923,480 results match your criteria paper [1]the


3C-GAN: class-consistent CycleGAN for malaria domain adaptation model.

Biomed Phys Eng Express 2021 Jun 24. Epub 2021 Jun 24.

Electrical and Computer Engineering, North South University, Plot, 15, Block B Kuril - NSU Rd, Dhaka, Dhaka, Dhaka, 1229, BANGLADESH.

Unpaired domain translation models with distribution matching loss such as CycleGAN are now widely being used to shift domain in medical images. However, synthesizing medical images using CycleGAN can lead to misdiagnosis of a medical condition as it might hallucinate unwanted features, especially if there's a data bias. This can potentially change the original class of the input image, which is a very serious problem. Read More

View Article and Full-Text PDF

Premature beats detection based on a novel convolutional neural network.

Physiol Meas 2021 Jun 24. Epub 2021 Jun 24.

Fudan University School of Basic Medical Sciences, Shanghai, CHINA.

Objective: Automatic detection of premature beats on long electrocardiogram (ECG) recordings is of great significance for clinical diagnosis. In this paper, we propose a novel deep learning model, the ECGDet, to detect premature beats, including premature ventricular contractions (PVCs) and supraventricular premature beats (SPBs) on single-lead long-term ECGs.

Approach: The ECGDet is proposed based on a convolutional neural network and squeeze-and-excitation network. Read More

View Article and Full-Text PDF

Generation of a nanobody-alkaline phosphatase fusion and its application in an enzyme cascade-amplified immunoassay for colorimetric detection of alpha fetoprotein in human serum.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 17;262:120088. Epub 2021 Jun 17.

College of Food Science and Engineering, Hainan University, Haikou 570228, China. Electronic address:

Sensitive detection of liver disease biomarkers can facilitate the diagnosis of primary hepatoma and other benign liver diseases, and the alpha fetoprotein (AFP) was selected as the model macromolecule in this work. Herein an enzyme cascade-amplified immunoassay (ECAIA) based on the nanobody-alkaline phosphatase fusion (Nb-ALP) and MnO nanoflakes was developed for detecting AFP. The bifunctional biological macromolecule Nb-ALP serves as the detection antibody and the reporter molecule. Read More

View Article and Full-Text PDF

Capturing and communicating impact of citizen science for policy: A storytelling approach.

J Environ Manage 2021 Jun 21;295:113082. Epub 2021 Jun 21.

Cornell Lab of Ornithology, Cornell University, Ithaca, NY, United States.

In response to the need for approaches to understand how citizen science is currently influencing environmental policy and associated decision making, we devised the Citizen Science Impact StoryTelling Approach (CSISTA). We iteratively designed instruments to be used as tools primarily for citizen science practitioners seeking to understand or communicate policy impacts. We then trialled the CSISTA and associated instruments on four exemplary citizen science initiatives, using different forms of inquiry and collaboration with respective initiative leaders. Read More

View Article and Full-Text PDF

Early-onset preeclampsia - The impact of antiphospholipid antibodies on disease severity.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 12;263:79-84. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objectives: Antiphospholipid antibodies have been associated with various obstetric complications, including recurrent pregnancy loss, preeclampsia, intrauterine growth restriction, placental insufficiency, and late fetal loss. Despite the amassed body of evidence emphasizing the association between antiphospholipid antibodies and preeclampsia, the severity of preeclampsia with regard to antiphospholipid antibodies status has not been elucidated. This study aimed to evaluate whether early-onset preeclampsia with severe features before 34 weeks' gestation is clinically different when associated with antiphospholipid antibodies. Read More

View Article and Full-Text PDF

Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 15;263:72-78. Epub 2021 Jun 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Center for Assisted Reproductive Technology, Division of Obstetrics and Gynecology, Careggi University Hospital, Florence, Italy. Electronic address:

Objective: The purpose of this study was to evaluate the vitamin B status related to the homocysteine pathway and the prevalence of polymorphisms of the MTHFR gene in infertile women programming homologous or heterologous ART.

