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Influence of current and previous smoking on current phenotype in Parkinson's disease.

J Neurol Sci 2021 Jun 8;427:117534. Epub 2021 Jun 8.

Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan.

Introduction: Although an inverse correlation between smoking and Parkinson's disease (PD) has been reported, research into the effect of smoking on current clinical progression remains limited for PD patients. Elucidation of a specific PD population who would benefit from smoking is challenging.

Methods: We evaluated 110 consecutive PD patients (mean age; 71. Read More

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Clinical Utility of Overlap Time for Incomplete Relaxation to Predict Cardiac Events in Heart Failure: Incomplete relaxation in heart failure.

J Card Fail 2021 Jun 12. Epub 2021 Jun 12.

Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, 2-50-1 Kuramoto, Tokushima, Japan.

Background: The overlap time of transmitral flow can be a novel marker of subclinical left ventricular (LV) dysfunction for predicting adverse events in heart failure (HF). We aimed to 1) investigate the role of overlap time of E-A wave in association with clinical parameters, and 2) evaluate whether the overlap time could add prognostic information with respect to other conventional clinical prognosticators in HF.

Methods: We prospectively evaluated 153 patients hospitalized with HF (mean age 68±15 years; 63% male). Read More

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IN VITRO and IN VIVO TRYPANOCIDAL ACTIVITY OF A BENZOFUROXAN DERIVATIVE AGAINST Trypanosoma cruzi.

Exp Parasitol 2021 Jun 12:108125. Epub 2021 Jun 12.

Department of Microbiology and Parasitology, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this disease: nifurtimox and benznidazole. Read More

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Unraveling the Interplay of Image Formation, Data Representation and Learning in CT-based COPD Phenotyping Automation: The Need for a Meta-Strategy.

Med Phys 2021 Jun 15. Epub 2021 Jun 15.

Siemens Healthineers, CT R&D Image Analytics, Forchheim, Germany.

Purpose: In the literature on automated phenotyping of Chronic Obstructive Pulmonary Disease (COPD), there is a multitude of isolated classical machine learning and deep learning techniques, mostly investigating individual phenotypes, with small study cohorts and heterogeneous meta-parameters, e.g. different scan protocols or segmented regions. Read More

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Mathematical modeling of the transmission of SARS-CoV-2-Evaluating the impact of isolation in São Paulo State (Brazil) and lockdown in Spain associated with protective measures on the epidemic of CoViD-19.

PLoS One 2021 15;16(6):e0252271. Epub 2021 Jun 15.

Division of Allergy and Immunology, General Hospital of the Medicine School of University of São Paulo, São Paulo, São Paulo, Brazil.

Coronavirus disease 2019 (CoViD-19), with the fatality rate in elder (60 years old or more) being much higher than young (60 years old or less) patients, was declared a pandemic by the World Health Organization on March 11, 2020. A mathematical model considering young and elder subpopulations under different fatality rates was formulated based on the natural history of CoViD-19 to study the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The model considered susceptible, exposed, asymptomatic, pre-symptomatic, mild CoViD-19, severe CoViD-19, and recovered compartments, besides compartments of isolated individuals and those who were caught by test. Read More

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Optimization of Large-Scale Production of Chrysodeixis includens nucleopolyhedrovirus for Its Use as a Biopesticide.

Neotrop Entomol 2021 Jun 15. Epub 2021 Jun 15.

Empresa Brasileira de Pesquisa Agropecuária, Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil.

The baculovirus Chrysodeixis includens nucleopolyhedrovirus (ChinNPV) is pathogenic to Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae) larvae, known as soybean looper, which is an important pest of soybean and bean. In this study, some parameters were tested to overcome the difficulties in the in vivo production of ChinNPV aiming to increase its use as a biopesticide. First, different combinations of larval instars (3rd and 4th instars), larval incubation temperatures (23 °C and 26 °C), and rearing densities (individually and 10 larvae/cup) were compared for larval weight and the production of occlusion bodies (OBs). Read More

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Evaluation of Long-Lasting Potential of Suprachoroidal Axitinib Suspension Via Ocular and Systemic Disposition in Rabbits.

