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Trueness of a device for intraoral scanning to capture the angle and distance between implants in edentulous mandibular arches.

J Prosthet Dent 2021 Apr 14. Epub 2021 Apr 14.

Professor, Department of Dentistry, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil. Electronic address:

Statement Of Problem: The digitalization of completely edentulous arches presents limitations because of the lack of anatomic structures for best-fit alignment during the image generation process of the scanner's software program.

Purpose: The purpose of this clinical study was to evaluate a new device for intraoral scanning and to analyze its usefulness in capturing the 3-dimensional (3D) position of implants in edentulous mandibular arches.

Material And Methods: The 3D positions of 40 implants in 10 participants with fixed interim mandibular prostheses were evaluated by comparing 3 scanning techniques. Read More

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Human resources for health coordination mechanisms: lessons from Bauchi and Cross River states of Nigeria.

J Public Health (Oxf) 2021 Apr;43(Supplement_1):i41-i45

World Health Organization, United Nations House, Plot 617, Diplomatic Zone, Central Area District, Abuja, Nigeria.

Background: Addressing the challenges of the health crisis requires collaboration by multiple sectors and stakeholders with a complementary role in a single platform that coordinates policy and programs relating to the health workforce for sustainability.

Methods: Information from purposefully selected stakeholders involved in human resources for health programs in two selected states of Nigeria was collected during a workshop attended by 60 participants drawn from government, multilateral agencies, the private sector, bilateral agencies, academia, professional associations, and regulatory bodies.

Results: Lessons learnt from Bauchi and Cross River states HRH platforms included successful joint planning and implementation human resources for health strategies that significantly mobilized resources and improved performance. Read More

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Free neighborhood choice boosts socially optimal outcomes in stag-hunt coordination problem.

Sci Rep 2021 Apr 8;11(1):7745. Epub 2021 Apr 8.

Department of Microeconomics and Public Economics, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Situations where independent agents need to align their activities to achieve individually and socially beneficial outcomes are abundant, reaching from everyday situations like fixing a time for a meeting to global problems like climate change agreements. Often such situations can be described as stag-hunt games, where coordinating on the socially efficient outcome is individually optimal but also entails a risk of losing out. Previous work has shown that in fixed interaction neighborhoods agents' behavior mostly converges to the collectively inefficient outcome. Read More

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Increased Driving Distance to Screening Colonoscopy Negatively Affects Bowel Preparation Quality: an Observational Study.

J Gen Intern Med 2021 Mar 31. Epub 2021 Mar 31.

Division of Gastroenterology, Department of Internal Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

Background: To prepare for colonoscopy, patients must consume a bowel purgative and travel from their home to the site of their procedure. The timing of bowel purgative ingestion predicts bowel preparation quality. Currently, it is not known if driving distance impacts bowel preparation quality or adenoma detection. Read More

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An assessment of risk factors for contracting rabies among dog bite cases recorded in Ward 30, Murewa district, Zimbabwe.

PLoS Negl Trop Dis 2021 Mar 31;15(3):e0009305. Epub 2021 Mar 31.

National University of Science and Technology, Faculty of Applied Science, Department of Environmental Science and Health, Bulawayo, Zimbabwe.

Background: Zoonoses are a major threat to human health. Worldwide, rabies is responsible for approximately 59 000 deaths annually. In Zimbabwe, rabies is one of the top 5 priority diseases and it is notifiable. Read More

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Development of a computable phenotype to identify a transgender sample for health research purposes: a feasibility study in a large linked provincial healthcare administrative cohort in British Columbia, Canada.

BMJ Open 2021 Mar 25;11(3):e040928. Epub 2021 Mar 25.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Objectives: Innovative methods are needed for identification of transgender people in administrative records for health research purposes. This study investigated the feasibility of using transgender-specific healthcare utilisation in a Canadian population-based health records database to develop a computable phenotype (CP) and identify the proportion of transgender people within the HIV-positive population as a public health priority.

