45,986 results match your criteria partial pressure

Endothelial Transient Receptor Potential V4 Channels Mediate Lung Ischemia-Reperfusion Injury.

Ann Thorac Surg 2021 May 4. Epub 2021 May 4.

Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA. Electronic address:

Background: Lung ischemia-reperfusion injury (IRI), involving severe inflammation and edema, is a major cause of primary graft dysfunction following transplant. Activation of transient receptor potential vanilloid 4 (TRPV4) channels modulates vascular permeability. Thus, this study tests the hypothesis that endothelial TRPV4 channels mediate lung IRI. Read More

View Article and Full-Text PDF

Impact of wearing a surgical and cloth mask during cycle exercise.

Appl Physiol Nutr Metab 2021 May 7. Epub 2021 May 7.

University of Waterloo, 8430, Department of Kinesiology, BMH 1110, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1;

We sought to determine the impact of wearing cloth or surgical masks on the cardiopulmonary responses to moderate-intensity exercise. Twelve subjects (n=5 females) completed three, 8-min cycling trials while breathing through a: non-rebreathing valve (laboratory control), cloth, or surgical mask. Heart rate (HR), oxyhemoglobin saturation (SpO2), breathing frequency (Fb), mouth pressure, partial pressure of end-tidal carbon dioxide (PetCO2) and oxygen (PetO2), dyspnea, were measured throughout exercise. Read More

View Article and Full-Text PDF

Blood Purification Techniques, Inflammatory Mediators and Mortality in COVID-19 Patients.

Tanaffos 2020 Dec;19(4):291-299

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Inflammatory mediators are an important component in the pathophysiology of the coronavirus disease 2019 (COVID-19). This study aimed to assess the effects of reducing inflammatory mediators using hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the mortality of patients with COVID-19.

Materials And Methods: Twelve patients with confirmed diagnosis of COVID-19 were included. Read More

View Article and Full-Text PDF
December 2020

Body Adiposity, But Not Elements of Objectively Measured Sedentary Behavior or Physical Activity, Is Associated With Circulating Liver Enzymes in Adults With Overweight and Obesity.

Front Endocrinol (Lausanne) 2021 20;12:655756. Epub 2021 Apr 20.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

Objective: We studied the associations between accelerometer-measured sedentary behavior (SB) and habitual physical activity (PA) as well as markers of body adiposity and other cardiometabolic risk factors with liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltransferase (GGT).

Methods: A total of 144 middle-aged adults (mean age 57 (SD 6.5) years) with overweight or obesity (mean body mass index [BMI] 31. Read More

View Article and Full-Text PDF

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

J Bone Miner Res 2021 May 6. Epub 2021 May 6.

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.

Recent advances indicate that bone and energy metabolism are closely related. However, little direct evidence on causality has been provided in humans. We aimed to assess the association of three bone-related biomarkers 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH) and osteocalcin (OCN) with several metabolic phenotypes, and investigate any causal relevance to the associations using a Mendelian randomization (MR) study. Read More

View Article and Full-Text PDF

Effects of Obstructive Sleep Apnea and CPAP on Cognitive Function.

Curr Neurol Neurosci Rep 2021 May 6;21(7):32. Epub 2021 May 6.

Department of Pulmonary Medicine, Naval Medical Center San Diego, 34800 Bob Wilson Drive, Building 3, 3rd floor, Suite 301, San Diego, CA, 92134, USA.

Purpose Of Review: Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete or partial upper airway obstruction during sleep. Studies indicate that OSA is an independent risk factor for cognitive decline in older patients. The purpose of this paper is to critically review the recent literature on the cognitive effects of untreated OSA and the benefits of treatment across cognitive domains. Read More

View Article and Full-Text PDF

Oxygen Promotes the Formation of MoSe at the Interface of CuZnSnSe/Mo.

J Phys Chem Lett 2021 May 6:4447-4452. Epub 2021 May 6.

Institute of Photoelectronic Thin Film Devices and Technology and Tianjin Key Laboratory of Thin Film Devices and Technology, Nankai University, Tianjin 300350, P. R. China.

