978,654 results match your criteria parameters


Maternal alpha-1-antitrypsin as a noval marker for growth restriction in pre-eclampsia.

J Obstet Gynaecol Res 2021 Sep 27. Epub 2021 Sep 27.

College of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, Baghdad, Iraq.

Aim: To verify the role of maternal serum levels of alpha-1-antitrypsin (AAT), an acute-phase inflammatory protein, as a marker for distinguishing between fetal growth restriction (FGR) and normal birth weight in pre-eclamptic women. We correlate serum AAT levels to the essential feto-maternal parameters for an earlier and cost-benefit diagnostic method, thus distinguishing between FGR and normal birth weight in pre-eclamptic women.

Methods: An observational study conducted at the University hospital recruited 100 pregnant women in 32/34 weeks of a singleton single tone pregnancy; all were pre-eclampsia cases. Read More

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September 2021

Investigation of Salivary RANKL and OPG Levels in Periodontitis Patients at Hospital Universiti Sains Malaysia.

Eur J Dent 2021 Sep 27. Epub 2021 Sep 27.

School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.

Background: This study was aimed to determine the levels of salivary receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) and its association with periodontal status among periodontitis patients.

Patients And Methods: A cross-sectional study was designed and performed at the Dental Clinic, Hospital Universiti Sains Malaysia (HUSM). Random sampling was employed to identify 88 participants into three groups: 30 mild periodontitis, 30 moderate to severe periodontitis, and 28 healthy (nonperiodontitis) patients. Read More

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September 2021

Pressure-deformation relations of elasto-capillary drops (droploons) on capillaries.

Soft Matter 2021 Sep 27. Epub 2021 Sep 27.

Institut Charles Sadron, CNRS UPR22 - Université de Strasbourg, Strasbourg, France.

An increasing number of multi-phase systems exploit complex interfaces in which capillary stresses are coupled with solid-like elastic stresses. Despite growing efforts, simple and reliable experimental characterisation of these interfaces remains a challenge, especially of their dilational properties. Pendant drop techniques are convenient, but suffer from complex shape changes and associated fitting procedures with multiple parameters. Read More

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September 2021

Blood pressure assessment with in-ear photoplethysmography.

Physiol Meas 2021 Sep 27. Epub 2021 Sep 27.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, CHINA.

Objective: In this study, we aimed to estimate blood pressure (BP) from in-ear photoplethysmography (PPG). This novel implementation provided an unobtrusive and steady way of recording PPG, whereas previous PPG measurements were mostly performed at the wrist, finger, or earlobe.

Methods: The time between forward and reflected PPG waves was very short at the ear site. Read More

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September 2021

Self-functional gold nanoprobes for intra-nuclear epigenomic monitoring of cancer stem-like cells.

Biosens Bioelectron 2021 Sep 23;195:113644. Epub 2021 Sep 23.

Keenan Research Center for Biomedical Science, Unity Health Toronto, Toronto, Ontario, M5B 1W8, Canada; Institute for Biomedical Engineering, Science and Technology (I BEST), Partnership Between Ryerson University and St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada; Nano-characterization Laboratory, Faculty of Engineering and Architectural Sciences, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada; Nano-Bio Interface Facility, Faculty of Engineering and Architectural Sciences, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.

Cancer epigenomic-environment is a core center of a tumor's genetic and epigenetic configuration. Surveying epigenomic-environment of cancer stem-like cells (CSC) is vital for developing novel diagnostic methods and improving current therapies since CSCs are among the most challenging clinical hurdles. To date, there exists no technique which can successfully monitor the epigenomics of CSC. Read More

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September 2021

Outliers in clinical symptoms as preictal biomarkers.

Epilepsy Res 2021 Sep 22;177:106774. Epub 2021 Sep 22.

CNRS UMR-7225, Pitié-Salpêtrière Hospital, Paris, France.

Previous findings have suggested that a preictal state might precede the epileptic seizure onset, which is the basis for seizure prediction attempts. Preictal states can be apprehended as outliers that differ from an interictal baseline and display clinical changes. We collected daily clinical scores from patients with epilepsy who underwent continuous video-EEG and assessed the ability of several outlier detection methods to identify preictal states. Read More

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September 2021

Adaptive risk prediction system with incremental and transfer learning.

