30,465 results match your criteria pancreatitis patients


Allergic manifestations in autoimmune gastrointestinal disorders.

Autoimmun Rev 2021 Sep 21:102958. Epub 2021 Sep 21.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address:

Allergic disorders target a young population, are increasing in both incidence and prevalence and are associated with significant disease burden. They result from the complex interplay between (epi)genetic and environmental factors, resulting in a Th2 inflammatory process targeting the epithelium of the respiratory tract (allergic rhinitis and asthma), skin (atopic dermatitis), and gastrointestinal tract (food allergy). Although the exact pathogenic mechanisms remain elusive, an altered immune system response in the gut is increasingly recognized as a relevant step. Read More

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September 2021

Does drainage or resection predict subsequent interventions and long-term quality of life in patients with Grade IV pancreatic injuries: A population-based analysis.

J Trauma Acute Care Surg 2021 Oct;91(4):708-715

From the Department of Surgery (C.G.B., A.W.K.), University of Calgary, Calgary, Alberta, Canada; Department of Surgery (W.L.B.), Scripps Clinic Medical Group, La Jolla, California; Department of Surgery (S.M.H.), University of British Columbia, Vancouver, BC, Canada; Department of Surgery (K.V., N.G.P.), Western University, London, Ontario, Canada; and Department of Surgery (M.K.), Cook County Hospital, Chicago, Illinois.

Background: Clinical equipoise remains significant for the treatment of Grade IV pancreatic injuries in stable patients (i.e., drainage vs. Read More

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October 2021

Lived Experience of Hereditary Chronic Pancreatitis - A Qualitative Interview Study.

Chronic Illn 2021 Sep 24:17423953211039774. Epub 2021 Sep 24.

Institute of Ethics, 88782History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany.

Objectives: Hereditary chronic pancreatitis is a rare condition characterized by intermittent acute episodes of pancreatitis and long-term impairment of pancreatic functions. However, the subjective perspective of individuals affected by hereditary chronic pancreatitis has been little studied. This qualitative study investigates the experience of hereditary chronic pancreatitis patients and their relatives because the awareness of the needs of those affected is an essential component of a patient-centered management of chronic conditions. Read More

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September 2021

Pediatric onset lupus nephritis in western India-is it different from the rest of the country?

Lupus 2021 Sep 24:9612033211045069. Epub 2021 Sep 24.

Department of Pediatrics, 410730All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan.

Aim: To determine the clinicopathological characteristics and outcomes of children diagnosed with lupus nephritis in a tertiary hospital in western Rajasthan and compare it with the data available from other parts of India.

Material And Methods: A retrospective review of children presenting to a tertiary care center in western Rajasthan, India, with a diagnosis of pediatric Systemic Lupus Erythematosus (p SLE), between July 2017 and July 2020 was done. Comparisons of pediatric lupus in western India to other parts of country were done. Read More

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September 2021

Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.

Cell Death Dis 2021 Sep 23;12(10):867. Epub 2021 Sep 23.

Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative capacity of beta cells might account for pancreatic endocrine insufficiency. Previously, we found that only a few pancreatic cytokeratin 5 positive (Krt5) cells differentiated into beta cells in the murine AP model, which was insufficient to maintain glucose homeostasis. Read More

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September 2021

Extracellular vesicles from pancreatic ductal adenocarcinoma EUS-FNA samples contain a protein barcode.

J Hepatobiliary Pancreat Sci 2021 Sep 23. Epub 2021 Sep 23.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, 514-8507, Japan.

Background: The survival rate of pancreatic ductal adenocarcinoma (PDAC) is very poor because early detection is difficult. Extracellular vesicles (EVs) are released from cells associating with the cellular condition and circulated in the blood. We aimed to identify EV proteins from endoscopic ultrasound-fine needle aspiration (EUS-FNA) biopsy samples in order to develop novel biomarkers for PDAC. Read More

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September 2021

Exploration of the Curative Effect of Early Enteral Nutrition Nursing on Patients with Severe Acute Pancreatitis and the Improvement of Patients' Mental Health and Inflammation Level.

J Healthc Eng 2021 11;2021:8784905. Epub 2021 Sep 11.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

In order to explore the curative effect of early enteral nutrition nursing on patients with severe acute pancreatitis and the improvement of patients' mental health and inflammation levels, this paper compares the curative effect of early enteral nutrition nursing and traditional care on patients with severe acute pancreatitis and the improvement effects of patients' mental health and inflammation levels through controlled trials. Moreover, this paper combines statistical methods for data processing and visually expresses data through statistical graphs and statistical tables. Through the comparison of experiments, it can be seen that the improvement effect in all aspects of patients in the test group is significantly higher than that in the control group. Read More

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September 2021

Assessment of pancreatitis associated with tocilizumab use using the United States Food and Drug Administration Adverse Event Reporting System database.