The contact, and thus the hole collection between CuZnSnSe (CZTSe) and Mo, is a crucial issue to improve the performance of CZTSe solar cells. In this work, a method to improve the back contact is explored by spraying NaPO on the surface of the Mo back contact. With the O provided from NaPO, extra MoO and MoO are formed at the surface of the back contact, and partial MoO is transformed into MoSe under high Se partial pressure during the selenization process. Read More

View Article and Full-Text PDF

Case Studies in Physiology: Untangling the cause of hypoxemia in an obese patient with acute leukemia.

J Appl Physiol (1985) 2021 May 6. Epub 2021 May 6.

Health and Human Physiology, University of Iowa, United Statesgrid.214572.7.

Diagnosing the cause of hypoxemia and dyspnea can be complicated in complex patients with multiple co-morbidities. This Case Study in Physiology describes an obese man admitted to the hospital for relapse of acute lymphoblastic leukemia, who experienced progressive hypoxemia, shortness of breath, and dyspnea on exertion during his hospitalization. After initial empirical treatment with diuresis and antibiotics failed to improve his symptoms, we applied a novel, recently described physiological method to estimate the arterial partial pressure of oxygen from the peripheral saturation measurement, and calculate the alveolar-arterial oxygen difference to discern the source of his hypoxemia and dyspnea. Read More

View Article and Full-Text PDF

Temporal inversion of the acid-base equilibrium in newborns: an observational study.

PeerJ 2021 14;9:e11240. Epub 2021 Apr 14.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Background: A considerable fraction of newborn infants experience hypoxia-ischaemia and metabolic acidosis at birth. However, little is known regarding the biological response of newborn infants to the pH drift from the physiological equilibrium. The aim of this study was to investigate the relationship between the pH drift at birth and postnatal acid-base regulation in newborn infants. Read More

View Article and Full-Text PDF

Evaluation of a Longitudinal Family Stress Model in a Population-Based Cohort.

Soc Dev 2020 Nov 13;29(4):1155-1175. Epub 2020 Mar 13.

Department of Psychology, Center for Growth and Human Developmental, and the Institute for Social Research, University of Michigan.

The Family Stress Model (FSM) is an influential family process model that posits that socioeconomic disadvantage impacts child outcomes via its effects on parents. Existing evaluations of the FSM are constrained by limited measures of socioeconomic disadvantage, cross-sectional research designs, and reliance on non-population-based samples. The current study tested the FSM in a subsample of the Fragile Families and Child Wellbeing Study ( = 2,918), a large population-based study of children followed from birth through age 9. Read More

View Article and Full-Text PDF
November 2020

A systematic review of the incidence, risk factors and prognosis of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease.

BMC Pulm Med 2021 May 5;21(1):150. Epub 2021 May 5.

Department of Intensive Care Medicine, Northern Hospital, Melbourne, Australia.

Introduction: Acute exacerbation (AE) is a devastating phenomenon and reported to be complicated with systemic autoimmune disease-associated interstitial lung disease (ILD). The aim of this study was to investigate the incidence and prognosis of AE of systemic autoimmune disease-ILD and clarify relevant clinical information predictive of these outcomes.

Method: This study was designed as a systematic review and meta-analysis. Read More

View Article and Full-Text PDF

Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.

N Z Vet J 2021 May 5:1-27. Epub 2021 May 5.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Aims: To compare the analgesic effect of morphine combined with maropitant and/or dexmedetomidine to morphine alone given at a higher dose, and to evaluate the pharmacokinetics of the drug combinations, in dogs undergoing ovariohysterectomy (OHE).

Methods: Forty client owned-dogs were randomised into four treatment groups (n=10 per group) each to receive a different analgesic protocol. After premedication with I/M acepromazine anaesthesia was induced with propofol to effect and maintained with isoflurane in 100% oxygen delivered via a circle system. Read More

View Article and Full-Text PDF

Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct.

