131,810 results match your criteria parkinson's disease

Postoperative Complication Rates after One-Level Cervical Spine Surgery in Patients with Parkinson's Disease: A Database Study.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, California; Department of Orthopedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.

Objective: Parkinson's Disease (PD) is a risk factor for worse surgical outcomes. The degree to which Parkinson's affects outcomes in cervical spine surgery is not well understood. Therefore, we characterize rates of postoperative complications among patients with PD who undergo cervical spine surgery. Read More

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TNF inhibitors have a protective role in the risk of dementia in patients with ankylosing spondylitis: Results from a nationwide study.

Pharmacol Res 2022 Jun 22:106325. Epub 2022 Jun 22.

Department of Medicine 'B', Sheba Medical Centre, Tel-Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Centre, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Objectives: Ankylosing spondylitis (AS) is a chronic progressive and debilitating form of arthritis with associated extra-articular features including uveitis, intestinal and lung apical inflammation and psoriasis. Putative associations between AS and neurologic disorders has been relatively overlooked. The purpose of this study is to assess the link between AS and major neurologic disorders and whether treatment with Tumor-Necrosis-Factor inhibitors (TNFi) has an impact on that association. Read More

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Chitosan mediated layer-by-layer assembly based graphene oxide decorated surface plasmon resonance biosensor for highly sensitive detection of β-amyloid.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Dist: Dhule, MS, India. Electronic address:

Alzheimer's disease (AD), and its consequent effect primarily clinical dementia, Parkinson's disease dementia, etc. currently bring potential avenues for diagnosis centered on identification of beta-amyloid (Aβ). Unfortunately, techniques engaged in AD core biomarker (Aβ) detection are majorly suffering from poor sensitivity and selectivity. Read More

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The role of Triggering Receptor Expressed on Myeloid Cells 2 in Parkinson's disease and other neurodegenerative disorders.

Behav Brain Res 2022 Jun 22:113977. Epub 2022 Jun 22.

Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität (FAU) Erlangen -Nürnberg, Erlangen, Germany. Electronic address:

Parkinson's disease (PD) is a progressive neurological disorder marked by cardinal clinical symptoms such as rigor, tremor, and akinesia. Albeit a loss of dopaminergic neurons from the substantia nigra pars compacta is causative for the movement impairments found in patients, molecular reasoning for this loss is still incomplete. In recent years, triggering factor expressed on myeloid cells (TREM2) gained attention in the field of neurodegeneration as it could be associated with different neurodegenerative disorders. Read More

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Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD 21225, USA.

Objectives: To evaluate sleep and affective (mood/anxiety) disorders as clinical predictors of incident Parkinson's disease (PD) among women ≥65 years of age.

Methods: We performed secondary analyses with available data from the Women's Health Initiative Clinical Trials and Observational Study linked to Medicare claims. Sleep, mood and anxiety disorders at baseline were defined using diagnostic codes. Read More

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The genesis and functional consequences of cortico-subthalamic beta augmentation and excessive subthalamic burst discharges after dopaminergic deprivation.

Exp Neurol 2022 Jun 22:114153. Epub 2022 Jun 22.

Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.. Electronic address:

The cardinal electrophysiological signs in Parkinson's disease (PD) include augmented beta oscillations in the motor cortex-subthalamic nucleus (MC-STN) axis and excessive burst discharges in STN. We have shown that excessive STN burst discharges have a direct causal relation with the locomotor deficits in PD. To investigate the correlation between the two cardinal signs, we characterized the courses of development of the electrophysiological abnormalities in the hemiparkinsonian rat model. Read More

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Mangiferin, a natural glucoxilxanthone, inhibits mitochondrial dynamin-related protein 1 and relieves aberrant mitophagic proteins in mice model of Parkinson's disease.

Phytomedicine 2022 Jun 16;104:154281. Epub 2022 Jun 16.

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Sunshine Southern Avenue, Fang-Shan District, Beijing 102488, China. Electronic address:

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease featured to mitochondrial dysfunction in neuronal cells. Dynamin-related protein 1 (Drp1) is an important regulator of mitochondrial fission and subsequent mitophagy. Mangiferin (MGF) is a glucosyl xanthone mainly derived from Mangifera indica L. Read More

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Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.

Phytomedicine 2022 Jun 15;104:154250. Epub 2022 Jun 15.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder involving the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Cellular clearance mechanisms, including the autophagy-lysosome pathway, are commonly affected in the pathogenesis of PD. The lysosomal Ca channel mucolipin TRP channel 1 (TRPML1) is one of the most important proteins involved in the regulation of autophagy. Read More

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Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease.