Sci Rep 2021 Sep 22;11(1):18818. Epub 2021 Sep 22.

Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.

Tocilizumab (TCZ) is used to treat rheumatoid arthritis and other systemic inflammatory disorders. There is some evidence suggesting the occurrence of pancreatitis following TCZ use. We aimed to determine the reporting of pancreatitis following TCZ use in comparison with other drugs using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database. Read More

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September 2021

miR-802 Suppress Acinar-to-Ductal Reprogramming during Early Pancreatitis and Pancreatic Carcinogenesis.

Gastroenterology 2021 Sep 18. Epub 2021 Sep 18.

Institute of Molecular Health Sciences, ETH Zürich, Otto-Stern-Weg 7, 8093 Zürich, Switzerland; Medical Faculty, University of Zürich, 8091 Zürich, Switzerland. Electronic address:

Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor that is almost uniformly lethal in humans. Activating mutations of KRAS are found in >90% of human PDACs and are sufficient to promote acinar-to-ductal metaplasia (ADM) during tumor initiation. The roles of miRNAs in oncogenic Kras-induced ADM are incompletely understood. Read More

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September 2021

[Interventional endoscopic treatment in acute pancreatitis].

Internist (Berl) 2021 Sep 21. Epub 2021 Sep 21.

Bereich Gastroenterologie, Klinik für Onkologie, Gastroenterologie, Hepatologie, Pneumologie und Infektiologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland.

Background: Acute pancreatitis (AP) represents a frequent gastrointestinal diseases. Approximately 80% of patients have a mild course of the disease and conservative treatment is sufficient; however, 20% of patients develop a severe AP with local and systemic complications. This article focuses on the currently recommended endoscopic management of severe AP. Read More

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September 2021

Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study.

Mediators Inflamm 2021 10;2021:4906768. Epub 2021 Sep 10.

Pancreas Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, China.

Several inflammation-related factors (IRFs) have been reported to predict organ failure of acute pancreatitis (AP) in previous clinical studies. However, there are a few shortcomings in these models. The aim of this study was to develop a new prediction model based on IRFs that could accurately identify the risk for organ failure in AP. Read More

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September 2021

External validation of Chronic Pancreatitis Prognosis Score(COPPS): A prospective cohort study.

Dig Liver Dis 2021 Sep 17. Epub 2021 Sep 17.

Divisions of Gastroenterology, School of Digestive and Liver Disease, IPGME&R, Kolkata, India. Electronic address:

Background: Prognostic stratification in ChronicPancreatitis(CP) remains suboptimal and cumbersome. Chronic Pancreatitis Prognostic Score(COPPS) was recently developed to predict one-year hospitalisations in CP.

Aim: External validation of COPPS in a geographically divergent patient population. Read More

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September 2021

Effects of QingYi decoction on inflammatory markers in patients with acute pancreatitis: A meta-analysis.

Phytomedicine 2021 Sep 8:153738. Epub 2021 Sep 8.

General Surgery Department, The First Affiliated Hospital of Dalian Medical University, Dalian, China; Institute of Integrative Medicine of Dalian Medical University, Dalian, China. Electronic address:

Introduction: It is widely accepted that inflammatory responses play a key role in acute pancreatitis (AP). We conducted a systematic review and meta-analysis to determine the effect of QingYi decoction on inflammatory markers.

Methods: The PubMed, EMBASE, Cochrane, CNKI, CBM, and WANFGANG databases were searched for randomized controlled trials published before December 2019. Read More

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September 2021

Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection.

BMC Infect Dis 2021 Sep 20;21(1):977. Epub 2021 Sep 20.

Department of Gastroenterology, Xiangya Hospital, Central South University, Xiangya Road, Changsha, 410008, China.

Background: Multidrug-resistant (MDR) Klebsiella pneumoniae infections, from pancreatic infections to bloodstream infections, influence the mortality of patients with acute pancreatitis (AP) on the condition of limited antibiotic choices. The aim of this study was to investigate the predictor of mortality among AP patients complicated with MDR-K. pneumoniae infections. Read More

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September 2021

Disconnected pancreatic duct syndrome and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: A systematic review and meta-analysis.

Dig Endosc 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Disconnected pancreatic duct syndrome (DPDS) frequently occurs in patients with acute necrotizing pancreatitis and resultant pancreatic fluid collection (PFC). We performed a systematic review and meta-analysis to evaluate outcomes of endoscopic ultrasound-guided treatment of PFCs according to the presence of DPDS.

Methods: Using PubMed, Embase, and the Cochrane database, we identified clinical studies published until January 2021 with data comparing outcomes of endoscopic ultrasound-guided drainage of PFCs between DPDS and non-DPDS patients. Read More

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September 2021

The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study.