Sci Prog 2021 Apr-Jun;104(2):368504211013632

Department of Quantitative Methods, College of Business Administration, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

The impact of lateral walls and partial slip with different waveforms on peristaltic pumping of couple stress fluid in a rectangular duct with different waveforms has been discussed in the current article. By means of a wave frame of reference the flow is explored travelling away from a fixed frame with velocity c. Peristaltic waves generated on horizontal surface walls of rectangular duct are considered using lubrication technique. Read More

View Article and Full-Text PDF

About the importance of purge time in molecular layer deposition of alucone films.

Dalton Trans 2021 May;50(17):5807-5818

TNO/Holst Centre, 5656 AE Eindhoven, Netherlands. and Department of Applied Physics, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.

The deposition rate and properties of MLD films are for a large part determined by what happens during the reactant exposure step. In some cases, however, the purge step is of equal importance, for example in MLD of alucone using trimethylaluminum (TMA) and ethylene glycol (EG). We show that infiltration of TMA into the alucone film followed by its continuous outgassing during the subsequent EG exposure step can lead to undesired CVD effects. Read More

View Article and Full-Text PDF

Pain relief in chronic pancreatitis: endoscopic or surgical treatment? a systematic review with meta-analysis.

Surg Endosc 2021 May 4. Epub 2021 May 4.

Serviço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUSP, Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Background And Aims: Pain is one of the consequences of chronic pancreatitis (CP) that has the greatest impact on the quality of life of patients. Endoscopic and surgical interventions, by producing a decrease in intraductal pancreatic pressure, can provide pain relief. This is the first systematic review that includes only randomized clinical trials (RTCs) comparing outcomes in the short-term (less than 2 years) and long-term (more than 2 years) between these two types of interventions. Read More

View Article and Full-Text PDF

Aerobic and anaerobic metabolic scaling in the burrowing freshwater crayfish Parastacus pugnax.

J Comp Physiol B 2021 May 4. Epub 2021 May 4.

Departamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.

Metabolic scaling is a well-known biological pattern. Theoretical scaling exponents near 0.67 and 0. Read More

View Article and Full-Text PDF

Gastrointestinal failure score in children with traumatic brain injury.

BMC Pediatr 2021 May 4;21(1):219. Epub 2021 May 4.

Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Jiangsu Province, 210008, Nanjing, China.

Background: To review the value of the gastrointestinal failure (GIF) score in children with different degrees of traumatic brain injury (TBI) by analyzing the correlation between outcome and gastrointestinal function.

Methods: A total of 165 children with TBI who were diagnosed and treated in the surgical intensive care unit (SICU) for longer than 72 h between August 2017 and September 2019 were analyzed. Admission parameters included sex, age, Glasgow Coma Scale (GCS) score, body mass index (BMI), leukocyte count, C-reactive protein (CRP), hemoglobin (Hb), hematocrit (Hct), blood glucose, lactic acid, procalcitonin (PCT), albumin, plasma osmotic pressure, prothrombin time (PT) and activated partial thromboplastin time (APTT). Read More

View Article and Full-Text PDF

Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.

BMC Infect Dis 2021 May 4;21(1):411. Epub 2021 May 4.

Gulhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey.

Background And Objectives: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. Ivermectin is among the drugs whose effectiveness in treatment has been investigated. In this study; it was aimed to investigate the presence of gene mutations that alter ivermectin metabolism and cause toxic effects in patients with severe COVID-19 pneumonia, and to evaluate the effectiveness and safety of ivermectin use in the treatment of patients without mutation. Read More

View Article and Full-Text PDF

Progressive Cellular Architecture in Microscale Gas Chromatography for Broad Chemical Analyses.

Sensors (Basel) 2021 Apr 29;21(9). Epub 2021 Apr 29.

Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA.

Gas chromatography is widely used to identify and quantify volatile organic compounds for applications ranging from environmental monitoring to homeland security. We investigate a new architecture for microfabricated gas chromatography systems that can significantly improve the range, speed, and efficiency of such systems. By using a cellular approach, it performs a partial separation of analytes even as the sampling is being performed. Read More

View Article and Full-Text PDF

Accuracy of Pulse Oximetry in the Presence of Fetal Hemoglobin-A Systematic Review.