Transl Vis Sci Technol 2021 Jun;10(7):19

Clearside Biomedical Inc., Alpharetta, GA, USA.

Purpose: Axitinib, a tyrosine kinase inhibitor, is a potent inhibitor of vascular endothelial growth factor (VEGF) receptors -1, -2 and -3. Suprachoroidal (SC) delivery of axitinib, combined with pan-VEGF inhibition activity of axitinib, has the potential to provide additional benefits compared to the current standard of care with intravitreal anti-VEGF-A agents. This study evaluated the ocular pharmacokinetics and systemic disposition of axitinib after SC administration in rabbits. Read More

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Utility of fractional exhaled nitric oxide in interstitial lung disease.

J Breath Res 2021 Jun 16;15(3). Epub 2021 Jun 16.

Department of Pulmonology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

The majority of interstitial lung diseases (ILDs) develop rapidly and are associated with a poor prognosis. Therefore, new noninvasive markers are needed to guide the classification and prognostication of ILD. We enrolled 95 patients with ILD, including dermatomyositis-associated ILD (69), Sjögren's syndrome-associated ILD (= 7), mixed connective tissue disease-associated ILD (= 9), idiopathic pulmonary fibrosis (= 5) and hypersensitivity pneumonitis (= 5), 82 patients with connective tissue disease but without ILD as well as 24 healthy controls, then evaluated fractional exhaled nitric oxide (FeNO50; 50 ml s) (Bisenkov20069-14), pulmonary function and high-resolution computed tomography (HRCT) scores. Read More

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Central sensitisation features are associated with neuropathic pain-like symptoms in patients with longstanding rheumatoid arthritis: a cross-sectional study using the central sensitisation inventory.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objectives: Several studies have indicated that arthralgia may be driven by central sensitisation. Central sensitivity syndrome (CSS) is a concept that unifies various symptoms due to central sensitisation. Recently, the central sensitisation inventory (CSI) was developed as a screening questionnaire to detect CSS. Read More

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Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11).

J Endocrinol Invest 2021 Jun 14. Epub 2021 Jun 14.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Hospital Trust of Verona, Piazzale Stefani 1, 37126, Verona, Italy.

Background: Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase (GCK) and glucose-6-phosphate catalytic subunit 2 (G6PC2) activity are involved in glucose homeostasis through glycolytic flux, and subsequent insulin secretion.

Aim: In this study, we evaluated the association between the genetic variability of G6PC2 and GCK genes and T2D-related quantitative traits. Read More

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Comparison of the effects of pre-dilution and post-dilution online hemodiafiltration on the levels of inflammatory markers, lymphocytes, and platelets.

J Artif Organs 2021 Jun 14. Epub 2021 Jun 14.

Hashimoto Clinic, 3-21-5, Hashimoto, Midori-ku, Sagamihara, Kanagawa, Japan.

Online hemodiafiltration (OL-HDF) is a blood purification therapy based on diffusion and ultrafiltration and is classified into two types according to the mode of addition of the substitution fluid: pre-dilution OL-HDF (pre-HDF) and post-dilution OL-HDF (post-HDF); we previously reported that pre-HDF is more biocompatible. However, we used lower blood and substitution flow rates in that study and may not have accurately simulated the treatment conditions used in Europe. In this study, we compared the biocompatibilities of the treatment conditions of pre-HDF, commonly used in Japan, and post-HDF, commonly used in Europe, to determine the most biocompatible treatment conditions. Read More

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New insights of phenolic compounds from optimized fruit extract of Ficus auriculata.

Sci Rep 2021 Jun 14;11(1):12503. Epub 2021 Jun 14.

Solar Energy Research Institute, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.

