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Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS-SPORE registry.

Transpl Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Nephrology, Clermont-Ferrand University Hospital, 3iHP, Clermont-Ferrand, France.

Introduction: Microsporidiosis is an emerging opportunistic infection in renal transplantation (RT) recipients. We aimed to describe its clinical presentation and treatment.

Materials And Methods: We collected microsporidiosis cases identified in RT recipients between 2005 and 2019 in six French centers from the Crystal, Divat and Astre prospective databases. Read More

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Negative regulation of melatonin secretion by melatonin receptors in ovine pinealocytes.

PLoS One 2021 29;16(7):e0255249. Epub 2021 Jul 29.

Physiologie de la Reproduction et des Comportements, Université de Tours, Nouzilly, France.

Melatonin (MLT) is a biological modulator of circadian and seasonal rhythms and reproduction. The photoperiodic information is detected by retinal photoreceptors and transmitted through nerve transmissions to the pineal gland, where MLT is synthesized and secreted at night into the blood. MLT interacts with two G protein-coupled receptors, MT1 and MT2. Read More

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Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes.

PLoS Biol 2021 Jul 29;19(7):e3001309. Epub 2021 Jul 29.

Université de Paris, CNRS, Institut Jacques Monod, Paris, France.

Ciliates are unicellular eukaryotes with both a germline genome and a somatic genome in the same cytoplasm. The somatic macronucleus (MAC), responsible for gene expression, is not sexually transmitted but develops from a copy of the germline micronucleus (MIC) at each sexual generation. In the MIC genome of Paramecium tetraurelia, genes are interrupted by tens of thousands of unique intervening sequences called internal eliminated sequences (IESs), which have to be precisely excised during the development of the new MAC to restore functional genes. Read More

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Emergence of Coupled Rotor Dynamics in Metal-Organic Frameworks via Tuned Steric Interactions.

J Am Chem Soc 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The Netherlands.

The organic components in metal-organic frameworks (MOFs) are unique: they are embedded in a crystalline lattice, yet, as they are separated from each other by tunable free space, a large variety of dynamic behavior can emerge. These rotational dynamics of the organic linkers are especially important due to their influence over properties such as gas adsorption and kinetics of guest release. To fully exploit linker rotation, such as in the form of molecular machines, it is necessary to engineer correlated linker dynamics to achieve their cooperative functional motion. Read More

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BEAUTY and the breast: is adjuvant chemotherapy the right time for a beauty boost? Lessons learned from a large randomized controlled trial.

Qual Life Res 2021 Jul 29. Epub 2021 Jul 29.

Social Sciences Research Unit, Gustave Roussy, Villejuif, France.

Purpose: Beauty care (BTC) is offered at many cancer hospitals having a great uptake among patients. Nevertheless, its benefits in the Quality of life (QoL) of cancer survivors have not been assessed so far.

Methods: Our study aims to determine whether BTC improves patients' QoL related to their body image measured by the BRBI scale of the QLQ-BR23 questionnaire at the end of adjuvant chemotherapy, after breast cancer (BC) surgery. Read More

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Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study.

Ann Intensive Care 2021 Jul 29;11(1):117. Epub 2021 Jul 29.

Unité de Santé Publique, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique, Hopital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 75012, Paris, France.

Purpose: At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.

Materials, Patients And Methods: We aimed at assessing the relevance of the Assistance Publique-Hôpitaux de Paris (AP-HP) clinical data warehouse for estimating the burden of the influenza epidemic on medical adult critical care units of the AP-HP, and outcome of patients during the flu season 2017-2018. This exploratory multi-site epidemiological study comprised all consecutive adult stays (n = 320) in 18 medical intensive care units (ICU) or intermediate care wards (ICW) for probable or confirmed Influenza virus infection during the 2017-2018 flu season. Read More

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Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature - The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11).

Cardiol Young 2021 Jul;31(7):1057-1188

Congenital Heart Surgery, Birmingham Women's and Children's Foundation Trust Hospital, University of Birmingham, Birmingham, UK.

Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The International Paediatric and Congenital Cardiac Code (IPCCC) is now utilized worldwide and has most recently become the paediatric and congenital cardiac component of the Eleventh Revision of the International Classification of Diseases (ICD-11). Read More

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Detection of deuterated methylcyanoacetylene, CHDCN, in TMC-1.

Astron Astrophys 2021 Jun 21;650. Epub 2021 Jun 21.

Grupo de Astrofísica Molecular, Instituto de Física Fundamental (IFF-CSIC), C/ Serrano 121, 28006 Madrid, Spain.

We report the first detection in space of the single deuterated isotopologue of methylcyanoacetylene, CHDCN. A total of fifteen rotational transitions, with = 8-12 and = 0 and 1, were identified for this species in TMC-1 in the 31.0-50. Read More

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How do clinical and socioeconomic factors impact on work disability in early axial spondyloarthritis? Five-year data from the DESIR cohort.

