6,160 results match your criteria parasite remains


Diagnosing Strongylus vulgaris in pooled fecal samples.

Vet Parasitol 2021 Jun 8;296:109494. Epub 2021 Jun 8.

Texas Tech University, School of Veterinary Medicine, Amarillo, TX, USA.

Strongylus vulgaris is the most pathogenic intestinal helminth parasite infecting horses. The migrating larvae in the mesenteric blood vessels can cause non-strangulating intestinal infarctions, which have a guarded prognosis for survival. Infections are typically diagnosed by coproculture, but a PCR test is available in some countries. Read More

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A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei.

mBio 2021 Jun 15:e0068721. Epub 2021 Jun 15.

York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom.

During mitosis, eukaryotic cells must duplicate and separate their chromosomes in a precise and timely manner. The apparatus responsible for this is the kinetochore, which is a large protein structure that links chromosomal DNA and spindle microtubules to facilitate chromosome alignment and segregation. The proteins that comprise the kinetochore in the protozoan parasite Trypanosoma brucei are divergent from yeast and mammals and comprise an inner kinetochore complex composed of 24 distinct proteins (KKT1 to KKT23, KKT25) that include four protein kinases, CLK1 (KKT10), CLK2 (KKT19), KKT2, and KKT3. Read More

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Status of Intestinal Helminth Infection in Schools Implementing the Home-Grown School Feeding Program and the Impact of the Program on Pupils in Anambra State, Nigeria.

Acta Parasitol 2021 Jun 14. Epub 2021 Jun 14.

Virology Department, College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Purpose: Intestinal helminthiasis among pupils is a major impediment to their well-being and development. This 2-year study determined how home-grown school feeding programme (HGSFP) impacted on pupils' school attendance and created opportunity for more children to assess interventions geared towards the prevention and possible elimination of intestinal helminthiasis.

Methods: Faecal samples were collected from 1677 consented pupils and examined for helminths using Kato-Katz technique. Read More

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Intensity and clinical morbidities of tungiasis in an impoverished south-west Nigerian community.

Parasite Epidemiol Control 2021 Aug 27;14:e00215. Epub 2021 May 27.

Department of Zoology, University of Ibadan, Ibadan, Nigeria.

Sand fleas infestation, , remains a neglected tropical disease of public-health concern in many countries. Tungiasis can lead to destruction of the feet causing serious discomfort and deformities. This study aim was to determine the intensity rate and clinical morbidities of tungiasis among the people living in Igbokoda, Ondo State, Nigeria. Read More

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Mechanisms of triggering malaria gametocytogenesis by AP2-G.

Parasitol Int 2021 Jun 11;84:102403. Epub 2021 Jun 11.

Department of Medical Zoology, Mie University School of Medicine, Mie, Tsu 514-8507, Japan.

The transcription factor (TF) AP2-G is essential for gametocytogenesis in the malaria parasite; however, it remains unclear if AP2-G determines commitment to sexual stage development fate in the schizont stage, or whether AP2-G directly initiates sexual stage differentiation and development beginning in the late-trophozoite stage. In this study, we addressed this issue by investigating the expression profile of AP2-G and determining genome-wide target genes in Plasmodium berghei. Fluorescence microscopy showed that AP2-G expression was first observed in the parasite 12 h after erythrocyte invasion and peaked at 18 h when sexual features were first manifested in early gametocytes. Read More

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Epidemiology and clinical features of intestinal protozoan infections detected by Real-time PCR in non-native children within an Italian tertiary care children's hospital: A cross-sectional study.

Travel Med Infect Dis 2021 Jun 9;43:102107. Epub 2021 Jun 9.

Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy; Department of Health Sciences, University of Florence, Italy. Electronic address:

Background: Enteric parasite infections are underestimated due to the limited sensitivity and specificity of microscopy, which remains the diagnostic gold standard in routine clinical practice. This could be a major problem in high-income countries, where the burden of parasitic diseases is low. In recent years, Multiplex Real-Time polymerase chain reaction (RT-PCR) based methods have been implemented. Read More

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Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis.