Comput Biol Med 2021 Sep 23;138:104886. Epub 2021 Sep 23.

The Chinese University of Hong Kong, Department of Obstetrics and Gynaecology, Hong Kong, China. Electronic address:

Currently, popular methods for prenatal risk assessment of fetal aneuploidies are based on multivariate probabilistic modelling, that are built on decades of scientific research and large-scale multi-center clinical studies. These static models that are deployed to screening labs are rarely updated or adapted to local population characteristics. In this article, we propose an adaptive risk prediction system or ARPS, which considers these changing characteristics and automatically deploys updated risk models. Read More

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September 2021

Prediction of arterial blood pressure waveforms from photoplethysmogram signals via fully convolutional neural networks.

Comput Biol Med 2021 Sep 21;138:104877. Epub 2021 Sep 21.

Department of Electronic Engineering & Information Science, University of Science and Technology of China, Hefei, 230026, China.

Cardiovascular disease (CVD) is one of the most serious diseases threatening human health. Arterial blood pressure (ABP) waveforms, containing vivid cardiovascular information, are of great significance for the diagnosis and the prevention of CVD. This paper proposes a deep learning model, named ABP-Net, to transform photoplethysmogram (PPG) signals into ABP waveforms that contain vital physiological information related to cardiovascular systems. Read More

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September 2021

A review on disposal and utilization of phytoremediation plants containing heavy metals.

Ecotoxicol Environ Saf 2021 Sep 24;226:112821. Epub 2021 Sep 24.

Department of Energy and Process Engineering, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. Electronic address:

The reasonable disposal of plant biomass containing heavy metals (HMs) is a difficult problem for the phytoremediation technology. This review summarizes current literature that introduces various disposal and utilization methods (heat treatment, extraction treatment, microbial treatment, compression landfill, and synthesis of nanomaterials) for phytoremediation plants with HMs. The operation process and technical parameters of each disposal method are different. Read More

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September 2021

The study of volatile products formation from the self-degradation of l-ascorbic acid in hot compressed water.

Food Chem 2021 Sep 17;371:131155. Epub 2021 Sep 17.

School of Chemistry & Environmental Engineering, Hubei Minzu University, Enshi, Hubei 445000, China; Hubei Key Laboratory of Biologic Resources Protection and Utilization, Hubei Minzu University, Enshi, Hubei 445000, China.

The volatile products (VPs) formation from the self-degradation of l-ascorbic acid (ASA) in hot compressed water (HCW) was investigated with different reaction parameters, such as time, temperature, pH and ratio of ASA/water. The results showed that various reaction parameters had varying degrees of influence on the reaction, while the most significant effect factor was the initial pH of the solution. Furfural was the major product under acidic conditions, while furan derivatives were the main products under alkaline conditions. Read More

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September 2021

Effects from disruption of mitochondrial electron transport chain function on bull sperm motility.

Theriogenology 2021 Sep 20;176:63-72. Epub 2021 Sep 20.

Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, United States. Electronic address:

Sperm mitochondrial function is essential for normal physiology and fertility, but the importance of mitochondrial activity to support specific sperm functions, such as motility, varies between species. It was previously believed that mitochondrial function was not necessary for bull sperm motility [1]; however, this theory is contradicted by recently reported findings that the upper fraction of bull sperm swim-up preparations had both high motility and elevated mitochondrial oxygen consumption rates [2]. The objective of this study was to investigate the relationship between mitochondrial function and motility in bull sperm. Read More

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September 2021

Assessment of hydrogeochemical characteristics and saltwater intrusion in selected coastal aquifers of southwestern India.

Mar Pollut Bull 2021 Sep 24;173(Pt A):112989. Epub 2021 Sep 24.

Department of Civil Engineering, Manipal Academy of Higher Education, Manipal 576104, India.