Design: The Comparative Outcomes and Service Utilization Trends (COAST) Study cohort comprises a data linkage between two provincial data sources: The British Columbia (BC) Centre for Excellence in HIV/AIDS Drug Treatment Program, which coordinates HIV treatment dispensation across BC and Population Data BC, a provincial data repository holding individual, longitudinal data for all BC residents (1996-2013). Read More

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Multiple Spatial Coordinates Influence the Prediction of Tactile Events Facilitated by Approaching Visual Stimuli.

Authors:
Tsukasa Kimura

Multisens Res 2021 Mar 15:1-21. Epub 2021 Mar 15.

The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, 567-0047, Japan.

Interaction with other sensory information is important for prediction of tactile events. Recent studies have reported that the approach of visual information toward the body facilitates prediction of subsequent tactile events. However, the processing of tactile events is influenced by multiple spatial coordinates, and it remains unclear how this approach effect influences tactile events in different spatial coordinates, i. Read More

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Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts.

Front Cell Infect Microbiol 2021 26;11:603291. Epub 2021 Feb 26.

Department of Endodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

High serum thyroid-stimulating hormone (TSH) levels are linked to many metabolic disorders, but the effects of TSH levels on the oral microbiota are still largely unknown. This study aimed to explore the association between the salivary microbiome in adults and serum TSH levels. Saliva and fasting blood samples were obtained from a health census conducted in Southeast China. Read More

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February 2021

Dynamic Alterations of Oral Microbiota Related to Halitosis in Preschool Children.

Front Cell Infect Microbiol 2021 26;11:599467. Epub 2021 Feb 26.

Department of Preventive Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: This longitudinal study was aimed to evaluate the dynamic shift in oral microbiota during the process of halitosis progression among preschool children.

Methods: The oral examinations, questionnaires and tongue coating specimens were collected at the baseline and 12-month follow-up. All children were oral healthy at the enrollment. Read More

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February 2021

Movement drift in optic ataxia reveals deficits in hand state estimation in oculocentric coordinates.

J Exp Psychol Hum Percept Perform 2021 Mar 11. Epub 2021 Mar 11.

Centre de Recherche en Neurosciences de Lyon (CRNL).

When vision is removed, limb position has been shown to progressively drift during repetitive arm movements. The posterior parietal cortex (PPC) is known to be involved in the processing of multisensory information, the formation of internal hand estimate, and online motor control. Here, we compared hand position drift between healthy controls and 2 patients with PPC damage to gain insight into the mechanisms underlying movement drift and investigate the possible role of the PPC in this process. Read More

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Improving Visualisation Design for Effective Multi-Objective Decision Making.

IEEE Trans Vis Comput Graph 2021 Mar 10;PP. Epub 2021 Mar 10.

Decision-makers across many professions are often required to make multi-objective decisions over increasingly larger volumes of data with several competing criteria. Data visualization is a powerful tool for exploring these complex solution spaces, but there is little research on its ability to support multi-objective decisions. In this paper, we explore the effects of visualization design and data volume on decision quality in multi-objective scenarios with complex trade-offs. Read More

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A contactless method to measure real-time finger motion using depth-based pose estimation.

Comput Biol Med 2021 Apr 17;131:104282. Epub 2021 Feb 17.

Bioengineering College of Chongqing University, Chongqing, China; Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China. Electronic address:

Background: Finger mobility plays a crucial role in everyday living and is a leading indicator during hand rehabilitation and assistance tasks. Depth-based hand pose estimation is a potentially low-cost solution for the clinical and home-based measurement of symptoms of limited human finger motion.

Objective: The purpose of this study was to achieve the contactless measurement of finger motion based on depth-based hand pose estimation using Azure Kinect depth cameras and transfer learning, and to evaluate the accuracy in comparison with a three-dimensional motion analysis (3DMA) system. Read More

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Deep brain stimulation effects on verbal fluency dissociated by target and active contact location.

Ann Clin Transl Neurol 2021 03 17;8(3):613-622. Epub 2021 Feb 17.

Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.

