353 results match your criteria parallel tpa

Topical Applications of a Novel Emollient Inhibit Inflammation in Murine Models of Acute Contact Dermatitis.

Biomed Res Int 2021 13;2021:5594646. Epub 2021 Apr 13.

Dermatology Hospital of Southern Medical University, Guangdong 510091, China.

The benefits of emollients for eczematous dermatitis and psoriasis have been thought to be due to the improvements in epidermal function, including epidermal permeability barrier, stratum corneum hydration, and stratum corneum pH. We determined here whether emollient can direct inhibit cutaneous inflammation. Ear inflammation was induced by topical application of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or 1-fluoro-2,4-dinitrofluorobenzene (DNFB). Read More

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Unraveling the Mechanism of Near-Infrared Thermally Activated Delayed Fluorescence of TPA-Based Molecules: Effect of Hydrogen Bond Steric Hindrance.

J Phys Chem A 2021 Apr 6;125(14):2905-2912. Epub 2021 Apr 6.

College of Computer Science and Electronic Engineering, Hunan University, Changsha 410082, China.

A recently synthesized novel molecule (named CAT-1) exhibits intriguing near-infrared (NIR) thermally activated delayed fluorescence (TADF) close to 1000 nm wavelength; however, the mechanism behind these intrinsic properties is not fully understood. Herein, we unravel that the fluorescence emission spectrum with a broad wavelength range (770-950 nm) of CAT-1 is primarily induced by hydrogen bond steric hindrance based on density functional theory and Marcus theory. It is found that the hydrogen bond steric hindrance plays a critical role in inhibiting the twist of the configuration of different excited states, which leads to the minor driving force for fast electron trapping between the excited states, as well as small internal reorganization energy caused by less changed geometric configuration. Read More

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The Pandemic's impacts on patients without Covid-19 on multidisciplinary aspects in emergency medicine care.

Intern Emerg Med 2021 Mar 1. Epub 2021 Mar 1.

Department of Medical Management, Sheba Medical Center, Ramat-Gan, Israel.

The emergence of Covid-19 has caused a pandemic and is a major public health concern. Covid-19 has fundamentally challenged the global health care system in all aspects. However, there is a growing concern for the subsequent detrimental effects of continuing delays or adjustments on time-dependent treatments for Covid-19 negative patients. Read More

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Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.

J Neuroinflammation 2021 Feb 20;18(1):52. Epub 2021 Feb 20.

UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Normandie Univ, Caen, France.

Background: Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such as neuroinflammation by activating microglia and increasing blood-brain barrier permeability. Read More

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February 2021

Three dimensional movement analysis of maxillary impacted canine using TADs: a pilot study.

Head Face Med 2021 Jan 15;17(1). Epub 2021 Jan 15.

Orthodontics Department, School of Dentistry University of Genova largo Rosanna Benzi, 10 16132, Genoa, Italy.

Background: The aim of the present study was to compare two different anchorage systems efficiency to disinclude impacted maxillary canines using as evaluation tool superimposed Cone Beam Computed Tomography (CBCTs).

Methods: The study has been conducted with two parallel groups with an allocation ratio of 1:1. Group test received treatment using as anchorage a miniscrew, control group was treated using an anchorage unit a trans palatal arch (TPA). Read More

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January 2021

Primary Ammonium Terephthalate Salts with High Moisture Resistance and Their Use in the Detection of OH Radicals.

Chempluschem 2020 Dec;85(12):2666-2671

Department of Applied Chemistry Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

A novel and practical method is proposed for the detection of gaseous OH radicals using a moisture-resistant organic salt composed of terephthalic acid (TPA) and n-alkylamine. When the alkyl chain length was greater than 8, the organic salt had a crystal structure in which the alkyl chains were arranged parallel to each other and zero-dimensional voids were adjacent to terephthalate (TA). Since the parallelly arranged alkyl chains acted as a hydrophobic block, the organic salts had excellent humidity durability. Read More

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December 2020

Systemic Inflammation Indices in Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator: Clinical Yield and Utility.