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Objectives: To investigate the impact of clinical and socioeconomic factors on work disability (WD) in early axial spondyloarthritis (axSpA).

Methods: Patients from the DESIR cohort with a clinical diagnosis of axSpA were studied over 5 years. Time to WD and potential baseline and time-varying predictors were explored, with a focus on socioeconomic (including ethnicity, education, job-type, marital/parental status) and clinical (including disease activity, function, mobility) factors. Read More

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Identification of molds with MALDI-TOF mass spectrometry: performance of the newly developed MSI-2 application in comparison with the Bruker filamentous fungi database and MSI-1.

J Clin Microbiol 2021 Jul 28:JCM0129921. Epub 2021 Jul 28.

AP-HP, Groupe Hospitalier La Pitié-Salpêtrière, Service de Parasitologie Mycologie, F-75013 Paris, France.

Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) represents a promising tool for the rapid and efficient identification of molds, but improvements are still necessary to achieve satisfactory results when identifying cryptic species. Here, we aimed to validate a new web application, MSI-2, which replaces MSI-1, an application that was built and deployed online in 2017. For the evaluation, we gathered 633 challenging isolates obtained from daily hospital practice that were first identified with DNA-based methods, and we submitted their corresponding mass spectra to three identification programs (Bruker, MSI-1 and MSI-2). Read More

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Evaluation of Physiological Parameters on Discomfort Glare Thresholds Using LUMIZ 100 Tool.

Transl Vis Sci Technol 2021 Jul;10(8):28

Department of Optics and Optometry and Vision Sciences, University of Valencia, Burjassot, Spain.

Purpose: To assess the links between discomfort glare sensitivity and physiological factors such as eye biometry, refraction, skin phototype, age, and gender among a large sample of healthy human subjects.

Methods: A total of 489 participants who were 20 to 70 years old (241 men, 248 women) underwent discomfort glare threshold measurements via the LUMIZ 100. Eye biometry and optical quality were measured using a Zeiss IOLMaster 700 biometer and i. Read More

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Twenty-One for 2021: The Most Influential Papers in Laryngology Since 2000.

Laryngoscope 2021 Jul 28. Epub 2021 Jul 28.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.

Objectives/hypothesis: To identify the most influential publications in laryngology since 2000.

Study Design: Modified Delphi process.

Methods: Samples of laryngologists drawn from editors of leading journals, organization officers, and thought leaders were invited to participate in a modified Delphi identification of influential laryngology papers. Read More

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Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula.

Pediatr Gastroenterol Hepatol Nutr 2021 Jul 5;24(4):392-402. Epub 2021 Jul 5.

Children's Hospital Zhejiang, University School of Medicine, Hangzhou, China.

Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA).

Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Read More

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Ileocecal Valve Sparing Resection for the Treatment of Benign Cecal Polyps Unsuitable for Polypectomy.

JSLS 2021 Apr-Jun;25(2)

Service de Chirurgie Digestive et Oncologique, Hôpital Ambroise Paré, 92104 Boulogne-Billancourt, France.

Background: Not all benign-appearance polyps are amenable to endoscopic removal and colectomy is required in some cases. This study aims to compare the early outcomes of cecal wedge resection with ileocecal valve sparring versus standard right colectomy in patients with endoscopically unresectable cecal polyps referred for surgery.

Methods: From Apr 2010 to Aug 2019, all consecutive patients who underwent cecal wedge resection or right colectomy in ten European centers for a presumed endoscopically benign polyp unsuitable for endoscopic resection were retrospectively analyzed. Read More

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Socio-emotional and motor engagement during musical activities in older adults with major neurocognitive impairment.

Sci Rep 2021 Jul 27;11(1):15291. Epub 2021 Jul 27.

Université de Lille, ULR 4072 - PSITEC - Psychologie: Interactions, Temps, Emotions, Cognition, 59000, Lille, France.

Although music therapy may engender clinical benefits in patients with neurodegenerative disease, the impacts of social and musical factors of such activities on socio-emotional and motor engagements are poorly understood. To address this issue, non-verbal behaviors of 97 patients with or without major cognitive impairment (CI) were assessed when listening to music or a metronome in front of a musician who was present physically (live) or virtually (video). Socio-emotional engagement was quantified as emotional facial expression production and gaze direction. Read More

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IVF impact on the risk of recurrence of endometrial adenocarcinoma after fertility-sparing management.

Reprod Biomed Online 2021 Jun 16. Epub 2021 Jun 16.

AP-HP, Department of Obstetrics and Gynecology, Hôpital Bichat-Claude Bernard, Paris, France; Université de Paris, Paris, France; Groupe PREFERE (Préservation de la fertilité et cancer de l'endomètre) Hôpital Bichat-Claude Bernard, Paris, France.

