291,453 results match your criteria participants group


High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.

Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.

Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:

Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.

Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More

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Deliberate practice in resuscitation training using a feedback device, and the effects of the physical characteristics of the rescuer on the acquisition and retention of cardiopulmonary resuscitation skills: Randomized clinical trial.

Int Emerg Nurs 2021 Jul 28;58:101037. Epub 2021 Jul 28.

Fundación San Juan de Dios, Centro de Ciencias de la Salud San Rafael, Universidad de Nebrija, Paseo de La Habana, 70, 28036 Madrid, Spain; UNINPSI, Dpto. de Psicología, Universidad Pontificia Comillas, Madrid, Spain. Electronic address:

Background: Cardiopulmonary resuscitation (CPR) skills decline rapidly and rescuers' physical characteristics could impact on their performance. Our aim was to analyse the effects of deliberate practice using a feedback device (FD) on the CPR performance of nursing students prior to, immediately after, and three months after training, considering their physical characteristics.

Method: Sixty nursing students participated in this randomized clinical trial (control group n = 28; training group n = 32). Read More

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The benefits of underwater vibrostimulation in the rehabilitation of children with impaired hearing.

Int J Pediatr Otorhinolaryngol 2021 Jul 24;149:110855. Epub 2021 Jul 24.

North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, 191015, Russia.

Introduction: Early intervention is crucial for the optimal speech and language development of children with impaired hearing. Underwater vibrostimulation could help develop behavioural reactions to low-frequency stimuli immediately after diagnosis and facilitate aural rehabilitation after hearing aid (HA) or cochlear implant (CI) activation.

Goals: To determine the limits of underwater vibrotactile stimuli perception and to measure the effect of vibrostimulation training on the aural rehabilitation of young children. Read More

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Validating a scale to measure respectful maternity care in Australia: Challenges and recommendations.

Midwifery 2021 Jul 14;103:103090. Epub 2021 Jul 14.

University of the Sunshine Coast, Sippy Downs, Queensland, Australia; The University of Queensland, Australia; Sunshine Coast Health Institute, Australia.

Objective: Respectful maternity care is a pervasive human rights issue, but little is known about its realisation in Australia. Two scales, developed in North America, measure key aspects of respectful maternity care: the Mothers on Respect Index and Mothers Autonomy in Decision Making scale. This study aimed to validate these two scales in Queensland, Australia, and to determine the extent to which women currently experience respectful maternity care and autonomy in decision making. Read More

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Computer use and cognitive decline among Japanese older adults: A prospective cohort study.

Arch Gerontol Geriatr 2021 Jul 18;97:104488. Epub 2021 Jul 18.

Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology Research Institute, Obu City, Japan.

Introduction: This study aimed to examine the prospective association between computer use and cognitive decline among community-dwelling Japanese older adults, considering the characteristics of computer users.

Methods: This four-year prospective cohort study was conducted in Obu, Japan. Participants who were cognitive intact at Wave 1 (2011-2012) were followed through the study period. Read More

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Decreased ventricular size and mass mediate the reduced exercise capacity in adolescents and adults born premature.

Early Hum Dev 2021 Jul 24;160:105426. Epub 2021 Jul 24.

Department of Pediatrics, Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, United States of America.

Background: Premature birth is associated with lower levels of cardiorespiratory fitness (CRF) but the underlying mechanisms responsible remain unclear. This study assessed whether differences in cardiac morphology or function mediate differences in CRF among adolescents and young adults born preterm.

Methods: Adolescents and young adults born moderately to extremely premature (gestational age ≤ 32 weeks or birth weight < 1500 g) and age-matched term born participants underwent resting cardiac MRI and maximal exercise testing. Read More

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The negative impact of increasing age and underlying cirrhosis on sensitivity of adenosine deaminase in the diagnosis of tuberculous peritonitis: a cross-sectional study in eastern China.

Int J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Department of Infectious Diseases, the First Affiliated Hospital of Wannan Medical College,Wuhu, 241000, China. Electronic address:

Background: This study aims to evaluate the correlation between adenosine deaminase (ADA) test for the diagnosis of tuberculous peritonitis (TBP) and patient age or cirrhosis status.

Methods: Clinical data of patients clinically diagnosed with TPB (n=132) or not (n=147) were assessed. ADA activity was compared among three age groups (< 45 yr, 45-60 yr, and ≥ 60 yr) and cirrhotic-related subgroups. Read More

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The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - a randomized proof of concept study.