In this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS as well as reducing power assays on total phenolic content (TPC). For the extraction purpose, the ultrasonic assisted extraction technique was employed. Read More

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Seventy eight children born small for gestational age without catch-up growth treated with growth hormone from the prepubertal stage until adult height age. An evaluation of puberty and changes in the metabolic profile.

Endocrinol Diabetes Nutr 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Endocrinology Unit, Vall d'Hebron University Hospital, Barcelona, Spain; Vall d'Hebron Research Institut, Paediatric Endocrinology, Vall d'Hebron University Hospital, Barcelona, Spain; Autonomous University of Barcelona, Barcelona, Spain.

A wide variation in height gain rate is observed in children small for gestational age (SGA) treated with growth hormone (GH). The aim of this study was to evaluate prepubertal and pubertal growth, height gain attained at adult age and to assess potential predictive factors in catch-up growth. Changes in metabolic profile were also analyzed. Read More

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Development of predictive models evaluating the spoilage-delaying effect of a bioprotective culture on different yeast species in yogurt.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Dairy Bioprotection, Chr. Hansen A/S, Boege Allé 10-12, 2970 Hoersholm, Denmark.

Yeast spoilage of fermented dairy products causes challenges for the dairy industry, including economic losses due to wasted product. Food cultures with bioprotective effects are becoming more widely used to help ensure product quality throughout product shelf life. To assist the dairy industry when evaluating product quality throughout shelf life and the effect of bioprotective cultures, we aimed to build stochastic models that provide reliable predictions of yeast spoilage in yogurt with and without bioprotective culture. Read More

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Evaluation of test characteristics of 2 ELISA tests applied to bulk tank milk and claw-trimming records for herd-level diagnosis of bovine digital dermatitis using latent class analysis.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 369 Sentrum, N-0102 Oslo, Norway.

Bovine digital dermatitis (DD) is an infectious claw disease with a negative effect on animal welfare and production. Treponema spp. is the main causative agent, and infected animals produce specific antibodies. Read More

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Differential Alterations in the Attentional Networks of People Living with HIV and Apathy: Preliminary Results and Pharmacoclinical Impact.

CNS Spectr 2021 Apr;26(2):143

Maimonides University, Buenos Aires, Argentina.

Objective: The objective was to determine alterations in the care of people living with human immunodeficiency virus (PLHIV) with depressive disorder without and with apathy to determine differential parameters.

Methods: We studied 69 PLHIV, negativized viral load, of both sexes (19 women and 44 men), with depressive disorder (F32.9-DSM IV), 20 with apathy and 26 without apathy; negativized viral load, in highly effective antiretroviral treatment without therapeutic failure in the last 2 years and without protease inhibitors; without psychopharmacological treatment (except anxiolytics) or dementia due to HIV (American Academy of Neurology) or comorbidities (hepatitis C, CNS or central vascular infections). Read More

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Single-Dose Pharmacokinetics of Amphetamine Extended-Release Oral Suspension (AMPH EROS) in 6-12-Year-Old Children with ADHD.

CNS Spectr 2021 Apr;26(2):163

Tris Pharma, Inc., Monmouth Junction, NJ, USA.

Methods: This Phase 1, open-label, single-dose, one-period, one-treatment PK study enrolled 12 children 6-12 y with ADHD. PK parameters for d- and l-amphetamine in plasma (Cmax, tmax, AUC0-8, and t1/2) were calculated and expressed as means, geometric means, and standard deviations. The primary endpoint was all objective PK measurements at 28 hours post-dose. Read More

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Effect of Deutetrabenazine on Metabolic Parameters in the Treatment of Tardive Dyskinesia.

CNS Spectr 2021 Apr;26(2):159-160

Teva Pharmaceuticals, Basel, Switzerland.

