23,179 results match your criteria parotid gland


Analysis of Clinical Characteristics and Prognosis of Patients With Periocular Malignant Melanoma in Korea.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul Department of Ophthalmology, Hospital, National Cancer Center, Gyeonggi-do, South Korea.

Objective: To report the clinical features of 20 patients with malignant melanoma and to evaluate the survival and prognosis of patients with malignant melanoma in Korea.

Methods And Analysis: The medical records of 20 patients with malignant melanoma treated between March 2004 and March 2020 were reviewed retrospectively. The demographic data, clinical characteristics, and outcomes were also reviewed. Read More

View Article and Full-Text PDF

A clinical pilot study of salivary gland secretion for xerostomia patients with Sjögren's syndrome using SPECT/CT.

Gerodontology 2021 Jul 20. Epub 2021 Jul 20.

Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Introduction: This study examined whether time-activity curves (TAC) can be used to differentiate between patients with and without Sjögren's syndrome using SPECT/CT.

Methods: Thirteen xerostomia patients (5 with Sjögren's syndrome and 8 without Sjögren's syndrome) underwent SPECT/CT. Salivary gland secretion data were digitally observed, producing separate time-activity curves (TAC) for the submandibular glands and parotid glands using SPECT/CT. Read More

View Article and Full-Text PDF

Computed tomography-guided transfacial buccal space core biopsy of deep head and neck space lesions: our experience.

Br J Oral Maxillofac Surg 2021 Apr 21. Epub 2021 Apr 21.

Departments of Clinical Radiology, Queen Alexandra Hospital, Portsmouth, UK.

Deep head and neck space lesions can present a number of diagnostic challenges due to their deep anatomical position and difficult access for diagnostic tissue sampling. We describe a series of percutaneous 'transfacial' buccal space computed tomography (CT)-guided core biopsies of these lesions and subsequent histological findings. Six patients underwent CT-guided core biopsy of deep parotid, parapharyngeal, or masticator space lesions over a 30-month period. Read More

View Article and Full-Text PDF

[A rare form of secondary orofacial pain: Herzenberg's disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(6):71-75

Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

A clinical analysis of a patient with a rare form of secondary facial pain (Herzenberg's disease) is presented. The conducted research and pharmacological tests made it possible to exclude such diseases as trigeminal neuralgia, stylohyoid syndrome, TMJ pain dysfunction, dental plexalgia, myofascial facial pain syndrome. The patient is consulted by a dental surgeon to exclude pathology of the parotid salivary gland and sialolithiasis. Read More

View Article and Full-Text PDF

DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.

Head Neck Pathol 2021 Jul 19. Epub 2021 Jul 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen (UKER), Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

DICER1, a member of the ribonuclease III family, is involved in the biogenesis of microRNAs and, hence, it influences gene expression regulation. DICER1 germline (associated with the inherited DICER1 syndrome) or somatic mutations have been linked to tumorigenesis in histogenetically diverse benign and malignant neoplasms in different organs including pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, nasal chondromesenchymal hamartoma, poorly differentiated thyroid carcinoma, thyroblastoma, intracranial sarcoma and gonadal Sertoli-Leydig cell tumors in addition to others. Moreover, rare botryoid (giant) fibroepithelial polyps may harbor this mutation. Read More

View Article and Full-Text PDF

Multiple Warthin Tumors With Epithelial-Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report.

Ear Nose Throat J 2021 Jul 19:1455613211028086. Epub 2021 Jul 19.

School and Hospital of Stomatology, 159344Jilin University, Changchun, China.

Multiple primary tumors of the parotid gland refer to the occurrence of 2 or more primary tumors in the ipsilateral or bilateral parotid gland metachronously or synchronously, which do not originate from postoperative recurrence or metastasis. Multiple primary tumors of the parotid gland, especially synchronous benign and malignant tumors, are extremely uncommon. A rare case of multiple Warthin tumors with epithelial-myoepithelial carcinoma of the ipsilateral parotid gland is reported as follows. Read More

View Article and Full-Text PDF

Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node.

Cancer Treat Res Commun 2021 Jul 11;28:100435. Epub 2021 Jul 11.

Department of Otolaryngology / Head & Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. Electronic address:

Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological investigation and multidisciplinary decision-making process of a heterotopic carcinoma ex pleomorphic adenoma arising in an intra-parotid lymph node. Read More

View Article and Full-Text PDF

A Primary Parotid Mucosa-Associated Lymphoid Tissue Non-Hodgkin Lymphoma in a Patient With Sjogren Syndrome.

Cureus 2021 Jun 16;13(6):e15679. Epub 2021 Jun 16.

Department of Pathology, Brooke Army Medical Center, San Antonio, USA.

