29,373 results match your criteria parotid

Parotid saliva H-NMR analysis for colon cancer metabolomics: A case report.

Spec Care Dentist 2021 Jul 22. Epub 2021 Jul 22.

Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.

Background: A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance ( H-NMR) profile of a patient diagnosed with colon cancer, and the subsequent changes 1 year after the end of chemotherapy. Read More

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Analysis of Clinical Characteristics and Prognosis of Patients With Periocular Malignant Melanoma in Korea.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul Department of Ophthalmology, Hospital, National Cancer Center, Gyeonggi-do, South Korea.

Objective: To report the clinical features of 20 patients with malignant melanoma and to evaluate the survival and prognosis of patients with malignant melanoma in Korea.

Methods And Analysis: The medical records of 20 patients with malignant melanoma treated between March 2004 and March 2020 were reviewed retrospectively. The demographic data, clinical characteristics, and outcomes were also reviewed. Read More

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Treatment strategies for Sjögren's syndrome with childhood onset: a systematic review of the literature.

Rheumatology (Oxford) 2021 Jul 20. Epub 2021 Jul 20.

Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London, Rayne Building, London, U.K.

Objectives: Sjögren's Syndrome (SS) with childhood onset is a rare autoimmune disease characterised by heterogeneous presentation. The lack of validated classification criteria makes it challenging to diagnose. Evidence-based guidelines for treatment of juvenile SS are not available due to the rarity of disease and the paucity of research in this patient population. Read More

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Surgical interventions for management of benign parotid tumors: A systematic review and network meta-analysis.

Head Neck 2021 Jul 20. Epub 2021 Jul 20.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China.

The impact of the extent of parotid surgery on postoperative complications has long been considered a topic of controversy. The aim of the current network meta-analysis (NMA) is to answer the following questions: (1) Does the extent of surgical resection of benign parotid tumors increase the risk of postoperative complications? (2) What is the best surgical intervention for treatment of benign parotid tumors that can provide an acceptable balance between tumor recurrence rate and other postoperative complications? A comprehensive search on PubMed, Embase, Scopus, and Cochrane library was conducted to identify the eligible studies. The outcome was the incidence of tumor recurrence, facial nerve weakness (temporary [TFW] or permanent [PFP]), Frey's syndrome (FS), sialocele, and salivary fistula. Read More

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A clinical pilot study of salivary gland secretion for xerostomia patients with Sjögren's syndrome using SPECT/CT.

Gerodontology 2021 Jul 20. Epub 2021 Jul 20.

Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Introduction: This study examined whether time-activity curves (TAC) can be used to differentiate between patients with and without Sjögren's syndrome using SPECT/CT.

Methods: Thirteen xerostomia patients (5 with Sjögren's syndrome and 8 without Sjögren's syndrome) underwent SPECT/CT. Salivary gland secretion data were digitally observed, producing separate time-activity curves (TAC) for the submandibular glands and parotid glands using SPECT/CT. Read More

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Calculation algorithms and penumbra: underestimation of dose in organs at risk in dosimetry audits.

Med Phys 2021 Jul 21. Epub 2021 Jul 21.

Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.

Purpose: The aim of this study is to investigate overdose to organs at risk (OARs) observed in dosimetry audits in Monte Carlo (MC) algorithms and Linear Boltzmann Transport Equation (LBTE) algorithms. The impact of penumbra modelling on OAR dose was assessed with adjustment of MC modelling parameters and the clinical relevance of the audit cases was explored with a planning study of spine and head and neck (H&N) patient cases.

Methods: Dosimetric audits performed by the Australian Clinical Dosimetry Service (ACDS) of 43 anthropomorphic spine plans and 1318 C-shaped target plans compared the planned dose to doses measured with ion chamber, microdiamond, film, and ion chamber array. Read More

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Computed tomography-guided transfacial buccal space core biopsy of deep head and neck space lesions: our experience.

Br J Oral Maxillofac Surg 2021 Apr 21. Epub 2021 Apr 21.

Departments of Clinical Radiology, Queen Alexandra Hospital, Portsmouth, UK.

