43,574 results match your criteria parker memorial

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.

J Med Chem 2021 Jul 22. Epub 2021 Jul 22.

IACS (Institute for Applied Cancer Science), University of Texas, MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.

Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology. We developed a class of inhibitors with a conformationally constrained bicyclo[3.1. Read More

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Observer reactions to workplace mistreatment: It's a matter of perspective.

J Occup Health Psychol 2021 Jul 22. Epub 2021 Jul 22.

Management School.

Workplace mistreatment regularly occurs in the presence of others (i.e., observers). Read More

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Effect of brief nicotine corrective messaging on nicotine beliefs in persons who use opioids.

Exp Clin Psychopharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychiatry.

This pilot study tested the effect of a brief nicotine education messaging exposure on beliefs about nicotine, nicotine-replacement therapy (NRT), and e-cigarettes. Participants ages 18 and older were recruited via Amazon Mechanical Turk to complete a 20-min online survey in April/May 2020 to assess relationships between opioid use, smoking, and other behaviors. Participants with past-month extra-medical opioid use completed questions on background characteristics and literacy and then were randomized in a 2:1 ratio of two conditions: nicotine education ( = 362) or no message control ( = 181). Read More

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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.

Nature 2021 Jul 21. Epub 2021 Jul 21.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

PD-1 blockade unleashes CD8 T cells, including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lymphocytes (TIL). However, the majority of TIL do not recognize tumour antigens, and little is known about transcriptional programs of MANA-specific TIL. Read More

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J Pediatr Adolesc Gynecol 2021 Jul 18. Epub 2021 Jul 18.

Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA. Electronic address:

Background: To describe a minimally-invasive, image-guided technique for obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome complicated by tubo-ovarian abscess (TOA).

Case: A 15-year-old female with OHVIRA syndrome presented with TOA. MRI abdomen/pelvis demonstrated a loculated pelvic mass and fluid collection near the obstructed left hemivagina. Read More

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H-scan trajectories indicate the progression of specific diseases.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, 14627-0231, USA.

Purpose: The ability of ultrasound to assess pathology is increasing with the development of quantitative parameters. Among these are a set of parameters derived from the recent H-scan analysis of subresolvable scattering. The emergence of these quantitative measures of tissue/ultrasound interactions now enables a study of the unique trajectories of multiparametric features in multidimensional space, representing the progression of specific diseases over time. Read More

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Food habits of indian crested porcupine (Hystrix indica) (Kerr 1792), in district Bagh, Azad Jammu and Kashmir.

Braz J Biol 2021 14;82:e243063. Epub 2021 Jul 14.

Department of Zoology, University of Azad Jammu and Kashmir Muzaffarabad, AJ&K Pakistan.

The Indian Crested Porcupine (Hystrix indica) is classified as an agricultural pest species. It feeds on plants and crops; hence, it is responsible for massive financial losses worldwide. The current study was conducted to assess the diet composition of Indian Crested Porcupine in District Bagh, Azad Jammu and Kashmir (AJ&K). Read More

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Addressing Population Health Care Transitions by Utilizing Swing Bed Post-Acute Care.

J Am Med Dir Assoc 2021 Mar 24;22(3):B11. Epub 2021 Feb 24.

Ste Genevieve County Memorial Hospital.

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A New Contact Killing Toxin Permeabilizes Cells and Belongs to a Broadly Distributed Protein Family.

mSphere 2021 Jul 21:e0031821. Epub 2021 Jul 21.

School of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.

Vibrio cholerae is an aquatic Gram-negative bacterium that causes severe diarrheal cholera disease when ingested by humans. To eliminate competitor cells in both the external environment and inside hosts, V. cholerae uses the type VI secretion system (T6SS). Read More

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Evaluation of the intervertebral disk, vertebral body, and spinal cord for changes secondary to percutaneous laser disk ablation.

Vet Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Biomedical Sciences, Rocky Vista University, Parker, Colorado, USA.

Objective: To evaluate the intervertebral disk, vertebral endplates, and spinal cord for perioperative changes secondary to percutaneous laser disk ablation (PLDA) and correlate findings to clinical outcomes in dogs receiving thoracolumbar PLDA.

Study Design: Blinded study.

Animals: Thirty dogs. Read More

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Reporting guideline for interventional trials of primary and incisional ventral hernia repair.

Br J Surg 2021 Jul 21. Epub 2021 Jul 21.

Centre for Medical Imaging, University College London, London, UK.