Neurosci Lett 2021 Jul 28:136146. Epub 2021 Jul 28.

Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

Introduction: Current treatments for cocaine use disorder (CUD) are not very effective and better treatments are needed. This study investigates the effectiveness of a combined intervention that targets the assumed underlying glutamate pathology in cocaine users. To this end, the combined effects of N-acetylcysteine (NAC) and working memory (WM) training on glutamate concentrations in the dorsal and rostral ACC were investigated in a randomized, double-blind placebo-controlled design. Read More

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Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study.

J Steroid Biochem Mol Biol 2021 Jul 28:105958. Epub 2021 Jul 28.

Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.

Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Read More

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Osteopathic Manual Treatment Compared to Kaltenborn-Evjenth Orthopedic Manual Therapy for Chronic Low Back Pain: A Randomized Study.

Altern Ther Health Med 2021 Jul 31. Epub 2021 Jul 31.

Context: Low back pain (LBP) is a painful pathology causing pain and disability despite treatment with the best evidence-based therapies. Osteopathic manual therapy (OMT) and Kaltenborn-Evjenth orthopedic manual therapy (KEOMT) are alternative treatments for LBP.

Objective: The study intended to evaluate the efficacy of OMT compared to that of KEOMT for patients with chronic LBP. Read More

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Effect of Acupressure on Pre-Exam Anxiety in Nursing Students.

Altern Ther Health Med 2021 Jul 31. Epub 2021 Jul 31.

Background: Academic stress and anxiety are experienced by students as a consequence of examinations.

Objective: The purpose of this study was to explore whether or not auricular acupressure therapy can reduce exam anxiety, state anxiety and trait anxiety in nursing students.

Methods/design: A single blinded randomized control trial was designed. Read More

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Group B Streptococcus Colonisation, Prevalence, Associated Risk Factors and Antimicrobial Susceptibility Pattern Among Pregnant Women Attending Antenatal Care at Dschang District Hospital, West Region of Cameroon: A hospital-based Cross-Sectional Study.

Int J Clin Pract 2021 Jul 31:e14683. Epub 2021 Jul 31.

Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, University of Dschang, Cameroon.

Background: Group B Streptococcus (GBS), also known as Streptococcus agalactiae, is a Gram-positive bacterium known for its ability to colonise the vaginal and rectal areas of the mother and is a leading cause of neonatal mortality and morbidity. This study aimed at determining the prevalence, associated risk factors and antimicrobial susceptibility of GBS colonization among pregnant women attending antenatal Care (ANC) at Dschang District Hospital.

Methods: This hospital-based cross-sectional study used a multistage sampling method to recruit a total of 621 consented pregnant women who attended ANC in Dchang District Hospital. Read More

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Cyclothymic Temperament is Associated with Poor Medication Adherence and Disordered Eating in Type 2 Diabetes Patients: A Case-Control Study.

Diabetes Ther 2021 Jul 31. Epub 2021 Jul 31.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Kimitsu Chuo Hospital, Sakurai 1010, Kisarazu, Chiba, 292-0822, Japan.

Introduction: Poor medication adherence and disordered eating are major self-care problems in patients with type 2 diabetes that worsen glycemic control and increase the risk of developing severe diabetes complications. Affective temperament, which remains mostly unchanged throughout life, is speculated to predict poor treatment response and high comorbidity. The aim of this study was to explore the link between affective temperament and poor glycemic control due to insufficient self-care. Read More

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The ocular surface findings in alopecia areata patients: clinical parameters and impression cytology.

Int Ophthalmol 2021 Jul 31. Epub 2021 Jul 31.

Dermatology Department, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey.

Purpose: The objective of this study was to examine the effects of alopecia areata (AA) on the ocular surface and conjunctival cytology.

Methods: A total of 48 subjects were included in the present study. Twenty-three subjects were assigned to group 1 as the patient group, and 25 healthy individuals were included in group 2 as the control group. Read More

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Clinical, immunological and virological SARS-CoV-2 phenotypes in obese and non-obese military health system beneficiaries.

J Infect Dis 2021 Jul 31. Epub 2021 Jul 31.

Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Background: The mechanisms underlying the association between obesity and COVID-19 severity remain unclear. After verifying that obesity was a correlate of severe COVID-19 in U.S. Read More

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Oral diadochokinetic rates across languages: Multilingual speakers comparison.

