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Inches, Centimeters, and Yards: Overlooked Definition Choices Inhibit Interpretation of Morphine Equivalence.

Clin J Pain 2021 Jun 11. Epub 2021 Jun 11.

Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA Institute for Pharmaceutical Outcomes & Policy, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Division of Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA UNC Hospitals Pain Management Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objective: Morphine-standardized doses are used in clinical practice and research to account for molecular potency. 90 milligrams of morphine equivalents (MME) per day are considered a "high dose" risk threshold in guidelines, laws, and by payers. Although ubiquitously cited, the "CDC definition" of daily MME lacks a clearly defined denominator. Read More

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Trends in Endotracheal Intubation During In-Hospital Cardiac Arrests: 2001-2018.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA. Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of Hospital Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Division of Pulmonary, Critical Care Medicine, and Sleep Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Objectives: Airway management during in-hospital cardiac arrest represents a fundamental component of resuscitative efforts, yet little is known about temporal trends in intubation during in-hospital cardiac arrest. Our objective was to investigate changes in in-hospital cardiac arrest airway management over time and in response to national guideline updates.

Design: Observational cohort study of a prospectively collected database. Read More

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Social connectedness and self-perceived health of older adults in New Zealand.

Health Soc Care Community 2021 Jun 11. Epub 2021 Jun 11.

School of Nursing, Midwifery and Health Practice, Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.

The objective of this research was to explore social connectedness and associations with self-perceived health amongst older adults in New Zealand at a population level. The data for this analysis were derived from the 2016 Health and Lifestyle Survey, a nationally representative survey administered via face-to-face interviews. The findings from this analysis of 1,374 respondents, all of whom were over the age of 55 years, highlight that being female, belonging to older age groups (above 70 years), being employed full-time or part-time, connecting online with known people, considering cultural connections to be important and not feeling isolated from others are significantly and positively associated with positive self-perceived health. Read More

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Paid sick leave benefits among essential frontline workers serving people experiencing homelessness in Canada during the COVID-19 pandemic.

Public Health 2021 Jun 7;195:142-144. Epub 2021 Jun 7.

Department of Psychiatry, University of Toronto, 1051 Queen Street West, Toronto, Ontario, Canada, M6J 1H4. Electronic address:

Objectives: This study examined the prevalence and factors associated with paid sick leave benefits among direct service providers who work with people experiencing homelessness.

Study Design: Cross-sectional study using an online survey disseminated during the second wave of the COVID-19 pandemic in Canada.

Methods: Survey data from 572 direct service providers working in the homeless, supportive housing, and harm reduction service sectors were analyzed for this study. Read More

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INTREPID: single- multiple-inhaler triple therapy for COPD in usual clinical practice.

ERJ Open Res 2021 Apr 7;7(2). Epub 2021 Jun 7.

Global Respiratory Franchise, GSK, Brentford, UK.

Introduction: Real-world trial data comparing single- with multiple-inhaler triple therapy (MITT) in COPD patients are currently lacking. The effectiveness of once-daily single-inhaler fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) and MITT were compared in usual clinical care.

Methods: INTREPID was a multicentre, randomised, open-label, phase IV effectiveness study comparing FF/UMEC/VI 100/62. Read More

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Factors influencing streaming to general practitioners in emergency departments: A qualitative study.

Int J Nurs Stud 2021 May 21;120:103980. Epub 2021 May 21.

York Trials Unit, Department of Health Sciences, University of York, York, United Kingdom YO10 5DD. Electronic address:

Background: Emergency Department attendance is increasing internationally, of which a significant proportion could be managed in general practice. In England, policies backed by substantial capital funding require such patients attending Emergency Departments be directed or 'streamed' to general practitioners working in or parallel to Emergency Departments. However, evidence for streaming is limited and the processes of streaming patients attending Emergency Departments to general practitioners lacks exploration. Read More

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Mental Disorders of Bangladeshi Students During the COVID-19 Pandemic: A Systematic Review.

Psychol Res Behav Manag 2021 31;14:645-654. Epub 2021 May 31.

Centre for Health Innovation, Networking, Training, Action and Research - Bangladesh (CHINTA Research Bangladesh), Savar, Dhaka, 1342, Bangladesh.