Pain Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of Neurology, Henan Provincial People's Hospital, Weiwu Road, Building 7, Zhengzhou, 450003, Henan Province, People's Republic of China.

Introduction: Pain in Parkinson's disease is poorly understood, and most patients with pain do not respond to dopaminergic drugs. We aimed to explore the mechanisms of dopa-responsive and -unresponsive pain by comparing such patients against patients without pain in terms of neural activity and functional connectivity in the brain.

Methods: We prospectively examined 31 Parkinson's patients with dopa-responsive pain, 51 with dopa-unresponsive pain and 93 without pain using resting-state functional magnetic resonance imaging. Read More

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Subthalamic nucleus deep brain stimulation programming settings do not correlate with Parkinson's disease severity.

Acta Neurochir (Wien) 2022 Jun 25. Epub 2022 Jun 25.

Department of Clinical Neurosciences, University of Calgary, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada.

Background: Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD). While the success of DBS is dependent on careful patient selection and accurate lead placement, programming parameters play a pivotal role in tailoring therapy on the individual level. Various algorithms have been developed to streamline the initial programming process, but the relationship between pre-operative patient characteristics and post-operative device settings is unclear. Read More

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Comparison of factors influencing fall recurrence in the young-old and old-old: a cross-sectional nationwide study in South Korea.

BMC Geriatr 2022 Jun 25;22(1):520. Epub 2022 Jun 25.

College of Nursing, Research Institute of Nursing Science, Kyungpook National University, 680 Gukchabosangro, Jung-gu, Daegu, 41944, Republic of Korea.

Background: Recurrent falls are a concerning problem in the elderly. Elderly people aged > 65 years who are prone to fall often require medical treatment for severe fall-related injuries, which is associated with a substantial financial burden. Therefore, this study aimed to identify factors related to recurrent falls in the community-dwelling young-old (65-74 years old) and old-old (≥ 75 years) in South Korea. Read More

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Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.

BMC Anesthesiol 2022 Jun 24;22(1):197. Epub 2022 Jun 24.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.

Background: Laryngeal mask airways have been widely used in clinical practice. The aim of this study was to investigate whether the remifentanil requirement for facilitation of i-gel insertion in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) surgery was different from that in non-PD (NPD) patients undergoing intracranial surgery.

Study Design: An up-and-down sequential allocation trial. Read More

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Can the administration of platelet lysates to the brain help treat neurological disorders?

Cell Mol Life Sci 2022 Jun 24;79(7):379. Epub 2022 Jun 24.

College of Biomedical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, 250 Wu-Xing Street, Taipei, 11031, Taiwan.

Neurodegenerative disorders of the central nervous system (CNS) and brain traumatic insults are characterized by complex overlapping pathophysiological alterations encompassing neuroinflammation, alterations of synaptic functions, oxidative stress, and progressive neurodegeneration that eventually lead to irreversible motor and cognitive dysfunctions. A single pharmacological approach is unlikely to provide a complementary set of molecular therapeutic actions suitable to resolve these complex pathologies. Recent preclinical data are providing evidence-based scientific rationales to support biotherapies based on administering neurotrophic factors and extracellular vesicles present in the lysates of human platelets collected from healthy donors to the brain. Read More

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The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic.

Nat Rev Neurol 2022 Jun 24. Epub 2022 Jun 24.

Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada.

Evidence for a close bidirectional link between the brain and the gut has led to a paradigm shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal dysfunction is a prominent feature. Over the past decade, numerous high-quality preclinical and clinical publications have shed light on the highly complex relationship between the gut and the brain in PD, providing potential for the development of new biomarkers and therapeutics. With the advent of high-throughput sequencing, the role of the gut microbiome has been specifically highlighted. Read More

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A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease.

NPJ Parkinsons Dis 2022 Jun 24;8(1):82. Epub 2022 Jun 24.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Tremor is one of the core symptoms of Parkinson's disease (PD), but its mechanism is poorly understood. The cerebellum is a growing focus in PD-related researches and is reported to play an important role in tremor in PD. The cerebellum may participate in the modulation of tremor amplitude via cerebello-thalamo-cortical circuits. Read More

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Phosphorylated alpha-synuclein in Iba1-positive macrophages in the skin of patients with Parkinson's disease.

