1,115 results match your criteria parameters vagina

Relationship of Urethral Dose and Genitourinary Toxicity Among Patients Receiving Vaginal High Dose Rate Interstitial Brachytherapy.

Clin Oncol (R Coll Radiol) 2021 Jun 4. Epub 2021 Jun 4.

University of Toronto, Department of Radiation Oncology, Toronto, Ontario, Canada; Sunnybrook Hospital, Toronto, Ontario, Canada. Electronic address:

Aims: Interstitial brachytherapy (ISBT) plays an important role in the management of locally advanced gynaecological malignancies. However, the relationship between urinary toxicity and dose to the urethra is not well understood. We sought to evaluate the correlation between urethral dose and the incidence of genitourinary complications among patients undergoing vaginal high dose rate ISBT. Read More

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The establishment of a 3D anatomical coordinate system for defining vaginal axis and spatial position.

Comput Methods Programs Biomed 2021 May 16;208:106175. Epub 2021 May 16.

Department of Bioengineering, University of Pittsburgh, 406 Benedum Hall, 3700 O'Hara Street, Pittsburgh, PA 15260, United States. Electronic address:

Background And Objective: Pelvic organ prolapse (POP), the herniation of the pelvic organs toward the vaginal opening, is a common pelvic floor disorder (PFD) whose etiology is poorly understood. Traditional methods for evaluating POP are often constrained to external vaginal examination, limited to 2D, or have poor reproducibility. We propose a reliable 3D anatomic coordinate system for standardized 3D assessment of pelvic anatomy using magnetic resonance imaging (MRI). Read More

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A simple and reliable refractometric method to determine the total solids concentration of the cervico-vaginal bovine mucus samples.

Heliyon 2021 May 10;7(5):e07010. Epub 2021 May 10.

Faculty of Veterinary Sciences of the National University of Rosario, S2170 Casilda, Argentina.

Cervico-vaginal mucus (CVM) is a viscoelastic substance continuously produced by secretory cells of the endocervix and the vagina of cows. Its physicochemical composition varies depending on the hormonal status of the estrous cycle. In veterinary medicine refractometry is a widely diffused technique to determine total solids (TS) content of biological samples, but there are not published data of CVM total solids from refractometric measures. Read More

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Impact of pre-brachytherapy magnetic resonance imaging on dose-volume histogram of locally advanced cervical cancer patients treated with radiotherapy including high-dose-rate brachytherapy.

J Contemp Brachytherapy 2021 Feb 18;13(1):32-38. Epub 2021 Feb 18.

Department of Radiation Oncology and Proton Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Purpose: This study investigated the suitability of brachytherapy technique selection based on pre-brachytherapy magnetic resonance imaging (MRI) findings in cervical cancer by evaluating dose-volume histogram parameters.

Material And Methods: We retrospectively evaluated data from 61 patients with cervical cancer who underwent pre-brachytherapy MRI within 7 days before their first high-dose-rate brachytherapy treatment, selected according to pre-brachytherapy MRI findings. Combined intracavitary brachytherapy with interstitial techniques (IC/ISBT) or interstitial brachytherapy (ISBT) were favored treatments for poor-responding tumors after concurrent chemoradiotherapy, asymmetrical tumors, bulky parametrial extensions, bulky primary disease, and extensive paravaginal or distal vaginal involvement. Read More

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February 2021

Pelvic exenteration for recurrent or advanced gynecologic malignancies - Analysis of outcome and complications.

Gynecol Oncol Rep 2021 May 31;36:100757. Epub 2021 Mar 31.

Department of Gynecology, Gynecological Oncology and Gynecological Endocrinology, University Hospital of Giessen and Marburg (UKGM), Marburg, Germany.

Pelvic exenterations are known to be a last resort therapeutic option for advanced or recurrent gynecologic malignancies, which are known to have poor prognosis. All women treated with anterior (APE) or total (TPE) pelvic exenteration at our University hospital within a five-year period were identified and their data retrospectively analysed. Parameters such as demographic information, tumor type and stage, previous therapy as well as complication rate and overall survival were evaluated. Read More

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Abdominal dioctophymosis in a domestic cat from the Peruvian rainforest confirmed morphologically and molecularly.