Study Design: We investigated 393 consecutive Caucasian women, referred to the Internal Medicine Clinic at the Center for Assisted Reproductive Technology, in order to be framed for their vascular risk before starting homologous or heterologous (oocyte donation) procedures. Total homocysteine, Vitamin B12, folate and vitamin B6 were measured. Read More

View Article and Full-Text PDF

Intravaginal 6.5 mg prasterone administration in postmenopausal women with overactive bladder syndrome: A pilot study.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 12;263:67-71. Epub 2021 Jun 12.

Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic University of Catania, Via S. Sofia 78, 95124 Catania, Italy.

Objective: The aim of this study was to evaluate the impact of vaginally prasterone administration on postmenopausal women with genitourinary syndrome of menopause (GSM) affected by overactive bladder syndrome (OAB). A secondary aim of this study was to assess the efficacy of prasterone on VVA and quality of life (QoL).

Study Design: Thirty-two postmenopausal women with GSM and referred OAB symptoms received treatment with daily intravaginal prasterone 6. Read More

View Article and Full-Text PDF

The influence of lifestyle of OB/GYN female residents on gynecological and obstetrical outcomes: A cross-sectional study.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 14;263:62-66. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To learn the influence of obstetrics and gynecology (OB/GYN) female residents' lifestyle on obstetric and gynecological characteristics compared to women matched by age from the general population.

Study Design: A cross-sectional multicenter study including OB/GYN female residents from ten different hospitals in Israel, who completed an internet questionnaire published during 2017-2018, that were compared to women matched by age from the general population. Questions dealt with lifestyle habits, obstetrical and gynecological outcomes. Read More

View Article and Full-Text PDF

Placental morphology and the prediction of underlying cardiovascular risk factors.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 6;263:56-61. Epub 2021 Jun 6.

Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall Room 563, 18 Stuart Street, Kingston, Ontario K7L 3N6, Canada; Department of Obstetrics and Gynaecology, Queen's University, Kingston Health Sciences Centre, 76 Stuart Street, Victory 4 Room 3-4-117, Kingston, Ontario K7L 2V7, Canada. Electronic address:

Objective: Pre-eclampsia is associated with an increased risk of future cardiovascular disease. Maladaptive placentation or malperfusion, as well as predisposing cardiovascular or metabolic risk for endothelial dysfunction, contribute to the systemic inflammatory response that establishes the origins of the disease. The purpose of this study was to investigate the relationship between placental size and cardiovascular risk when assessed at six months postpartum in women who experienced pre-eclampsia. Read More

View Article and Full-Text PDF

Open-legs axial plane: A standardized methodology and reference values for fetal genital biometry in mid-trimester ultrasound.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 15;263:50-55. Epub 2021 Jun 15.

Prenatal Diagnosis Unit, Department of Obstetrics, HGU Santa Lucía, Cartagena, Spain.

Background: Evaluation of the external genitalia is an important part of prenatal ultrasound. However, there is no standardized methodology that includes biometric measurements and normative data to be able to carry out this evaluation.

Objective: To develop a standardized methodology for fetal genital biometry and obtain reference values for use in mid-trimester ultrasound. Read More

View Article and Full-Text PDF

First assessment of bone mineral density in healthy pregnant women by means of Radiofrequency Echographic Multi Spectrometry (REMS) technology.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 15;263:44-49. Epub 2021 Jun 15.

Department of Medicine and Surgery, Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy. Electronic address:

Objective: The maternal bone structure is the largest calcium reserve for the fetus during pregnancy, and this is claimed to lead to a bone mineral density (BMD) reduction in pregnant women. The primary outcome of the present work was to assess the BMD in a group of healthy pregnant women.

Study Design: In this prospective case - control observational study, a non-consecutive group of pregnant women with uncomplicated pregnancy at or >37 weeks were enrolled at the unit of Obstetrics and Gynecology, University of Parma, from February to December 2020. Read More

View Article and Full-Text PDF

IMU-based knee flexion, abduction and internal rotation estimation during drop landing and cutting tasks.

J Biomech 2021 Jun 13;124:110549. Epub 2021 Jun 13.

School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Anterior cruciate ligament (ACL) injury is a common and severe knee injury in sports. Knee flexion, abduction and internal rotation angles are considered crucial biomechanical indicators of the ACL injury risk but currently are computed in a laboratory with an optical motion capture. This paper introduces an inertial measurement unit (IMU) based algorithm for knee flexion, abduction and internal rotation estimation during ACL injury risk assessment tests, including drop landing and cutting tasks. Read More

View Article and Full-Text PDF

Influence of causal language on causal understanding: A comparison between Swiss German and Turkish.

