467 results match your criteria paniculata extracts


and : From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation.

Molecules 2020 Apr 16;25(8). Epub 2020 Apr 16.

Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal.

and are two plant species with important application in African traditional medicine, particularly in Angola, in the treatment of several diseases. However, scientific studies concerning these species are scarce. The goal of this work was to know better which medicinal approaches are used by the Huíla population in Angola by means of ethnobotanical surveys. Read More

View Article and Full-Text PDF

Hepatoprotective Activity of BV-7310, a Proprietary Herbal Formulation of , , and , in Alcohol-Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl, Induced Liver Damage in Rats.

Evid Based Complement Alternat Med 2020 25;2020:6428906. Epub 2020 Mar 25.

Bioved Pharmaceuticals, Inc., 1929 OToole Way, San Jose, CA 95131, USA.

Excessive alcohol consumption is a worldwide threat with severe morbidity and mortality. Other than abstinence, there is still no FDA-approved drug for alcoholic liver disease (ALD). Liver is the primary site of ethanol metabolism and hence gets the most damage from excessive drinking. Read More

View Article and Full-Text PDF

Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study.

Pharmaceuticals (Basel) 2020 Mar 14;13(3). Epub 2020 Mar 14.

Phytomed AB, Bofinkvagen 1, 31275 Vaxtorp, Sweden.

Background: The current and potential uses of adaptogens are mainly related to treatment of stress-induced fatigue, impaired cognitive function, mental illness, and behavioral- and age-related disorders. However, clinical evidence regarding the efficacy of adaptogens is limited. The primary aim of this study is to determine whether a combination of adaptogenic plant extracts from and (Adaptra Forte) could be used as effective and safe treatment for impaired cognitive, memory, or learning ability functions and sleep disorders. Read More

View Article and Full-Text PDF

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of .

Front Med (Lausanne) 2020 21;7. Epub 2020 Feb 21.

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

Lyme disease is the most common vector-borne disease in the US and Europe. Although the current recommended Lyme antibiotic treatment is effective for the majority of Lyme disease patients, about 10-20% of patients continue to suffer from persisting symptoms. There have been various anecdotal reports on the use of herbal extracts for treating patients with persisting symptoms with varying degree of improvements. Read More

View Article and Full-Text PDF
February 2020

Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors.

Cardiovasc Hematol Agents Med Chem 2020 ;18(2):111-123

Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal District, Tamilnadu, India.

Background And Objectives: The present investigation is intended to prepare a Poly Herbal Formulation (PHF) with Piper nigrum (fruits), Terminalia paniculata (bark) and Bauhinia purpurea (bark) and assess their antioxidant and glucose-lowering effects utilizing in vitro models.

Methods: The individual plant methanolic extracts and PHF are exposed to phytochemical examination and to distinguish the bioactive factors by GC-MS. We assessed the antioxidant properties of individual plant extracts and the PHF by using the DPPH scavenging method, H2O2 scavenging assay, TBARS assay and total antioxidant estimation. Read More

View Article and Full-Text PDF

Classification of Andrographis paniculata extracts by solvent extraction using HPLC fingerprint and chemometric analysis.

BMC Res Notes 2020 Feb 4;13(1):56. Epub 2020 Feb 4.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Objective: Andrographis paniculata, widely used as an antidiabetic in Indonesian traditional medicines (jamu), contains chemical compounds whose concentration is related to its therapeutic effects. The concentration of solvents used for extraction will also affect the number of compounds extracted. Therefore, a quality control method is needed to ensure consistency in quantifying these compounds in A. Read More

View Article and Full-Text PDF
February 2020

Cytotoxicity and Synergistic Effect of Biogenically Synthesized Ternary Therapeutic Nano Conjugates Comprising Plant Active Principle, Silver and Anticancer Drug on MDA-MB-453 Breast Cancer Cell Line.

Asian Pac J Cancer Prev 2020 Jan 1;21(1):195-204. Epub 2020 Jan 1.