Parasitol Int 2021 Aug 18;83:102359. Epub 2021 Apr 18.

Laboratorio de Epidemiologia y Economía Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Av. Circunvalación 2800, San Borja. Lima, Peru.

A case of abdominal dioctophymosis in a domestic cat was found in San Juan Bautista district, the Peruvian rainforest, in the Loreto department of Peru. The pet went to a veterinary clinic for a routine ovariohysterectomy during which a large nematode was found in the abdominal cavity. The nematode was morphologically identified as an adult female of Dioctophyme sp. Read More

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Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report.

Int J Clin Pharmacol Ther 2021 Apr 16. Epub 2021 Apr 16.

The vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candidiasis (VVC). A 32-year-old woman suffered from chills, fatigue, and chest distress after receiving one 80-mg terconazole vaginal suppository for the treatment of uncomplicated VVC. Then, the symptom persisted for 10 hours until the residue of terconazole was removed, and the vagina was repeatedly washed with iodophor. Read More

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Vaginal Fractional Carbon Dioxide Laser Treatment and Changes in Vaginal Biomechanical Parameters.

Lasers Surg Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, 3525408, Israel.

Background And Objectives: Vaginal fractional carbon dioxide (CO ) laser treatment has emerged in the past two decades as a non-surgical option for vaginal tightening. Mounting evidence supports the effectiveness and safety of this treatment for female sexual dysfunction. A newly developed vaginal tactile imaging (VTI) technique accurately evaluates the biomechanical parameters of the female pelvic floor and vagina, including tissue elasticity, pelvic support, and pelvic muscle function in high definition. Read More

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Effects of Spermine and Spermidine supplemented extenders on post-thaw Spermatological Parameters in Stallion Semen Cryopreservation.

Cryobiology 2021 06 29;100:72-76. Epub 2021 Mar 29.

Ankara University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, 06110, Ankara, Turkey.

In this study, the effects of polyamines, Spermine and Spermidine, on long-term preservation and post-thaw spermatological parameters were evaluated. Moreover, determination of the most suitable polyamine and its dose that can be added to standard extenders were aimed. Four adult Arabian stallions were used in the study. Read More

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Chemopreventive effects of Melastoma malabathricum L. extract in mammary tumor model via inhibition of oxidative stress and inflammatory cytokines.

Biomed Pharmacother 2021 May 2;137:111298. Epub 2021 Mar 2.

School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon, 440-746, Republic of Korea. Electronic address:

The objective of this study was to evaluate the anticancer effects of Melstoma malabathricum L. (MM) MDA-MB-231 human breast cancer and in vivo mammary tumor model and decipher the potential mechanism. The phyto-constituents in the extract have been identified by liquid chromatography-mass spectrometry (LC-MS). Read More

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An operator-independent artificial finger can differentiate anterior vaginal wall indentation parameters between control and prolapse patients.

J Biomech 2021 05 14;120:110378. Epub 2021 Mar 14.

University of Texas Southwestern Medical Center, USA. Electronic address:

In this study, the reproducibility and validity of an automated artificial finger for evaluating properties of vaginal wall tissue was assessed. The effect of angle and rate of indentation on displacing the anterior vaginal wall (AVW) was studied in control and prolapse patients. Following IRB approval, an automated artificial finger equipped with a calibrated piezoresistive sensor at its tip was used to induce 3-second AVW deformation sequences (10°, 15°, and 20° indentation). Read More

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Smoking in women with chronic vaginal discomfort is not associated with decreased abundance of Lactobacillus spp. but promotes Mobiluncus and Gardnerella spp. overgrowth - secondary analysis of trial data including microbio-me analysis.

Ceska Gynekol 2021 ;86(1):22-29

Background: Smoking is considered a risk factor for bacterial vaginosis. It is currently unknown which parameters of the vaginal environment are affected and how smoking triggers the disease.