Front Immunol 2021 25;12:663041. Epub 2021 May 25.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people. The anthelmintic drug, praziquantel, is the mainstay treatment option, although its molecular mechanism of action remains poorly defined. Praziquantel treatment damages the outermost surface of the parasite, the tegument, liberating surface antigens from dying worms that invoke a robust immune response which in some subjects results in immunologic resistance to reinfection. Read More

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Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia.

Sci Rep 2021 Jun 10;11(1):12306. Epub 2021 Jun 10.

Department of Tropical Medicine, School of Public Health and Tropical Medicine, and Vector-Borne and Infectious Disease Research Center, Tulane University, 1440 Canal St., New Orleans, LA, 70112, USA.

Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and analyzed for blood feeding sources, parasite diversity and gut microbiota composition through a metagenomic and deep sequencing approach. Read More

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4-Chlorophenylthioacetone-derived thiosemicarbazones as potent antitrypanosomal drug candidates: Investigations on the mode of action.

Bioorg Chem 2021 May 25;113:105018. Epub 2021 May 25.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil; Faculdade de Medicina, Programa em Ciências da Saúde: Infectologia e Medicina Tropical, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Chagas disease (ChD), caused by Trypanosoma cruzi, remains a challenge for the medical and scientific fields due to the inefficiency of the therapeutic approaches available for its treatment. Thiosemicarbazones and hydrazones present a wide spectrum of bioactivities and are considered a platform for the design of new anti-T. cruzi drug candidates. Read More

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Pathological lesions of the digestive tract in free-ranging mountain gorillas (Gorilla beringei beringei).

Am J Primatol 2021 Jun 7:e23290. Epub 2021 Jun 7.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

The finding of parasites and bacterial pathogens in mountain gorilla feces and oral lesions in gorilla skeletal remains has not been linked to pathological evidence of morbidity or mortality. In the current study, we conducted a retrospective study of digestive tracts including oral cavity, salivary glands, esophagus, stomach, intestines (gastrointestinal tract [GI]), liver, and pancreas of 60 free-ranging mountain gorillas from Uganda, Rwanda, and the Democratic Republic of Congo that died between 1985 and 2007. We reviewed clinical histories and gross pathology reports and examined histological sections. Read More

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The role of HPV-induced epigenetic changes in cervical carcinogenesis (Review).

Biomed Rep 2021 Jul 20;15(1):60. Epub 2021 May 20.

Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.

Cervical cancer is associated with infection by certain types of human papillomaviruses (HPVs), and this affects women worldwide. Despite the improvements in prevention and cure of HPV-induced cervical cancer, it remains the second most common type of cancer in women in the least developed regions of the world. Epigenetic modifications are stable long-term changes that occur in the DNA, and are part of a natural evolutionary process of necessary adaptations to the environment. Read More

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A Profound Membrane Reorganization Defines Susceptibility of Infected Red Blood Cells to Lysis by Granulysin and Perforin.

Front Immunol 2021 19;12:643746. Epub 2021 May 19.

Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and metabolic requirements. Read More

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Molecular characterization of Trypanosoma vivax in tsetse flies confirms the presence of the virulent Tvv4 genotype in Kenya: Potential implications for the control of trypanosomiasis in Shimba Hills.

Infect Genet Evol 2021 Jun 4;93:104953. Epub 2021 Jun 4.

International Centre of Insect Physiology and Ecology, P. O. Box 30772-00100, Nairobi, Kenya.

Trypanosoma vivax is a vector-borne protozoan parasite of livestock endemic to Africa and South America. To date, fifteen genotypes of the parasite have been described in vertebrate and insect hosts in East Africa. However, information regarding T. Read More

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Transcriptome analysis provides insights into copper toxicology in piebald naked carp (Gymnocypris eckloni).

BMC Genomics 2021 Jun 5;22(1):416. Epub 2021 Jun 5.

College of Eco-Environmental Engineering, Qinghai University, Xining, 810016, China.

Background: Copper was used for many years in aquaculture operations as an effective algaecide or a parasite treatment of fish. It is an essential nutrient with numerous functions in organisms, but is toxic at high concentrations. However, the toxicity of copper to fish remains unclear. Read More

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Chronic Toxoplasma gondii infection and sleep-wake alterations in mice.

CNS Neurosci Ther 2021 Jun 4. Epub 2021 Jun 4.