Angiology 2021 03 6;72(3):279-284. Epub 2020 Nov 6.

Department of Neurology and Neurological Intensive Care Unit, 64005Hacettepe University Hospitals, Sihhiye, Ankara, Turkey.

Inflammation indices derived from complete blood counts (CBCs) have been proposed to estimate benefit and risk of intravenous (IV) tissue plasminogen activator (tPA) in acute ischemic stroke. In 165 acute ischemic patients, the neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio, and systemic immune-inflammation index (SII) were calculated before and 24 hours after IV tPA. The area under receiver operating characteristic (AUC-ROC) curves, and positive and negative likelihood ratios (+LR,-LR) were produced to measure their diagnostic accuracy and clinical utility for tPA effectiveness, hemorrhage risk and third-month prognosis. Read More

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A novel arthroscopically assisted reduction technique for three patterns of posterolateral tibial plateau fractures.

J Orthop Surg Res 2020 Sep 3;15(1):376. Epub 2020 Sep 3.

Intensive Care Unit, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Street, Linhai, 317000, Zhejiang Province, China.

Background: Posterolateral tibial plateau fractures (PTPF) remain a challenge for orthopedics surgeons because the special anatomical structures of the posterolateral corner of knee joint including the fibular head, the lateral collateral ligament, and the peroneal nerve, which impedes the exposure of the fracture fragments and need irregular implants to get a stable fixation. The purpose of present study was to introduce a new articular fracture fragments restoration technique for three patterns of PTPF and investigate the relationship between associated soft injuries and fracture patterns.

Methods: From May 2016 to April 2018, 31 patients with PTPF who had undertaken arthroscopically assisted reduction and fixation (AARF) were enrolled in present study. Read More

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September 2020

Physicochemical and Antioxidant Properties of Wheat Bread Enriched with Hazelnuts and Walnuts.

Foods 2020 Aug 8;9(8). Epub 2020 Aug 8.

Department of Technology and Quality of Plant Products, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, SK-949 76 Nitra, Slovakia.

The aim of this study was to evaluate the effect of wheat bread enrichment using hazelnuts and walnuts (1%, 3%, 6%, 9%) on the nutritional value and selected physicochemical and antioxidant properties. The dough and bread yield, volume, specific volume and porosity were also determined. The crumb texture was analyzed by texture profile analysis (TPA) test using a texture meter. Read More

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Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres.

J Infect Dis 2021 Mar;223(5):848-853

Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

Background: Whole-genome sequencing (WGS) of Treponema pallidum subspecies pallidum (TPA) has been constrained by the lack of in vitro cultivation methods for isolating spirochetes from patient samples.

Methods: We built upon recently developed enrichment methods to sequence TPA directly from primary syphilis chancre swabs collected in Guangzhou, China.

Results: By combining parallel, pooled whole-genome amplification with hybrid selection, we generated high-quality genomes from 4 of 8 chancre-swab samples and 2 of 2 rabbit-passaged isolates, all subjected to challenging storage conditions. Read More

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Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema: A Randomized Clinical Trial.

JAMA Pediatr 2020 04;174(4):332-340

Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Importance: Clinical guidelines recommend that children with pleural empyema be treated with chest tube insertion and intrapleural fibrinolytics. The addition of dornase alfa (DNase) has been reported to improve outcomes in adults but remains unproven in children.

Objective: To determine if intrapleural tissue plasminogen activator (tPA) and DNase is more effective than tPA and placebo at reducing hospital length of stay in children with pleural empyema. Read More

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T-Pattern Detection and Analysis (TPA) With THEME: A Mixed Methods Approach.

Front Psychol 2019 10;10:2663. Epub 2020 Jan 10.

Human Behavior Laboratory, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

This work, which was started in the early 1970s, was inspired by social interaction analysis based on direct observation and careful coding of behaviors according to a list of behavioral (mostly ethological) categories, especially the ethological work of N. Tinbergen, K. Lorenz, and K. Read More

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January 2020

Membrane Localization and Lipid Interactions of Common Lipid-Conjugated Fluorescence Probes.