Aim Of The Study: The primary objective is to estimate the effect size of smoking on vaginal pH and the Nugent score in patients with chronic vulvovaginal discomfort prior to the development of episode of vaginosis. Read More

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Vaginal dose-surface maps in cervical cancer brachytherapy: Methodology and preliminary results on correlation with morbidity.

Brachytherapy 2021 May-Jun;20(3):565-575. Epub 2021 Mar 17.

Department of Radiation Oncology, University Medical Centre Utrecht, the Netherlands.

Purpose: The purpose of the study was to develop a methodology for vaginal dose-surface maps (DSMs) in patients with cervix cancer and to investigate dose-surface histogram metrics as predictors for vaginal stenosis (St) and mucositis (Muc).

Methods And Materials: Thirty-one patients with locally advanced cervix cancer with no vaginal St/Muc (CTCAE-v3) G ≥ 2 at baseline were analyzed. Patients were divided in four morbidity groups: 15 with St/Muc G0/1, 6 with St G ≥ 2, 4 with St/Muc G ≥ 2, and 6 with Muc G ≥ 2. Read More

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Antioxidant effect of Elamipretide on bull's sperm cells during freezing/thawing process.

Andrology 2021 Mar 6. Epub 2021 Mar 6.

Department of Ruminant Science, West Pomeranian University of Technology, Szczecin, Poland.

Background: Spermatozoa are subjected to drastic changes in temperature, ice crystal formation, and diverse types of stresses (chemical, physical, osmotic, and oxidative) during the cryopreservation process, which severely compromise sperm quality and fertility. In this study, we aimed to investigate the protective role of Elamipretide in the cryopreservation of bull's spermatozoa.

Materials And Methods: The study included 36 healthy Simmental bulls with an average age of 2 ± 0. Read More

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Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate.

Life Sci 2021 Apr 9;271:119198. Epub 2021 Feb 9.

Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil. Electronic address:

The aim of this study was to evaluate whether high levels of exogenous testosterone (T) interfere in prostate morphogenesis. Pregnant females were exposed to subcutaneous injections of T cypionate (500 μg/animal) at gestational days 20 and 22. Male and female pups were euthanized at postnatal days 1 and 15. Read More

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Diagnostic Methods for Vaginal Stenosis and Compliance to Vaginal Dilator Use: A Systematic Review.

J Sex Med 2021 03 29;18(3):493-514. Epub 2021 Jan 29.

Titular professor, Department of Biophysics and Biometrics, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Background: Vaginal stenosis (VS) is a common side effect of pelvic radiotherapy for gynecological cancer in women. It has a high incidence variability, likely due to unstandardized and subjective assessment methods. Furthermore, even though the worldwide standard treatment for VS is vaginal dilation, low compliance rates have been noted. Read More

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The Prevalence of Vaginal Flatus in Women With Pelvic Floor Disorders and Its Impact on Sexual Function.

J Sex Med 2021 03 24;18(3):487-492. Epub 2021 Jan 24.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Division of Urogynecology, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan.

Background: Vaginal flatus is involuntarily passing gas from the vagina. Women seldom voluntarily report it, and related data are limited.

Aim: To investigate the prevalence of vaginal flatus in women with pelvic floor disorders and its impact on sexual function. Read More

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Factors predicting the presence of concomitant enterocele and rectocele in patients with external rectal prolapse.

Ann Coloproctol 2021 Jan 12. Epub 2021 Jan 12.

Department of Gastroenterological Surgery, Kameda Medical Center, Kamogawa, Japan.

Purpose: External rectal prolapse (ERP) is frequently associated with other pelvic disorders, such as enterocele, rectocele, and perineal descent. Evacuation proctography makes it possible to visualize the development of such anatomical abnormalities. The aim of this study was to identify the variables that would predict associated abnormalities in patients with ERP. Read More

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January 2021

Application of CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem.

Nutrients 2021 Jan 6;13(1). Epub 2021 Jan 6.

Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.

In this study, the cervicovaginal environment of women with reproductive failure (repetitive abortion, infertility of unknown origin) was assessed and compared to that of healthy fertile women. Subsequently, the ability of CECT5713 to increase pregnancy rates in women with reproductive failure was evaluated. Vaginal pH and Nugent score were higher in women with reproductive failure than in fertile women. Read More

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January 2021

Oestrus Synchronisation with Progesterone-containing Sponge and Equine Chorionic Gonadotropin in Pirlak Ewes During the Non-breeding Season: Can Toryum Improve Fertility Parameters?