Department of Pharmacognosy, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

Drug delivery through biogenically synthesized silver nanoparticles (AgNPs) in cancer treatment is exerted by smaller size entailing high surface area and synergistic effects of embedded biomolecules.  In this study, prepared ternary conjugates of silver with plant active compound and anticancer drug towards reducing the dose through synergy, rendered by Electrostatic Attraction (EA) of functionalized drug on to the surface of biogenically synthesized AgNPs. The biogenic synthesis resulted in particles of nanometer range as well as serving reducing and capping agents. Read More

View Article and Full-Text PDF
January 2020

Effect of and leaf extracts on selected biochemical indices in model of neurotoxicity.

Drug Chem Toxicol 2020 Jan 3:1-10. Epub 2020 Jan 3.

Functional Foods and Nutraceuticals Unit of Biochemistry Department, Federal University of Technology, Akure, Nigeria.

Aluminum (Al)-induced toxicity in fruit fly ( is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extracts of and leaves on Al-induced toxicity in wild type The flies were exposed to diets containing 40 mM AlCl, and the alkaloid extracts (0. Read More

View Article and Full-Text PDF
January 2020

Two flavonoid-based compounds from as novel human carbonic anhydrase isozyme II inhibitors detected by a resazurin yeast-based assay.

J Microbiol Biotechnol 2020 Apr;30(4):552-560

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Human carbonic anhydrase isozyme II has been used as protein target for disorder treatment including glaucoma. Current clinically used sulfonamide-based CA inhibitors can induce side effects, and so alternatives are required. This study aimed to investigate a natural CA inhibitor from . Read More

View Article and Full-Text PDF

Combined use of and chemotherapeutics for metastatic oesophageal cancer: a pre-clinical study.

Hong Kong Med J 2019 12;25 Suppl 9(6):43-46

Department of Surgery, The Chinese University of Hong Kong.

View Article and Full-Text PDF
December 2019

Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide.

Molecules 2019 Dec 24;25(1). Epub 2019 Dec 24.

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Centre for Standardization of Chinese Medicines, 1200 Cailun Road, Shanghai 201203, China.

Ulcerative colitis (UC) is usually accompanied with symptoms of abdominal pain, diarrhea, and bloody stool, which impair the quality of life of patients. Previous studies have shown that extracts, which have andrographolide (AND) as their main compound, can relieve UC symptoms in patients. The aim of the study was to investigate the alleviating effect of AND on UC using the oxazolone (OXZ)-induced UC rat model. Read More

View Article and Full-Text PDF
December 2019

A network-based analysis of key pharmacological pathways of Andrographis paniculata acting on Alzheimer's disease and experimental validation.

J Ethnopharmacol 2020 Apr 20;251:112488. Epub 2019 Dec 20.

Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013, Zhejiang, PR China. Electronic address:

Ethnopharmacological Relevance: Andrographis paniculata (AP) is a native plant with anti-inflammatory and antioxidant properties and used as an official herbal medicine. Recently more and more researches have indicated that AP shows pharmacological effects on Alzheimer's disease (AD) but its mechanism is unclear.

Aims Of The Study: Network pharmacology approach combined with experimental validation was developed to reveal the underlying molecular mechanisms of AP in treating AD. Read More

View Article and Full-Text PDF

Can the methanolic extract of Andrographis paniculata be used as a supplement to anti-snake venom to normalize hemostatic parameters: A thromboelastographic study.

J Ethnopharmacol 2020 Apr 17;252:112480. Epub 2019 Dec 17.

Department of Biochemistry, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address:

Ethnopharmacological Relevance Of Andrographis Paniculata: The whole plant (including leaves and roots) is used in traditional Ayurveda and Siddha medicine to treat various clinical conditions such as fever, respiratory tract infections, colic pain, liver disorders, diabetes, hypertension, and inflammation. It is also used as an antidote for snake-bite, poisonous bites of insects and recommended as a dietary supplement to boost immunity.