Objective: Deep brain stimulation (DBS) improves motor symptoms in Parkinson's disease (PD), but it can also disrupt verbal fluency with significant costs to quality of life. The current study investigated how variability of bilateral active electrode coordinates along the superior/inferior, anterior/posterior, and lateral/medial axes in the subthalamic nucleus (STN) or the globus pallidus interna (GPi) contribute to changes in verbal fluency. We predicted that electrode location in the left hemisphere would be linked to changes in fluency, especially in the STN. Read More

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Geometric models reveal behavioural and neural signatures of transforming experiences into memories.

Nat Hum Behav 2021 Feb 11. Epub 2021 Feb 11.

Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

How do we preserve and distort our ongoing experiences when encoding them into episodic memories? The mental contexts in which we interpret experiences are often person-specific, even when the experiences themselves are shared. Here we develop a geometric framework for mathematically characterizing the subjective conceptual content of dynamic naturalistic experiences. We model experiences and memories as trajectories through word-embedding spaces whose coordinates reflect the universe of thoughts under consideration. Read More

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February 2021

Heterogeneous Urban Exposures and Prevalent Hypertension in the Helsinki Capital Region, Finland.

Int J Environ Res Public Health 2021 01 29;18(3). Epub 2021 Jan 29.

Environmental Health Unit, Department of Health Security, Finnish Institute for Health and Welfare, Neulaniementie 4, P.O. Box 95, FI-70701 Kuopio, Finland.

Urban dwellers are simultaneously exposed to several environmental health risk factors. This study aimed to examine the relationship between long-term exposure to fine particulate matter (PM, diameter < 2.5 µm) of residential-wood-burning and road-traffic origin, road-traffic noise, green space around participants' homes, and hypertension. Read More

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January 2021

Exocentric coding of the mapping between valence and regions of space: Implications for embodied cognition.

Acta Psychol (Amst) 2021 Mar 5;214:103264. Epub 2021 Feb 5.

MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Converging evidence has established that positive concepts presented on a computer screen are associated with upper regions of space, and negative concepts with a lower region of space. One explanation for this is that understanding positive or negative concepts requires the re-experiencing of direction, whereby "happy is up" and "sad is down." However, it is unclear how the regions of space are encoded in these paradigms, space can be encoded in relation to oneself (egocentrically) or in object centred coordinates that are independent of oneself (exocentrically). Read More

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Enhanced Health Facility Surveys to Support Malaria Control and Elimination across Different Transmission Settings in the Philippines.

Am J Trop Med Hyg 2021 Jan 18. Epub 2021 Jan 18.

1Department of Parasitology, Research Institute for Tropical Medicine, Muntinlupa, Philippines.

Following substantial progress in malaria control in the Philippines, new surveillance approaches are needed to identify and target residual malaria transmission. This study evaluated an enhanced surveillance approach using rolling cross-sectional surveys of all health facility attendees augmented with molecular diagnostics and geolocation. Facility surveys were carried out in three sites representing different transmission intensities: Morong, Bataan (pre-elimination), Abra de Ilog, Occidental Mindoro (stable medium risk), and Rizal, Palawan (high risk, control). Read More

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January 2021

Disruption of the Atrophy-based Functional Network in Multiple Sclerosis Is Associated with Clinical Disability: Validation of a Meta-Analytic Model in Resting-State Functional MRI.

Radiology 2021 Apr 2;299(1):159-166. Epub 2021 Feb 2.

From the Department of Radiology (F.L.C., B.T., P.T.F.), Research Imaging Institute (F.L.C., C.G.F., S.D., J.P.G., P.T.F.), Joe R. and Teresa Lozano Long School of Medicine (F.L.C., M.F., R.S.R., B.T., P.T.F.), and Department of Neurology (R.S.R., P.T.F.), The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC7800, San Antonio, TX 78229-3900; Division of Methodology, Measurement and Statistical Analysis, Texas State University, San Marcos, Tex (L.P.); Department of Radiology, Division of Neuroradiology, The University of Texas Southwestern Medical Center, Dallas, Tex (F.F.Y.); Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass (S.Y.H.); Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass (S.Y.H.); and South Texas Veteran Health Care System, Research Service, San Antonio, Tex (P.T.F.).