Background: Deutetrabenazine, a novel vesicular monoamine transporter 2 (VMAT2) inhibitor, is approved by the FDA for treatment of tardive dyskinesia (TD) in adults. Dopamine-receptor antagonists (DRAs) are associated with worsening of metabolic parameters, including weight gain, hyperlipidemia, and elevated blood glucose. This post hoc analysis assessed the short- and long-term effects of deutetrabenazine treatment on weight and metabolic parameters in individuals treated for TD. Read More

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Comparative Bioavailability of Amphetamine Extended-Release Oral Suspension and Extended-Release Mixed Amphetamine Salts.

CNS Spectr 2021 Apr;26(2):163

Tris Pharma, Inc., Monmouth Junction, NJ, USA.

Purpose: This open-label, single-dose, randomized, two-period, two-treatment, two-sequence, crossover study evaluated the comparative bioavailability between amphetamine extended-release oral suspension (treatment A: AMPH EROS, Dyanavel XR 2.5 mg/mL, 18.8 mg amphetamine base per 7. Read More

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Change in the postoperative intervertebral space height and its impact on clinical and radiological outcomes after ACDF surgery using a zero-profile device: a single-Centre retrospective study of 138 cases.

BMC Musculoskelet Disord 2021 Jun 14;22(1):543. Epub 2021 Jun 14.

Department of Orthopedic Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Rd, Chengdu, 610041, Sichuan, China.

Background: The effects of postoperative intervertebral height (IH) changes on the clinical and radiological outcomes after anterior cervical decompression and fusion (ACDF) surgery using a zero-profile device remain unclear.

Methods: We retrospectively reviewed patients who had undergone ACDF using a zero-profile device from March 2012 to February 2016 at our institution. Based on the postoperative IH variation, the patients were divided into group A with postoperative IH 0 to 2 mm, group B with postoperative IH 2 to 4 mm, and group C with postoperative IH greater than 4 mm. Read More

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Clinical effect of a novel transpedicular reducer for reduction and bone grafting combined with pedicle screw fixation for thoracolumbar burst fractures.

BMC Musculoskelet Disord 2021 Jun 14;22(1):540. Epub 2021 Jun 14.

Department of Spinal Surgery, The Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, Zunyi, 563099, Guizhou, China.

Background: Short-segment transpedicular screw fixation is a common method for the treatment of thoracolumbar burst fractures (TBFs),but this technique has many problems. Therefore,the purpose of this article is to observe and evaluate the clinical efficacy of a novel transpedicular reducer that we designed for fractured vertebral body reduction and bone grafting in the treatment of TBFs.

Methods: From July 2018 to November 2020, 70 cases of TBFs were included. Read More

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Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study.

Diabetes Metab J 2021 Jun 15. Epub 2021 Jun 15.

Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Read More

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Administration time of misoprostol affects fertility rate in artificially inseminated Kivircik ewes with frozen-thawed ram semen.

Anim Reprod 2018 Aug 16;15(2):156-160. Epub 2018 Aug 16.

Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Uludag University, Gorukle/Bursa, 16059, Turkey.

The aim of this study was to determine the effects of the administration time of misoprostol (11 h (Miso11) and 6 h (Miso6) before artificial insemination) on fertility rates in Kivircik ewes (control: n = 41, Miso11: n = 32 and Miso6: n = 33) during breeding season. Artificial insemination (AI) was performed 48 h after sponge removal using frozen-thawed semen (150 million sperm per dose in 0.25 ml straws). Read More

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Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study.

Blood Purif 2021 Jun 14:1-10. Epub 2021 Jun 14.

Zan Mitrev Clinic, Skopje, North Macedonia.

Introduction: Coronavirus disease 2019 (COVID-19) is characterized by hyperinflammation and coagulopathy. Severe cases often develop respiratory distress, requiring mechanical ventilation and with critical cases progressing to acute respiratory distress syndrome. Control of hyperinflammation has been proposed as a possible therapeutic avenue for COVID-19; extracorporeal blood purification (EBP) modalities offer an attractive mean to ameliorate maladaptive inflammation. Read More

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An unsupervised multi-scale framework with attention-based network (MANet) for lung 4D-CT registration.

Phys Med Biol 2021 Jun 14. Epub 2021 Jun 14.