J Exp Child Psychol 2021 Jun 21;210:105182. Epub 2021 Jun 21.

Department of Psychology, University of Zurich, 8050 Zurich, Switzerland; Center for the Interdisciplinary Study of Language Evolution (ISLE), 8032 Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, 8050 Zurich, Switzerland.

Young children have difficulties in understanding untypical causal relations. Although we know that hearing a causal description facilitates this understanding, less is known about what particular features of causal language are responsible for this facilitation. Here, we asked two questions. Read More

View Article and Full-Text PDF

Obstructive sleep apnea and incidence of malignant tumors: a meta-analysis.

Sleep Med 2021 Jun 21;84:195-204. Epub 2021 Jun 21.

Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, China. Electronic address:

Objectives: This paper assessed the connection between obstructive sleep apnea (OSA) and the incidence of malignant tumors.

Methods: PubMed, Cochrane, Scopus, Health Source Nursing Academic Edition, EMBASE, and Web of Sciences were searched until the date of July 25, 2020. The analysis included an assessment of the overall incidence of OSA malignancies, the incidence of OSA malignancies by age and gender, and the incidence of different types of malignancies in patients with OSA. Read More

View Article and Full-Text PDF

The Japanese lamprey (Lethenteron camtschaticum) expresses functional lysophosphatidic acid receptors.

Biochem Biophys Res Commun 2021 Jun 21;568:1-7. Epub 2021 Jun 21.

Division of Molecular Neurobiology, Department of Life Science, Kindai University, Higashiosaka, Japan. Electronic address:

Lysophosphatidic acid (LPA) signaling plays diverse roles in the development of various vertebrates such as mammals and fish. The lamprey is a fish that retains ancestral features of vertebrates, but information regarding lamprey LPA receptor genes is limited. Here, using information from the lamprey genome database, we cloned two LPA receptor genes, Lpar1 and Lpar5, from the Japanese lamprey (Lethenteron camtschaticum). Read More

View Article and Full-Text PDF

COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center.

Epilepsy Behav 2021 Jun 21;122:108160. Epub 2021 Jun 21.

Department of Epileptology, University Hospital of Bonn, Bonn, Germany.

Introduction: Due to the high demand for information regarding COVID-19 vaccination in people with epilepsy (PWE), we assessed the symptoms and seizure control of PWE following their COVID-19 vaccination.

Methods: All adult patients who were treated at our center were asked to report on their vaccination status and, if vaccinated, about their experiences following their first COVID-19 vaccination with regard to adverse effects and seizure control.

Results: Fifty-four PWE have already received their first vaccination against COVID-19 (27 female, 20% seizure free, 96<% on antiseizure medication) and were included in the study. Read More

View Article and Full-Text PDF

The emergence of objectivity: Fleck, Foucault, Kuhn and Hacking.

Authors:
Luca Sciortino

Stud Hist Philos Sci 2021 Jun 21;88:128-137. Epub 2021 Jun 21.

Ecampus University, Via Isimbardi 10, 22060, Novedrate, CO, Italy. Electronic address:

The analytical notions of 'thought style', 'paradigm', 'episteme' and 'style of reasoning' are some of the most popular frameworks in the history and philosophy of science. Although their proponents, Ludwik Fleck, Thomas Kuhn, Michel Foucault, and Ian Hacking, are all part of the same philosophical tradition that closely connects history and philosophy, the extent to which they share similar assumptions and objectives is still under debate. In the first part of the paper, I shall argue that, despite the fact that these four thinkers disagree on certain assumptions, their frameworks have the same explanatory goal - to understand how objectivity is possible. Read More

View Article and Full-Text PDF

Value management and model pluralism in climate science.

Stud Hist Philos Sci 2021 Jun 21;88:120-127. Epub 2021 Jun 21.