Ann Clin Transl Neurol 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, National Hospital Organization Sendai Nishitaga Hospital, Sendai, Japan.

Background: Increasing evidence suggests that alpha-synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p-αSyn) deposits in autonomic fibers in IPD are a biomarker in the skin, but other tissue localizations have not been fully investigated.

Objective: It has been previously suggested that αSyn aggregates activate peripheral macrophages and that peripheral macrophages ingest pathological αsyn aggregates in aged rats or IPD patients. Read More

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Is essential tremor a family of diseases or a syndrome? A family of diseases.

Int Rev Neurobiol 2022 23;163:7-29. Epub 2022 Mar 23.

The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, United States. Electronic address:

It is now well-established that essential tremor (ET) can manifest with different clinical presentations and progressions (i.e., upper limb tremor, head tremor, voice tremor, lower limb tremor, task- or position-specific tremor, or a combination of those). Read More

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Does essential tremor increase risk of cognitive impairment and dementia? Yes.

Int Rev Neurobiol 2022 9;163:195-231. Epub 2022 Apr 9.

Department of Neurology, Parkinson's Disease and Movement Disorders Center, Boston Medical Center, Boston, Massachusetts, United States; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States. Electronic address:

Essential Tremor (ET), by definition, is a disorder of movement. Yet over the years, epidemiologic, clinical, pathologic, and neuroimaging studies have converged to reveal a cognitive side of ET. The cognitive symptoms in ET are heterogeneous and are likely to reflect heterogeneous underlying mechanisms. Read More

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Prevalence and clinical aspects of depression in Parkinson's disease: a systematic review and meta‑analysis of 129 studies.

Neurosci Biobehav Rev 2022 Jun 21:104749. Epub 2022 Jun 21.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Depression is one of the most important non-motor symptoms in Parkinson's disease (PD), but its prevalence and related clinical characteristics are unclear. To this end, we performed a systematic review and meta-analysis based on 129 studies, including 38304 participants from 28 countries. Overall, the prevalence of depression in PD was 38%. Read More

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Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression.

Toxicol Appl Pharmacol 2022 Jun 21:116137. Epub 2022 Jun 21.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.

Workers in the oil and gas industry are at risk for exposure to a number of physical and chemical hazards at the workplace. Chemical hazard risks include inhalation of crude oil or its volatile components. While several studies have investigated the neurotoxic effects of volatile hydrocarbons, in general, there is a paucity of studies assessing the neurotoxicity of crude oil vapor (COV). Read More

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Age-dependent neurodegeneration and neuroinflammation in a genetic A30P/A53T double-mutated α-synuclein mouse model of Parkinson's disease.

Neurobiol Dis 2022 Jun 21:105798. Epub 2022 Jun 21.

Department of Neurology, University Hospital of Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany. Electronic address:

The pathogenesis of Parkinson's disease (PD) is closely interwoven with the process of aging. Moreover, increasing evidence from human postmortem studies and from animal models for PD point towards inflammation as an additional factor in disease development. We here assessed the impact of aging and inflammation on dopaminergic neurodegeneration in the hmα-SYN-39 mouse model of PD that carries the human, A30P/A53T double-mutated α-synuclein gene. Read More

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Model-based quantitative optimization of deep brain stimulation and prediction of parkinson's states.

Neuroscience 2022 Jun 21. Epub 2022 Jun 21.

Department of Precision Instruments, Tsinghua University, Beijing, China. Electronic address:

Although the exact etiology of Parkinson's disease (PD) is still unknown, there are a variety of treatments available to alleviate its symptoms according to the development stage of PD. Deep brain stimulation (DBS), the most common surgical treatment for advanced PD, accurately locates and implants stimulating electrodes at specific targets in the brain to deliver high-frequency electrical stimulation that alters the excitability of the corresponding nuclei. However, for different patients and stages of PD development, there exists a choice of the optimal DBS protocol. Read More

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Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.

Cell 2022 Jun;185(13):2292-2308.e20

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building (BSB), 1105 N. University Ave, Ann Arbor, MI 48109, USA. Electronic address:

Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of macromolecules. Read More

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Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.

J Am Chem Soc 2022 Jun 24. Epub 2022 Jun 24.

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark.

α-Synuclein (α-Syn) is an intrinsically disordered protein which self-assembles into highly organized β-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences α-Syn structure and self-assembly; however, the basis for this remains unclear. Here we characterize the chemical and physical effects of mild oxidation on monomeric α-Syn and its aggregation. Read More

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The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Exploratory Analysis of Phase 2/3 Clinical Trial.

