266,951 results match your criteria parallel pathways

Treatment Effects and Lip Profile Changes Following Surgical Mandibular Advancement Versus Premolar Extractions in Class II Div 1 Malocclusion: A Randomized Controlled Trial.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Government Dental Center ADC R&R Hospital, New Delhi Government Dental Center, Pune Jabalpur Hospital, Jabalpur Institute of Dental Sciences, Mumbai, India.

Abstract: No randomized controlled trial has compared the treatment outcome between surgical mandibular advancement and premolar extractions in class II malocclusion. This 2-arm parallel randomized controlled trial evaluated the treatment effects and lip profile changes in skeletal class II adult patients subjected to bilateral sagittal split ramus osteotomy for mandibular advancement and those treated with premolar extractions. Seventy skeletal class II patients were accessed and forty-six subjects who fulfilled inclusion criteria were distributed randomly into Group CG (patients: 23, mean age: 21. Read More

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Cognitive Behavioral Therapy for Sleep Disturbance and Fatigue Following Acquired Brain Injury: Predictors of Treatment Response.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia (Drs Ymer, McKay, Wong, Grima, and Ponsford); Monash Epworth Rehabilitation Research Centre, Melbourne, Australia (Drs Ymer, McKay, Wong, Frencham, Grima, Nguyen, and Ponsford and Ms Tran); Department of Psychology, Epworth Rehabilitation, Melbourne, Australia (Drs Ymer, McKay, and Nguyen); and School of Psychology and Public Health, La Trobe University, Melbourne, Australia (Dr Wong).

Objective: To identify factors associated with treatment response to cognitive behavioral therapy for sleep disturbance and fatigue (CBT-SF) after acquired brain injury (ABI).

Setting: Community dwelling.

Participants: Thirty participants with a traumatic brain injury or stroke randomized to receive CBT-SF in a parent randomized controlled trial. Read More

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Patterns of protein adsorption in ion-exchange particles and columns: Evolution of protein concentration profiles during load, hold, and wash steps predicted for pore and solid diffusion mechanisms.

J Chromatogr A 2021 Jul 14;1653:462412. Epub 2021 Jul 14.

Department of Biotechnology, BOKU Vienna, Vienna, Austria. Electronic address:

Elucidation of protein transport mechanism in ion exchanges is essential to model separation performance. In this work we simulate intraparticle adsorption profiles during batch adsorption assuming typical process conditions for pore, solid and parallel diffusion. Artificial confocal laser scanning microscopy images are created to identify apparent differences between the different transport mechanisms. Read More

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Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.

Anal Chem 2021 Jul 28. Epub 2021 Jul 28.

Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.

We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a transformative system enabling high-speed sampling and label-free analysis. The ADE technology delivers nanoliter droplets in a touchless manner with high speed, precision, and accuracy. Subsequent sample dilution within the OPI, in concert with the capabilities of modern ESI-MS, eliminates the laborious sample preparation and method development required in current approaches. Read More

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Stereoselective Self-Assembly of DNA Binding Helicates Directed by the Viral β-Annulus Trimeric Peptide Motif.

Bioconjug Chem 2021 Jul 28. Epub 2021 Jul 28.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2'-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions. Read More

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A mixed methods study to evaluate participatory mapping for rural water safety planning in western Kenya.

PLoS One 2021 28;16(7):e0255286. Epub 2021 Jul 28.

School of Geography and Environmental Science, University of Southampton, Highfield, Southampton, United Kingdom.

Water safety planning is an approach to ensure safe drinking-water access through comprehensive risk assessment and water supply management from catchment to consumer. However, its uptake remains low in rural areas. Participatory mapping, the process of map creation for resource management by local communities, has yet to be used for rural water safety planning. Read More

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Basking shark sub-surface behaviour revealed by animal-towed cameras.

PLoS One 2021 28;16(7):e0253388. Epub 2021 Jul 28.

Hatherly Laboratories, University of Exeter, College of Life & Environmental Sciences, Exeter, United Kingdom.

While biologging tags have answered a wealth of ecological questions, the drivers and consequences of movement and activity often remain difficult to ascertain, particularly marine vertebrates which are difficult to observe directly. Basking sharks, the second largest shark species in the world, aggregate in the summer in key foraging sites but despite advances in biologging technologies, little is known about their breeding ecology and sub-surface behaviour. Advances in camera technologies holds potential for filling in these knowledge gaps by providing environmental context and validating behaviours recorded with conventional telemetry. Read More

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Developing a model for estimating the activity of colonic microbes after intestinal surgeries.

PLoS One 2021 28;16(7):e0253542. Epub 2021 Jul 28.

Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States of America.