Deep head and neck space lesions can present a number of diagnostic challenges due to their deep anatomical position and difficult access for diagnostic tissue sampling. We describe a series of percutaneous 'transfacial' buccal space computed tomography (CT)-guided core biopsies of these lesions and subsequent histological findings. Six patients underwent CT-guided core biopsy of deep parotid, parapharyngeal, or masticator space lesions over a 30-month period. Read More

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[A rare form of secondary orofacial pain: Herzenberg's disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(6):71-75

Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

A clinical analysis of a patient with a rare form of secondary facial pain (Herzenberg's disease) is presented. The conducted research and pharmacological tests made it possible to exclude such diseases as trigeminal neuralgia, stylohyoid syndrome, TMJ pain dysfunction, dental plexalgia, myofascial facial pain syndrome. The patient is consulted by a dental surgeon to exclude pathology of the parotid salivary gland and sialolithiasis. Read More

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DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case.

Head Neck Pathol 2021 Jul 19. Epub 2021 Jul 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen (UKER), Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

DICER1, a member of the ribonuclease III family, is involved in the biogenesis of microRNAs and, hence, it influences gene expression regulation. DICER1 germline (associated with the inherited DICER1 syndrome) or somatic mutations have been linked to tumorigenesis in histogenetically diverse benign and malignant neoplasms in different organs including pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, nasal chondromesenchymal hamartoma, poorly differentiated thyroid carcinoma, thyroblastoma, intracranial sarcoma and gonadal Sertoli-Leydig cell tumors in addition to others. Moreover, rare botryoid (giant) fibroepithelial polyps may harbor this mutation. Read More

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A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era.

Aging (Albany NY) 2021 Jul 19;13(undefined). Epub 2021 Jul 19.

Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Background: Dry mouth sensation cannot be improved completely even though parotids are spared correctly. Our purpose is to develop a nomogram to predict the moderate-to-severe late radiation xerostomia for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) in intensity modulated radiation therapy (IMRT) / volumetric modulated arc radiotherapy (VMAT) era.

Methods: A dataset of 311 patients was retrospectively collected between January 2010 and February 2013. Read More

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Multiple Warthin Tumors With Epithelial-Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report.

Ear Nose Throat J 2021 Jul 19:1455613211028086. Epub 2021 Jul 19.

School and Hospital of Stomatology, 159344Jilin University, Changchun, China.

Multiple primary tumors of the parotid gland refer to the occurrence of 2 or more primary tumors in the ipsilateral or bilateral parotid gland metachronously or synchronously, which do not originate from postoperative recurrence or metastasis. Multiple primary tumors of the parotid gland, especially synchronous benign and malignant tumors, are extremely uncommon. A rare case of multiple Warthin tumors with epithelial-myoepithelial carcinoma of the ipsilateral parotid gland is reported as follows. Read More

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Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node.

Cancer Treat Res Commun 2021 Jul 11;28:100435. Epub 2021 Jul 11.

Department of Otolaryngology / Head & Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. Electronic address:

Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological investigation and multidisciplinary decision-making process of a heterotopic carcinoma ex pleomorphic adenoma arising in an intra-parotid lymph node. Read More

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Serum microRNAs as xerostomia biomarkers in oropharyngeal cancer patients undergoing radiotherapy.

Int J Radiat Oncol Biol Phys 2021 Jul 16. Epub 2021 Jul 16.

Medical University of Lodz, Department of Biostatistics and Translational Medicine, Lodz, Poland; Dana-Farber Cancer Institute, Harvard Medical School, Department of Radiation Oncology, Boston, USA. Electronic address:

Purpose: Severe xerostomia is noted in the majority of patients irradiated for oropharyngeal cancer (OPC). Extracellular microRNAs (miRNAs) may serve as effective tools allowing prediction of radiation-related toxicity. The aim of this study was to create an efficient prognostic miRNA-based test for severe, patient-rated xerostomia 3 months after primary treatment. Read More

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Spatially resolved sampling for untargeted metabolomics: A new tool for salivomics.

iScience 2021 Jul 24;24(7):102768. Epub 2021 Jun 24.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.

Saliva is a complex bodily fluid composed of metabolites secreted by major and minor glands, as well as by-products of host oral cells, oral bacteria, gingival crevicular fluid, and exogenous compounds. Major salivary glands include the paired parotid, submandibular, and sublingual glands. The secreted fluids of the salivary glands vary in composition, flow rate, site of release, and clearance suggesting that different types of saliva fulfill different functions and therefore can provide unique biological information. Read More

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Photobiomodulation in the treatment of xerostomia associated with hyposalivation in a pediatric patient with systemic scleroderma.