The principal objective of this study is to assess the saltwater intrusion and hydrogeochemical processes that affect groundwater geochemistry in the coastal aquifers of southwestern India. Groundwater samples were collected seasonally and the physico-chemical parameters determined on-site. Major ions were determined in the laboratory. Read More

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September 2021

Microalgae Chlorella vulgaris and Scenedesmus dimorphus co-cultivation with landfill leachate for pollutant removal and lipid production.

Bioresour Technol 2021 Sep 21;342:126003. Epub 2021 Sep 21.

School of Resource and Environmental Sciences, Hubei Key Laboratory of Biomass-Resources Chemistry and Environmental Biotechnology, and Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Wuhan University, Wuhan 430079, PR China. Electronic address:

In this study, landfill leachate was pre-treated with NaClO, and then diluted to 5%, 10% and 15% for microalgae growth of Chlorella vulgaris and Scenedesmus dimorphus in the mono- and co-culture modes to investigate the nutrient removal and growth characteristics of microalgae. The results revealed that landfill leachate with the 10% dilution rate was conducive for microalgae growth and exhibited robust biomass growth and the highest nutrient removal efficiency. The co-culture biomass in 10% landfill leachate achieved 0. Read More

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September 2021

Preparation of core-shell [email protected] composite microspheres with wrinkled morphology and its microwave absorption.

J Colloid Interface Sci 2021 Sep 9;607(Pt 2):1036-1049. Epub 2021 Sep 9.

School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China; Shaanxi Engineering and Research Center for Functional Polymers on Adsorption and Separation, Sunresins New Materials Co. Ltd, Xi'an 710072, China. Electronic address:

In this work, we successfully synthesize the core-shell structure [email protected] dioxide ([email protected]) composite microspheres with wrinkled surface through a three-step method and build up the relationship between the TiO layer thickness and the microwave absorption property. The absorbing mechanism of the novel microsphere is revealed. Interface polymerization is applied for preparation of wrinkled poly glycidyl methacrylate/divinylbenzene polymer microspheres (PGMA/PDVB); Then, TiO layer is controllably coated on the surface of PGMA/PDVB microspheres by hydrolysis of tetrabutyl titanate (TBT); [email protected] composite microspheres are obtained by vacuum carbonization with PGMA/[email protected] microspheres as the precursor. Read More

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September 2021

Roles of energy dissipation and asymmetric wettability in spontaneous imbibition dynamics in a nanochannel.

J Colloid Interface Sci 2021 Sep 14;607(Pt 2):1023-1035. Epub 2021 Sep 14.

State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, China; Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of the Ministry of Education, Wuhan University, Wuhan 430072, China.

Hypothesis: The imbibition dynamics is controlled by energy dissipation mechanisms and influenced by asymmetric wettability in a nanochannel. We hypothesize that the imbibition dynamics can be described by a combined model of the Lucas-Washburn equation and the Cox-Voinov law considering velocity-dependent contact angles.

Methods: Molecular dynamics simulations are utilized to investigate the imbibition dynamics. Read More

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September 2021

Screening of lactate dehydrogenase inhibitor from bioactive compounds in natural products by electrophoretically mediated microanalysis.

J Chromatogr A 2021 Sep 15;1656:462554. Epub 2021 Sep 15.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China. Electronic address:

Lactate dehydrogenase (LDH) is a key enzyme in the glycolysis, which has been reported that the expression of LDH is elevated in a variety of cancer types and can promote tumor invasion and metastasis. Therefore, LDH has come to be an emerging therapeutic target for cancer. In this work, we described a new strategy for rapid screening of LDH inhibitors from natural products by integrating electrophoretically mediated microanalysis (EMMA), transverse diffusion of laminar flow profiles (TDLFP) and rapid pressure direction switching. Read More

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September 2021

How do the printing parameters of Fused Filament Fabrication and structural voids influence the degradation of biodegradable devices?

Acta Biomater 2021 Sep 24. Epub 2021 Sep 24.

National Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, China; State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, 410082, China. Electronic address:

Fused Filament Fabrication (FFF), a commonly used additive manufacturing technology, is now employed widely in biomedical fields for fabricating geometrically complex biodegradable devices. Structural voids arising from the printing process exist within the objects manufactured by FFF. This paper reveals the underlying mechanism of how the printing parameters and voids affect the degradation behaviours of devices made of biodegradable polyesters. Read More

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September 2021

Salinity-dependent impacts on the effects of antiepileptic and antihistaminic drugs in Ruditapes philippinarum.

