method: Descriptive longitudinal study carried out in a PICU. The sample consisted of 65 critically ill children admitted to the PICU, with more than 24 h of hospitalization, excluding children with neurological or cognitive impairment, hearing and visual impairment, chronic encephalopathy and declining consent to participate in the study. Read More

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Predictors of sleep quality in medical students during COVID-19 confinement.

Encephale 2021 Mar 18. Epub 2021 Mar 18.

Psychiatry Department, Farhat Hached University Hospital, Ibn Jazzar Avenue, Sousse 4000, Tunisia; University of Sousse, Tunisia; Faculty of medicine of Sousse, Sousse, Tunisia.

Objectives: We aimed to assess sleep quality of Tunisian medical students during home confinement due to the COVID-19 pandemic, and to analyze the relationship between sleep quality and sociodemographic, clinical, confinement-related and psychological variables.

Methods: A correlational cross-sectional study was conducted from April 11th to May 3rd 2020. Medical students who have been in home confinement and who accepted to participate in an online survey were targeted. Read More

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Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1.

Cancer Metab 2021 Apr 16;9(1):16. Epub 2021 Apr 16.

National Centre for Cell Science, Pune, 411007, India.

Background: Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alternative splicing events. SMAR1, being a MARBP and an important tumor suppressor, is known to regulate the splicing of various cancer-associated genes. Read More

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Movement asymmetries in horses presented for pre purchase or lameness examination.

Equine Vet J 2021 Apr 16. Epub 2021 Apr 16.

Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: The increasing popularity of objective gait analysis makes application in pre-purchase examinations (PPE) a logical next step. Therefore, there is a need to have more understanding of asymmetry during a PPE in horses described on clinical evaluation as subtly lame.

Objectives: To objectively compare asymmetry in horses raising minor vet concerns in a PPE and in horses raising major vet concerns with that found in horses presented with subtle single-limb lameness, and to investigate the effect of age/discipline on the clinicians' interpretation of asymmetry on the classification of minor vet concerns in a PPE. Read More

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LXRβ is involved in the control of platelet production from megakaryocytes.

Blood Cells Mol Dis 2021 Apr 13;89:102568. Epub 2021 Apr 13.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Liver X receptor β (LXRβ), a nuclear receptor involved in important cellular processes such as cholesterol, glucose and fatty acid metabolism, was suggested to be involved in platelet aggregation but its detailed roles are not clear. In the present study, we evaluated the contribution of LXRβ to platelet functions and production. In the systemic collagen-epinephrine thrombosis mouse model, LXRβ-deficient mice showed increased area of blood clots compared with control wide-type littermates. Read More

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A predictive framework based on brain volume trajectories enabling early detection of Alzheimer's disease.

Comput Med Imaging Graph 2021 Apr 2;90:101910. Epub 2021 Apr 2.

Data used in the preparation of this article was obtained from the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) funded by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) which was made available at the ADNI database. The AIBL researchers contributed data but did not participate in analysis or writing of this report. AIBL researchers are listed at www.aibl.csiro.au.

We present a framework for constructing predictive models of cognitive decline from longitudinal MRI examinations, based on mixed effects models and machine learning. We apply the framework to detect conversion from cognitively normal (CN) to mild cognitive impairment (MCI) and from MCI to Alzheimer's disease (AD), using a large collection of subjects sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging (AIBL). We extract subcortical segmentation and cortical parcellation from corresponding T1-weighted images using FreeSurfer v. Read More

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Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: A multinational cross-sectional study.

PLoS One 2021 16;16(4):e0238666. Epub 2021 Apr 16.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

The Covid-19 pandemic has placed unprecedented pressure on healthcare systems and workers around the world. Such pressures may impact on working conditions, psychological wellbeing and perception of safety. In spite of this, no study has assessed the relationship between safety attitudes and psychological outcomes. Read More

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LGB´s Arts Affinity: An Empirical Study of Theater Audiences Based on Motivations.

J Homosex 2021 Apr 16:1-20. Epub 2021 Apr 16.

Department of Applied Economics, Universitat de València, València, Spain.

The extended belief of gay people being more creative and showing higher interest toward arts lacks robust empirical support. The pioneer study on this issue highlighted that LGB´s arts participation was mostly explained by demographic factors such as level of studies, residence and family situation, which suggests that differences due to sexual orientation tend to fade. In this paper, we put forward the hypothesis that sexual orientation influences motivations to participate, which emphasizes their role and heterogeneity. Read More

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Medialization of the Hip's Center with Periacetabular Osteotomy: Validation of Assessment with Plain Radiographs.