Autops Case Rep 2021 14;11:e2020220. Epub 2020 Dec 14.

Universidade Estadual de São Paulo (Unesp), Faculdade de Odontologia de Araraquara, Departamento de Morfologia e Clínica Infantil, Araraquara, SP, Brasil.

Scleroderma is a rare autoimmune disease characterized by excessive collagen production. The oral manifestations of the patient with scleroderma can include microstomia, xerostomia, and changes in the resorption teeth. We report the case of a 7-year-old female patient diagnosed with systemic scleroderma where photobiomodulation therapy was used to treat xerostomia associated with hyposalivation. Read More

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December 2020

A Primary Parotid Mucosa-Associated Lymphoid Tissue Non-Hodgkin Lymphoma in a Patient With Sjogren Syndrome.

Cureus 2021 Jun 16;13(6):e15679. Epub 2021 Jun 16.

Department of Pathology, Brooke Army Medical Center, San Antonio, USA.

The salivary gland tumors are rare entities and the majority of these are benign. However, there are some entities such as prior neck radiation, certain infections, and systemic diseases which should raise the clinical suspicion for a malignant lesion. Patients with Sjogren syndrome are at increased risk for a salivary gland neoplasm, specifically non-Hodgkin lymphoma. Read More

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Congenital Cheek Fistula: A Rare Case of Developmental Abnormality in the Buccal Area.

Cureus 2021 Jun 15;13(6):e15657. Epub 2021 Jun 15.

Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.

A congenital cheek fistula is a rare malformation in the buccal area. Here, we report the case of a congenital cheek fistula in a 50-year-old woman who visited our clinic with complaints of swelling and pain in her left cheek. Physical examination revealed a small hole in the left corner of the mouth present since birth. Read More

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Radiation Recall Dermatitis in Patients Treated With Immune Checkpoint Inhibitors: A Case Report and Literature Review.

Cureus 2021 Jun 9;13(6):e15548. Epub 2021 Jun 9.

Radiation Oncology, Hacettepe University Medical School, Ankara, TUR.

Radiation recall dermatitis (RRD) is defined as a skin reaction in the previously irradiated area triggered by a systemic agent's administration. The use of immune checkpoint inhibitors (ICI) alone and in combination with other treatments is increasing in many cancers. ICI-associated radiation recall reactions such as dermatitis, pneumonia, and myelitis have been reported so far. Read More

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Release of secretory immunoglobulin A by submandibular gland via β adrenergic receptor stimulation.

Arch Oral Biol 2021 Jul 14;129:105209. Epub 2021 Jul 14.

Laboratory of Molecular Biology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan. Electronic address:

Objective: Secretory immunoglobulin A (sIgA) is important for mucosal immunity due to the inhibition of pathogen infection. The submandibular gland is known to secrete more sIgA than the parotid and sublingual glands. In this study, we focused on the relationship between the secretion of accumulated intracellular sIgA and β-adrenergic receptor stimulation, and clarified the autonomic regulatory mechanism of sIgA secretion in submandibular gland cells using dispersed gland cells. Read More

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Is extracapsular dissection for pleomorphic adenoma rather a euphemism for enucleation that jeopardises the intactness of the capsule?

Br J Oral Maxillofac Surg 2021 Mar 9. Epub 2021 Mar 9.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

The aim of this study was to compare several surgical modalities with respect to the incidence of positive margins and focal capsular exposure of pleomorphic adenoma of the parotid gland. The clinical records and histopathological findings of all patients who underwent parotidectomy for pleomorphic adenoma between 2006 and 2020 were retrospectively evaluated (n = 845). The lesion was removed by extracapsular dissection in 577 cases (68%) and facial nerve dissection in 268 (32%). Read More

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A very rare case of bilateral capillary hemangioma of lower lip and face: A case report.

Indian J Dent Res 2021 Jan-Feb;32(1):131-133

Department of Oral Medicine and Radiology, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India.

Hemangioma is a relatively common benign proliferation of blood vessel that primarily develops during childhood. It is a most common benign tumor of vascular origin is the region of head and neck. The common sites are lips, tongue, buccal mucosa, and palate in oral cavity. Read More

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Case Report: Very Late, Atypical Extra-Medullary Relapse in a Patient With Acute Promyelocytic Leukemia (APL) Rescued With a Transplant-Free Approach.