Background In multiple sclerosis (MS), gray matter (GM) atrophy exhibits a specific pattern, which correlates strongly with clinical disability. However, the mechanism of regional specificity in GM atrophy remains largely unknown. Recently, the network degeneration hypothesis (NDH) was quantitatively defined (using coordinate-based meta-analysis) as the atrophy-based functional network (AFN) model, which posits that localized GM atrophy in MS is mediated by functional networks. Read More

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Vision shapes tactile spatial perspective taking.

J Exp Psychol Gen 2021 Feb 1. Epub 2021 Feb 1.

Institut des Systèmes Intelligents et de Robotique (ISIR, CNRS UMR 7222), Sorbonne Université.

Information from the environment can be perceived according to ego-centered or decentered spatial perspectives. Different spatial perspectives can be adopted when perceiving not only visual but also auditory or tactile information. Because vision may be dominant in setting up spatial information processing, visual loss might affect perspective taking in other sensory modalities. Read More

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February 2021

The Temporal Relationship Between Ecological Pain and Life-Space Mobility in Older Adults With Knee Osteoarthritis: A Smartwatch-Based Demonstration Study.

JMIR Mhealth Uhealth 2021 01 13;9(1):e19609. Epub 2021 Jan 13.

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States.

Background: Older adults who experience pain are more likely to reduce their community and life-space mobility (ie, the usual range of places in an environment in which a person engages). However, there is significant day-to-day variability in pain experiences that offer unique insights into the consequences on life-space mobility, which are not well understood. This variability is complex and cannot be captured with traditional recall-based pain surveys. Read More

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January 2021

Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system.

Sci Rep 2021 Jan 8;11(1):203. Epub 2021 Jan 8.

Department of Kinesiology, University of Maryland, College Park, MD, 20742, USA.

Motor synergies are neural organizations of a set of redundant motor effectors that interact with one another to compensate for each other's error and ensure the stabilization of a performance variable. Recent studies have demonstrated that central nervous system synergistically coordinates its numerous motor effectors through Bayesian multi-sensory integration. Deficiency in sensory synergy weakens the synergistic interaction between the motor effectors. Read More

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January 2021

Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 01 4;4(1):e2032236. Epub 2021 Jan 4.

Department of Psychiatry, University of Pennsylvania, Philadelphia.

Importance: Functional neuroimaging is a valuable tool for understanding how patients with chronic pain respond to painful stimuli. However, past studies have reported heterogenous results, highlighting opportunities for a quantitative meta-analysis to integrate existing data and delineate consistent associations across studies.

Objective: To identify differential brain responses to noxious stimuli in patients with chronic pain using functional magnetic resonance imaging (fMRI) while adhering to current best practices for neuroimaging meta-analyses. Read More

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January 2021

Shifts in the Bacterial Community of Supragingival Plaque Associated With Metabolic-Associated Fatty Liver Disease.

Front Cell Infect Microbiol 2020 15;10:581888. Epub 2020 Dec 15.

Department of Endodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Metabolic-associated fatty liver disease (MAFLD), also known as the hepatic manifestation of metabolic disorders, has become one of the most common chronic liver diseases worldwide. The associations between some oral resident microbes and MAFLD have been described. However, changes to the oral microbial community in patients with MAFLD remain unknown. Read More

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December 2020

Efficacy of oral brush cytology cell block immunocytochemistry in the diagnosis of oral leukoplakia and oral squamous cell carcinoma.

J Oral Pathol Med 2020 Dec 26. Epub 2020 Dec 26.

Australian Centre for Oral Oncology Research and Education, Nedlands, WA, Australia.

Objectives: This study assessed the efficacy of using oral liquid-based brush cytology and cell block immunocytochemistry in the diagnosis of oral leukoplakia as minimally invasive diagnostic adjuncts.