Clin Gastroenterol Hepatol 2021 Sep 17. Epub 2021 Sep 17.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

Background And Aims: The aims of this study were to: 1) assess the performance of the pancreatitis activity scoring system (PASS) in a large intercontinental AP cohort, 2) investigate whether a modified PASS, yields a similar predictive accuracy and produces distinct early trajectories between severity subgroups.

Methods: Data was prospectively collected through the APPRENTICE consortium (2015-2018) involving 22 centers from four continents. AP severity was categorized per Revised Atlanta Classification. Read More

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September 2021

Comparative efficacy of different methods for difficult biliary cannulation in ERCP: a systematic review and network meta-analysis.

Gastrointest Endosc 2021 Sep 17. Epub 2021 Sep 17.

Center for Advanced Therapeutic Endoscopy (CATE), Porter Adventist Hospital/PEAK Gastroenterology, Denver, Colorado, USA. Electronic address:

Background And Aims: Several methods with variable efficacy have been proposed for difficult biliary cannulation in ERCP. We assessed the comparative efficacy of different strategies for difficult biliary cannulation, through a network meta-analysis combining direct and indirect treatment comparisons.

Methods: We identified 17 randomized controlled trials (RCTs) (2015 patients) that compared the efficacy of different adjunctive methods for difficult biliary cannulation (needle-knife techniques, pancreatic guidewire-assisted technique, pancreatic-assisted technique, and transpancreatic sphincterotomy) either with each other or with persistence with the standard cannulation techniques. Read More

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September 2021

[Imaging diagnostics of chronic pancreatitis].

Internist (Berl) 2021 Sep 20. Epub 2021 Sep 20.

Medizinische Klinik II, Bereich Gastroenterologie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.

Chronic pancreatitis is characterized by recurrent inflammatory episodes. The diagnosis is based on the detection of pathognomonic morphological alterations by ultrasound-based methods as well as computed tomography and magnetic resonance imaging. In addition, imaging techniques play an important role for the differential diagnostics of potential complications in patients with chronic pancreatitis and for regular monitoring of patients with increased cancer risk. Read More

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September 2021

Efficacy of Graded Emergency Nursing on Acute Pancreatitis Patients: A Meta-Analysis.

Iran J Public Health 2021 Jun;50(6):1097-1107

Department of Anesthesiology, Jinan Central Hospital, Jinan 250013, China.

Background: The efficacy of graded emergency nursing on acute pancreatitis (AP) patients was evaluated by the Meta-analysis system.

Methods: The databases of CNKI, WanFang, VIP, PubMed, the Cochrane Library and Web of Science were searched by computer in January 2021. The references were screened according to the inclusion and exclusion criteria. Read More

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A prospective study on quality in endoscopic retrograde cholangiopancreatography (ERCP): trend in Italy from the REQUEST study.

Endosc Int Open 2021 Oct 16;9(10):E1563-E1571. Epub 2021 Sep 16.

Department of Gastroenterology, Nuovo Regina Margherita Hospital, Roma, Italy.

Endoscopic retrograde cholangiopancreatography (ERCP) is a complex procedure with a relatively high rate of adverse events. Data on training of operators and fulfillment of quality indicators in Italy are scarce. The goal of this study was to assess the overall quality of ERCP in Italy compared to international standards. Read More

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October 2021

IgG4-Related Disease: Mimickers and Diagnostic Pitfalls.

J Clin Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

From the Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Servicio de Reumatología, Hospital Privado Universitario de Córdoba, Córdoba Sección de Reumatología, Hospital José María Cullen, Santa Fe, Argentina.

Background: The tendency of IgG4-related disease (IgG4-RD) to form pseudotumors, as well as its multisystemic nature, makes it the perfect mimicker of many conditions. Moreover, some clinical, serological, radiological, or histological features of the disease might be shared with some mimickers.Recently, 4 clinical phenotypes have been identified, and patients grouped in each phenotype have distinctive demographic, clinical, and serological features and outcomes, and, as expected, for each phenotype, a set of differential diagnoses should be considered. Read More

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September 2021

Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients.

Pancreatology 2021 Sep 10. Epub 2021 Sep 10.

Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland. Electronic address:

Purpose: Loss of function variants of the transient receptor potential cation channel, subfamily V, member 6 (TRPV6) have been recently associated with chronic pancreatitis (CP) in Japanese, German and French patients. Here, we investigated the association of TRPV6 variants with CP in independent European cohorts of early-onset CP patients from Poland and Germany.

Patients And Methods: We enrolled 152 pediatric CP patients (median age 8. Read More

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September 2021

Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT).

Pancreatology 2021 Sep 4. Epub 2021 Sep 4.

