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Development of an EQ-5D Value Set for India Using an Extended Design (DEVINE) Study: The Indian 5-Level Version EQ-5D Value Set.

Value Health 2022 Jul 5;25(7):1218-1226. Epub 2022 Jan 5.

Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: This study aimed to develop the Indian 5-level version EQ-5D (EQ-5D-5L) value set, which is a key input in health technology assessment for resource allocation in healthcare.

Methods: A cross-sectional survey using the EuroQol Group's Valuation Technology was undertaken in a representative sample of 3548 adult respondents, selected from 5 different states of India using a multistage stratified random sampling technique. The participants were interviewed using a computer-assisted personal interviewing technique. Read More

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The correlation of forkhead box protein M1 (FOXM1) with gestational diabetes mellitus in maternal peripheral blood and neonatal umbilical cord blood.

Taiwan J Obstet Gynecol 2022 Jul;61(4):652-656

Department of Obstetrics and Gynecology National Taiwan University Hospital; No.8, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 10041, Taiwan, ROC.

Objective: The transcription activator FOXM1 was found to be essential for beta cell expansion and glucose homeostasis during pregnancy in a mouse model. We assumed that the mechanism would be similar in humans. Thus, we aimed to determine the correlation, if any, between FOXM1 and gestational diabetes mellitus in pregnant women. Read More

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Factors associated with post-stroke social participation: a quantitative study based on the ICF framework.

Ann Phys Rehabil Med 2022 Jun 29:101686. Epub 2022 Jun 29.

Université Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France; Hospices Civils de Lyon, Pôle Santé Publique, F-69008 Lyon, France.

Background: Post-stroke social participation is a major determinant of quality of life and life satisfaction. However, few data relating to participation determinants are available, especially the influence of psychological factors and factors related to the living environment.

Objectives: This study investigated determinants of post-stroke social participation within the International Classification of Functioning, Disability and Health framework. Read More

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The Utility of the Brokamp Area Deprivation Index as a Pre-Screen for Social Risk in Primary Care.

J Pediatr 2022 Jun 29. Epub 2022 Jun 29.

Vanderbilt University Medical Center, 1211 Medical Center Dr., Nashville, TN 37232, USA.

Objectives: To assess the relationship between an area deprivation index (ADI) and a social determinant of health (SDoH) measure within a diverse sample. A pre-screening tool based on routinely collected information could reduce clinical burden by identifying patients impacted by SDoH for comprehensive assessment.

Study Design: 499 consented pediatric patient-families who spoke English, Spanish, or Arabic, and had a child ≤12 years receiving primary care at a large academic institution were enrolled. Read More

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The Impact of Key Secular Trends During the first Three Waves the COVID-19 Pandemic.

Ann Epidemiol 2022 Jun 29. Epub 2022 Jun 29.

Sharp HealthCare.

Importance: Patient age, comorbidity burden, and disease severity at presentation are the major factors associated with surviving COVID-19. Hospital-level factors including ICU occupancy may confer additional risk to individual patients, particularly at times of maximal stress on healthcare systems. The interaction of patient- and hospital-level factors over time during pandemic disease remains an area of active exploration. Read More

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Time Outdoors in Reducing Myopia: A School-Based Cluster Randomized Trial with Objective Monitoring of Outdoor time and Light Intensity.

Ophthalmology 2022 Jun 29. Epub 2022 Jun 29.

Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai 200030, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of ocular fundus diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China. Electronic address:

Purpose: To evaluate the efficacy of time outdoors per school day over 2 years on myopia onset and shift.

Design: A prospective, cluster-randomized, examiner-masked, three-arm trial.

Participants: A total of 6295 students aged 6 to 9 years from 24 primary schools in Shanghai, China, stratified and randomized by school in a 1:1:1 ratio to control (n=2037), test I (n=2329), or test II (n=1929) group. Read More

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Aggression, micro-aggression, and abuse against Health Care Providers during the COVID-19 pandemic. A Latin American Survey.

Curr Probl Cardiol 2022 Jun 29:101296. Epub 2022 Jun 29.

Division of Cardiology, Queen's University, Kingston, Ontario, Canada. Electronic address:

The COVID-19 pandemic has had tremendous consequences globally. Notably, increasing complaints of verbal and physical violence against health care providers have been reported. A cross-sectional electronic survey was conducted between January 11th and February 28th, 2022 to delineate the violent behavior against front-line health professionals in Latin America. Read More

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Reliability and validity of the Chinese version of the Oxford Depression Questionnaire (ODQ-Chinese).