Children (Basel) 2021 Apr 30;8(5). Epub 2021 Apr 30.

Research Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Auenbruggerplatz 34/II, 8036 Graz, Austria.

Continuous monitoring of arterial oxygen saturation by pulse oximetry (SpO2) is the main method to guide respiratory and oxygen support in neonates during postnatal stabilization and after admission to neonatal intensive care unit. The accuracy of these devices is therefore crucial. The presence of fetal hemoglobin (HbF) in neonatal blood might affect SpO2 readings. Read More

View Article and Full-Text PDF

FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice.

Blood Adv 2021 May;5(9):2385-2390

Division of Experimental Hematology and Cancer Biology.

Sickle cell anemia (SCA) results from an abnormal sickle hemoglobin (HbS). HbS polymerizes upon deoxygenation, resulting in red blood cell (RBC) sickling and membrane damage that cause vaso-occlusions and hemolysis. Sickle RBCs contain less adenosine triphosphate and more 2,3-diphosphoglycerate than normal RBCs, which allosterically reduces hemoglobin (Hb) oxygen (O2) affinity (ie, increases the partial pressure of oxygen at which hemoglobin is 50% saturated with oxygen [P50]), potentiating HbS polymerization. Read More

View Article and Full-Text PDF

A severity-of-illness score in patients with tuberculosis requiring intensive care.

S Afr Med J 2021 Mar 2;111(3):245-249. Epub 2021 Mar 2.

Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

Background: We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of tuberculosis (TB) in the intensive care unit (ICU). Parameters included septic shock, HIV infection with a CD4 count <200 cells/µL, renal dysfunction, a ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (P/F) <200 mmHg, a chest radiograph demonstrating diffuse parenchymal infiltrates, and no TB treatment on admission.

Objectives: To prospectively validate the severity-of-illness scoring system in patients with TB requiring intensive care, and to refine and simplify the score in order to expand its clinical utility. Read More

View Article and Full-Text PDF

Dielectric Relaxation and Magnetic Structure of A-Site-Ordered Perovskite Oxide Semiconductor CaCuFeTaO.

Inorg Chem 2021 May 3. Epub 2021 May 3.

Guangxi Key Laboratory of Optical and Electronic Materials and Devices, Guilin University of Technology, Guilin 541004, China.

A new perovskite oxide semiconductor, CaCuFeTaO, was synthesized through a high-pressure and high-temperature approach. The compound possesses an 3̅ space group, where it crystallizes to an A-site-ordered but B-site partial ordered quadruple perovskite structure. Spin ordering occurs around 150 K owing to the antiferromagnetic coupling between Fe spins and ferromagnetic coupling between Cu spins. Read More

View Article and Full-Text PDF

Comparison of ETCO2 Value and Blood Gas PCO2 Value of Patients Receiving Non-invasive Mechanical Ventilation Treatment in Emergency Department.

SN Compr Clin Med 2021 Apr 27:1-5. Epub 2021 Apr 27.

Department of Emergency Medicine, Mugla Sitki Kocman University Training Research Hospital, Mugla, Turkey.

Capnography is the non-invasive measurement and graphic representation of the partial pressure of CO2 in expiration. Although there are many studies in the literature comparing the partial pressure of carbon dioxide (pCO2) and end-tidal CO2 (ETCO2) values in patients who underwent IMV (invasive mechanical ventilation), there are no studies showing their interchangeable applicability in patients who received NIMV (non-IMV). We aimed to evaluate whether the use of ETCO2 in the treatment process can replace pCO2 use in patients scheduled for NIMV treatment in the emergency department. Read More

View Article and Full-Text PDF

Case Report: Extended Clinical Spectrum of the Neonatal Diabetes With Congenital Hypothyroidism Syndrome.

Front Endocrinol (Lausanne) 2021 16;12:665336. Epub 2021 Apr 16.