Background: The unprecedented COVID-19 pandemic has become a global burden disrupting peoples' quality of life. Students being an important cohort of a country, their mental health during this pandemic has been recognized as a concerning issue. Therefore, the prevalence and associated risk factors of Bangladeshi students' mental health sufferings (ie, depression, anxiety, and stress) are systematically reviewed herein for the first time. Read More

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Childcare Attendance and Academic Achievement at Age 16 Years.

JAMA Pediatr 2021 Jun 7. Epub 2021 Jun 7.

School of Public Health, University of Montreal, Montreal, Quebec, Canada.

Importance: Low school preparedness is linked to high school dropout, poor employment, and negative outcomes. Childcare attendance may increase school readiness and foster academic achievement.

Objective: To explore whether childcare attendance was associated with academic achievement at the end of compulsory schooling (age 16 years in the UK), whether maternal education level was a moderator, and the benefit-cost ratio of childcare regarding productivity returns of academic achievement. Read More

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Outcome after treatment of pediatric supratentorial ependymoma: long-term follow-up of a single consecutive institutional series of 26 patients.

Br J Neurosurg 2021 Jun 7:1-9. Epub 2021 Jun 7.

Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

Background: Long-term outcome after surgical treatment of supratentorial ependymoma (STE) in children has not been extensively reported.

Findings: We identified 26 children who underwent primary tumor resection of STE between 1953 and 2011, with at least 8 years follow-up. Ten patients (38%) had anaplastic and 16 had low grade ependymoma. Read More

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Expensive Childcare and Short School Days = Lower Maternal Employment and More Time in Childcare? Evidence from the American Time Use Survey.

Socius 2019 Jan 29;5:1-14. Epub 2019 Jul 29.

University of Maryland, College Park, College Park, MD, USA.

This study investigates the relationship between maternal employment and state-to-state differences in childcare cost and mean school day length. Pairing state-level measures with an individual-level sample of prime working-age mothers from the American Time Use Survey (2005-2014; n = 37,993), we assess the multilevel and time-varying effects of childcare costs and school day length on maternal full-time and part-time employment and childcare time. We find mothers' odds of full-time employment are lower and part-time employment higher in states with expensive childcare and shorter school days. Read More

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January 2019

Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice.

Mol Ther Nucleic Acids 2021 Jun 20;24:951-960. Epub 2021 Apr 20.

Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.

Cardiosphere-derived cell exosomes (CDC) and YF1, a CDC-derived non-coding RNA, elicit therapeutic bioactivity in models of myocardial infarction and hypertensive hypertrophy. Here we tested the hypothesis that YF1, a 56-nucleotide Y RNA fragment, could alleviate cardiomyocyte hypertrophy, inflammation, and fibrosis associated with hypertrophic cardiomyopathy (HCM) in transgenic mice harboring a clinically relevant mutation in cardiac troponin I (cTnI). By quantitative PCR, YF1 was detectable in bone marrow, spleen, liver, and heart 30 min after intravenous (i. Read More

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Design and Implementation of Flexible Advanced Training in Rheumatology: Report of a pilot program.

Intern Med J 2021 Jun 6. Epub 2021 Jun 6.

Department of Rheumatology, Level 6 West, Main Building, Concord General Repatriation Hospital, Concord, NSW, 2139.

Background: Training in medicine is highly demanding and coincides with critical life tasks including relationship development, childbearing, and rearing. The rigid requirements of training programs risk precluding successful achievement of these extracurricular roles, forcing choices between work and other life commitments. Flexible employment structures that facilitate the development of high-quality physicians are needed. Read More

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Promoting recovery in daily life: study protocol for a randomized controlled trial.

BMC Psychol 2021 Jun 2;9(1):91. Epub 2021 Jun 2.

Saarland University, Campus A2 4, 66123, Saarbrücken, Germany.

Background: Work-related stress shows steadily increasing prevalence rates and has tangible consequences for individual workers, their organizations, and society as a whole. One mechanism that may help offset the negative outcomes of work-related stress on employees' well-being is recovery. Recovery refers to the experience of unwinding from one's job when not at work. Read More

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Estimating the effects of non-pharmaceutical interventions on the number of new infections with COVID-19 during the first epidemic wave.

