116,482 results match your criteria pancreatic cancer


Age-related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats.

Aging Cell 2021 Jun 22:e13425. Epub 2021 Jun 22.

Department of Geriatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Liver ageing not only damages liver function but also harms systemic metabolism. To better understand the mechanisms underlying liver ageing, we transplanted the livers of young rats to young and old rats and performed untargeted metabolomics to detect changes in the metabolites in the liver tissues and sera. A total of 153 metabolites in the livers and 83 metabolites in the sera were different between the old and young rats that did not undergo liver transplantation; among these metabolites, 7 different metabolites were observed in both the livers and sera. Read More

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Influence of Klebsiella pneumoniae and quinolone treatment on prognosis in patients with pancreatic cancer.

Br J Surg 2021 Jun;108(6):709-716

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: An increasing body of evidence suggests that microbiota may promote progression of pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that gammaproteobacteria (such as Klebsiella pneumoniae) influence survival in PDAC, and that quinolone treatment may attenuate this effect.

Methods: This was a retrospective study of patients from the Massachusetts General Hospital (USA) and Ludwig-Maximilians-University (Germany) who underwent preoperative treatment and pancreatoduodenectomy for locally advanced or borderline resectable PDAC between January 2007 and December 2017, and for whom a bile culture was available. Read More

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Immune-related genes and correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

The aim of this study was to identify the immune- and locus-associated genes in pancreatic ductal adenocarcinoma and evaluate their value in prognosis. The pancreatic ductal adenocarcinoma stromal and immune scores were calculated with the estimation of stromal and immune cells in malignant tumor tissues using expression data algorithm. The authors screened the differentially expressed genes to generate immune- and stromal-related differentially expressed genes. Read More

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Consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer: achievements and future directions.

Curr Opin Gastroenterol 2021 Jun 21. Epub 2021 Jun 21.

Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: To answer several important clinical questions, the Consortium for the study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) research consortium has established several ongoing clinical cohort studies focused on pancreatitis in adults and children, pancreatic cancer, and diabetes associated with pancreatic disease. These will provide a unique resource for clinical and basic science research into these hard-to-treat diseases.

Recent Findings: The cause, natural history, and prognosis of acute relapsing and chronic pancreatitis in adults and children are being delineated. Read More

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Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study.

Br J Surg 2021 Jun 22. Epub 2021 Jun 22.

Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Background: Use of neoadjuvant therapy for elderly patients with pancreatic cancer has been debatable. With FOLFIRINOX (folinic acid, 5-fluorouracil, irinotecan, oxaliplatin) or gemcitabine plus nab-paclitaxel (GnP) showing tremendous effects in improving the overall survival of patients with borderline resectable and locally advanced pancreatic cancer, there is no definitive consensus regarding the use of this regimen in the elderly.

Methods: This study evaluated the eligibility of elderly patients with borderline resectable or locally advanced pancreatic cancer for neoadjuvant therapy. Read More

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The risk of pancreatic adenocarcinoma following SARS-CoV family infection.

Sci Rep 2021 Jun 21;11(1):12948. Epub 2021 Jun 21.

Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), London BioScience Innovation Centre, London, UK.

COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. Read More

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METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N-methyladenosine-dependent YTHDF binding.

Nat Commun 2021 06 21;12(1):3803. Epub 2021 Jun 21.

Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA data and separated 200 paired oesophageal squamous cell carcinoma (ESCC) specimens and their adjacent normal tissues and demonstrated that methyltransferase-like 3 (METTL3) is highly expressed in tumour tissues. Read More

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Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation.

Cancer Discov 2021 Jun 21. Epub 2021 Jun 21.

Memorial Sloan Kettering Cancer Center.

Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung adenocarcinomas (LUADs) amenable to targeted therapy, transformation to small cell lung cancer (SCLC) is a recognized resistance mechanism. Defining molecular mechanisms of neuroendocrine (NE) transformation in lung cancer has been limited by a paucity of pre-/post-transformation clinical samples. Read More

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The role of FOLFIRINOX in metastatic pancreatic cancer: a meta-analysis.

World J Surg Oncol 2021 Jun 21;19(1):182. Epub 2021 Jun 21.

Department of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Northwest Street 41, Haishu District, Ningbo, 315010, Zhejiang, China.

Background: The prognosis of pancreatic cancer (PC) is extremely poor, and most patients with metastatic PC still receive palliative care. Here, we report the efficacy and safety of FOLFIRINOX (oxaliplatin, irinotecan, leucovorin, 5-fluorouracil) in the treatment of metastatic PC.