Clin Orthop Relat Res 2021 May;479(5):1040-1049

L. M. Fowler, J. J. Nepple, C. Devries, J. C. Clohisy, Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Background: Periacetabular osteotomy (PAO) increases acetabular coverage of the femoral head and medializes the hip's center, restoring normal joint biomechanics. Past studies have reported data regarding the degree of medialization achieved by PAO, but measurement of medialization has never been validated through a comparison of imaging modalities or measurement techniques. The ilioischial line appears to be altered by PAO and may be better visualized at the level of the inferior one-third of the femoral head, thus, an alternative method of measuring medialization that begins at the inferior one-third of the femoral head may be beneficial. Read More

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A Gamified, Social Media-Inspired, Web-Based Personalized Normative Feedback Alcohol Intervention for Lesbian, Bisexual, and Queer-Identified Women: Protocol for a Hybrid Trial.

JMIR Res Protoc 2021 Apr 16;10(4):e24647. Epub 2021 Apr 16.

HeadsUp Labs, Department of Psychology, Loyola Marymount University, Los Angeles, CA, United States.

Background: Sexual minority women are more likely to drink alcohol, engage in heavy drinking, and experience alcohol-related problems than heterosexual women. However, culturally tailored interventions for this population have been slow to emerge.

Objective: This type 1 effectiveness-implementation trial examines the feasibility and efficacy of a gamified, culturally tailored, personalized normative feedback (PNF) alcohol intervention for sexual minority women who psychologically identify as lesbian, bisexual, or queer (LBQ). Read More

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Length-weight growth analysis up to 12 months of age in three groups according to the dietary pattern followed from pregnant mothers and children during the first year of life.

Minerva Pediatr (Torino) 2021 Apr 16. Epub 2021 Apr 16.

Unicusano University, Rome, Italy.

Background: The aim of the present study is to analyse the length-weight growth up to 12 months of age in three groups considering the respective dietary pattern followed from the pregnant mothers and from the infants during the first year of the life. Moreover, the cultural inference of vegetarianism has been studied.

Methods: Between September 2017 and May 2018, more than 100 mothers have been proposed to participate in this study. Read More

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Recruitment of population-based controls for ALS cases from the National ALS Registry.

Amyotroph Lateral Scler Frontotemporal Degener 2021 Apr 16:1-7. Epub 2021 Apr 16.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA, and.

In 2010, the United States Agency for Toxic Substances and Disease Registry (ATSDR) created the National ALS Registry (Registry) to examine the epidemiology of ALS and potential risk factors. We are currently recruiting population-based controls for an epidemiologic case-control study to examine ALS environmental risk factors using this Registry. To date, we have recruited 181 non-diseased, population-based controls for comparison to Registry cases ( = 280). Read More

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A Student Telephone Intervention for Primary Care Patient Safety During the COVID-19 Pandemic.

PRiMER 2021 24;5:10. Epub 2021 Feb 24.

Brown University/Kent Hospital/Care New England Family Medicine Residency, Pawtucket, RI.

Background And Objectives: During the COVID-19 pandemic, medical students were unable to participate in clinical learning for several weeks. Many primary care patients no-showed to appointments and did not receive care. We implemented a telephone outreach program using medical students to call primary care patients who no-showed to appointments and did not receive care. Read More

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February 2021

User experience (re)design and evaluation of a self-guided, mobile health app for adolescents with mild Traumatic Brain Injury.

J Form Des Learn 2020 Dec 6;4(2):51-64. Epub 2020 Jan 6.

Cincinnati Children's Hospital Medical Center.

Mild Traumatic Brain Injury (mTBI) is a significant cause of morbidity for adolescents. Currently, there is a lack of evidence-based interventions to address common sequelae of mTBI. To address this gap, we designed a program to promote recovery for adolescents following mTBI. Read More

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December 2020

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Mol Cell Oncol 2021 22;8(2):1892444. Epub 2021 Mar 22.

Department of Biochemistry, Wakayama Medical University, Wakayama, Japan.

The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates. Read More

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Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis.

J Immunol Res 2021 29;2021:6657785. Epub 2021 Mar 29.

Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Background: Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of () with recombinant IGF-I induces accelerated lesion development. Read More

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Combined Electric and Acoustic Stimulation (EAS) in Children: Investigating Benefit Afforded by Bilateral Versus Unilateral Acoustic Hearing.

Otol Neurotol 2021 Apr 14. Epub 2021 Apr 14.

Hearts for Hearing, Tulsa, Oklahoma Boys Town National Research Hospital, Omaha, Nebraska Vanderbilt University Medical Center, Nashville, Tennessee.

Purpose: Electric and acoustic stimulation (EAS) with preserved hearing in the implanted ear provides benefit for speech understanding, spatial hearing, and quality of life in adults. However, there is limited research on EAS outcomes in children. The aims of this study were to estimate the magnitude of EAS-related benefit on speech understanding in children with preserved acoustic hearing and to determine what role acoustic interaural time difference (ITD) sensitivity may have on said EAS benefit. Read More

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The challenges of becoming and being a clinician manager: a qualitative exploration of the perception of medical doctors in senior leadership roles at a large Australian health service.