Research Question: Do IVF treatments after conservative management of endometrial atypical hyperplasia or grade 1 endometrial adenocarcinoma (AH/EC) increase the risk of disease recurrence?

Design: This is a prospective cohort study from a national registry from January 2008 to July 2019. Sixty patients had an AH/EC and received progestin treatment using chlormadinone acetate for at least 3 months. After remission, 31 patients underwent IVF and 29 did not. Read More

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[Muscle Relaxant And Reversal Practices And Impact Of Reversal Modalities On Operating Room And Postoperative Room Duration - Results Of A Delphi Study].

Ann Pharm Fr 2021 Jul 24. Epub 2021 Jul 24.

Department of Anesthesia, Hospital Paris Saint Joseph, 185 Rue Raymond Losserand, 75014 Paris, France.

Objective: The objectives of this Delphi study are to describe muscle relaxant and reversal practices in France and to seek a consensus on the impact of the reversal method on the time spent in the OR and PACU.

Method: A two-round Delphi survey was conducted on a panel of French anesthetists involved in colectomies, hysterectomies or bariatric surgery. The questionnaire was designed in collaboration with a scientific committee and was intended to assess neuromuscular blockade reversal techniques and their impact on time spent in the OR and PACU. Read More

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Pharmacokinetics of intravenous paracetamol (acetaminophen) and ductus arteriosus closure after premature birth.

Clin Pharmacol Ther 2021 Jul 27. Epub 2021 Jul 27.

PEDEGO Research Unit and MRC Oulu, University of Oulu, Oulu, Finland.

In preterm infants, a high risk of hemodynamically significant patent ductus arteriosus (PDA) exists and its persistence is associated with an increased risk of severe morbidity. Current pharmacological options include ibuprofen or indomethacin. However, treatment by indomethacin or ibuprofen of a large PDA was shown to reduce early pulmonary hemorrhage and later medical treatment but had no effect on neonatal death or morbidity. Read More

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A comparison of children's diet and movement behaviour patterns derived from three unsupervised multivariate methods.

PLoS One 2021 27;16(7):e0255203. Epub 2021 Jul 27.

Institute of Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.

Background: Behavioural patterns are typically derived using unsupervised multivariate methods such as principal component analysis (PCA), latent profile analysis (LPA) and cluster analysis (CA). Comparability and congruence between the patterns derived from these methods has not been previously investigated, thus it's unclear whether patterns from studies using different methods are directly comparable. This study aimed to compare behavioural patterns derived across diet, physical activity, sedentary behaviour and sleep domains, using PCA, LPA and CA in a single dataset. Read More

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Sleeping through a pandemic: impact of COVID-19 related restrictions on narcolepsy and idiopathic hypersomnia.

J Clin Sleep Med 2021 Jul 27. Epub 2021 Jul 27.

Sleep Disorders Unit, University Hospital Pitié-Salpêtrière, APHP-Sorbonne, Paris, France.

Study Objectives: To assess the impact of COVID-19 related restrictions on narcolepsy type 1 (NT2), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).

Methods: Participants with NT1, NT2 and IH followed in a university hospital completed an online 78-question survey assessing demographic, clinical and occupational features of the population during the first COVID-19 related lockdown.

Results: The 219 /851 (25. Read More

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Single Port Donor Nephrectomy Via Modified Pfannenstiel Incision: Initial Preclinical Experience in A Cadaveric Model and Description of Technique.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Cleveland Clinic Foundation, Glickman Urologic Institute, 9500 Euclid Ave, Cleveland, Ohio, United States, 44195;

Objective: To describe the surgical technique for the single port (SP) transperitoneal donor nephrectomy through a modified Pfannenstiel incision using the da Vinci SP surgical system (Intuitive Surgical, Sunnyvale, CA, USA) on a cadaver.

Patients & Methods: In a male cadaver, the SP surgical system was used to perform transperitoneal donor nephrectomy. A 3 cm modified Pfannenstiel incision was made. Read More

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The impact of lasers in percutaneous nephrolithotomy outcomes: results from a systematic review and meta-analysis of randomized comparative trials.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Ng Teng Fong General Hospital, 242949, Urology, Singapore, Singapore;

Background Percutaneous nephrolithotomy (PCNL) is the first choice treatment of renal stones larger than 2 cm. We aimed to evaluate if lasers perform as equal as non-laser devices in patients with kidney stones candidate to PCNL. Materials and methods A comprehensive literature search was performed in MEDLINE via PubMed, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) to assess the differences in the perioperative course, incidence of postoperative complications, and stone free-rate (SFR) in patients with kidney stones undergoing laser versus non-laser PCNL in randomized studies. Read More

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Metabolic syndrome is not associated to an increased risk of low bone mineral density in men at risk for osteoporosis.