Background: The large intestine provides a compensatory role in energy recovery when surgical interventions such as extensive small intestinal resections or bypass operations lower the efficiency of nutrient absorption in the upper gastrointestinal (GI) tract. While microorganisms in the colon are known to play vital roles in recovering energy, their contributions remain to be qualified and quantified in the small intestine resection.

Objective: We develop a mathematical model that links nutrient absorption in the upper and lower GI tract in two steps. Read More

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Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir.

J Gen Virol 2021 Jul;102(7)

Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Rapid repurposing of existing drugs as new therapeutics for COVID-19 has been an important strategy in the management of disease severity during the ongoing SARS-CoV-2 pandemic. Here, we used high-throughput docking to screen 6000 compounds within the DrugBank library for their potential to bind and inhibit the SARS-CoV-2 3 CL main protease, a chymotrypsin-like enzyme that is essential for viral replication. For 19 candidate hits, parallel fluorescence-based protease-inhibition assays and Vero-CCL81 cell-based SARS-CoV-2 replication-inhibition assays were performed. Read More

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Comparison of Unit Resolution Versus High-Resolution Accurate Mass for Parallel Reaction Monitoring.

J Proteome Res 2021 Jul 28. Epub 2021 Jul 28.

Department of Genome Sciences, University of Washington, 3720 15th Street NE, Seattle, Washington 98195, United States.

Parallel reaction monitoring (PRM) is an increasingly popular alternative to selected reaction monitoring (SRM) for targeted proteomics. PRM's strengths over SRM are that it monitors all product ions in a single spectrum, thus eliminating the need to select interference-free product ions prior to data acquisition, and that it is most frequently performed on high-resolution instruments, such as quadrupole-orbitrap and quadrupole-time-of-flight instruments. Here, we show that the primary advantage of PRM is the ability to monitor all transitions in parallel and that high-resolution data are not necessary to obtain high-quality quantitative data. Read More

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Exploratory Qualitative Analysis of Early Literacy Engagement in Latinx Parents of a Child With a Cleft.

J Craniofac Surg 2021 Jul-Aug 01;32(5):1817-1821

Department of Psychiatry and Behavioral Sciences, University of Washington and Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA.

Abstract: Literacy interventions are needed for children born with orofacial clefts, particularly for Latinx children who may experience multiple risk factors. To collect formative data for intervention design, focus groups and interviews were completed with 18 Latinx parents of children ages 13 to 49 months with orofacial clefts. Interviews focused on literacy experiences and practices. Read More

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Hydrogen and Halogen Bonding in Homogeneous External Electric Fields: Modulating the Bond Strengths.

Chemistry 2021 Jul 28. Epub 2021 Jul 28.

University of North Carolina at Greensboro, Department of Nanoscience, 2907 E. Gate City Blvd, 27401, Greensboro, UNITED STATES.

Recent years have witnessed various fascinating phenomena arising from the interactions of noncovalent bonds with homogeneous external electric fields (EEFs). Here we performed a computational study to interpret the sensitivity of intrinsic bond strengths to EEFs in terms of steric effect and orbital interactions. The block-localized wavefunction (BLW) method, which combines the advantages of both ab initio valence bond (VB) theory and molecular orbital (MO) theory, and the subsequent energy decomposition (BLW-ED) approach were adopted. Read More

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Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study.

Neurol Sci 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Background: Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on treatment with levodopa. Read More

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Breaking bad news about glaucoma: a SPIKES strategy primer.

Int Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

Department of Ophthalmology, Government Medical College and Hospital, Sector-32, Chandigarh, India.

Purpose: Most ophthalmic physicians are not formally trained for breaking the news of having sight threatening diseases, requiring lifelong therapy. This study aims to ascertain physician practices and patients' experiences regarding delivery of bad news.

Methods: An online, anonymous questionnaire was sent to 400 ophthalmologists practising glaucoma to gather information as to how they deliver bad news to their patients. Read More

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4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo.

Endocr Connect 2021 Jul 28;10(8):861-872. Epub 2021 Jul 28.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

Plasma free fatty acids (FFAs) are elevated in obesity and can induce insulin resistance via endoplasmic reticulum (ER) stress. However, it is unknown whether hepatic insulin resistance caused by the elevation of plasma FFAs is alleviated by chemical chaperones. Rats received one of the following i. Read More

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Giant tunneling electroresistance arising from reversible partial barrier metallization in the NaTiO/BaTiO/LaTiO ferroelectric tunnel junction.

Phys Chem Chem Phys 2021 Jul 27. Epub 2021 Jul 27.

Key Laboratory of Materials Physics, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China. and Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230026, China.