Sci Total Environ 2021 Sep 16;806(Pt 1):150369. Epub 2021 Sep 16.

Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In coastal systems, pollutants as pharmaceutical drugs exert changes from the molecular to the organism level in marine bivalves. Besides pollutants, coastal systems are prone to changes in environmental parameters, as the alteration of salinity values because of Climate Change. Together, these stressors (pharmaceutical drugs and salinity changes) can exert different threats than each stressor acting individually; for example, salinity can change the physical-chemical properties of the drugs and/or the sensitivity of the organisms to them. Read More

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September 2021

Biochar as environmental armour and its diverse role towards protecting soil, water and air.

Sci Total Environ 2021 Sep 21;806(Pt 1):150444. Epub 2021 Sep 21.

United Nations University, Institute for Integrated Management of Material Fluxes and of Resources (UNUFLORES) Ammonstrasse 74, 01067, Dresden, Germany. Electronic address:

Biochar has been of considerable importance for various environmental applications in recent years. It has exhibited substantial advantages like favourable structural and surface properties, easy process of preparation and widely available feedstocks. These set of exceptional properties make it an efficient, cost-effective and environment friendly source for diversified elimination of pollutants. Read More

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September 2021

Multifunctional capacity of CoMnFe-LDH/LDO activated peroxymonosulfate for p-arsanilic acid removal and inorganic arsenic immobilization: Performance and surface-bound radical mechanism.

Sci Total Environ 2021 Sep 20;806(Pt 1):150379. Epub 2021 Sep 20.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.

Organoarsenic contaminants existing in water body threat human health and ecological environment due to insufficient bifunctional treatment technologies for organoarsenic degradation and inorganic arsenic immobilization. In order to safely and efficiently treat organoarsenic contaminants discharged into the aquatic environment, Co-Mn-Fe layered double hydroxide (CoMnFe-LDH) and Co-Mn-Fe layered double oxide (CoMnFe-LDO) were fabricated and employed as peroxymonosulfate (PMS) activator for organoarsenic degradation and inorganic arsenic immobilization, and p-arsanilic acid (p-ASA) was selected as target pollutant. Results demonstrated that the satisfactory removal of p-ASA (100. Read More

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September 2021

Treatment of osteoporosis after hip fracture is associated with lower all-cause mortality: A nationwide population study.

Bone 2021 Sep 24:116216. Epub 2021 Sep 24.

Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Purpose: Mortality after osteoporotic hip fractures is high. Postoperative care is as important as surgery itself to prevent a second fracture and improve outcomes, and the effect of anti-osteoporosis treatment after hip fractures on overall mortality is controversial. This nationwide population study aimed to determine whether anti-osteoporosis treatment might reduce overall mortality after hip fracture surgery. Read More

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September 2021

The Effect of Short-Term High-Caloric Feeding and Fasting on Bone Microarchitecture.

Bone 2021 Sep 24:116214. Epub 2021 Sep 24.

Neuroendocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114.

Background: States of chronic overnutrition and undernutrition are both associated with impaired bone health and increased fracture risk but there are no data on bone microarchitecture following short-term controlled nutritional challenges.

Objective: The purpose of our study was to evaluate the impact of short-term high-caloric feeding and fasting on bone microarchitecture. We hypothesized that both high-caloric feeding and fasting would have negative effects on microarchitecture. Read More

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September 2021

Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease.

Eur J Pharm Sci 2021 Sep 24:106020. Epub 2021 Sep 24.

Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China. Electronic address:

An ophthalmic solution of naringenin (NAR) based on dipotassium glycyrrhizinate (DG) micelle solubilization, called DG-NAR, was prepared, and its effect on dry eye disease (DED) was evaluated. DG-NAR was a clear, colorless aqueous solution with small micelle size (24.75±0. Read More

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September 2021

Metreleptin treatment of non-HIV lipodystrophy syndromes.