Aim Of The Study: In-vitro thromboelastographic evaluation of the efficacy of methanolic extract of Andrographis paniculata (MAP) and polyvalent anti-snake venom (ASV) in neutralizing the Naja naja (N. Read More

View Article and Full-Text PDF

Quantitative Determination of Andrographolide and Related Compounds in Extracts and Biological Evaluation of Their Anti-Inflammatory Activity.

Foods 2019 Dec 14;8(12). Epub 2019 Dec 14.

Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans CEDEX 2, France.

Extraction, isolation and characterization of () products were developed. Three natural diterpenes compounds were obtained and one was used for chemical modifications. Evaluation of their inhibition of TNFα induced NFκB transcriptional activity. Read More

View Article and Full-Text PDF
December 2019

Comparative laboratory efficacy of novel botanical extracts against Tribolium castaneum.

J Sci Food Agric 2020 Mar 20;100(4):1541-1546. Epub 2019 Dec 20.

Indian Institute of Food Processing Technology (Ministry of Food Processing Industries, Government of India), Thanjavur, India.

Background: Citrus sinensis, Allium sativum, Ocimum basilicum, Mentha spicata, Curcuma longa, Carica papaya, Andrographis paniculata, Azadirachta indica, Cymbopogon citratus and Acorus calamus were compared in the form of extracts of chloroform, hexane and aqueous media for their effectiveness in repelling Tribolium castaneum. Filter paper of 9 cm in diameter was cut into halves. Using a micro-pipette, each extract was applied to one half of the filter paper. Read More

View Article and Full-Text PDF

Risk factors associated with the severity of adverse drug reactions by Xiyanping injection: A propensity score-matched analysis.

J Ethnopharmacol 2020 Mar 22;250:112424. Epub 2019 Nov 22.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Lane, Dongcheng District, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Xiyanping injection (XYP), extraction of Andrographis paniculate (Andrographis paniculata (Burm. f.) Nees, chuan xin lian), is a Chinese patent medicine approved to treat bronchitis in China. Read More

View Article and Full-Text PDF

Gold Nanoparticles (AuNPs) Conjugated with Andrographolide Ameliorated Viper () Venom-Induced Toxicities in Animal Model.

J Nanosci Nanotechnol 2020 06;20(6):3404-3414

Laboratory of Toxinology and Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, Kolkata 700009, India.

Andrographolide, a diterpenoid compound found in the aerial parts of (a well known anti snake venom plant) was conjugated with gold nanoparticle (andrographolide-AuNPs) and its efficacy against venom (DRRV) induced local damage, organ toxicity and inflammatory response was evaluated in animal models. Ethical clearance was obtained before animal experiments. Andrographolide-AuNPs was formed by adsorption method. Read More

View Article and Full-Text PDF

Metabolite profiling of Andrographis paniculata (Burm. f.) Nees. young and mature leaves at different harvest ages using H NMR-based metabolomics approach.

Sci Rep 2019 11 14;9(1):16766. Epub 2019 Nov 14.

Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

Andrographis paniculata (Burm. F.) Nees. Read More

View Article and Full-Text PDF
November 2019

Herbal medicinal products for inflammatory bowel disease: A focus on those assessed in double-blind randomised controlled trials.

Phytother Res 2020 Jan 7;34(1):77-93. Epub 2019 Nov 7.

Unità Operativa Complessa di Farmacologia, Direzione Sanitaria, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, 00168, Italy.

Inflammatory bowel disease patients frequently use herbal products as complementary or alternative medicines to current pharmacotherapies and obtain information on them mainly from the internet, social media, or unlicensed practitioners. Clinicians should therefore take a more active role and become knowledgeable of the mechanisms of action and potential drug interactions of herbal medicines for which evidence of efficacy is available. The therapeutic efficacy and safety of several herbal medicines have been studied in double-blind randomised controlled trials (RCTs). Read More

View Article and Full-Text PDF
January 2020

Investigation of the Antibacterial Activity and Cytotoxicity of Biogenic Silver Nanoparticles as Potent Therapeutics.