UCLouvain, Earth and Life Institute, Belgium. Electronic address:

Non-epistemic values pervade climate modelling, as is now well documented and widely discussed in the philosophy of climate science. Recently, Parker and Winsberg have drawn attention to what can be termed "epistemic inequality": this is the risk that climate models might more accurately represent the future climates of the geographical regions prioritised by the values of the modellers. In this paper, we promote value management as a way of overcoming epistemic inequality. Read More

View Article and Full-Text PDF

Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis.

Biochem Biophys Res Commun 2021 Jun 21;567:183-189. Epub 2021 Jun 21.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Colon cancer is a common human cancer worldwide. The survival rate of late staged or metastatic colon cancer patients remains low even though the effectiveness of treatment in colon cancer has greatly improved. Research on tumorigenesis mechanisms and discovery of novel molecular target for treating colon cancer is critical. Read More

View Article and Full-Text PDF

Atmospheric deposition of inorganic nutrients to the Western North Pacific Ocean.

Sci Total Environ 2021 Jun 11;793:148401. Epub 2021 Jun 11.

Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea; OJEong Resilience Institute, Korea University, Seoul 02841, Republic of Korea. Electronic address:

We evaluated the potential impacts of atmospheric deposition on marine productivity and inorganic carbon chemistry in the northwestern Pacific Ocean (8-39°N, 125-157°E). The nutrient concentration in atmospheric total suspended particles decreased exponentially with increasing distance from the closest land-mass (Asia), clearly revealing anthropogenic and terrestrial contributions. The predicted mean depositional fluxes of inorganic nitrogen were approximately 34 and 15 μmol m d to the west and east of 140°E, respectively, which were at least two orders of magnitude greater than the inorganic phosphorus flux. Read More

View Article and Full-Text PDF

Ammonium promoting methane oxidation by stimulating the Type Ia methane-oxidizing bacteria in tidal flat sediments of the Yangtze River estuary.

Sci Total Environ 2021 Jun 15;793:148470. Epub 2021 Jun 15.

Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences, Fudan University, Shanghai, China. Electronic address:

Estuary and coastal environments have essential ecosystem functions in greenhouse gas sinks and removal of nitrogen pollution. Methane-oxidizing bacteria (MOB) and ammonia-oxidizing bacteria (AOB) communities play critical functions in the estuary's tidal flat sediments. Therefore, the effects of ammonium on MOB communities and methane on AOB communities need to be further explained. Read More

View Article and Full-Text PDF

Temporal and spatial characteristics of PAHs in oysters from the Pearl River Estuary, China during 2015-2020.

Sci Total Environ 2021 Jun 17;793:148495. Epub 2021 Jun 17.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China.

Estuary connects the inland freshwater and open seawater, which may become a sink for pollutants from land-derived outflows, especially for persistent organic pollutants (e.g., polycyclic aromatic hydrocarbons, PAHs). Read More

View Article and Full-Text PDF

Association between postpartum low-carbohydrate-diet scores and glucose levels in Chinese women.

Nutrition 2021 May 8;89:111305. Epub 2021 May 8.

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangzhou, China. Electronic address:

Objectives: Views on the relationship between a low-carbohydrate diet (LCD) and glucose levels are controversial, and no study, to our knowledge, has examined this association in postpartum women. We aimed to explore the association between postpartum LCD scores and glucose levels.

Methods: We included 500 postpartum women from a prospective cohort study in Guangzhou, China, during 2017 and 2018. Read More

View Article and Full-Text PDF

Variational policy search using sparse Gaussian process priors for learning multimodal optimal actions.

Neural Netw 2021 Jun 12;143:291-302. Epub 2021 Jun 12.

Graduate School of Science and Technology, Division of Information Science, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, Japan. Electronic address:

Policy search reinforcement learning has been drawing much attention as a method of learning a robot control policy. In particular, policy search using such non-parametric policies as Gaussian process regression can learn optimal actions with high-dimensional and redundant sensors as input. However, previous methods implicitly assume that the optimal action becomes unique for each state. Read More

View Article and Full-Text PDF

Adaptive neural network asymptotic tracking control for nonstrict feedback stochastic nonlinear systems.

Neural Netw 2021 Jun 12;143:283-290. Epub 2021 Jun 12.