PLoS One 2021 2;16(6):e0252827. Epub 2021 Jun 2.

Basel Academy for Quality and Research in Medicine, Basel, Switzerland.

The novel coronavirus (SARS-CoV-2) has rapidly developed into a global epidemic. To control its spread, countries have implemented non-pharmaceutical interventions (NPIs), such as school closures, bans of small gatherings, or even stay-at-home orders. Here we study the effectiveness of seven NPIs in reducing the number of new infections, which was inferred from the reported cases of COVID-19 using a semi-mechanistic Bayesian hierarchical model. Read More

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Assessment of Irrigation Water Use Efficiency in Citrus Orchards Using AHP.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

Department of Economics and Social Sciences, Universitat Politècnica de València, 46022 Valencia, Spain.

Irrigation water use efficiency, the small size of the orchards, and part-time farmers are major issues for Spanish citriculture. How should irrigation water use efficiency be assessed? Does irrigation water use efficiency improve when increasing the size of the orchards? Are full-time farmers more efficient in irrigation water use than part-time ones? To address these three questions, we propose to apply a new multicriteria approach based on the analytic hierarchy process (AHP) technique and the participation of a group of experts. A new synthetic irrigation efficiency index (IEI) was proposed and tested using data from an irrigation community (IC) and a cooperative of farmers in the East of Spain. Read More

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The Effectiveness of Different Concepts of Bracing in Adolescent Idiopathic Scoliosis (AIS): A Systematic Review and Meta-Analysis.

J Clin Med 2021 May 15;10(10). Epub 2021 May 15.

Department of Orthopaedic Surgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.

Brace treatment is the most common noninvasive treatment in adolescent idiopathic scoliosis (AIS); however it is currently not fully known whether there is a difference in effectiveness between brace types/concepts. All studies on brace treatment for AIS were searched for in PubMed and EMBASE up to January 2021. Articles that did not report on maturity of the study population were excluded. Read More

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Comparison of self-reported and public registered absenteeism among people on long-term sick leave due to musculoskeletal disorders: criterion validity of the iMTA Productivity Cost Questionnaire.

Eur J Health Econ 2021 Jun 1. Epub 2021 Jun 1.

Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway.

Objective: To evaluate criterion validity of the iMTA Productivity Cost Questionnaire (iPCQ) by comparing iPCQ-reported occurrence and duration of long-term absenteeism (> 4 weeks) with public registry data collected from the Norwegian Labour and Welfare Administration (NAV) among people on sick leave due to musculoskeletal disorders.

Method: Baseline data from a cohort study was used, in which people on sick leave for at least 4 weeks due to musculoskeletal disorders were recruited electronically through the NAV website. To compare the occurrence of long-term absenteeism overall agreement between the two methods was measured by percentages. Read More

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Evaluating online learning engagement of nursing students.

Nurse Educ Today 2021 May 26;104:104985. Epub 2021 May 26.

University of Hong Kong School of Nursing, Hong Kong. Electronic address:

Background: Previous studies suggest that increased learning satisfaction may encourage learning engagement in an online learning environment.

Objectives: To evaluate the level of learning engagement and its relationship with students' perceived learning satisfaction in an online clinical nursing elective course.

Design: A prospective interventional study. Read More

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Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome.

Front Aging Neurosci 2021 13;13:661284. Epub 2021 May 13.

Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.

In recent years several F-labeled amyloid PET (Aβ-PET) tracers have been developed and have obtained clinical approval. There is evidence that Aβ-PET perfusion can provide surrogate information about neuronal injury in neurodegenerative diseases when compared to conventional blood flow and glucose metabolism assessment. However, this paradigm has not yet been tested in neurodegenerative disorders with cortical and subcortical affection. Read More

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Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents.

Front Behav Neurosci 2021 14;15:652636. Epub 2021 May 14.

Cohen Veterans Bioscience, New York City, NY, United States.

Posttraumatic stress disorder (PTSD) is a mental health condition triggered by experiencing or witnessing a terrifying event that can lead to lifelong burden that increases mortality and adverse health outcomes. Yet, no new treatments have reached the market in two decades. Thus, screening potential interventions for PTSD is of high priority. Read More

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Flexible rostering in nursing student clinical placements: A qualitative study of student and staff perceptions of the impact on learning and student experience.