J Affect Disord 2022 Jun 29. Epub 2022 Jun 29.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China. Electronic address:

Backgrounds: Emotional blunting is regularly reported in depressed patients on antidepressant treatment. It is uncertain whether this phenomenon represents residual symptoms of depression or side-effects of antidepressant treatment. At present, there is no adequate instrument to measure this phenomenon in China. Read More

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The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study.

J Affect Disord 2022 Jun 29. Epub 2022 Jun 29.

Alzheimer Centrum Limburg, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands; Department of Psychiatry and Neuropsychology, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands; School of Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine & Life Sciences, Maastricht University, Maastricht, the Netherlands. Electronic address:

Background: Individuals with depression often show an adverse cardiometabolic risk profile and might represent a distinct depression subtype. The aim of this study was to investigate whether a cardiometabolic depression subtype could be identified and to investigate its association with demographics and clinical characteristics (severity, symptomatology, anti-depressant use, persistence and cognitive functioning).

Methods: We used data from The Maastricht Study, a population-based cohort in the southern part of The Netherlands. Read More

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Farm living and allergic rhinitis from childhood to young adulthood - prospective results of the GABRIEL study.

J Allergy Clin Immunol 2022 Jun 29. Epub 2022 Jun 29.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital. LMU Munich, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany; Munich Centre of Health Sciences (MC-Health), Munich, Germany. Electronic address:

Background: Growing up on a farm is associated with a reduced prevalence of respiratory allergies in childhood. It is unknown whether this protective effect remains into adulthood.

Objectives: We aimed to prospectively investigate the relationship between farm exposure and prevalence of allergic rhinitis and wheeze from childhood to early adulthood. Read More

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Associations of air pollution with COVID-19 positivity, hospitalisations, and mortality: Observational evidence from UK Biobank.

Environ Pollut 2022 Jun 29:119686. Epub 2022 Jun 29.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, United States; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Medicine, St Mary's Campus, Imperial College London, London, W2 1PG, United Kingdom; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, United States. Electronic address:

Individual-level studies with adjustment for important COVID-19 risk factors suggest positive associations of long-term air pollution exposure (particulate matter and nitrogen dioxide) with COVID-19 infection, hospitalisations and mortality. The evidence, however, remains limited and mechanisms unclear. We aimed to investigate these associations within UK Biobank, and to examine the role of underlying chronic disease as a potential mechanism. Read More

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Aberrant mitochondrial DNA methylation and declined pulmonary function in a population with polycyclic aromatic hydrocarbon composition in particulate matter.

Environ Res 2022 Jun 29:113797. Epub 2022 Jun 29.

Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:

Air pollution exposure has been found to be associated with epigenetic modification of the mitochondrial genome, which could subsequently induce adverse health outcomes. However, very limited studies exist regarding the association between fine particulate matter (PM) exposure and pulmonary function at the molecular level of mitochondrial epigenetic changes. This study aimed to investigate the association of platelet mitochondrial DNA (mtDNA) methylation with occupational PM exposure and pulmonary function. Read More

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Short-term effects of the toxic component of traffic-related air pollution (TRAP) on lung function in healthy adults using a powered air purifying respirator (PAPR).

Environ Res 2022 Jun 29:113745. Epub 2022 Jun 29.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Short-term exposure to traffic-related air pollution (TRAP) are associated with reduced lung function. However, TRAP is a mixture of various gaseous pollutants and particulate matter (PM), and therefore it is unknown that which components of TRAP are responsible for the respiratory toxicity. Using a powered air-purifying respirator (PAPR), we conducted a randomized, double-blind, crossover trial in which 40 adults were exposed to TRAP for 2 h at the sidewalk of a busy road. Read More

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Risk Factors for Post-Repair Elevated Mitral Gradient: A Post-Hoc Analysis of a Randomized Trial.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Department of Surgery, University of Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, ON, Canada. Electronic address:

Background: Pre-discharge elevated mean mitral gradients (>5mmHg) may occur after repair for degenerative mitral regurgitation. We sought to identify risk factors associated with elevated gradients as well as to evaluate its impact on functional outcomes at 12 months in this sub-analysis of the Canadian Mitral Research Alliance (CAMRA) CardioLink-2 trial.

Methods: 104 degenerative mitral regurgitation patients undergoing mitral repair were randomized to either a leaflet resection or preservation strategy. Read More

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Contraceptive method denial as downward contraceptive coercion: a mixed-methods mystery client study in Western Kenya.

Contraception 2022 Jun 29. Epub 2022 Jun 29.

Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.

Objective: Measures of contraceptive method denial are limited, as are qualitative data to contextualize these experiences. This study uses mixed methods to quantify the frequency of method denial in Western Kenya and describe how this barrier impacts contraceptive access.