Int J Lang Commun Disord 2021 Jul 31. Epub 2021 Jul 31.

Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City, Taiwan.

Background: It is unclear whether oral diadochokinetic rate (oral-DDK) performance is affected by different languages within a multilingual country.

Aims: This study investigated the effects of age, sex, and stimulus type (real word in L1, L2 vs. non-word) on oral-DDK rates among healthy Malaysian-Malay speakers in order to establish language- and age-sensitive norms. Read More

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Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A).

Am J Med Genet A 2021 Jul 30. Epub 2021 Jul 30.

National Eye Institute, Bethesda, Maryland, USA.

Sensorineural hearing loss (SNHL) is characteristic of Usher syndrome type 2 (USH2), but less is known about SNHL in nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) and olfaction in USH2A-associated retinal degeneration. The Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) is a natural history study that enrolled 127 participants, 80 with USH2 and 47 with ARRP. Hearing was measured by pure-tone thresholds and word recognition scores, and olfaction by the University of Pennsylvania Smell Identification Test (UPSIT). Read More

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Investigating the spectral features of the brain meso-scale structure at rest.

Hum Brain Mapp 2021 Jul 31. Epub 2021 Jul 31.

Rehab Technologies Lab, Istituto Italiano di Tecnologia, Genova, Italy.

Recent studies provide novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative, and core-periphery. However, the spectral properties of the brain meso-scale remain mostly unexplored. To fill this knowledge gap, we investigated how the meso-scale structure is organized across the frequency domain. Read More

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Lower 24-h urinary potassium excretion is negatively associated with excessive daytime sleepiness in the general population.

Sleep Breath 2021 Jul 31. Epub 2021 Jul 31.

Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, National Health Committee Key Laboratory of Hypertension Clinical Research China, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.

Objectives: Uncertainty remains about the association of potassium (K) intake and sleepiness. Therefore, we aimed to explore the relationship between K excretion using 24-h urine samples and excessive daytime sleepiness (EDS) in the general population.

Methods: In a cross-sectional study, we used multi-stage proportional random sampling to obtain a study sample aged ≥ 18 years from Emin, China between March and June 2019. Read More

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Role of cardiac magnetic resonance strain analysis in patients with hypoplastic left heart syndrome in evaluating right ventricular (dys)function: a systematic review.

Eur J Cardiothorac Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Objectives: Right ventricular dysfunction predicts death in patients with hypoplastic left heart syndrome (HLHS), but differences in morphology and loading conditions make calculation of the ejection fraction (EF), a challenging measure of its function. Our goal was to evaluate how strain measurements with cardiac magnetic resonance feature tracking could be used to evaluate right ventricular function in patients with HLHS.

Methods: A systematic search of the literature was performed by 2 independent researchers using the terms 'population', 'intervention', 'comparison', 'outcome' and 'time criteria'. Read More

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Demodex folliculorum (Trombidiformes: Demodicidae) and Demodex brevis Prevalence in an Extreme Environment of Chile.

J Med Entomol 2021 Jul 31. Epub 2021 Jul 31.

Molecular Parasitology Unit, Medical Technology Department, Faculty of Health Sciences, University of Antofagasta, Avenida Universidad de Antofagasta 02800, Antofagasta, Chile.

The prevalence of mites of the genus Demodex and their associations with host age, gender, workplace, and comorbid skin and ocular conditions were studied in participants in Antofagasta, Chile, which is in a region with an extreme environment. We examined 680 participants aged 18-88 yr using standardized surface skin biopsies. Among them, Demodex had a prevalence of 13. Read More

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Exploring cannabidiol effects on inflammatory markers in individuals with cocaine use disorder: a randomized controlled trial.

Neuropsychopharmacology 2021 Jul 30. Epub 2021 Jul 30.

Faculty of Medicine, Department of Psychiatry and Addictology, Université de Montréal, Montreal, QC, Canada.

Cocaine use disorder (CUD) is a major public health issue associated with physical, social, and psychological problems. Excessive and repeated cocaine use induces oxidative stress leading to a systemic inflammatory response. Cannabidiol (CBD) has gained substantial interest for its anti-inflammatory properties, safety, and tolerability profile. Read More

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Differential Impact of Home Nurse Contact After Discharge by Financial Strain, Primary Care Access, and Medical Complexity.

Hosp Pediatr 2021 Jul 30. Epub 2021 Jul 30.

