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Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways.

Biomed Pharmacother 2021 Apr 10;139:111567. Epub 2021 Apr 10.

Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.

This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hypertension. In deoxycorticosterone acetate-salt rats, SR-5, SR-8, SR-9, and SR-10 reduced blood pressure and normalized renal functions. In isolated rat aortic rings, SR-5, SR-8, SR-9, and SR-10 relaxed phenylephrine (PE) and K-induced contractions. Read More

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Relative snowpack response to elevation, temperature and precipitation in the Crown of the Continent region of North America 1980-2013.

Authors:
Len Broberg

PLoS One 2021 13;16(4):e0248736. Epub 2021 Apr 13.

Environmental Studies Program, University of Montana, Missoula, Montana, United States of America.

Water availability in western Canada and the United States is dependent on the accumulation of snowpack in the montane regions and threatened by increased winter temperature and more precipitation as rain linked to climate change. In order to make reasoned decisions to adapt to climate change managers require knowledge of the role of temperature and precipitation in SWE development and data to distinguish the relative retention response of snowpack regions to expected temperature and precipitation regime shifts at the watershed scale. Using the Daymet interpolated 1 km2 dataset, effects of elevation, temperature (Tmax, Tmin and Tavg) and precipitation on April 1 SWE in the Crown of the Continent were tested by linear regression and Kendall correlation. Read More

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Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.

Arch Pharm Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, People's Republic of China.

Over the past 100 years, Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) roots have been used to cure thromboangiitis obliterans (TAO) in local clinics. This study aimed to confirm the anti-thrombotic efficacy of 12 phenolic acids obtained from RSMA and to clarify the possible underlying mechanisms. Read More

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A pilot study on EORTC or PERCIST for the prediction of progression-free survival with nivolumab therapy in advanced or metastatic gastric cancers: A STROBE-compliant article.

Medicine (Baltimore) 2021 Apr;100(15):e25494

Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544.

Abstract: Recent breakthrough results from immune checkpoint inhibitors (ICIs) have paved the way to a new era of cancer immunotherapy, and have thus led to a paradigm shift of cancer treatment. In particular, inhibition of the antiprogrammed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis with ICI, including nivolumab and pembrolizumab, has been emerging as a novel treatment strategy for advanced gastric cancers. An accurate noninvasive assessment of the response to ICI is important for the management of patients with advanced or metastatic gastric cancer. Read More

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Feline ocular toxoplasmosis: seroprevalence, diagnosis and treatment outcome of 60 clinical cases.

Pol J Vet Sci 2021 Mar;24(1):51-61

Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, PO: 12211, Egypt.

Toxoplasmosis is one of the most important protozoa zoonotic diseases worldwide. The present study describes the clinical, seroprevalence findings with ocular toxoplasmosis and the outcome of medicinal treatment of these cats. This study was carried out on 105 cats with various ocular signs, no historical evidence of ocular trauma or drug/vaccine exposure for at least 3 months prior to admission, and without clinical or laboratory evidence of other systemic diseases. Read More

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Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China.

Sci Rep 2021 Apr 12;11(1):7857. Epub 2021 Apr 12.

Institute of Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

Given that a substantial proportion of the subgroup of COVID-19 patients that face a severe disease course are younger than 60 years, it is critical to understand the disease-specific characteristics of young COVID-19 patients. Risk factors for a severe disease course for young COVID-19 patients and possible non-linear influences remain unknown. Data were analyzed from COVID-19 patients with clinical outcome in a single hospital in Wuhan, China, collected retrospectively from Jan 24th to Mar 27th. Read More

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The white matter is a pro-differentiative niche for glioblastoma.

Nat Commun 2021 04 12;12(1):2184. Epub 2021 Apr 12.

Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK.

Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression outside of these niches remains unclear. Here we identify the white matter as a differentiative niche for glioblastomas with oligodendrocyte lineage competency. Read More

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A phase 1 study of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor in Chinese patients with advanced breast cancer.

Biomark Res 2021 Apr 12;9(1):24. Epub 2021 Apr 12.

Jiangsu Hengrui Medicine Co. Ltd, Shanghai, China.

Background: Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerability, pharmacokinetics, safety, and preliminary antitumor activity of dalpiciclib in patients with advanced breast cancer (ABC).

Methods: In this open-label, phase 1 study, Chinese patients who had failed standard therapy were enrolled to receive oral dalpiciclib in 3 + 3 dose-escalation pattern at doses of 25-175 mg. Read More

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Synthesis of ultralight three-dimensional nitrogen-doped reduced graphene oxide/multi-walled carbon nanotubes/zinc ferrite composite aerogel for highly efficient electromagnetic wave absorption.

J Colloid Interface Sci 2021 Mar 29;596:364-375. Epub 2021 Mar 29.

School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.

Developing light-weight, thin thickness and high-efficiency electromagnetic wave (EMW) absorbers was regarded as an effective strategy for dealing with the increasingly serious problem of electromagnetic radiation pollution. Herein, nitrogen-doped reduced graphene oxide/multi-walled carbon nanotubes/zinc ferrite (NRGO/MWCNTs/ZnFeO) composite aerogel was synthesized via solvothermal followed by hydrothermal and lyophilization processes. Morphological characterization results manifested that the attained ternary composite aerogel displayed unique three-dimensional porous netlike structure, which was composed of partial stack of adjacent NRGO sheets entangled by MWCNTs and decorated with ZnFeO microspheres. Read More

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