J Vet Res 2020 Dec 6;64(4):573-579. Epub 2020 Nov 6.

Department of Animal Breeding and Husbandry, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.

Introduction: The aim of the study was to determine the effect of the vitamins, omega-3 polyunsaturated fatty acid and minerals in the supplement Toryum administered before and during oestrus synchronisation on some fertility parameters of ewes during the non-breeding season.

Material And Methods: The experimental animals were clinically healthy Pirlak ewes, 55-75 days postpartum, aged 2-4 years and weighing 40-50 kg. A sponge was inserted into the vagina for 10 d (G1, n = 30; G2, n = 30) or 14 d (G3, n = 30; G4, n = 30) for oestrus synchronisation, and on the day of removal, 400 IU equine chorionic gonadotropin was injected. Read More

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December 2020

Maternal and neonatal anthropometric analyses: Determining birth outcomes in low-risk pregnancies at Alex Ekwueme Federal University Teaching Hospital, Abakaliki.

Int J Gynaecol Obstet 2020 Dec 10. Epub 2020 Dec 10.

Department of Obstetrics and Gynecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria.

Objective: To assess the input of maternal and neonatal body physique anthropometries to birth outcomes.

Methods: A prospective study of 177 full-term births at Alex Ekwueme Federal Teaching Hospital Abakaliki from July to December, 2019. Maternal and neonatal anthropometric parameters and birth outcomes: mode of delivery and Apgar score were considered in this study. Read More

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December 2020

Excess dose-related parameters (Vex, Rex, and iRex): novel predictors and late toxicity correlations in cervical cancer image-guided adaptive brachytherapy.

J Contemp Brachytherapy 2020 Oct 30;12(5):441-453. Epub 2020 Oct 30.

Mount Vernon Cancer Centre, Northwood, United Kingdom.

Purpose: In this paper, excess dose is originally proposed to represent the dose outside the target volume that encompass only organs at risk (OARs), not the whole dose volume of isodose surface volume (ISV). By means of spatial consideration, excess dose-related parameters would also compensate inconsistent applicator positions and OARs motion, which may deviate the identical dose small-volume assumption of D. Late toxicity correlations of these parameters were investigated. Read More

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October 2020

Consensus and recommendations on vaginal-cuff Brachytherapy of the Spanish Brachytherapy Groups of SEOR and SEFM.

Clin Transl Oncol 2021 Jun 25;23(6):1193-1200. Epub 2020 Nov 25.

Complejo Hospitalario Navarra, Pamplona, Spain.

Purpose/objective(s): On October 5, 2018, a meeting of the Spanish Society of Radiation Oncology (SEOR) Brachytherapy Group was held, in collaboration with the Spanish Society of Medical Physics (SEFM), with the aim of preparing a consensus document on postoperative vaginal-cuff brachytherapy (VCBT).

Materials/methods: A survey including 42 questions was sent to Spanish Radiation Oncology Centres before the meeting. The survey items included: experience in VCBT, technique indications, previous patient preparation, applicator type, implant procedure, computerized tomography (CT) simulation, definition of target volumes and organs at risk (OAR), dose prescription, fractionation, treatment planning, dosimetric parameters and constraints to OAR. Read More

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Single Layer Centrifugation Improves the Quality of Fresh Donkey Semen and Modifies the Sperm Ability to Interact with Polymorphonuclear Neutrophils.

Animals (Basel) 2020 Nov 16;10(11). Epub 2020 Nov 16.

Equine Reproduction Service, Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Autonomous University of Barcelona, E-08193 Bellaterra (Cerdanyola del Vallès), Spain.

This study sought to determine whether single layer centrifugation (SLC) of fresh donkey semen with Equicoll has any impact on sperm quality parameters and on the modulation of endometrial reaction following semen deposition using an in vitro model. Seventeen ejaculates from five jackasses were obtained using an artificial vagina and diluted in a skim-milk extender. Samples were either selected through SLC (Equicoll) or non-treated (control). Read More

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November 2020

A uniaxial force and stiffness model of the vagina during laparoscopic sacrocolpopexy.