Tunneling electroresistance (TER) is the change in tunneling resistance induced by ferroelectric polarization reversal in ferroelectric tunnel junctions (FTJs), and how to achieve a giant TER has always been a central topic in the study of FTJs. In this work, by considering the NaTiO3/BaTiO3/LaTiO3 junction with asymmetric polar interfaces as an example, we propose a novel scheme to realize a giant TER based on the reversible partial metallization of ferroelectric barrier upon the switching of ferroelectric polarization. Density functional theory calculations indicate that high on-state and low off-state conductances are obtained and the TER ratio is as high as 3. Read More

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Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study.

Acta Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To evaluate ocular hypotensive efficacy and the safety of sovesudil (formally known as PHP-201), a novel Rho-associated protein kinase (ROCK) inhibitor, in patients with normal-tension glaucoma (NTG).

Design: Multicentre, prospective, double-masked, randomized, placebo-controlled, parallel clinical study.

Methods: Patients with NTG (unmedicated baseline IOP ≤ 21 mmHg) were randomized in 3 groups and treated with sovesudil in concentrations of 0. Read More

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Lack of predictive value of retinal oxygen saturation for visual outcome after angiostatic treatment of branch retinal vein occlusion.

Acta Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark.

Purpose: Previous studies have shown that the retinal oxygen saturation in central retinal vein occlusion treated with anti-VEGF compound has no predictive value for visual outcome after 12 months. It is of interest to evaluate whether this conclusion is similar for patients with branch retinal vein occlusion among whom only some patients are treated.

Methods: Retinal oxygen saturation, visual acuity and central retinal thickness were studied at the time of referral and after six and 12 months in 111 patients successively referred to the Department of Ophthalmology, Aarhus University Hospital, with a venous occlusion affecting branches peripheral from the central retinal venule. Read More

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4-Dimensional Flow by Cardiac Magnetic Resonance Informs Surgical Planning in Partial Anomalous Pulmonary Venous Return.

JACC Case Rep 2020 Apr 15;2(4):672-677. Epub 2020 Apr 15.

Division of Cardiology, Children's National Health System, Washington, DC.

Four-dimensional flow cardiac magnetic resonance enhances the visualization of blood flow in a 3-dimensional volume throughout the cardiac cycle, thus dramatically improving visualization of pulmonary venous anatomy by cardiac magnetic resonance. We demonstrate the impact of 4-dimensional flow on diagnosis and surgical planning for partial anomalous pulmonary venous return. (). Read More

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Senning Procedure for Physiological Atrial Inversion With Left Atrial Isomerism.

JACC Case Rep 2019 Dec 18;1(4):516-522. Epub 2019 Dec 18.

Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare System, Hollywood, Florida.

We present the case of an infant with left atrial isomerism with complex pulmonary and systemic venous connections that resulted in physiological parallel circulation in the setting of ventriculoarterial concordance who was surgically treated using the Senning procedure. This case highlights a rare cause for cyanosis due to poor mixing from a parallel circulation and an issue with nomenclature. (). Read More

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December 2019

Validation and implementation of the Panbio COVID-19 Ag rapid test for the diagnosis of SARS-CoV-2 infection in symptomatic hospital healthcare workers.

2021 Jun 16;3(2):100142. Epub 2021 Apr 16.

Department of Medical Microbiology, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands.

Background: RT-PCR is the current recommended laboratory method to diagnose SARS-CoV-2 in healthcare workers (HCW). As RT-PCR is not widely available and is time-consuming, it limits decision making on removal from and return to work of possibly contagious HCW.

Aim: In this study we evaluated the Panbio™ COVID-19 Ag rapid test (PanbioCAgRT) in 825 hospital HCW. Read More

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Effect of a Nutritionally Balanced Diet Comprising Whole Grains and Vegetables Alone or in Combination with Probiotic Supplementation on the Gut Microbiota.

Prev Nutr Food Sci 2021 Jun;26(2):121-131

Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea.

Dysbiosis is a microbial imbalance, which often causes diseases and can be triggered by diet. Here, we deter-mined the effect of a nutritionally balanced diet rich in vegetables and whole grains alone and/or in combination with probiotics on the gut microbiota of healthy adults. We conducted a parallel-group randomized trial enrolling 63 healthy participants who were administered either a balanced diet (B-diet group), a probiotic capsule containing PMO 08 (probiotics group), or a balanced diet plus probiotic capsule (synbiotics group) once daily for 2 weeks. Read More

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Understanding the Process and Challenges for Return-to-Work Post-Hematopoietic Cell Transplantation from a Musculoskeletal Perspective: A Narrative Review.

Occup Ther Int 2021 6;2021:5568513. Epub 2021 Jul 6.

Rehabilitation Association for Hematopoietic Cell Transplantation, Gloucester, UK.