Study Design: We estimate the frequency of method denial using data from mystery clients deployed to 57 randomly selected public-sector facilities located in Western Kenya. Read More

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Association of Vitamin B Status With Risk of Dementia in Cohort Studies: A Systematic Review and Meta-analysis.

J Am Med Dir Assoc 2022 Jun 29. Epub 2022 Jun 29.

School of Nursing, Peking university, Beijing, China. Electronic address:

Objective: To examine the association between B vitamins status and the risk of dementia in older adults through a systematic review and meta-analysis of cohort studies.

Design: Systematic review and meta-analysis.

Setting And Participants: Older adults aged ≥60 years from community, nursing home, institution, or hospital. Read More

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New Onset (Incidence) of Epilepsy and Seizures in Nursing Home Residents.

J Am Med Dir Assoc 2022 Jun 30. Epub 2022 Jun 30.

Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Objective: The point prevalence of epilepsy is high in nursing homes (NH), but the incidence of epilepsy after admission is unknown. This study was done to determine the incidence of epilepsy/seizure (epi/sz) comorbid with other conditions in older adult NH residents.

Design: Retrospective evaluation of Minimum Data Set records to identify new onset epi/sz in NH residents. Read More

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Thromboprophylactic low-molecular-weight heparin versus standard of care in unvaccinated, at-risk outpatients with COVID-19 (ETHIC): an open-label, multicentre, randomised, controlled, phase 3b trial.

Lancet Haematol 2022 Jun 29. Epub 2022 Jun 29.

Thrombosis Research Institute, London, UK. Electronic address:

Background: COVID-19 is associated with inflammation and an increased risk of thromboembolic complications. Prophylactic doses of low-molecular-weight heparin have been used in hospitalised and non-critically ill patients with COVID-19. We aimed to evaluate the efficacy and safety of prophylactic low-molecular-weight heparin (enoxaparin) versus standard of care (no enoxaparin) in at-risk outpatients with COVID-19. Read More

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Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial.

Lancet Haematol 2022 Jun 29. Epub 2022 Jun 29.

Department of Angiology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.

Background: COVID-19 is a viral prothrombotic respiratory infection. Heparins exert antithrombotic and anti-inflammatory effects, and might have antiviral properties. We aimed to investigate whether thromboprophylaxis with enoxaparin would prevent untoward hospitalisation and death in symptomatic, but clinically stable outpatients with COVID-19. Read More

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The effectiveness of intensive home treatment as a substitute for hospital admission in acute psychiatric crisis resolution in the Netherlands: a two-centre Zelen double-consent randomised controlled trial.

Lancet Psychiatry 2022 Jun 29. Epub 2022 Jun 29.

Department of Research, Arkin, Amsterdam, Netherlands; Vrije Universiteit Department Clinical Psychology, Amsterdam, The Netherlands.

Background: Although de-institutionalisation has been underway for decades, admission to hospital followed by low-intensity outpatient care remains the usual treatment for patients with an acute psychiatric crisis. Intensive home treatment has been developed for patients in a severe psychiatric crisis as an alternative to inpatient care. This study aimed to evaluate the potential of intensive home treatment to reduce bed-days and its clinical effectiveness compared with treatment as usual. Read More

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Using a mediating model of death attitude and meaning in life to understand nursing students attitude about hospice care.

Nurse Educ Today 2022 Jun 24;116:105448. Epub 2022 Jun 24.

School of Nursing, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA.

Background: Nurse-led hospice teams are an emerging trend in contemporary health care practice in China. However, Chinese nursing students are often ill-prepared to work in hospice care. Study findings on the attitude of nursing students toward the care of people who are dying and death varied among different countries and regions. Read More

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Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: A systematic review and diagnostic test accuracy meta-analysis.

Tuberculosis (Edinb) 2022 Jun 24;135:102230. Epub 2022 Jun 24.

Division of Infectious Diseases, Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Cerebrospinal fluid (CSF) Ziehl-Neelsen acid-fast bacilli (AFB) smear is a rapid, cheap, widely available test for tuberculous meningitis (TBM). Yet, reported test sensitivity is highly variable. We performed a systematic review and meta-analysis for CSF AFB smear vs. Read More

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An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females.

EBioMedicine 2022 Jun 29;81:104128. Epub 2022 Jun 29.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK.

Background: There are known differences in vaccine reactogenicity and immunogenicity by sex. Females have been shown to report greater reactogenicity and generate higher humoral and cellular immune responses than males following vaccination with several different vaccines. Whether this is also the case for COVID-19 vaccines is currently unknown, as COVID-19 vaccine study data disaggregated by sex are not routinely reported. Read More

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The use of practice education facilitators to strengthen the clinical learning environment for nursing students: A realist review.