Clin Biomech (Bristol, Avon) 2021 01 4;81:105204. Epub 2020 Nov 4.

KU Leuven, Department of Mechanical Engineering, Celestijnenlaan 300, Leuven, Belgium.

Background: Laparoscopic sacrocolpopexy is the preferred procedure for restoring vaginal vault prolapse. An assistant uses a vaginal manipulator to position and tension the vault such that the surgeon can dissect the bladder, rectum and vault to eventually suture a synthetic mesh used to suspend the vagina to the longitudinal anterior vertebral ligament. Vaginal vault manipulation requires application of high forces for long periods of time. Read More

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January 2021

Plan-Optimization Method for Central-shielding Pelvic Volumetric-modulated Arc Therapy for Cervical Cancer.

In Vivo 2020 Nov-Dec;34(6):3611-3618

Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Aim: To establish a method of plan optimization in pelvic volumetric-modulated arc therapy (VMAT) for cervical cancer using the central-shielding (CS) principle.

Patients And Methods: We created external beam VMAT plans for eight cases with non-bulky stage I-IIb using the CS principle based on the Japanese standard guideline. Clinical target volumes (CTVs) for whole-pelvis (WP) irradiation were created using published guidelines, and CTVs for CS irradiation were created by subtracting the uterus corpus and 4 cm-wide regions centered at the cervix and vagina from the CTVs for WP irradiation. Read More

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A retrospective study of the incidence and predisposing factors of third- and fourth-degree perineal tears.

Saudi Med J 2020 Nov;41(11):1241-1244

Department of Obstetrics and Gynecology, Abha Maternity and Children Hospital, Abha, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the rates of third- and fourth-degree tears and related predisposing factors for the tears in singleton vaginal deliveries. Methods: This was a retrospective study of third- and fourth-degree perineal tears in all women who underwent vaginal delivery in a tertiary hospital in Assir region between January 2014 and December 2019. There are approximately 5000 deliveries per year at the Abha Maternity and Children Hospital. Read More

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November 2020

Quantification of zearalenone and α-zearalenol in swine liver and reproductive tissues using GC-MS.

Toxicon X 2020 Dec 9;8:100058. Epub 2020 Sep 9.

School of Plant and Environmental Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.

The mycotoxin zearalenone (ZEN) is a common contaminant of swine feed which has been related to a wide range of reproductive anomalies in swine, such as pelvic organ prolapse, anestrous, and pseudopregnancy. New information is needed to understand how ZEN and related metabolites accumulate in swine reproductive tissues. We conducted a feeding study to track ZEN and the metabolite α-zearalenol (α-ZEL) in swine liver and reproductive tissues. Read More

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December 2020

Medium-term effects on voiding function after pelvic reconstructive surgery of advanced pelvic organ prolapse: Is postoperative uroflowmetry necessary?

Eur J Obstet Gynecol Reprod Biol 2021 Mar 23;258:447-451. Epub 2020 Sep 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Objective: To evaluate the necessity of postoperative repetitive uroflowmetry and postvoid residual volume (PVR) in women with advanced anterior vaginal prolapse.

Method: Women with anterior vaginal prolapse stages III and IV who underwent surgery were included in this prospective cohort study. The surgical procedures included laparoscopic sacrocolpopexy (LSC), transvaginal mesh repair (TVM) and native tissue repair (NTR). Read More

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Cloacal malformation: A rare case report and review of prenatal imagings.

Medicine (Baltimore) 2020 Oct;99(42):e21839

Department of Gynaecology, the Second Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Cloacal malformation (CM) is a serious type of anorectal and urogenital tract malformation. However, prenatal ultrasound (US) detection of CM is challenging. In this paper, we reported a rare case of CM prenatally diagnosed by US and magnetic resonance imaging (MRI), as well as reviewed the prenatal US and MRI characteristics of CM in the literature. Read More

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October 2020