The salivary gland tumors are rare entities and the majority of these are benign. However, there are some entities such as prior neck radiation, certain infections, and systemic diseases which should raise the clinical suspicion for a malignant lesion. Patients with Sjogren syndrome are at increased risk for a salivary gland neoplasm, specifically non-Hodgkin lymphoma. Read More

View Article and Full-Text PDF

Congenital Cheek Fistula: A Rare Case of Developmental Abnormality in the Buccal Area.

Cureus 2021 Jun 15;13(6):e15657. Epub 2021 Jun 15.

Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.

A congenital cheek fistula is a rare malformation in the buccal area. Here, we report the case of a congenital cheek fistula in a 50-year-old woman who visited our clinic with complaints of swelling and pain in her left cheek. Physical examination revealed a small hole in the left corner of the mouth present since birth. Read More

View Article and Full-Text PDF

Release of secretory immunoglobulin A by submandibular gland via β adrenergic receptor stimulation.

Arch Oral Biol 2021 Jul 14;129:105209. Epub 2021 Jul 14.

Laboratory of Molecular Biology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan. Electronic address:

Objective: Secretory immunoglobulin A (sIgA) is important for mucosal immunity due to the inhibition of pathogen infection. The submandibular gland is known to secrete more sIgA than the parotid and sublingual glands. In this study, we focused on the relationship between the secretion of accumulated intracellular sIgA and β-adrenergic receptor stimulation, and clarified the autonomic regulatory mechanism of sIgA secretion in submandibular gland cells using dispersed gland cells. Read More

View Article and Full-Text PDF

Is extracapsular dissection for pleomorphic adenoma rather a euphemism for enucleation that jeopardises the intactness of the capsule?

Br J Oral Maxillofac Surg 2021 Mar 9. Epub 2021 Mar 9.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

The aim of this study was to compare several surgical modalities with respect to the incidence of positive margins and focal capsular exposure of pleomorphic adenoma of the parotid gland. The clinical records and histopathological findings of all patients who underwent parotidectomy for pleomorphic adenoma between 2006 and 2020 were retrospectively evaluated (n = 845). The lesion was removed by extracapsular dissection in 577 cases (68%) and facial nerve dissection in 268 (32%). Read More

View Article and Full-Text PDF

Synchronous occurrence of IgG4-related sialadenitis and ductal carcinoma of the parotid gland: a case report.

Gland Surg 2021 Jun;10(6):2069-2075

Department of Surgery, School of Medicine, University of Seville, Seville, Spain.

Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Read More

View Article and Full-Text PDF

Deformable image registration to assist clinical decision for radiotherapy treatment adaptation for head and neck cancer patients.

Biomed Phys Eng Express 2021 Jul 15. Epub 2021 Jul 15.

Inst of Communication & Computer Systems, National Technical University of Athens, 9, Iroon Polytechniou Str., Zografos, 15773 Athens, Athens, 15773, GREECE.

Head and neck (H&N) cancer patients often present anatomical and geometrical changes in tumors and organs at risk (OARs) during radiotherapy treatment. These changes may result in the need to adapt the existing treatment planning, using an expert's subjective opinion, for offline adaptive radiotherapy and a new treatment planning before each treatment, for online adaptive radiotherapy. In the present study, a fast methodology is proposed to assist in planning adaptation clinical decision using tumor and parotid glands percentage volume changes during treatment. Read More

View Article and Full-Text PDF

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Authors:
Giulio Cantù

Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214

Former Director of Otorhinolaryngology and Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy.

View Article and Full-Text PDF

Quantitative Analysis and Pathological Basis of Signal Intensity on T2-Weighted MR Images in Benign and Malignant Parotid Tumors.

Cancer Manag Res 2021 7;13:5423-5431. Epub 2021 Jul 7.

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Objective: To investigate the value of the signal intensity on T2-weighted magnetic resonance (MR) imaging using quantitative analysis in the differentiation of parotid tumors.

Materials And Methods: MR data of 80 pleomorphic adenomas (PAs), 68 Warthin tumors (WTs), and 34 malignant tumors (MTs) confirmed by surgery and histology were retrospectively analyzed. The signal intensities of tumor, normal parotid gland, spinal cord, and buccal subcutaneous fat were measured, and the signal intensity ratios (SIRs) between the tumor and the three references were calculated. Read More

View Article and Full-Text PDF

Malignant salivary gland tumours: Single-centre experience of 108 patients.

Clin Otolaryngol 2021 Jul 14. Epub 2021 Jul 14.

Department of Otolaryngology - Head and Neck Surgery, Imperial College Healthcare NHS Trust, London, UK.

●A functioning facial nerve is a critical structure that limits the margin of resection in parotid malignancies. There was no difference in disease-free survival with close or negative resection margins. ●Microscopic positive (R1) resection margins were associated with poorer disease free survival, but this was not statistically significant, implying that more functional and less radical surgery may be acceptable when followed by adjuvant therapy. Read More

View Article and Full-Text PDF

Parotid lymphoepithelial cysts revealing HIV infection in a 12-year-old girl: A case report.