J Endocrinol Invest 2021 Jul 27. Epub 2021 Jul 27.

Department of Clinical Medicine and Surgery, Federico II University, 80131, Naples, Italy.

Purpose: We have recently demonstrated a significant association between osteoporosis (Op) and metabolic syndrome (MetS) in Caucasian women examined by Dual-energy X-ray absorptiometry (DXA) for suspected Op. This cross-sectional study was performed to evaluate the association between MetS and Op in Caucasian men enrolled in the same geographical area, with identical criteria and in the same time range.

Methods: Among subjects enrolled in the SIMON study, we selected the medical records of all free-living men who performed a contextual evaluation of both bone mineral density (BMD) by DXA and MetS constitutive elements (arterial blood pressure, waist circumference, serum levels of triglycerides, high-density lipoprotein cholesterol, and fasting glucose). Read More

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Percutaneous venopulmonary artery extracorporeal membrane oxygenation for right heart failure after left ventricular assist device insertion.

Interact Cardiovasc Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Hôpital Européen Georges Pompidou, Département de Chirurgie Cardio-vasculaire, Assistance Publique Hôpitaux de Paris, Paris, France.

Objectives: Right ventricular failure after left ventricular assist device (LVAD) insertion is associated with significant mortality and morbidity. Mechanical support options include right ventricular assist devices, venoarterial extracorporeal membrane oxygenation (ECMO) and venopulmonary artery ECMO, the latter often involving central cannulation. We sought to evaluate the feasibility and early outcomes of a truly percutaneous venopulmonary artery (pVPA) ECMO strategy, with the potential advantage of bedside removal once weaned. Read More

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Atrio-oesophageal fistula following atrial fibrillation ablation: how to manage this dreaded complication?

Interact Cardiovasc Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital,Department of Cardiac Surgery, Paris, France.

Objectives: Atrio-oesophageal fistula is a rare but serious complication of radiofrequency catheter ablation of atrial fibrillation. Therapeutic options are surgery, oesophageal stenting and conservative treatment (antibiotics and anticoagulation). However, there are no guidelines available. Read More

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Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.

Nat Immunol 2021 Aug 26;22(8):1030-1041. Epub 2021 Jul 26.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8 T cells in human hepatitis C virus (HCV) infection before and after treatment. Read More

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Epidemic mitigation by statistical inference from contact tracing data.

Proc Natl Acad Sci U S A 2021 08;118(32)

Statistical Physics of Computation Laboratory, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

Contact tracing is an essential tool to mitigate the impact of a pandemic, such as the COVID-19 pandemic. In order to achieve efficient and scalable contact tracing in real time, digital devices can play an important role. While a lot of attention has been paid to analyzing the privacy and ethical risks of the associated mobile applications, so far much less research has been devoted to optimizing their performance and assessing their impact on the mitigation of the epidemic. Read More

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Remarks on the analysis of steady-state responses: Spurious artifacts introduced by overlapping epochs.

Cortex 2021 Jul 7. Epub 2021 Jul 7.

Cognitive Neuroimaging Unit, CNRS ERL 9003, INSERM U992, CEA, Université Paris-Saclay, NeuroSpin Center, Gif/Yvette, France. Electronic address:

Periodic and stable sensory input can result in rhythmic and stable neural responses, a phenomenon commonly referred to as neural entrainment. Although the use of neural entrainment to investigate the regularities the brain tracks has increased in recent years, the methods used for its quantification are not well-defined in the literature. Here we argue that some strategies used in previous papers, are inadequate for the study of steady-state response, and lead to methodological artefacts. Read More

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STRONG: metagenomics strain resolution on assembly graphs.

Genome Biol 2021 Jul 26;22(1):214. Epub 2021 Jul 26.

The iThree institute, University of Technology Sydney, 15 Broadway, Ultimo, 2007, NSW, Australia.

We introduce STrain Resolution ON assembly Graphs (STRONG), which identifies strains de novo, from multiple metagenome samples. STRONG performs coassembly, and binning into metagenome assembled genomes (MAGs), and stores the coassembly graph prior to variant simplification. This enables the subgraphs and their unitig per-sample coverages, for individual single-copy core genes (SCGs) in each MAG, to be extracted. Read More

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Frequency and Risk Factors of Severe Postoperative Bleeding After Proctological Surgery: A Retrospective Case-Control Study.

Ann Coloproctol 2021 Jul 27. Epub 2021 Jul 27.

Proctologic Surgery, Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France.

Purpose: The aim of this study was to assess frequency and risk factors of severe bleeding after proctological surgery requiring hemostatic surgery observed after publication of the French guidelines for anticoagulant and platelet-inhibitor treatment.

Methods: All patients who underwent proctological surgery between January 2012 and March 2017 in a referral center were included. Delay, severity of bleeding, and need for blood transfusion were recorded. Read More

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