Langmuir 2019 09 29;35(36):11902-11911. Epub 2019 Aug 29.

Institute for Medical Physics and Biophysics, Medical Department , Leipzig University , Leipzig , Germany.

Lateral segregation of lipids in model and biological membranes has been studied intensively in the last decades using a comprehensive set of experimental techniques. Most methods require a probe to report on the biophysical properties of a specific molecule in the lipid bilayer. Because such probes can adversely affect the results of the measurement and perturb the local membrane structure and dynamics, a detailed understanding of probe behavior and its influence on the properties of its direct environment is important. Read More

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September 2019

Identification and Clinical Validation of a Novel 4 Gene-Signature with Prognostic Utility in Colorectal Cancer.

Int J Mol Sci 2019 Aug 5;20(15). Epub 2019 Aug 5.

Department of Pathology, Anatomic Pathology Section, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Colorectal cancer (CRC) is a high burden disease with several genes involved in tumor progression. The aim of the present study was to identify, generate and clinically validate a novel gene signature to improve prediction of overall survival (OS) to effectively manage colorectal cancer. We explored The Cancer Genome Atlas (TCGA), COAD and READ datasets (597 samples) from The Protein Atlas (TPA) database to extract a total of 595 candidate genes. Read More

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Nurse-Initiated Acute Stroke Care in Emergency Departments.

Stroke 2019 May 16:STROKEAHA118020701. Epub 2019 May 16.

School of Medicine and Public Health, University of Newcastle, NSW, Australia (P.M., C.D.).

Background and Purpose- We aimed to evaluate the effectiveness of an intervention to improve triage, treatment, and transfer for patients with acute stroke admitted to the emergency department (ED). Methods- A pragmatic, blinded, multicenter, parallel group, cluster randomized controlled trial was conducted between July 2013 and September 2016 in 26 Australian EDs with stroke units and tPA (tissue-type plasminogen activator) protocols. Hospitals, stratified by state and tPA volume, were randomized 1:1 to intervention or usual care by an independent statistician. Read More

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Comparison of several non-specific skin mucus immune defences in three piscine species of aquaculture interest.

Fish Shellfish Immunol 2019 Jun 9;89:428-436. Epub 2019 Apr 9.

Departament Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 643, E-08028, Barcelona, Spain. Electronic address:

Fish skin mucus is a viscous and semipermeable barrier made mainly of water, glycoproteins and soluble proteins. It represents an important defence against the environment and previous studies have reported the presence of different substances involved in immune defence responses in it. The aim of the present work was to characterize skin mucus protease activity by zymography and esterase activity of the subfamily of carboxylesterases in three species of interest for aquaculture: gilthead sea bream, sea bass and meagre. Read More

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Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling.

Transl Psychiatry 2019 02 21;9(1):100. Epub 2019 Feb 21.

EA 4475, Pharmacologie de la circulation cérébrale, Université Paris Descartes, 75006, Paris, France.

Post-traumatic stress disorder (PTSD) is a trauma- and stress-related disorder with dysregulated fear responses and neurobiological impairments, notably at neurotrophic and inflammation levels. Understanding the mechanisms underlying this disease is crucial to develop PTSD models that meet behavioral and neurobiological validity criteria as well as innovative therapeutic approaches. Serotonin 2C receptors (5-HT2CR) are known for their important role in anxiety, and mice having only the fully edited VGV isoform of 5-HT2CR, which thereby overexpressed brain 5-HT2CR, are of special interest to study PTSD predisposition. Read More

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February 2019

Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin.

Genes Cells 2019 Mar;24(3):202-213

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.

Fascin, an actin-bundling protein, is present in the filopodia and lamellipodia of growth cones. However, few studies have examined lamellipodial fascin because it is difficult to observe. In this study, we evaluated lamellipodial fascin. Read More

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Selective parallel G-quadruplex recognition by a NIR-to-NIR two-photon squaraine.