Ann Med Surg (Lond) 2021 Jul 16;67:102338. Epub 2021 Apr 16.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

Introduction: and importance: benign lymphoepithelial cysts are benign lesions consisting of one or more cysts of the salivary glands or neck regions that occur in 3-6% of patients with positive HIV serology. The objective of this work is to discuss the link between HIV and benign lymphoepithelial cysts.

Case Presentation: The authors report a case of benign lymphoepithelial parotid cysts in a 12-year-old girl who underwent a partial parotidectomy. Read More

View Article and Full-Text PDF

Evaluation of skin doses for cone-beam computed tomography in dentomaxillofacial imaging: A preclinical study.

PLoS One 2021 12;16(7):e0254510. Epub 2021 Jul 12.

Department of Oral and Craniomaxillofacial Surgery, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Purpose: Evaluation of skin organ doses in six different cone-beam computed tomography scanners (CBCT) dedicated to dentomaxillofacial imaging. Our hypothesis is that the dose varies between different devices, protocols and skin areas.

Materials And Methods: An anthropomorphic adult head and neck phantom was used to which a dosimeter (Waterproof Farmer® Chamber, PTW, Freiburg, Germany) was attached to anatomic landmarks of both parotid glands, both ocular lenses, the thyroid gland and the neurocranium. Read More

View Article and Full-Text PDF

Mesenchymal Neoplasms of Salivary Glands: A Clinicopathologic Study of 68 Cases.

Head Neck Pathol 2021 Jul 12. Epub 2021 Jul 12.

Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, 1400 NW 12th Avenue, Miami, FL, 33136, USA.

Salivary gland neoplasms are uncommon, and most exhibit epithelial differentiation. Mesenchymal neoplasms of the salivary gland are rare, and the incidence ranges from 1.9% to 5%. Read More

View Article and Full-Text PDF

Parathyroid hemangioma.

Autops Case Rep 2021 25;11:e2021270. Epub 2021 May 25.

Mount Sinai Medical Center, Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Miami Beach, FL, USA.

Background: Hemangiomas are benign neoplasms of capillary proliferation that arise from a developmental anomaly where angioblastic mesenchyme fails to form canals. Most hemangiomas arise in the head and neck region, either superficially in the skin or deeper within endocrine organs such as the parotid gland. Parathyroid hemangiomas, however, are extremely rare, with only five cases previously reported in the literature. Read More

View Article and Full-Text PDF

Deep Learning for Differentiating Benign From Malignant Parotid Lesions on MR Images.

Front Oncol 2021 23;11:632104. Epub 2021 Jun 23.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose/objectivess: Salivary gland tumors are a rare, histologically heterogeneous group of tumors. The distinction between malignant and benign tumors of the parotid gland is clinically important. This study aims to develop and evaluate a deep-learning network for diagnosing parotid gland tumors the deep learning of MR images. Read More

View Article and Full-Text PDF

A Diagnostically Challenging Parotid Gland Tumor With Hybrid Features.

Cureus 2021 Jun 2;13(6):e15383. Epub 2021 Jun 2.

Internal Medicine, Jersey Shore University Medical Center/Saint Francis Medical Center Program, Trenton, USA.

Salivary gland tumors are relatively uncommon with most being benign. When diagnosed the most common benign and malignant tumors are pleomorphic adenoma and mucoepidermoid carcinoma (MEC), respectively. However, not uncommonly, it is difficult to differentiate between the histopathological entities, leading to a diagnostic dilemma that can impact a patient's treatment and prognosis. Read More

View Article and Full-Text PDF

The Diagnostic Performance of Early Sjögren's Syndrome Autoantibodies in Juvenile Sjögren's Syndrome: The University of Florida Pediatric Cohort Study.

Front Immunol 2021 25;12:704193. Epub 2021 Jun 25.

Center for Orphaned Autoimmune Disorders (COAD), College of Dentistry, University of Florida, Gainesville, FL, United States.

Objectives: The aim of this study was to evaluate the clinical validity of early Sjögren's syndrome (SS) autoantibodies (eSjA), which were originally marketed for early diagnosis of SS, for juvenile SS (JSS) in a recently identified pediatric cohort.

Methods: A total of 105 symptomatic subjects with eSjA results available were evaluated at the Center for Orphaned Autoimmune Disorders at the University of Florida and enrolled for this study. JSS diagnosis was based on the 2016 ACR/EULAR SS criteria. Read More

View Article and Full-Text PDF

Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma.

Laryngoscope 2021 Jul 10. Epub 2021 Jul 10.

Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

Objective: The histological grade of parotid gland carcinoma (PGC) is an important prognostic factor; however, the diagnosis prior to treatment has been challenging to make. This study aimed to investigate whether the pretreatment clinical findings, including hematological inflammatory, nutritional, and immune markers, could predict the histological grade of PGC.

Study Design: Retrospective study. Read More

View Article and Full-Text PDF

Quantitative dynamic contrast-enhanced MRI and readout segmentation of long variable echo-trains diffusion-weighted imaging in differentiating parotid gland tumors.

Neuroradiology 2021 Jul 9. Epub 2021 Jul 9.

Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Cha-Zhong Road, Fuzhou, Fujian, 350005, People's Republic of China.

Purpose: To evaluate the ability of quantitative dynamic contrast-enhanced (DCE)-MRI and readout segmentation of long variable echo-trains diffusion-weighted imaging (RESOLVE-DWI) in differentiating parotid tumors (PTs) with different histological types.

Methods: In this retrospective study, 123 patients with 145 histologically proven PTs who underwent both RESOLVE-DWI and DCE-MRI were enrolled including 51 pleomorphic adenomas (PAs), 52 Warthin's tumors (WTs), 27 other benign neoplasms (OBNs), and 15 malignant tumors (MTs). Quantitative parameters of DCE-MRI (K, K, and V) and the apparent diffusion coefficient (ADC) of lesions were calculated and analyzed. Read More

View Article and Full-Text PDF

Differentiation of Benign and Malignant Parotid Gland Tumors with MRI and Diffusion Weighted Imaging.

Medeni Med J 2021 18;36(2):138-145. Epub 2021 Jun 18.

Istanbul Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Department of Radiology, Istanbul, Turkey.

Objective: This study investigated the effectivity of Magnetic Resonance Imaging (MRI) findings and Apparent Diffusion Coefficient (ADC) value in evaluating parotid gland tumors (PGTs), and aimed to reduce the biopsy procedure before surgery.

Methods: This retrospective study included 54 PGTs of 42 patients' (24 female, 18 male, mean age; 51.4±15. Read More

View Article and Full-Text PDF

Three-dimensional cone-beam computed tomographic sialography in the diagnosis and management of primary Sjögren syndrome: Report of 3 cases.

Imaging Sci Dent 2021 Jun 11;51(2):209-216. Epub 2021 Mar 11.

Department of Public Health, Texila American University, Georgetown, Guyana.

Sjögren syndrome is a chronic autoimmune inflammatory disease characterized by lymphocytic infiltration of exocrine glands, predominantly the parotid and lacrimal glands, thereby resulting in oral and ocular dryness. It has been reported to occur most frequently in women between 40 and 50 years of age. Sjögren syndrome has an insidious onset, is slowly progressive, and presents a wide range of clinical manifestations, leading to delays or challenges in the diagnosis. Read More

View Article and Full-Text PDF

Effects of 1 year of training on the performance of ultrasonographic image interpretation: A preliminary evaluation using images of Sjögren syndrome patients.

Imaging Sci Dent 2021 Jun 29;51(2):129-136. Epub 2021 Jan 29.

Department of Oral and Maxillofacial Radiology, Aichi Gakuin University School of Dentistry, Nagoya, Japan.

Purpose: This study investigated the effects of 1 year of training on imaging diagnosis, using static ultrasonography (US) salivary gland images of Sjögren syndrome patients.

Materials And Methods: This study involved 3 inexperienced radiologists with different levels of experience, who received training 1 or 2 days a week under the supervision of experienced radiologists. The training program included collecting patient histories and performing physical and imaging examinations for various maxillofacial diseases. Read More

View Article and Full-Text PDF

Ictal Hypersalivation and Salivary Gland Enlargement in a Patient With Acquired Frontal Lobe Epilepsy.

Cureus 2021 May 29;13(5):e15319. Epub 2021 May 29.

Pediatric Neurology, Louisiana State University Health Sciences Center, New Orleans, USA.

Hypersalivation is a well-known ictal semiology of benign Rolandic epilepsy and other childhood epilepsy syndromes. There are also occasional reports of adults with temporal, parietal, or frontal lobe epilepsy in which hypersalivation is a prominent seizure manifestation. Notably lacking are reports linking salivary gland enlargement to ictal hypersalivation. Read More

View Article and Full-Text PDF

Uncommon Metastasizing Site of Adrenocortical Carcinoma.

Cureus 2021 May 27;13(5):e15267. Epub 2021 May 27.

Surgical Oncology, All India Institute of Medical Sciences, Patna, IND.

Adrenocortical carcinoma (ACC) is a very rare tumor having a poor prognosis. Approximately 25% of these cases may present with metastases at the time of diagnosis. Common sites of metastasis are lung, liver, and lymph nodes. Read More

View Article and Full-Text PDF