Shandong Provincial Third Hospital, Jinan, Shandong, CHINA.

Deformable image registration (DIR) of 4D-CT is very important in many radiotherapeutic applications including tumor target definition, image fusion, dose accumulation and response evaluation. It is a challenging task to performing accurate and fast DIR of lung 4D-CT images due to its large and complicated deformations. In this study, we propose an unsupervised multi-scale DIR framework with attention-based network (MANet). Read More

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The impact of real-time fMRI denoising on online evaluation of brain activity and functional connectivity.

J Neural Eng 2021 Jun 14. Epub 2021 Jun 14.

Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 73136, USA, Tulsa, Oklahoma, 74136, UNITED STATES.

Objective: Comprehensive denoising is imperative in fMRI analysis to reliably evaluate neural activity from the blood oxygenation level dependent signal. In real-time fMRI, however, only a minimal denoising process has been applied and the impact of insufficient denoising on online brain activity estimation has not been assessed comprehensively. This study evaluated the noise reduction performance of online fMRI processes in a real-time estimation of regional brain activity and functional connectivity. Read More

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Thiobarbituric acid reactive substances in dogs with spontaneous hypercortisolism.

Domest Anim Endocrinol 2021 May 15;77:106634. Epub 2021 May 15.

Department of Veterinary Clinical Pathology, School of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre-RS, Brazil.

Thiobarbituric acid reactive substances (TBARS) are laboratory markers of oxidative stress, which can be used to evaluate the lipid peroxidation that characterizes cell membrane damage caused by excess free radicals. This prospective study aimed to assess TBARS as a parameter of lipid peroxidation in dogs with spontaneous hypercortisolism (HC) at the time of diagnosis, and after trilostane treatment. Furthermore, it aimed to investigate the correlations between TBARS levels, and laboratory and cardiovascular parameters. Read More

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Factors associated with the detection of norovirus among asymptomatic adults.

Clin Microbiol Infect 2021 Jun 11. Epub 2021 Jun 11.

Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Objectives: Little is known regarding asymptomatic norovirus infection and its risk factors in healthy adults. This study investigated norovirus detection in stool and its associated factors among asymptomatic healthy adults in a high-income country.

Methods: This prospective cross-sectional study conducted from February 2016 to January 2017 at a teaching hospital in Japan included apparently healthy adults aged ≥18 years who underwent voluntary health check-ups. Read More

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Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase.

Exp Gerontol 2021 Jun 11:111449. Epub 2021 Jun 11.

Multidisciplinary Institute of Health, Anísio Teixeira Campus, Federal University of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitória da Conquista, Bahia, Brazil. Electronic address:

Aging in women is characterized by extreme hormonal changes leading them to develop a chronic low-grade inflammation that is linked to the development of systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM). In this scenario, physical activity emerges as an interesting methodology, since it seems to be connected to a decrease in serum levels of some pro-inflammatory cytokines. Nevertheless, most studies evaluate these cytokines in an isolated manner not considering the influence of comorbidities on the responsiveness of participants to the benefits of physical activity. Read More

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Higher coracoacromial ligament thickness, critical shoulder angle and acromion index are associated with rotator cuff tears in patients who undergo arthroscopic rotator cuff repair.

Arthroscopy 2021 Jun 11. Epub 2021 Jun 11.

Istanbul Basaksehir Pine and Sakura City Training and Research Hospital, Istanbul, Turkey.

Purpose: To evaluate the effect of several shoulder anatomical parameters in the development of rotator cuff tear (RCT).

Methods: Between 2014 and 2018, all consecutive patients who underwent arthroscopic rotator cuff repair due to full-thickness rotator cuff tear with a minimum 2-year follow-up were identified. Inclusion criteria were (1) age>18 years, (2) patients with degenerative RCT, (3) full-thickness RCTs, (4) patients underwent arthroscopic RCR due to unresponsive conservative treatment, (5) minimum 2-year follow-up period. Read More

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