Institut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

Aim: Toxoplasma gondii (Tg) is an intracellular parasite infecting more than a third of the human population. Yet, the impact of Tg infection on sleep, a highly sensitive index of brain functions, remains unknown. We designed an experimental mouse model of chronic Tg infection to assess the effects on sleep-wake states. Read More

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Neutrophils vs. amoebas: Immunity against the protozoan parasite Entamoeba histolytica.

Authors:
Carlos Rosales

J Leukoc Biol 2021 Jun 4. Epub 2021 Jun 4.

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Entamoeba histolytica is a protozoan parasite with high prevalence in developing countries, and causes amoebiasis. This disease affects the intestine and the liver, and is the third leading cause of human deaths among parasite infections. E. Read More

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Molecular identification of and in long-tailed macaques () in Lopburi, Thailand.

Vet World 2021 Apr 13;14(4):884-888. Epub 2021 Apr 13.

Department of Veterinary Technology, Faculty of Veterinary Technology, Kasetsart University, Bangkok, Thailand.

Background And Aim: and are helminthic intestinal parasites that infect humans and other animals, including non-human primates. However, molecular detection of these parasites remains scarce in long-tailed macaques (), which coexist with human communities in Thailand. Thus, this study aimed to molecularly confirm the occurrence of spp. Read More

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Host-multiparasite interactions in amphibians: a review.

Parasit Vectors 2021 Jun 3;14(1):296. Epub 2021 Jun 3.

Lendület Evolutionary Ecology Research Group, Plant Protection Institute, Centre for Agricultural Research, Eötvös Loránd Research Network, Herman Ottó út 15, Budapest, 1022, Hungary.

Parasites, including viruses, bacteria, fungi, protists, helminths, and arthropods, are ubiquitous in the animal kingdom. Consequently, hosts are frequently infected with more than one parasite species simultaneously. The assessment of such co-infections is of fundamental importance for disease ecology, but relevant studies involving non-domesticated animals have remained scarce. Read More

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Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains.

J Cell Biol 2021 Aug 3;220(8). Epub 2021 Jun 3.

Department of Biochemistry, University of Oxford, Oxford, UK.

The kinetochore is the macromolecular protein complex that assembles onto centromeric DNA and binds spindle microtubules. Evolutionarily divergent kinetoplastids have an unconventional set of kinetochore proteins. It remains unknown how kinetochores assemble at centromeres in these organisms. Read More

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Prevalence and risk factors of parasitic diseases among Saudi children: An updated review.

Saudi Med J 2021 Jun;42(6):612-619

From the Department of Biology, Collage of Science, Taif University, Taif, Kingdom of Saudi Arabia.

Intestinal parasite infection (IPI) is a declining global health problem. However, in certain parts of the world, the misconception that certain diseases are avoided owing to the existence of prevention strategies, medication and the frequency of awareness campaigns remains underestimated. Recent studies in Saudi Arabia have reported high prevalence rates for IPI; however, the prevalence in Saudi Arabia varies from city to city and from age group to age group. Read More

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Dietary intake, intestinal infection, and safe drinking water among children with anemia in Peru: a cross-sectional analysis.

BMC Nutr 2021 Jun 3;7(1):11. Epub 2021 Jun 3.

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Background: Anemia is a major public health concern that is present in 41.7% of children under 5 worldwide. The prevalence of anemia in Peru was 43. Read More

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First demonstration of Strongyloides parasite from an imported pet meerkat - Possibly a novel species in the stercoralis/procyonis group.

Parasitol Int 2021 May 30;84:102399. Epub 2021 May 30.

Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, 889-1692 Miyazaki, Japan. Electronic address:

Strongyloides is a genus of parasitic nematodes of vertebrates that contains over 50 species, each with a variable host range. A recent molecular phylogenetic analysis on this genus showed that Strongyloides spp. from various carnivore hosts form a strongly supported clade together with Strongyloides stercoralis, a major pathogen of humans and dogs (named the "stercoralis/procyonis group"). Read More

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Detection and genetic characterisation of Toxoplasma gondii circulating in free-range chickens, pigs and seropositive pregnant women in Benue state, Nigeria.

PLoS Negl Trop Dis 2021 Jun 2;15(6):e0009458. Epub 2021 Jun 2.

Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom.

Toxoplasma gondii parasites present strong but geographically varied signatures of population structure. Populations sampled from Europe and North America have commonly been defined by over-representation of a small number of clonal types, in contrast to greater diversity in South America. The occurrence and extent of genetic diversity in African T. Read More

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Immunoregulatory molecules secreted by .

Parasitology 2021 Jun 2:1-7. Epub 2021 Jun 2.

Lydia Becker Institute for Immunology and Inflammation, ManchesterM13 9PT, UK.

Trichuris, whipworm nematode infections are prevalent in humans, domestic livestock and mammals. All share an epithelial dwelling niche and similar life cycle with the chronic infections that follow implying that immune evasion mechanisms are operating. Nematode excretory secretory (ES) products have been shown to be a rich source of immunomodulatory molecules for many species. Read More

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Ticks, Hair Loss, and Non-Clinging Babies: A Novel Tick-Based Hypothesis for the Evolutionary Divergence of Humans and Chimpanzees.

Authors:
Jeffrey G Brown

Life (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Independent Researcher, Saddle Brook, NJ 07663, USA.

Human straight-legged bipedalism represents one of the earliest events in the evolutionary split between humans ( spp.) and chimpanzees ( spp.), although its selective basis is a mystery. Read More

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The holobiont transcriptome of teneral tsetse fly species of varying vector competence.

BMC Genomics 2021 May 31;22(1):400. Epub 2021 May 31.

Department of Biology, Eberly College of Arts and Sciences, West Virginia University, Morgantown, WV, 26505, USA.

Background: Tsetse flies are the obligate vectors of African trypanosomes, which cause Human and Animal African Trypanosomiasis. Teneral flies (newly eclosed adults) are especially susceptible to parasite establishment and development, yet our understanding of why remains fragmentary. The tsetse gut microbiome is dominated by two Gammaproteobacteria, an essential and ancient mutualist Wigglesworthia glossinidia and a commensal Sodalis glossinidius. Read More

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An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis.

Acta Trop 2021 May 28;221:105988. Epub 2021 May 28.

Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, (4400) Salta, Argentina. Electronic address:

Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of the genus Leishmania. It is a major health problem in many tropical and subtropical regions of the world and can produce three different clinical manifestations, among which cutaneous leishmaniasis has a higher incidence in the world than the other clinical forms. There are no recognized and reliable means of chemoprophylaxis or vaccination against infections with different forms of leishmaniasis. Read More

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DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in .

Front Cell Dev Biol 2021 13;9:633195w. Epub 2021 May 13.

Laboratório de Genética Bioquímica, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

DNA topoisomerases are enzymes that modulate DNA topology. Among them, topoisomerase 3α is engaged in genomic maintenance acting in DNA replication termination, sister chromatid separation, and dissolution of recombination intermediates. To evaluate the role of this enzyme in , the etiologic agent of Chagas disease, a topoisomerase 3α knockout parasite (TcTopo3α KO) was generated, and the parasite growth, as well as its response to several DNA damage agents, were evaluated. Read More

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Cost-effectiveness analysis of the integrated control strategy for schistosomiasis japonica in a lake region of China: a case study.

Infect Dis Poverty 2021 May 28;10(1):79. Epub 2021 May 28.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research On Tropical Diseases, Shanghai, 200025, China.

Background: Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and long-term sequelae. An integrated control strategy implemented in the Peoples' Republic of China has been shown to be effective to control or interrupt the transmission of schistosomiasis. The objective of this study is to estimate the disease burden of schistosomiasis and assess the cost-effectiveness of the integrated control strategy focused on different major interventions at three stages for schistosomiasis control in a lake setting, to provide reference for policy making or planning. Read More

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Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis.

Malar J 2021 May 26;20(1):236. Epub 2021 May 26.

African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria.

Background: Malaria remains a public health burden especially in Nigeria. To develop new malaria control and elimination strategies or refine existing ones, understanding parasite population diversity and transmission patterns is crucial.

Methods: In this study, characterization of the parasite diversity and structure of Plasmodium falciparum isolates from 633 dried blood spot samples in Nigeria was carried out using 12 microsatellite loci of P. Read More

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