Front Bioeng Biotechnol 2019 9;7:239. Epub 2019 Oct 9.

Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, Bangladesh.

Biogenic nanoparticles are the smartest weapons to deal with the multidrug-resistant "superbugs" because of their broad-spectrum antibacterial propensity as well as excellent biocompatibility. The aqueous biogenic silver nanoparticles (Aq-bAgNPs) and ethanolic biogenic silver nanoparticles (Et-bAgNPs) were synthesized using aqueous and ethanolic extracts of stem, respectively, as reducing agents. Electron microscopic images confirmed the synthesis of almost spherical shaped biogenic silver nanoparticles (bAgNPs). Read More

View Article and Full-Text PDF
October 2019

antioxidant activity of Roxb. - An ethnomedicinal plant.

Ayu 2019 Oct-Dec;40(4):256-261. Epub 2021 Jan 14.

Departments of Dravyaguna, ITRA, Jamnagar, Gujarat, India.

Background: Roxb. (Family-Convolvulaceae) has been reported for its potential ethno medicinal value. Leaf, stem, bark, and root of this plant are being used either single or in the mixture of the whole part in different disease conditions by different tribes. Read More

View Article and Full-Text PDF
January 2021

Excito-repellency Activity of Andrographis paniculata (Lamiales: Acanthaceae) Against Colonized Mosquitoes.

J Med Entomol 2020 01;57(1):192-203

Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.

Excito-repellency activity of plant extracts have been increasingly studied as mosquito repellents. In this study, the crude extract of Andrographis paniculata was evaluated for its noncontact repellency, contact excitation (irritancy + repellency), and knockdown/toxicity response against five colonized mosquitoes; Aedes aegypti (L.), Aedes albopictus (Skuse), Anopheles dirus Peyton & Harrison, Anopheles epiroticus Linton & Harbach, and Culex quinquefasciatus Say (Diptera: Culicidae) using an excito-repellency assay system under laboratory-controlled conditions. Read More

View Article and Full-Text PDF
January 2020

Antioxidant Effect of Extracts from Native Chilean Plants on the Lipoperoxidation and Protein Oxidation of Bovine Muscle.

Molecules 2019 Sep 7;24(18). Epub 2019 Sep 7.

Departamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.

The present study investigated the antioxidant potential and the ability to inhibit lipid and protein oxidation in bovine meat of four native Chilean species: canelo (), nalca (), tiaca (), and ulmo (). Phenolic acids (gallic, chlorogenic, caffeic, and coumaric) and flavonoids (catechin, epicatechin, and rutin) were identified and quantified by HPLC-MS/MS. extract exhibited the highest antioxidant capacity evaluated by oxygen radical absorption capacity-red pyrogallol method (ORAC-PGR) and ferric ion reducing antioxidant power (FRAP) assays. Read More

View Article and Full-Text PDF
September 2019

Microcos paniculata: a review on its botany, traditional uses, phytochemistry and pharmacology.

Chin J Nat Med 2019 Aug;17(8):561-574

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

The shrub Microcos paniulata (MPL; Tiliaceae), distributed in south China, south and southeast Asia, yields a phytomedicine used to treat heat stroke, fever, dyspepsia, diarrhea, insect bites and jaundice. Phytochemical investigations on different parts of MPL indicate the presence of flavonoids, alkaloids, triterpenoids and organic acids. The MPL leaves, fruits, barks and roots extracts showed antidiarrheal, antimicrobial and insecticidal, anti-inflammation, hepatoprotective, cardiovascular protective, blood lipids reducing, analgesic, jaundice-relieving and antipyretic activities, etc. Read More

View Article and Full-Text PDF

Efficacy of Andrographis paniculata supplements induce a non-specific immune system against the pathogenicity of Aeromonas hydrophila infection in Indian major carp (Labeo rohita).