Pediatric Endocrinology Division, Children's Hospital, University of Bonn, Bonn, Germany.

Background: Neonatal diabetes with congenital hypothyroidism (NDH) syndrome is a rare condition caused by homozygous or compound heterozygous mutations in the GLI-similar 3 coding gene . Almost 20 patients have been reported to date, with significant phenotypic variability.

Case Presentation: We describe a boy with a homozygous deletion (exons 5-9) in the gene, who presents novel clinical aspects not reported previously. Read More

View Article and Full-Text PDF

Metabolomic Profiling of Aqueous Humor and Plasma in Primary Open Angle Glaucoma Patients Points Towards Novel Diagnostic and Therapeutic Strategy.

Front Pharmacol 2021 14;12:621146. Epub 2021 Apr 14.

Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Glaucoma is the second leading cause of blindness globally characterized by progressive loss of retinal ganglion cells (RGCs) and irreversible visual deficiency. As the most common type of glaucoma, primary open angle glaucoma (POAG) is currently an unmet medical need with limited therapy by lowering intraocular pressure (IOP). However, some patients continue to progress even though their IOP are controlled. Read More

View Article and Full-Text PDF

Effects of Ultrasound-Guided Bilateral Cervical Plexus Block Combined with General Anesthesia in Patients Undergoing Total Parathyroidectomy and Partial Gland Autotransplantation Surgery.

Local Reg Anesth 2021 23;14:75-83. Epub 2021 Apr 23.

Department of Orthopaedics, The 960th Hospital of the People's Liberation Army Joint Logistical Support Force, Jinan, Shandong, People's Republic of China.

Background: The aim of this study is to evaluate the effect of ultrasound-guided bilateral cervical plexus block on general anesthesia, postoperative analgesia, and surgical outcomes in patients undergoing total parathyroidectomy with autotransplantation.

Patients And Methods: Forty-eight ASA III-IV patients with hyperparathyroidism secondary to renal failure were included: 24 patients received ultrasound-guided bilateral superficial and deep cervical plexus block combined with general anesthesia (group A), and 24 patients received general anesthesia alone (group B). Postoperative patient-controlled intravenous analgesia was provided with sufentanil 2 μg/kg. Read More

View Article and Full-Text PDF

Medial Knee Arthrosis: A Pathology with a Progressive Evolution.

Rev Bras Ortop (Sao Paulo) 2021 Apr 22;56(2):133-137. Epub 2020 Jul 22.

Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Medial arthrosis of the knee is an evolutionary pathology that occurs due to progressive muscle imbalance. The muscles of the knee region have a large imbalance caused by the difference of power and lever arm. With the progression of life, this imbalance manifests itself more importantly, especially due to the loss of muscle strength due to aging. Read More

View Article and Full-Text PDF

Lung cancer with partial anomalous pulmonary venous connection in a different lobe: a case report.

J Cardiothorac Surg 2021 May 1;16(1):122. Epub 2021 May 1.

Department of General Thoracic Surgery, Nihonkai General Hospital, 30 Akiho-cho, Sakata, Yamagata, Japan.

Background: Anomalous pulmonary venous connection (APVC) is a congenital malformation in which the pulmonary veins connect to the systemic venous system but not to the left atrium. APVC can be classified as total or partial (PAPVC). PAPVC is rare among surgical patients with lung cancer, and most cases are detected incidentally during surgery. Read More

View Article and Full-Text PDF

Protective factors against preterm infants to develop significant patent ductus arteriosus.

Pediatr Neonatol 2021 Apr 3. Epub 2021 Apr 3.

Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Identifying preterm infants with a higher likelihood of spontaneous patent ductus arteriosus (PDA) closure would be desirable. This study aimed to examine daily PDA status during the first week of life for very low birthweight (VLBW, <1500 g) preterm infants and to develop a scoring system to predict spontaneous PDA closure.

Methods: We enrolled VLBW infants admitted between January 2016 and January 2017 and performed daily echocardiographic screening for PDA existence. Read More

View Article and Full-Text PDF