Methods: Seventy-two patients diagnosed clinically with either oral leukoplakia (OLK) or oral squamous cell carcinoma were included. Oral brush samples using Orcellex brushes were obtained from all participants directly before undergoing surgical biopsy. Read More

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December 2020

Social exclusion reliably engages the default network: A meta-analysis of Cyberball.

Neuroimage 2021 02 29;227:117666. Epub 2020 Dec 29.

Laboratory of Brain and Cognition, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada; Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, Verdun, QC, Canada; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada. Electronic address:

Social exclusion refers to the experience of being disregarded or rejected by others and has wide-ranging negative consequences for well-being and cognition. Cyberball, a game where a ball is virtually tossed between players, then leads to the exclusion of the research participant, is a common method used to examine the experience of social exclusion. The neural correlates of social exclusion remain a topic of debate, particularly with regards to the role of the dorsal anterior cingulate cortex (dACC) and the concept of social pain. Read More

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February 2021

Impact of short-term dental dehydration on in-vivo dental color and whiteness.

J Dent 2021 Feb 6;105:103560. Epub 2021 Jan 6.

Department of Optics, Faculty of Science, University of Granada, Campus Fuente Nueva, Edificio Mecenas, S/N 18071, Granada, Spain; Department of Physics, Faculty of Sciences, University of Craiova, 13 AI Cuza Street, Craiova, 200585, Romania. Electronic address:

Objective: To determine in-vivo chromatic and whiteness changes produced by short-term dental dehydration.

Methods: Spectral reflectance of 452 upper incisors (226 centrals and 226 laterals) of 113 participants were measured using a spectroradiometer at baseline and after short-term dehydration (minutes 2, 4, 6, 8 and 10). CIE L*a*b* color coordinates (L*, a*, b*, C* and h) and whiteness index for dentistry (WI) were calculated. Read More

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February 2021

Multichannel acoustic source and image dataset for the cocktail party effect in hearing aid and implant users.

Sci Data 2020 12 17;7(1):440. Epub 2020 Dec 17.

Department of ENT, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, 3008, Switzerland.

The Cocktail Party Effect refers to the ability of the human sense of hearing to extract a specific target sound source from a mixture of background noises in complex acoustic scenarios. The ease with which normal hearing people perform this challenging task is in stark contrast to the difficulties that hearing-impaired subjects face in these situations. To help patients with hearing aids and implants, scientists are trying to imitate this ability of human hearing, with modest success so far. Read More

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December 2020

SFU-store-nav: A multimodal dataset for indoor human navigation.

Data Brief 2020 Dec 18;33:106539. Epub 2020 Nov 18.

School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.

This article describes a dataset collected in a set of experiments that involves human participants and a robot. The set of experiments was conducted in the computing science robotics lab in Simon Fraser University, Burnaby, BC, Canada, and its aim is to gather data containing common gestures, movements, and other behaviours that may indicate humans' navigational intent relevant for autonomous robot navigation. The experiment simulates a shopping scenario where human participants come in to pick up items from his/her shopping list and interact with a Pepper robot that is programmed to help the human participant. Read More

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December 2020

Emotional determinants of life-space through GPS and ecological momentary assessment in schizophrenia: What gets people out of the house?

Schizophr Res 2020 10 24;224:67-73. Epub 2020 Oct 24.

University of California San Diego Department of Psychiatry, San Diego, CA, United States of America; Veterans Affairs San Diego Healthcare System, San Diego, CA, United States of America.

Background: Previous research employing global positioning satellite (GPS) data and ecological momentary assessment (EMA) has shown a smaller life-space (distance traveled from home) was associated with poorer community functioning and more severe negative symptoms in people with schizophrenia. Momentary emotional experiences may influence how much time is spent outside of the home. We evaluated the associations between emotional experiences in relation to life-space among people with schizophrenia compared to healthy controls (HCs). Read More

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October 2020

Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study.

Restor Neurol Neurosci 2020 ;38(6):407-417

Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction.

Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex.

Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29. Read More

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January 2020