Environ Sci Pollut Res Int 2020 Jul 30;27(19):23420-23436. Epub 2019 Jul 30.

Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tirunelveli, Tamil Nadu, 627 412, India.

Aeromonas hydrophila, an opportunistic fish pathogen, which causes several major diseases including skin ulcer and haemorrhagic septicemia, contributes considerably to the lethality in aquaculture. Chemical and antibiotic treatment employed against A. hydrophila for disease management are expensive and consequently prompted the advent of drug resistance among the pathogens. Read More

View Article and Full-Text PDF

Diterpenoid Lactones with Anti-Inflammatory Effects from the Aerial Parts of .

Molecules 2019 Jul 26;24(15). Epub 2019 Jul 26.

Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510641, China.

(AP) has been widely used in China for centuries to treat various diseases, and especially to treat inflammation. Diterpenoid lactones are the main anti-inflammatory components of AP. However, systematic chemical composition and biological activities, as well as key pharmacophores, of these diterpenoid lactones from AP have not yet been clearly understood. Read More

View Article and Full-Text PDF

Development and evaluation of emulsifiable concentrate formulation containing Sophora alopecuroides L. extract for the novel management of Asian citrus psyllid.

Environ Sci Pollut Res Int 2019 Jul 28;26(21):21871-21881. Epub 2019 May 28.

Guangdong Engineering Research Center for Insect Behavior Regulation, College of Agriculture, South China Agricultural University, Guangzhou, 510642, China.

Utilization of non-host plants semiochemicals to mediate insect behavior offers a promising opportunity for novel management of insect pests in field crops and fruits. Therefore, there is still a substantial opportunity for the development of natural prophylactic as an eco-friendly approach in the novel pest management programs. Sophora alopecuroides extract has been used as a natural pesticide in the control of agricultural and household pests, but the low persistence effect and rapid biodegradability limit its use on a wider scale in pest management programs. Read More

View Article and Full-Text PDF

The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf.

Iran J Pharm Res 2019 ;18(1):383-390

Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Iran.

Tyrosinase is a key enzyme in melanin production. Therefore, tyrosinase inhibitors are used in cosmetic and medicinal industries to prevent or treat overproduction of melanin such as melasma, solar lentigo and post inflammatory melanoderma. Due to safety of natural whitening agents, in the present study, anti-tyrosinase and anti-melanogenesis activities of some selected red macroalgae of the Persian Gulf were investigated. Read More

View Article and Full-Text PDF
January 2019

A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis.

Phytother Res 2019 May 10;33(5):1469-1479. Epub 2019 Apr 10.

Institute of Pharmacology and Morphophysiology, Facultad de Ciencias Veterinarias Universidad Austral de Chile, Valdivia, Chile.

Andrographis paniculata Wall (Acanthaceae) is becoming more recognized for its anti-inflammatory and antioxidant properties. A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of an andrographolide-containing supplement, ParActin® (300 and 600 mg daily), on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain reduction in patients with knee osteoarthritis. Joint stiffness, physical function, changes in the SF-36 quality of life questionnaire, a fatigue scale, and safety were also evaluated. Read More

View Article and Full-Text PDF

Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models.

Phytomedicine 2019 Jul 12;60:152886. Epub 2019 Mar 12.

Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants (CUHK), The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. Electronic address:

Background: Esophageal cancer (EC) is a malignant gastrointestinal cancer with high morbidity worldwide and is the fourth leading cause of cancer-related deaths in China. Even though surgery and/or chemotherapy/chemoradiation might achieve good therapeutic response, recurrence rate is high due to cancer metastasis. Hence, the use of alternative adjuvant treatments, such as herbal medicines, for metastatic EC remains a great desire of the patients. Read More

View Article and Full-Text PDF