Front Oncol 2021 29;11:699886. Epub 2021 Jun 29.

Haematology Unit, St. Eugenio Hospital, Rome, Italy.

Relapses of acute promyelocytic leukemia (APL) beyond 7 years from the first molecular remission are exceptional, and it is unclear whether these relapses represent a new, therapy-related leukemia rather than a delayed relapse of the original leukemic clone. The increase extra-medullary relapses (ER) in the era of all-trans retinoic acid (ATRA) therapy suggests a potential correlation between ATRA therapy and ER, and several potential explanations have been proposed. The gold standard post-remission approach, particularly for patients in late relapse, has not yet been established. Read More

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Synchronous occurrence of IgG4-related sialadenitis and ductal carcinoma of the parotid gland: a case report.

Gland Surg 2021 Jun;10(6):2069-2075

Department of Surgery, School of Medicine, University of Seville, Seville, Spain.

Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Read More

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Deformable image registration to assist clinical decision for radiotherapy treatment adaptation for head and neck cancer patients.

Biomed Phys Eng Express 2021 Jul 15. Epub 2021 Jul 15.

Inst of Communication & Computer Systems, National Technical University of Athens, 9, Iroon Polytechniou Str., Zografos, 15773 Athens, Athens, 15773, GREECE.

Head and neck (H&N) cancer patients often present anatomical and geometrical changes in tumors and organs at risk (OARs) during radiotherapy treatment. These changes may result in the need to adapt the existing treatment planning, using an expert's subjective opinion, for offline adaptive radiotherapy and a new treatment planning before each treatment, for online adaptive radiotherapy. In the present study, a fast methodology is proposed to assist in planning adaptation clinical decision using tumor and parotid glands percentage volume changes during treatment. Read More

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Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Giulio Cantù

Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214

Former Director of Otorhinolaryngology and Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy.

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Quantitative Analysis and Pathological Basis of Signal Intensity on T2-Weighted MR Images in Benign and Malignant Parotid Tumors.

Cancer Manag Res 2021 7;13:5423-5431. Epub 2021 Jul 7.

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Objective: To investigate the value of the signal intensity on T2-weighted magnetic resonance (MR) imaging using quantitative analysis in the differentiation of parotid tumors.

Materials And Methods: MR data of 80 pleomorphic adenomas (PAs), 68 Warthin tumors (WTs), and 34 malignant tumors (MTs) confirmed by surgery and histology were retrospectively analyzed. The signal intensities of tumor, normal parotid gland, spinal cord, and buccal subcutaneous fat were measured, and the signal intensity ratios (SIRs) between the tumor and the three references were calculated. Read More

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Intraparotid Recurrence of Papillary Thyroid Carcinoma After Thyroidectomy Coincident With Declining Thyroglobulin Levels: A Case Report and Review of the Literature.

Ear Nose Throat J 2021 Jul 14:1455613211033124. Epub 2021 Jul 14.

King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.

Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy. Intraparotid recurrence of PTC is, however, rare. Most parotid malignancies are either primary or metastatic from cancer outside the head and neck. Read More

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Malignant salivary gland tumours: Single-centre experience of 108 patients.

Clin Otolaryngol 2021 Jul 14. Epub 2021 Jul 14.

Department of Otolaryngology - Head and Neck Surgery, Imperial College Healthcare NHS Trust, London, UK.

●A functioning facial nerve is a critical structure that limits the margin of resection in parotid malignancies. There was no difference in disease-free survival with close or negative resection margins. ●Microscopic positive (R1) resection margins were associated with poorer disease free survival, but this was not statistically significant, implying that more functional and less radical surgery may be acceptable when followed by adjuvant therapy. Read More

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Parotid lymphoepithelial cysts revealing HIV infection in a 12-year-old girl: A case report.

Ann Med Surg (Lond) 2021 Jul 16;67:102338. Epub 2021 Apr 16.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

Introduction: and importance: benign lymphoepithelial cysts are benign lesions consisting of one or more cysts of the salivary glands or neck regions that occur in 3-6% of patients with positive HIV serology. The objective of this work is to discuss the link between HIV and benign lymphoepithelial cysts.

Case Presentation: The authors report a case of benign lymphoepithelial parotid cysts in a 12-year-old girl who underwent a partial parotidectomy. Read More

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