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Department of Surgery, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Background/objectives: The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT.

Methods: We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip in 78 patients before and after TPIAT using dual-energy X-ray absorptiometry (DXA, n = 78 pre-TPIAT, n = 65 paired pre- and 12 months post-TPIAT, n = 33 paired 12 and 18 months post-TPIAT), and tested for association with clinical history including age, smoking status, and medications using paired and two-sample t-tests, linear regression, and Fisher's exact test. Read More

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September 2021

PERCUTANEOUS ULTRASOUND-GUIDED PUNCTURE AND CATHETER DRAINAGE METHODS IN THE TREATMENT OF FLUID COLLECTIONS FOLLOWING ACUTE PANCREATITIS.

Wiad Lek 2021 ;74(8):1794-1799

NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Objective: The aim: Improve the treatment outcomes of patients with fl uid collections following acute pancreatitis using an ultrasound-guided puncture and catheter drainage methods.

Patients And Methods: Materials and methods: 67 patients with acute pancreatitis complicated by fl uid collections were divided into two groups. The fi rst group (comparison group) consisted of 32 patients who underwent percutaneous ultrasound-guided puncture and catheter drainage interventions in addition to conservative therapy. Read More

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September 2021

Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early-stage acute pancreatitis.

Neurogastroenterol Motil 2021 Sep 18:e14249. Epub 2021 Sep 18.

Department of Gastroenterology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.

Background/aims: Gastrointestinal (GI) dysmotility in acute pancreatitis (AP) aggravates inflammation and results in severe complications. This study aimed to explore effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) on abdominal pain, GI dysmotility, and inflammation in AP patients.

Methods: Forty-two AP patients were blindly randomized to receive TEA (n = 21) at acupoints PC6 and ST36 or Sham-TEA (n = 21) at sham points for 2 days. Read More

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September 2021

Systemic lupus erythematous presenting with hemorrhagic shock caused by gastric penetration of pancreatic pseudocyst: a case report.

J Med Case Rep 2021 Sep 18;15(1):460. Epub 2021 Sep 18.

Department of General Surgery, Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Systemic lupus erythematous that causes various organ damage is rarely associated with pancreatic lesion. To the best of our knowledge, no cases presenting with hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis have been reported. Herein, we report a case of hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis. Read More

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September 2021

[Conservative or surgical treatment of chronic pancreatitis?]

Internist (Berl) 2021 Sep 16. Epub 2021 Sep 16.

Medizinische Klinik und Poliklinik II, Klinikum der Universität München, LMU München, München, Deutschland.

The cardinal symptom of chronic pancreatitis is severe belt-like upper abdominal pain, which requires immediate and adequate treatment. Furthermore, advanced stage chronic pancreatitis is often associated with complications, such as pancreatic pseudocysts, pancreatic duct stones and stenosis as well as biliary stenosis. The various endoscopic and surgical treatment options for chronic pancreatitis patients have been controversially discussed for decades. Read More

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September 2021

Endoscopic ultrasonographic diagnosis of pancreatic tuberculosis in immunocompetent patients-A case series from eastern India.

Indian J Gastroenterol 2021 Sep 16. Epub 2021 Sep 16.

Division of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, 700 020, India.

Tubercular involvement of pancreas is rare. It presents as a focal lesion of pancreas on cross sectional imaging. Endosonography with fine-needle aspiration (EUS-FNA) is crucial for a timely presurgical diagnosis. Read More

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September 2021

Prognostic Value of Glucose-to-Lymphocyte Ratio in Critically Ill Patients with Acute Pancreatitis.

Int J Gen Med 2021 8;14:5449-5460. Epub 2021 Sep 8.

Department of Gastroenterology, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, 409000, People's Republic of China.

Background: Glucose metabolism and systemic inflammation have been associated with prognosis in acute pancreatitis (AP) patients. However, the possible value as a prognostic marker of the glucose-to-lymphocyte ratio (GLR) has not been evaluated in critically ill patients with AP.

Methods: This study included 1,133 critically ill patients with AP from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database, who were randomly divided into the training cohort (n=806) and the validation cohort (n=327) at a ratio of 7:3. Read More

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September 2021

Elucidating the Potential Side Effects of Current Anti- Seizure Drugs for Epilepsy.

Curr Neuropharmacol 2021 Aug 26. Epub 2021 Aug 26.

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor. Malaysia.

Over the decades, various interventions have been developed and utilized to treat epilepsy. However, majority of epileptic patients are often first prescribed with anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as a first line of defense to suppress their seizures and regain their quality of life. ASDs exert their anti-convulsant effects through various mechanisms of action including regulation of ion channels, blocking of glutamate-mediated stimulating neurotransmitter interaction, and enhancing the inhibitory GABA transmission. Read More

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