Int J Nurs Stud 2022 Apr 20;134:104258. Epub 2022 Apr 20.

Faculty of Health and Social Sciences, Department of Nursing and Health Sciences, University of South-Eastern Norway, Drammen, Norway. Electronic address:

Background: Research suggests that the interventions of practice education facilitators, who liaise between the higher education institution and the clinical placement sites, may strengthen the clinical learning environment for nursing students. However, there is a lack of evidence concerning the value of these roles in nursing education.

Objective: The objective of this study was to explore how, under what circumstances and why the practice education facilitator role can strengthen the clinical learning environment for nursing students. Read More

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False memory in posttraumatic stress disorder and borderline personality disorder.

Psychiatry Res 2022 Apr 6;314:114547. Epub 2022 Apr 6.

Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany. Electronic address:

Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) have been associated with an increased generation of false memories. We aimed to disentangle disorder-specific false memory in individuals with PTSD and BPD using the Deese-Roediger-McDermott (DRM) paradigm. It measures the tendency to mistakenly remember stimuli that are associated with actually presented material, but have not been presented. Read More

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Plantar fasciitis injury status influences foot mechanics during running.

Clin Biomech (Bristol, Avon) 2022 Jun 27;97:105712. Epub 2022 Jun 27.

University of Nevada, Las Vegas, 4505 S Maryland Pkwy, Las Vegas, NV 89154, United States.

Background: The biomechanical factors related to plantar fasciitis are not well understood. A history of injury is considered a risk factor for subsequent injury, but it is unknown if differences in mechanics exist before, during, and after injury. This study compared gait mechanics among individuals with plantar fasciitis, resolved plantar fasciitis, and uninjured controls. Read More

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Body sway and movement strategies for control of postural stability in people with spinocerebellar ataxia type 3: A cross-sectional study.

Clin Biomech (Bristol, Avon) 2022 Jun 24;97:105711. Epub 2022 Jun 24.

Programa de Pós-Graduação em Ciências da Reabilitação, Centro Universitário Augusto Motta - UNISUAM, Rio de Janeiro, Brazil. Electronic address:

Background: Postural instability with an excessive body sway is a disabling manifestation in spinocerebellar ataxia type 3. Whether the larger body sway reflects distinct movement strategies for postural control remains uncertain. This study compared the control of postural stability of people with spinocerebellar ataxia type 3 with healthy subjects using body sway and movement strategy analyses derived from bi- and three-dimensional posturography. Read More

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Does attributing mental states to a robot influence accessibility of information represented during reading?

Acta Psychol (Amst) 2022 Jun 29;228:103660. Epub 2022 Jun 29.

S4HRI: Social Cognition in Human Robot Interaction Unit, Istituto Italiano di Tecnologia, Genova, Italy.

When we read fiction, we encounter characters that interact in the story. As such, we encode that information and comprehend the stories. Prior studies suggest that this comprehension process is facilitated by taking the perspective of characters during reading. Read More

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Psychological distress is independently related to new coronary events at 8 years' follow-up in elderly primary care patients with hypertension.

J Psychosom Res 2022 Jun 25;160:110980. Epub 2022 Jun 25.

Department of Medical and Clinical Psychology, Tilburg University, the Netherlands.

Objective: Occurrence of psychological distress in hypertensive patients could have a negative synergistic effect on future cardiovascular events (CVEs). The aim of this study was to determine the association between anxiety or depressive symptoms in elderly hypertensive primary care patients and the development of new CVEs and all-cause mortality.

Methods: A prospective cohort study was conducted in five Dutch general practices between June 2010 and January 2012. Read More

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Five-factor model personality traits and grip strength: Meta-analysis of seven studies.

J Psychosom Res 2022 Jun 11;160:110961. Epub 2022 Jun 11.

Department of Geriatrics, College of Medicine, Florida State University, USA. Electronic address:

Objective: To examine the association between Five-Factor Model personality traits and grip strength.

Method: Adults aged 16 to 104 years old (N > 40,000) were from the Health and Retirement Study, the Midlife in the United States Study, The English Longitudinal Study of Aging, the National Health and Aging Trends Survey, the United Kingdom Household Longitudinal Study, and the Wisconsin Longitudinal Study graduate and sibling samples. Participants had data on personality traits, demographic factors, grip strength, and mediators such as depressive symptoms, physical activity, body mass index (BMI), and c-reactive protein (CRP). Read More

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