Chem Sci 2018 Nov 14;9(44):8375-8381. Epub 2018 Sep 14.

Universität Würzburg , Institut für Organische Chemie , Am Hubland , 97074 Würzburg , Germany . Email:

Fluorescence imaging probes for specific G-quadruplex (G4) conformations are of considerable interest in biomedical research. Herein, we present the synthesis and the binding properties of a new water-soluble near-infrared (NIR) amphiphilic squaraine dye () which is capable of selective detection of parallel over non-parallel and non G4 topologies. The striking changes in its linear optical response upon binding to parallel G4s give rise to high fluorescence quantum yields ( ≈ 0. Read More

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November 2018

Low concentrations of cadmium chloride promotes protein translation and improve cell line productivity.

Biotechnol Bioeng 2019 03 4;116(3):569-580. Epub 2019 Jan 4.

Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.

Protein translation has emerged as a critical bottleneck for overall productivity of biological molecules. An augmentation of protein translation can be achieved by cell line engineering or by sophisticated vector design. However, for industrial process development purposes, identification of media additives that promote translation will be of great value, obviating the generation of new host platforms. Read More

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Importance of the Reactant-State Potentials of Chromium(V)-Oxo Complexes to Determine the Reactivity in Hydrogen-Atom Transfer Reactions.

Inorg Chem 2018 Nov 23;57(21):13929-13936. Epub 2018 Oct 23.

Department of Chemistry, Faculty of Pure and Applied Sciences , University of Tsukuba , 1-1-1 Tennoudai , Tsukuba , Ibaraki 305-8571 , Japan.

A new chromium(V)-oxo complex, [Cr(O)(6-COO-py-tacn)] (1; 6-COO-py-tacn = 1-(6-carboxylato-2-pyridylmethyl)-4,7-dimethyl-1,4,7-triazacyclononane), was synthesized and characterized to evaluate the reactivity of Cr(O) complexes in a hydrogen-atom transfer (HAT) reaction by comparing it with that of a previously reported Cr(O) complex, [Cr(O)(6-COO-tpa)] (2; 6-COO-tpa = N, N-bis(2-pyridylmethyl)- N-(6-carboxylato-2-pyridylmethyl)amine). Definitive differences of these two Cr(O) complexes were observed in resonance Raman scatterings of the Cr-O bond (ν = 911 cm for 1 and 951 cm for 2) and the reduction potential (0.73 V vs SCE for 1 and 1. Read More

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November 2018

Screening for syphilis with dual algorithms: analysis of discordant and concordant serology results in a population with a low prevalence of syphilis.

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):178-184. Epub 2018 Oct 12.

Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Currently, many laboratories have switched the traditional screening algorithm (TSA) to reverse screening algorithm (RSA) for the efficiencies in high-volume syphilis screening. However, confusions have been arisen regarding this paradigm shift.

Objective: To compare the performance of two algorithms with head-to-head mode. Read More

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January 2019

A Randomized Trial of the Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Intermediate-Risk Pulmonary Embolism: The OPTALYSE PE Trial.

JACC Cardiovasc Interv 2018 07;11(14):1401-1410

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: The aim of this study was to determine the lowest optimal tissue plasminogen activator (tPA) dose and delivery duration using ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk (submassive) pulmonary embolism.

Background: Previous trials of USCDT used tPA over 12 to 24 h at doses of 20 to 24 mg for acute pulmonary embolism.

Methods: Hemodynamically stable adults with acute intermediate-risk pulmonary embolism documented by computed tomographic angiography were randomized into this prospective multicenter, parallel-group trial. Read More

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Glycative and oxidative stress are associated with altered thrombus composition in diabetic patients with ST-elevation myocardial infarction.

Int J Cardiol 2017 Sep;243:9-14

Department of Cardiology, Universitat Autònoma de Barcelona, Barcelona, Spain; Laboratory of Experimental Cardiology, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI).

Aims: To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the potential association of these differences with glycated haemoglobin levels and markers of oxidative stress.