Nurse Educ Pract 2021 May 24;54:103096. Epub 2021 May 24.

School of Health Sciences City, University of London, Northampton Square, London EC1V 0HB, UK. Electronic address:

Aim: To explore whether a flexible rostering system for nursing students during their clinical placements enhanced their experience and contributed to a positive learning environment.

Background: In England, attrition from nursing programmes is an enduring issue, often related to student experience of clinical placements. Students juggle caring responsibilities, academic assessment and additional part-time jobs to mitigate financial hardship, while they are undertaking the clinical placement aspect of their courses. Read More

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ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

Stem Cell Reports 2021 Jun 27;16(6):1398-1408. Epub 2021 May 27.

Histogen, San Diego, CA, USA.

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here. Read More

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The Unintended Consequences of the Pandemic: The New Normal for College Students in South Korea and Taiwan.

Front Public Health 2021 11;9:598302. Epub 2021 May 11.

Department of Sociology, National Sun Yat-sen University, Kaohsiung, Taiwan.

This study attempts to compare the impacts of the coronavirus (COVID-19) pandemic on college students' lifestyles and mental health conditions in South Korea and Taiwan. As the COVID-19 outbreak has spread across the globe, it has brought significant changes to college campuses worldwide. College students have been heavily affected by the closure, as online learning has become increasingly common in higher education institutions. Read More

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Excited Catatonia in Autism Spectrum Disorder: A Case Series.

Front Psychiatry 2021 11;12:674335. Epub 2021 May 11.

GME Psychiatry, Orange Park Medical Center, Orange Park, FL, United States.

Autistic catatonia is an under-recognized debilitating syndrome with long-lasting negative effects for families, healthcare workers, and high-cost to the healthcare system. In this report, we describe two cases of excited catatonia in young men diagnosed with autism. Both endured a delay to diagnosis and difficulty to obtain appropriate treatment. Read More

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Cross Cultural Workers for women and families from migrant and refugee backgrounds: a mixed-methods study of service providers perceptions.

BMC Womens Health 2021 05 27;21(1):222. Epub 2021 May 27.

School of Women's and Children's Health, University of NSW (UNSW), Sydney, NSW, 2052, Australia.

Background: Women from migrant and refugee backgrounds who live in high-income countries are at increased risk of adverse perinatal outcomes, including mental health issues, preterm birth and maternal and infant mortality. There is a need to implement and evaluate models of care to meet their specific needs in order to improve health outcomes, their experiences of care, and overcome barriers to access. In Sydney, Australia, a unique model of care was implemented to support women and families from migrant and refugee backgrounds to access health and community-based services through the continuum of pregnancy to the early parenting period. Read More

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Nurses' assessments of horizontal collaboration in municipal health and care services for older adults: A cross-sectional study.

Res Nurs Health 2021 May 25. Epub 2021 May 25.

Centre for Care Research, NTNU-Norwegian University of Science and Technology, Gjøvik, Norway.

Interprofessional and interorganizational collaboration is considered key to achieving high-quality care and positive patient outcomes, but there is limited research into how nurses working in nursing homes and home care services perceive collaboration with other municipal health and care service providers and how their assessments of collaboration vary with individual characteristics and context. The objective of this study was to map variation in nurses' assessments of horizontal collaboration with core care services for older adults, specifically nursing homes, home care services, general practitioners, the allocation office and physio- and occupational therapy services. The study draws on findings from a nationwide cross-sectional survey on posthospital care for older adults, conducted among nurses working in nursing homes and home care services in Norway (N = 3717). Read More

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Factors That Influence Maternal Feeding Decisions for Toddlers: Extending the Theory of Planned Behavior.

J Nutr Educ Behav 2021 May 22. Epub 2021 May 22.

Department of Kinesiology and Health Promotion, College of Education, University of Kentucky, Lexington, KY.

Objective: To use the Theory of Planned Behavior (TPB) to assess mothers' behavioral intentions to provide toddlers with a healthy diet and see if the addition of the parental role construction (PRC) variable strengthened the TPB.

Design: An online survey using data gathered from preliminary research and a previously validated survey.

Participants: The final sample consisted of 148 mothers. Read More

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