Presse Med 2021 Sep 24:104070. Epub 2021 Sep 24.

Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, F-59000 Lille, France; University of Lille, F-59000 Lille, France; INSERM U1190, European Genomic Institute for Diabetes, F-59000 Lille, France.. Electronic address:

Lipodystrophy syndromes (LS) constitute a group of rare diseases of the adipose tissue, characterized by a complete or selective deficiency of the fat mass. These disorders are associated with important insulin resistance, cardiovascular and metabolic comorbidities that impact patient's survival and quality of life. Management is challenging and includes diet, physical activity, and specific pharmacological treatment of LS-associated comorbidities. Read More

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September 2021

Empirical Bayes estimation of pairwise maximum entropy model for nonlinear brain state dynamics.

Neuroimage 2021 Sep 24:118618. Epub 2021 Sep 24.

Center for Systems and Translational Brain Science, Institute of Human Complexity and Systems Science, Yonsei University, Seoul, Republic of Korea; Department of Nuclear Medicine, Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Cognitive Science, Yonsei University, Seoul, Republic of Korea. Electronic address:

The pairwise maximum entropy model (pMEM) has recently gained widespread attention to exploring the nonlinear characteristics of brain state dynamics observed in resting-state functional magnetic resonance imaging (rsfMRI). Despite its unique advantageous features, the practical application of pMEM for individuals is limited as it requires a much larger sample than conventional rsfMRI scans. Thus, this study proposes an empirical Bayes estimation of individual pMEM using the variational expectation-maximization algorithm (VEM-MEM). Read More

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September 2021

Comparative analysis of erythrocyte hemolysis, plasma parameters and metabolic features in red crucian carp (Carassius auratus red var) and triploid hybrid fish following Aeromonas hydrophila challenge.

Fish Shellfish Immunol 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, PR China.

Aeromonas hydrophila can pose a great threat to survival of freshwater fish. In this study, A. hydrophila challenge could promote the erythrocyte hemolysis, increase free hemoglobin (FHB) level and generate malondialdehyde (MDA) production in plasma but decrease the levels of total antioxidant capacity (T-AOC), total superoxide dismutase (SOD), catalase (CAT), alkaline phosphatase (ALP) and lysozyme (LZM) of red crucian carp (RCC, 2N = 100) and triploid hybrid fish (3N fish, 3N = 150) following A. Read More

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September 2021

Photoperiodic modulation of ovarian metabolic, survival, proliferation and gap junction markers in adult golden hamster, Mesocricetus auratus.

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 24:111083. Epub 2021 Sep 24.

Pineal Research Lab, Reproduction Biology Unit, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, U.P., India. Electronic address:

Female reproductive physiology is greatly dependent on tight regulation of metabolic and survival factors. Photoperiod regulates female reproductive rhythms but very less information exists explaining whether photoperiod could modulate thyroid hormone homeostasis, metabolic/energy parameters along with survival, proliferation and gap junction proteins in the ovary of a long-day breeder, Mesocricetus auratus. Adult female hamsters were exposed to different photoperiodic regimes i. Read More

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September 2021

AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).

Toxicol Lett 2021 Sep 24. Epub 2021 Sep 24.

Institute for Agri-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.

Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants. They are constantly detected in terrestrial, ocean, and atmospheric systems, and it is of particular concern that these fat-soluble xenobiotics may have a negative impact on human health. This study aimed to evaluate the toxic effect and underlying mechanism of decabromodiphenyl ether (BDE-209) on human liver in a HepG2 cell model. Read More

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September 2021

T Cell-Based RAS Activity and Insulin Levels in Obese Subjects with Low Grade Inflammation.

Am J Med Sci 2021 Sep 24. Epub 2021 Sep 24.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: Obesity is a major contributor to inflammation and oxidative stress that are key underlying causes for insulin resistance (IR) and diabetes. Accumulated evidence suggest that RAS may serve as a strong link between IR and obesity. We investigated RAS activity in circulating T cells by obese subjects with and without angiotensin (Ang) II stimulation in presence or not of IR and of low-grade inflammation. Read More

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September 2021