James M. Anderson Center for Health System Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: The Hospital to Home Outcomes (H2O) trials examined the effectiveness of postdischarge nurse support on reuse after pediatric discharge. Unexpectedly, children randomly assigned to a nurse visit had higher rates of reuse than those in the control group. Participants in randomized control trials are heterogeneous. Read More

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Self-management challenges following hospital discharge for patients with multimorbidity: a longitudinal qualitative study of a motivational interviewing intervention.

BMJ Open 2021 07 30;11(7):e046896. Epub 2021 Jul 30.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Objectives: The aim of this study was to describe challenges in self-management activities among people with multimorbidity during a 4-week post-discharge period.

Design: This is a longitudinal qualitative study using data from a randomised controlled trial (RCT) of motivational interviewing (MI) sessions.

Setting: The RCT was conducted at six wards in two hospitals-one university hospital and one general hospital in Stockholm, Sweden, during 2016-2018. Read More

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Missing data in randomised controlled trials of rheumatoid arthritis drug therapy are substantial and handled inappropriately.

RMD Open 2021 Jul;7(2)

Divison of Rheumatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA

Objectives: To analyse the amount, reporting and handling of missing data, approach to intention-to-treat (ITT) principle application and sensitivity analysis utilisation in randomised clinical trials (RCTs) of rheumatoid arthritis (RA). To assess the trend in such reporting 10 years apart (2006 and 2016).

Methods: Parallel group drug therapy RA RCTs with a clinical primary endpoint. Read More

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Long-Term Outcome After Venoarterial Extracorporeal Membrane Oxygenation as Bridge to Left Ventricular Assist Device Preceding Heart Transplantation.

J Cardiothorac Vasc Anesth 2021 Jul 3. Epub 2021 Jul 3.

Department of Cardiac Surgery, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: To determine if venoarterial extracorporeal membrane oxygenation (VA ECMO) as a bridge to left ventricular assist device (LVAD) in heart transplant (HT) candidates (ie, double bridge to HT) was associated with increased morbidity and mortality when compared to LVAD bridging to HT (ie, single bridge to HT).

Design: A retrospective analysis of patients undergoing LVAD support from 2011 to 2020. A Kaplan-Meier survival curve and Cox-Mantel hazard ratios (HR) were calculated during LVAD support and after HT. Read More

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Development and Validation of a Predictive Score for Prolonged Mechanical Ventilation After Cardiac Surgery.

J Cardiothorac Vasc Anesth 2021 Jul 10. Epub 2021 Jul 10.

Sorbonne Université, Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Anesthesiology and Critical Care Medicine, Institute of Cardiology, GRC 29, Pitié-Salpêtrière Hospital, Paris, France. Electronic address:

Objectives: The authors aimed to identify risk factors associated with prolonged mechanical ventilation (PMV) after scheduled cardiac surgery under cardiopulmonary bypass (CPB).

Design: A single-center, observational study.

Setting: Tertiary hospital. Read More

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Precannulation International Normalized Ratio is Independently Associated With Mortality in Veno-Arterial Extracorporeal Membrane Oxygenation.

J Cardiothorac Vasc Anesth 2021 Jul 8. Epub 2021 Jul 8.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

Objectives: To explore whether precannulation international normalized ratio (INR) is associated with in-hospital mortality in venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients.

Design: A retrospective, observational cohort study.

Setting: A quaternary care academic medical center. Read More

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Healthcare professionals' perceptions of malnutrition management and oral nutritional supplement prescribing in the community: A qualitative study.

Clin Nutr ESPEN 2021 Aug 7;44:415-423. Epub 2021 May 7.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Republic of Ireland; UCD Institute of Food and Health, University College Dublin, Dublin, Republic of Ireland. Electronic address:

Background & Aim: Protein-energy malnutrition is under-recognised in the community despite being common in older adults due to physiological and social changes which are often compounded by chronic disease. This qualitative study aimed to explore the opinions of healthcare professionals (HCPs) working in the primary care and community settings about the management of malnutrition and the prescription of oral nutritional supplements (ONS), often included in the treatment of malnutrition.

Methods: Twelve healthcare professional (HCP) focus groups with 75 participants were conducted: community dietitians (n = 17), registered dietitians working in industry (n = 5), community and residential care nurses (n = 22), physiotherapists (n = 12), pharmacists (n = 9), occupational therapists (n = 6) and speech and language therapists (n = 4). Read More

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