Background: Primary and incisional ventral hernia trials collect unstandardized inconsistent data, limiting data interpretation and comparison. This study aimed to create two minimum data sets for primary and incisional ventral hernia interventional trials to standardize data collection and improve trial comparison. To support these data sets, standardized patient-reported outcome measures and trial methodology criteria were created. Read More

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College-Based Transition Services' Impact on Self-Determination for Youth With Intellectual and Developmental Disabilities.

Intellect Dev Disabil 2021 Aug;59(4):269-282

Meg Grigal and Maria Paiewonsky, Institute for Community Inclusion, University of Massachusetts Boston.

Most youth in transition services with labels of intellectual and developmental disabilities (IDD) have poorer employment outcomes than their peers with other or without disabilities. One alternative approach to address this challenge provides youth with IDD access to transition services in the context of a college or university campus. College-based transition services (CBTS) provide students with IDD access to college courses, internships, and employment during their final 2 to 3 years of secondary education. Read More

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Characterization and dose-mapping of an X-ray blood irradiator to assess application potential for the sterile insect technique (SIT).

Appl Radiat Isot 2021 Jul 10;176:109859. Epub 2021 Jul 10.

Joint FAO / IAEA Centre of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna International Centre, PO Box 100, 1400 Vienna, Austria. Electronic address:

Self-contained gamma irradiators have been extensively used to reproductively sterilize insects for the sterile insect technique (SIT). More recently, the use of X-ray generators has gained attention due to the reduced investment, logistic, regulatory and safety requirements involved in the procurement, transport and operation of these machines compared with gamma irradiators. In this study, we evaluated a commercially available, "off-the-shelf" X-ray blood irradiator and found it suitable for insect irradiation in the frame of the SIT. Read More

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The Future Nephrology Workforce: There Will Be One.

Clin J Am Soc Nephrol 2021 Jul 19. Epub 2021 Jul 19.

S Sozio, Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.

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Assessing the impact of HIV support groups on antiretroviral therapy adherence and viral suppression in the African cohort study.

BMC Infect Dis 2021 Jul 20;21(1):694. Epub 2021 Jul 20.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Background: Support groups for people living with HIV (PLWH) may improve HIV care adherence and outcomes. We assessed the impact of support group attendance on antiretroviral therapy (ART) adherence and viral suppression in four African countries.

Methods: The ongoing African Cohort Study (AFRICOS) enrolls participants at 12 clinics in Kenya, Uganda, Tanzania, and Nigeria. Read More

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Efficiency of Prolonged Prone Positioning for Mechanically Ventilated Patients Infected with COVID-19.

J Clin Med 2021 Jul 1;10(13). Epub 2021 Jul 1.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Hypoxemia of the acute respiratory distress syndrome can be reduced by turning patients prone. Prone positioning (PP) is labor intensive, risks unplanned tracheal extubation, and can result in facial tissue injury. We retrospectively examined prolonged, repeated, and early versus later PP for 20 patients with COVID-19 respiratory failure. Read More

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Retrospective Review of Multitarget Stool DNA as a Screening Test for Colorectal Cancer.

Am Surg 2021 Jul 18:31348211031844. Epub 2021 Jul 18.

1745Brookwood Baptist Health Systems, Birmingham, AL, USA.

Objectives: To review the effectiveness of noninvasive multitarget stool DNA testing as a screening test for colorectal cancer.

Methods: We performed a retrospective review of patients referred to 2 high volume outpatient procedural centers for colonoscopy for positive Cologuard test. Positive findings for colorectal cancer based on pathologic findings and also advanced adenomas were recorded. Read More

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Long-term exposure to air pollution and liver cancer incidence in six European cohorts.

Int J Cancer 2021 Jul 18. Epub 2021 Jul 18.

Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adult cohorts which were recruited between 1985 and 2005, pooled within the 'Effects of low-level air pollution: A study in Europe' (ELAPSE) project, and followed for the incidence of liver cancer until 2011 to 2015. The annual average exposure to nitrogen dioxide (NO ), particulate matter with diameter < 2. Read More

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Genetic mapping and phenotypic analysis of in .

MicroPubl Biol 2021 13;2021. Epub 2021 Jul 13.

Illinois State University, Normal, IL USA.

Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in identified growth control phenotypes in the developing eye. One mutant line from this screen, , was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. Read More

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Photonic Curing of Solution-Processed Oxide Semiconductors with Efficient Gate Absorbers and Minimal Substrate Heating for High-Performance Thin-Film Transistors.

ACS Omega 2021 Jul 25;6(27):17323-17334. Epub 2021 Jun 25.

Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities, 4-174 Keller Hall, 200 Union Street Southeast, Minneapolis, Minnesota 55455, United States.

In this study, photonic curing is used to rapidly and effectively convert metal-oxide sol-gels to realize high-quality thin-film transistors (TFTs). Photonic curing offers advantages over conventional thermal processing methods such as ultrashort processing time and compatibility with low-temperature substrates. However, previous work on photonically cured TFTs often results in significant heating of the entire substrate rather than just the thin film at the surface. Read More

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Rapid and robust cysteine bioconjugation with vinylheteroarenes.

Chem Sci 2021 Jul 7;12(26):9060-9068. Epub 2021 Jun 7.

Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK

Methods for residue-selective and stable modification of canonical amino acids enable the installation of distinct functionality which can aid in the interrogation of biological processes or the generation of new therapeutic modalities. Herein, we report an extensive investigation of reactivity and stability profiles for a series of vinylheteroarene motifs. Studies on small molecule and protein substrates identified an optimum vinylheteroarene scaffold for selective cysteine modification. Read More

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Barriers and Motivators to Opioid Treatment Among Suburban Women Who Are Pregnant and Mothers in Caregiver Roles.

Front Psychol 2021 1;12:688429. Epub 2021 Jul 1.

Department of Sociology, Bentley University, Waltham, MA, United States.

Women of childbearing age who misuse opioids are a particularly vulnerable population, and their barriers to treatment are unique because of their caregiver roles. Research on treatment for opioid use generally draws from urban and rural areas. This study fills a gap in research that focuses on barriers and motivators to opioid treatment in suburban areas. Read More

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Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture.

ACS Biomater Sci Eng 2021 Jul 25;7(7):2864-2879. Epub 2020 Jun 25.

Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, 30332, United States of America.

Advances in microscale 3D cell culture systems have helped to elucidate cellular physiology, understand mechanisms of stem cell differentiation, produce pathophysiological models, and reveal important cell-cell and cell-matrix interactions. An important consideration for such studies is the choice of material for encapsulating cells and associated extracellular matrix (ECM). This Review focuses on the use of alginate hydrogels, which are versatile owing to their simple gelation process following an ionic cross-linking mechanism in situ, with no need for procedures that can be potentially toxic to cells, such as heating, the use of solvents, and UV exposure. Read More

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Oncologic outcomes of endometrial cancer in patients with low-volume metastasis in the sentinel lymph nodes: An international multi-institutional study.

Gynecol Oncol 2021 Jul 14. Epub 2021 Jul 14.

Turkish Society of Gynecologic Oncology, Istanbul, Turkey; Department of Gynecologic Oncology, Koc University School of Medicine, Istanbul, Turkey.

Objective: To assess oncologic outcomes in endometrial cancer patients with low-volume metastasis (LVM) in the sentinel lymph nodes (SLNs).

Methods: Patients with endometrial cancer and SLN-LVM (≤2 mm) from December 3, 2009, to December 31, 2018, were retrospectively identified from 22 centers worldwide. Patients with International Federation of Gynecology and Obstetrics (FIGO) stage IV, adnexal involvement, or unknown adjuvant therapy (ATx) were excluded. Read More

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Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020.

Semin Arthritis Rheum 2021 Jul 8. Epub 2021 Jul 8.

Division of Rheumatology, Department of Medicine, and Division of Clinical Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, United States.

Objective: The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group aims to develop composite response criteria for ANCA-Associated Vasculitis (AAV).

Methods: The project follows the OMERACT approach for composite measures: (i) choose relevant domains; (ii) define high-quality instruments; (iii) decide on a scoring system approach; (iv) put through the OMERACT Filter 2.1 for validation. Read More

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Gender Analysis of Publishing Among Medical Students in Dermatology.

J Am Acad Dermatol 2021 Jul 14. Epub 2021 Jul 14.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO. Electronic address:

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Wireless Soft Scalp Electronics and Virtual Reality System for Motor Imagery-Based Brain-Machine Interfaces.

Adv Sci (Weinh) 2021 Jul 17:e2101129. Epub 2021 Jul 17.

George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Motor imagery offers an excellent opportunity as a stimulus-free paradigm for brain-machine interfaces. Conventional electroencephalography (EEG) for motor imagery requires a hair cap with multiple wired electrodes and messy gels, causing motion artifacts. Here, a wireless scalp electronic system with virtual reality for real-time, continuous classification of motor imagery brain signals is introduced. Read More

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