College of Intelligent Systems Science and Engineering, Harbin Engineering University, Harbin, 150001, China; Key laboratory of Intelligent Technology and Application of Marine Equipment (Harbin Engineering University), Ministry of Education, Harbin, 150001, China. Electronic address:

The adaptive neural network asymptotic tracking control issue of nonstrict feedback stochastic nonlinear systems is studied in our article by adopting backstepping algorithm. Compared with the existing research, the hypothesis about unknown virtual control coefficients (UVCC) is overcome in the control design. By using the bound estimation scheme and some smooth functions, associating with approximation-based neural network, the asymptotic tracking controller is recursively constructed. Read More

View Article and Full-Text PDF

Exponential passivity of discrete-time switched neural networks with transmission delays via an event-triggered sliding mode control.

Neural Netw 2021 Jun 15;143:271-282. Epub 2021 Jun 15.

Department of Basic, Qinghai University, Xining 810016, China.

This paper investigates the exponential passivity of discrete-time switched neural networks (DSNNs) with transmission delays via an event-triggered sliding mode control (SMC). Firstly, a novel discrete-time switched SMC scheme is constructed on the basis of sliding mode control method and event-triggered mechanism. Next, a state observer with transmission delays is designed to estimate the system state. Read More

View Article and Full-Text PDF

Performance evaluation of Emergency Department patient arrivals forecasting models by including meteorological and calendar information: A comparative study.

Comput Biol Med 2021 Jun 3;135:104541. Epub 2021 Jun 3.

Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Denmark.

The volume of daily patient arrivals at Emergency Departments (EDs) is unpredictable and is a significant reason of ED crowding in hospitals worldwide. Timely forecast of patients arriving at ED can help the hospital management in early planning and avoiding of overcrowding. Many different ED patient arrivals forecasting models have previously been proposed by using time series analysis methods. Read More

View Article and Full-Text PDF

COVID-19 pandemic and innovation activities in the global airline industry: A review.

Environ Int 2021 Jun 21;156:106719. Epub 2021 Jun 21.

Kent Business School, University of Kent, Kent ME4 4TE, United Kingdom. Electronic address:

Despite the valuable contributions of scholars to the COVID-19 pandemic, limited scholarly attention has been paid to the opportunities unleashed by the crisis. As many industries have been turned upside down and markets rendered uncertain, the crisis is also propelling waves of innovation activities. In this paper, we developed the concept of "CoviNovation" to denote the firm's innovation emerging from, rooted in or accelerated by the crisis. Read More

View Article and Full-Text PDF

Fabrication of magnetic [email protected] microporous organic network nanosphere for efficient extraction of hydroxylated polycyclic aromatic hydrocarbons and p-nitrophenol from wastewater samples.

J Chromatogr A 2021 Jun 15;1651:462347. Epub 2021 Jun 15.

College of Chemistry, Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin 300071, China. Electronic address:

Herein, we report the fabrication of a novel, well-defined core-double-shell-structured magnetic [email protected]@naphthyl microporous organic network (MON), [email protected]@NMON, for the efficient magnetic extraction of hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and p-nitrophenol (p-Npn) from wastewater samples. The hierarchical nanospheres were designed and constructed with the FeO nanoparticle core, the inner shell of a polydopamine (PDA) layer, and the outer shell of a porous naphthyl MON (NMON) coating, allowing efficient and synergistic extraction of OH-PAHs and p-Npn via hydrophobic, hydrogen bonding, and π-π interactions. The [email protected]@NMON nanospheres were well characterized and employed as an efficient sorbent for magnetic solid-phase extraction (MSPE) coupled with high performance liquid chromatography (HPLC) for analyzing of OH-PAHs and p-Npn. Read More

View Article and Full-Text PDF

Clowning during COVID-19 - A survey of European Healthcare Clowning Organisations highlights the role of humour and art in the healthcare system.

Public Health 2021 Jun 21;196:82-84. Epub 2021 Jun 21.

RED NOSES International, Wattgasse 48, 1170 Vienna, Austria. Electronic address:

Objectives: This paper presents the findings of a Europe-wide survey that investigates the impact of COVID-19 on Healthcare Clowning Organisations and encourages the healthcare community to reflect on the role of medical clowning within the healthcare system.

Study Design: Online survey.

Methods: The survey was conducted in June 2020. Read More

View Article and Full-Text PDF