Methods: Intracoronary thrombi from consecutive thrombus aspiration procedures in STEMI patients, 25 diabetic and 28 non-diabetic, were analyzed by immunofluorescence with confocal microscopy. Read More

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September 2017

Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial.

Trials 2017 06 24;18(1):293. Epub 2017 Jun 24.

The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Background: A randomized controlled trial of adults with empyema recently demonstrated decreased length of stay in hospital in patients treated with intrapleurally administered dornase alfa and fibrinolytics compared to fibrinolytics alone. Whether this treatment strategy is safe and effective in children remains unknown.

Methods/design: This study protocol is for a superiority, placebo-controlled, parallel-design, multicenter randomized controlled trial. Read More

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Dendritic nanotubes self-assembled from stiff polysaccharides as drug and probe carriers.

J Mater Chem B 2017 Apr 20;5(14):2616-2624. Epub 2017 Mar 20.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Dendritic nanotubes (DNTs) with hydrophobic cavities were constructed directly from rigid branched β-1,3-d-glucan (AF1) in aqueous solution, and the AF1 sample was isolated from the fruiting bodies of Auricularia auricula-judae, a household nutritional food. The structure of AF1 dendritic nanotubes was demonstrated with a transmission electron microscope (TEM) and a scanning electron microscope (SEM), and a schematic diagram was proposed to describe the formation process, which was supported by the results of static/dynamic light scattering (SLS/DLS) and atomic force microscopy (AFM). In solution, a sequential self-assembly of the AF1 chains in a parallel manner occurred to form lamellas followed by self-curling into nanotubes with the mean diameters from 20 to 80 nm, depending on the concentration and molecular weight of AF1, through hydrogen bonding and hydrophilic/hydrophobic interaction. Read More

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Specific networks of plasma acute phase reactants are associated with the severity of chronic obstructive pulmonary disease: a case-control study.

Int J Med Sci 2017 15;14(1):67-74. Epub 2017 Jan 15.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain;; Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Virgen del Rocío. Seville, Spain;; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

A detailed understanding of the intricate relationships between different acute phase reactants (APRs) in chronic obstructive pulmonary disease (COPD) can shed new light on its clinical course. In this case-control study, we sought to identify the interaction networks of a number of plasma APRs in COPD, with a special focus on their association with disease severity. COPD cases and healthy smoking controls (3:1 ratio) were recruited in our outpatient pulmonary clinic. Read More

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Feasibility and Efficacy of Nurse-Driven Acute Stroke Care.

J Stroke Cerebrovasc Dis 2017 May 21;26(5):987-991. Epub 2016 Dec 21.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, Texas. Electronic address:

Background: Acute stroke care requires rapid assessment and intervention. Replacing traditional sequential algorithms in stroke care with parallel processing using telestroke consultation could be useful in the management of acute stroke patients. The purpose of this study was to assess the feasibility of a nurse-driven acute stroke protocol using a parallel processing model. Read More

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Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.

Cell Death Dis 2016 11 10;7(11):e2466. Epub 2016 Nov 10.

Inserm, Inserm UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen-Normandie, GIP Cyceron, Caen, France.

N-methyl-d-aspartate receptors (NMDARs) are ion channels whose synaptic versus extrasynaptic localization critically influences their functions. This distribution of NMDARs is highly dependent on their lateral diffusion at the cell membrane. Each obligatory subunit of NMDARs (GluN1 and GluN2) contains two extracellular clamshell-like domains with an agonist-binding domain and a distal N-terminal domain (NTD). Read More

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November 2016

Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Cancer Res 2017 01 4;77(1):62-73. Epub 2016 Nov 4.

University Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, Paris, France.

Chromosome segregation during mitosis is monitored by the mitotic checkpoint and is dependent upon DNA methylation. ZBTB4 is a mammalian epigenetic regulator with high affinity for methylated CpGs that localizes at pericentromeric heterochromatin and is frequently downregulated in cancer. Here, we report that decreased ZBTB4 expression correlates with high genome instability across many frequent human cancers. Read More

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January 2017