The current paper seeks to inform healthcare professionals on how adapting various components of return to work (RTW) programs that are already in use by other musculoskeletal rehabilitation settings can help optimize return to work process for patients with or without musculoskeletal manifestations, posthematopoietic cell transplantation. Since there is no universally agreed RTW structure for hematopoietic cell transplant patients, a narrative approach has been taken utilizing evidence from the existing musculoskeletal return to work assessment publications to help draw parallel for the hematopoietic cell transplant patients. Databases were searched including PUBMED, CINHAL, AMED, SCOPUS, and Cochrane using keywords RTW, functional restoration program, hematopoietic cell transplant, bone marrow transplant, stem cell transplant, and musculoskeletal functional assessment. Read More

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A new Palaearctic species of the subgenus (Diptera, Tipulidae) from the West Caucasus with a survey of the species group.

Zookeys 2021 13;1048:145-175. Epub 2021 Jul 13.

Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119991, Russia Lomonosov Moscow State University Moscow Russia.

The species group in the subgenus Lunatipula is redefined and now consists of five species native to the Caucasus. () is described as new to science, and variations in the male terminalia in two populations are noted. Two subspecies ( and ) are elevated to species rank. Read More

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Impact of Intrauterine Administration of Human Chorionic Gonadotropin before Intrauterine Insemination in Infertile Women: A Randomized Controlled Trial.

J Hum Reprod Sci 2021 Apr-Jun;14(2):156-161. Epub 2021 Jun 28.

Department of Obstetrics and Gynaecology, IVF and Fertility Research Centre, ESI-PGIMSR, New Delhi, India.

Background: Implantation is the rate-limiting step in the success of both intrauterine Insemination (IUI) and fertilization cycles. Numerous interventions that target various local signals have been tried to improve the implantation and clinical pregnancy rate (CPR). The most significant of these signals is human chorionic gonadotropin (hCG) which acts as immunomodulator and improves implantation by decidualization of the endometrial stromal cells, trophoblast invasion, proliferation of uterine natural killer cells, stimulation of endometrial angiogenesis, and maintenance of progesterone secretion by the corpus luteum. Read More

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Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience.

Indian J Crit Care Med 2021 Jul;25(7):791-794

All India Institute of Medical Sciences, Patna, Bihar, India.

Background: Gargling had been reported to have some roles in the prevention and treatment of respiratory tract infections. The purpose of this study was to assess the ability of regular gargling using 7.5% sodium bicarbonate to eliminate SARS-CoV-2 in the oropharynx and nasopharynx. Read More

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How Robust are the Evidences that Formulate Surviving Sepsis Guidelines? An Analysis of Fragility and Reverse Fragility of Randomized Controlled Trials that were Referred in these Guidelines.

Indian J Crit Care Med 2021 Jul;25(7):773-779

Department of Critical Care, Holy Family Hospital, Delhi, India.

Objectives: "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016" provides guidelines in regard to prompt management and resuscitation of sepsis or septic shock. The study is aimed to assess the robustness of randomized controlled trials (RCTs) that formulate these guidelines in terms of fragility index and reverse fragility index.

Method: RCTs that contributed to these guidelines having parallel two-group design, 1:1 allocation ratio, and at least one dichotomous outcome were included in the study. Read More

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A New ICU Delirium Prevention Bundle to Reduce the Incidence of Delirium: A Randomized Parallel Group Trial.

Indian J Crit Care Med 2021 Jul;25(7):754-760

Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, Delhi, India.

Introduction: Although various preventive strategies have been advocated, delirium is common in critically ill patients and is associated with increased morbidity, mortality, and long-term adverse effects. The efficacy of a novel delirium prevention bundle in mechanically ventilated critically ill patients was investigated in this study.

Methods: In this randomized controlled trial, 50 mechanically ventilated adult patients in a tertiary care medical-surgical intensive care unit (ICU) were randomized to receive either delirium prevention bundle protocol or standard of care protocol. Read More

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Safe distancing in the time of COVID-19.

Eur J Oper Res 2021 Jul 10. Epub 2021 Jul 10.

Automation & Control, Department of Electronic Systems, Aalborg University, Fredrik Bajers Vej 7C, Aalborg 9220, Denmark.

The spread of viruses such as SARS-CoV-2 brought new challenges to our society, including a stronger focus on safety across all businesses. Many countries have imposed a minimum social distance among people in order to ensure their safety. This brings new challenges to many customer-related businesses, such as restaurants, offices, theaters, etc. Read More

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Robust topological designs for extreme metamaterial micro-structures.

Sci Rep 2021 Jul 27;11(1):15221. Epub 2021 Jul 27.

College of Engineering, Swansea University, Bay Campus, Swansea, SA1 8EN, UK.

We demonstrate that the consideration of material uncertainty can dramatically impact the optimal topological micro-structural configuration of mechanical metamaterials. The robust optimization problem is formulated in such a way that it facilitates the emergence of extreme mechanical properties of metamaterials. The algorithm is based on the bi-directional evolutionary topology optimization and energy-based homogenization approach. Read More

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