Cannabis Cannabinoid Res 2022 Jun 24. Epub 2022 Jun 24.

Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil.

Cannabidiol (CBD) is one of the main nonpsychoactive components of and may represent an alternative treatment for Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) in patients with Parkinson's disease (PD) and REM (Rapid Eye Movement) sleep behavior disorder (RBD). Our purpose was a exploratory analysis to evaluate the CBD's efficacy to improve the severity of RLS/WED symptoms in patients with PD and RBD. A exploratory analysis of a phase II/III, a parallel, double-blind, placebo-controlled clinical trial was conducted in 18 patients with RLS/WED and PD plus RBD associated. Read More

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Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming.

Cell Reprogram 2022 Jun 24. Epub 2022 Jun 24.

Faculty of Pharmacy, Université de Montréal, Montreal, Canada.

Understanding the pathophysiology of CNS-associated neurological diseases has been hampered by the inaccessibility of patient brain tissue to perform live analyses at the molecular level. To this end, neural cells obtained by differentiation of patient-derived induced pluripotent stem cells (iPSCs) are considerably helpful, especially in the context of monogenic-based disorders. More recently, the use of direct reprogramming to convert somatic cells to neural cells has emerged as an alternative to iPSCs to generate neurons, astrocytes, and oligodendrocytes. Read More

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[Atypical Parkinson's syndrome in old age].

Z Gerontol Geriatr 2022 Jun 24. Epub 2022 Jun 24.

Klinikum Nürnberg, Paracelsus Medizinische Privatuniversität, Breslauerstr. 201, 90471, Nürnberg, Deutschland.

Atypical Parkinson syndromes represent a neuropathologically heterogeneous group and include the clinical entities dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). The DLB and MSA are characterized by deposition of the protein alpha-synuclein (synucleinopathy), PSP and CBD are characterized by deposition of tau protein, often in the form of neurofibrillary tangles in nerve and glial cells (tauopathy). Misfolding and aggregation of the aforementioned proteins causes degeneration of the affected cell populations but the disease also spreads to anatomically neighboring brain regions, thus contributing to disease progression. Read More

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Isolated REM sleep behaviour disorder: current diagnostic procedures and emerging new technologies.

J Neurol 2022 Jun 24. Epub 2022 Jun 24.

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Australia.

Isolated REM sleep behaviour disorder (iRBD) is characterised by dream enactment behaviours, such as kicking and punching while asleep, and vivid/violent dreams. It is now acknowledged as a prodromal phase of neurodegenerative disease-approximately 80% of people with iRBD will develop dementia with Lewy Bodies, Parkinson's disease or another degenerative brain disease within 10 years. It is important that neurologists and other clinicians understand how to make an early accurate diagnosis of iRBD so that affected people can have the opportunity to take part in clinical trials. Read More

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Epigallocatechin Gallate (EGCG) for Parkinson's Disease.

Clin Exp Pharmacol Physiol 2022 Jun 24. Epub 2022 Jun 24.

National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, Hubei, China.

In the last couple of decades, we have experienced increased use of nutraceuticals worldwide with a demand for organic foods, which has been elevated to an extent probably unmatched with other periods of our civilization. One of the nutraceuticals that gained attention is epigallocatechin gallate (EGCG), a polyphenol in green tea. It has been suggested that diseases of the central nervous system (CNS) can benefit from consuming some antioxidants, despite current results showing little evidence for their use in preventing and treating these diseases. Read More

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Psychotropic medication use and Parkinson's disease risk amongst older women.

Ann Clin Transl Neurol 2022 Jun 24. Epub 2022 Jun 24.

Department of Family and Community Medicine (Emeritus), School of Medicine, University of Nevada (Reno), Auburn, California, 95602, USA.

Objective: To examine associations of antidepressant, anxiolytic and hypnotic use amongst older women (≥65 years) with incident Parkinson's Disease (PD), using data from Women's Health Initiative linked to Medicare claims.

Methods: PD was defined using self-report, first diagnosis, medications and/or death certificates and psychotropic medications were ascertained at baseline and 3-year follow-up. Cox regression models were constructed to calculate adjusted hazard ratios (aHR) with 95% confidence intervals (CI), controlling for socio-demographic, lifestyle and health characteristics, overall and amongst women diagnosed with depression, anxiety and/or sleep disorders (DASD). Read More

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