BMC Health Serv Res 2021 Apr 15;21(1):351. Epub 2021 Apr 15.

Colac Area Health, Colac Victoria, Australia.

Background: In Australia, activity-based funding models have emphasized the need for hospitals to be accountable for their clinical performance. Clinician managers, with medical backgrounds are essential to ensuring high quality clinical performance and operational management of hospital services. The purpose of this study is to 1. Read More

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A qualitative examination of the current management of opioid use disorder and barriers to prescribing buprenorphine in a Canadian emergency department.

BMC Emerg Med 2021 Apr 15;21(1):48. Epub 2021 Apr 15.

Department of Family and Community Medicine, University of Toronto, Toronto, Canada.

Background: Emergency departments (EDs) across Canada are increasingly prescribing buprenorphine for opioid use disorder (OUD). The objective of this study was to identify the current knowledge, attitudes, and behaviours of ED physicians on the management of OUD in the ED, including barriers and facilitators to prescribing buprenorphine.

Methods: We purposefully selected emergency physicians from one ED in Toronto which had recently received education on OUD management and had a new addiction medicine follow-up clinic, to participate in semi-structured interviews. Read More

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circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis.

J Recept Signal Transduct Res 2021 Apr 15:1-10. Epub 2021 Apr 15.

Department of Nuclear Medicine, Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University, Yunnan, Kunming, People's Republic of China.

Papillary thyroid cancer (PTC) is a common tumor malignancy of the endocrine system worldwide. Recently, circular RNAs (circRNAs) have been reported to participate in diverse pathological processes, especially in tumorigenesis. However, the functional role and mechanism of circRNA pleckstrin and Sec7 domain containing 3 (circ-PSD3) in PTC are still unclear. Read More

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Nurse educator knowledge, attitude and skills towards using high-fidelity simulation: A study in the vocational education sector.

Nurse Educ Pract 2021 Mar 31;53:103048. Epub 2021 Mar 31.

Nursing & Midwifery Monash University, P.O. Box 527, Frankston 3199, Australia; Peninsula Health Frankston, 3199, Australia; Federation University Australia, P.O. Box 859, Berwick 3806, Australia. Electronic address:

High-fidelity simulation has become an essential educational approach in nurse education globally. Several studies have explored the experience of undergraduate nursing students and educators with high-fidelity simulation; however, none have explored the experience of students in the vocational educational sector. The aim of the study was to explore nurse educators' knowledge, attitude and skills toward using high-fidelity simulation in the setting of vocational education. Read More

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Gene expression profiling of early Parkinson's disease patient reveals redox homeostasis.

Neurosci Lett 2021 Apr 12;753:135893. Epub 2021 Apr 12.

Neurotoxin Research Center of Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, PR China. Electronic address:

Parkinson's disease (PD) is slowly progressive. Due to the lack of specific and sensitive biomarkers, the majority of PD patients are in the advanced stages when diagnosed. This study aimed to investigate biomarkers for early PD diagnosis. Read More

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Factors Associated with Participation in Elementary School-Based SARS-CoV-2 Testing - Salt Lake County, Utah, December 2020-January 2021.

MMWR Morb Mortal Wkly Rep 2021 Apr 16;70(15):557-559. Epub 2021 Apr 16.

During December 3, 2020-January 31, 2021, CDC, in collaboration with the University of Utah Health and Economic Recovery Outreach Project,* Utah Department of Health (UDOH), Salt Lake County Health Department, and one Salt Lake county school district, offered free, in-school, real-time reverse transcription-polymerase chain reaction (RT-PCR) saliva testing as part of a transmission investigation of SARS-CoV-2, the virus that causes COVID-19, in elementary school settings. School contacts of persons with laboratory-confirmed SARS-CoV-2 infection, including close contacts, were eligible to participate (1). Investigators approached parents or guardians of student contacts by telephone, and during January, using school phone lines to offer in-school specimen collection; the testing procedures were explained in the preferred language of the parent or guardian. Read More

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Visfatin Regulates Inflammatory Mediators in Mouse Intestinal Mucosa Through Toll-Like Receptors Signaling Under Lipopolysaccharide Stress.

Arch Immunol Ther Exp (Warsz) 2021 Apr 15;69(1):11. Epub 2021 Apr 15.

College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Visfatin is a multifunctional protein involved in inflammatory immune stress. The aim of current study was to explore the role of visfatin in lipopolysaccharide (LPS)-induced intestinal mucosal inflammation and to confirm its cellular effect in inflammatory immune response through silencing of Toll-like receptors (TLRs). We divided Kunming mice into three groups: Saline group, LPS group, and LPS + visfatin group and performed hematoxylin and eosin staining, immunohistochemistry, quantitative polymerase chain reaction, Western blot, enzyme linked immunosorbent assay and RNA-seq analysis. Read More

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