J Biomech Eng 2021 Nov 21. Epub 2021 Nov 21.
Vanderbilt University, Department of Biomedical Engineering, 5824 Stevenson Center, Nashville, TN 37232, USA; Vanderbilt University Medical Center, Department of Orthopaedic Surgery, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232; Vanderbilt University Medical Center, Vanderbilt Center for Bone Biology, 1211 Medical Center Dr., Nashville, TN 37212; Vanderbilt University Medical Center, Department of Medicine, 1211 Medical Center Dr., Nashville, TN 37217.
Delayed long bone fracture healing and nonunion continue to be a significant socioeconomic burden. While mechanical stimulation is known to be an important determinant of the bone repair process, understanding how the magnitude, mode, and commencement of interfragmentary strain (IFS) affect fracture healing can guide new therapeutic strategies to prevent delayed healing or non-union. Mouse models provide a means to investigate the molecular and cellular aspects of fracture repair, yet there is only one commercially available, clinically-relevant, locking intramedullary nail (IMN) currently available for studying long bone fractures in rodents. Read More