Methods: We searched PubMed, Web of Science, EBSCO, and Cochrane library databases for articles that described efficacy and safety of FOLFIRINOX in patients with metastatic PC, from January 1996 to July 2020. Read More

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[Sarcopenia and Cachexia-associated Risk in Surgery].

Zentralbl Chir 2021 Jun 21;146(3):277-282. Epub 2021 Jun 21.

Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik RWTH Aachen, Deutschland.

Cachexia is defined as a multifactorial syndrome characterised by involuntary progressive weight loss due to a decrease in skeletal muscle mass, with or without a reduction in adipose tissue. The breakdown of muscle tissue is known as sarcopenia. This is clinically defined as loss of muscle mass and/or muscle strength, with loss of muscle strength being more important than muscle mass. Read More

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Potential Cost-Effectiveness of Risk-Based Pancreatic Cancer Screening in Patients With New-Onset Diabetes.

J Natl Compr Canc Netw 2021 Jun 21:1-9. Epub 2021 Jun 21.

1CHOICE Institute, Department of Pharmacy, University of Washington, Seattle, Washington.

Background: There are no established methods for pancreatic cancer (PAC) screening, but the NCI and the Pancreatic Cancer Action Network (PanCAN) are investigating risk-based screening strategies in patients with new-onset diabetes (NOD), a group with elevated PAC risk. Preliminary estimates of the cost-effectiveness of these strategies can provide insights about potential value and inform supplemental data collection. Using data from the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) risk model validation study, we assessed the potential value of CT screening for PAC in those determined to be at elevated risk, as is being done in a planned PanCAN Early Detection Initiative trial. Read More

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Reducing variability among treatment machines using knowledge-based planning for head and neck, pancreatic, and rectal cancer.

J Appl Clin Med Phys 2021 Jun 20. Epub 2021 Jun 20.

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Purpose: This study aimed to assess dosimetric indices of RapidPlan model-based plans for different energies (6, 8, 10, and 15 MV; 6- and 10-MV flattening filter-free), multileaf collimator (MLC) types (Millennium 120, High Definition 120, dual-layer MLC), and disease sites (head and neck, pancreatic, and rectal cancer) and compare these parameters with those of clinical plans.

Methods: RapidPlan models in the Eclipse version 15.6 were used with the data of 28, 42, and 20 patients with head and neck, pancreatic, and rectal cancer, respectively. Read More

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The Role of Olaparib in Metastatic Pancreatic Cancer.

Cancer Med J 2021 Dec 11;4(3):89-91. Epub 2021 May 11.

Northwell Health Cancer Institute, Lake Success, NY 11042, USA.

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December 2021

YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer.

Front Mol Biosci 2021 2;8:625731. Epub 2021 Jun 2.

Department of Oncology, Liuzhou People's Hospital, Liuzhou, China.

Yes-associated protein-1 (YAP1) is an important effector of the Hippo pathway and has crosstalk with other cancer signaling pathways. It induces an immunosuppressive tumor microenvironment by activating pathways in several cellular components. However, the mechanisms by which it drives immune infiltration in pancreatic cancer remain poorly understood. Read More

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Overexpression of Interferon-Inducible Protein 16 Promotes Progression of Human Pancreatic Adenocarcinoma Through Interleukin-1β-Induced Tumor-Associated Macrophage Infiltration in the Tumor Microenvironment.

Front Cell Dev Biol 2021 4;9:640786. Epub 2021 Jun 4.

Department of Traditional Chinese Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.

Activation of inflammasomes has been reported in human pancreatic adenocarcinoma (PAAD); however, the expression pattern and functional role of inflammasome-related proteins in PAAD have yet to be identified. In this study, we systemically examined the expression and role of different inflammasome proteins by retrieving human expression data. Several genes were found to be differentially expressed; however, only interferon-inducible protein 16 (IFI16) expression was found to be adversely correlated with the overall survival of PAAD patients. Read More

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Identifying Critical States of Complex Diseases by Single-Sample Jensen-Shannon Divergence.

Front Oncol 2021 4;11:684781. Epub 2021 Jun 4.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

Motivation: The evolution of complex diseases can be modeled as a time-dependent nonlinear dynamic system, and its progression can be divided into three states, i.e., the normal state, the pre-disease state and the disease state. Read More

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FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGF/Smad-Independent Pathways in Gastric Cancer.

Front Oncol 2021 4;11:649029. Epub 2021 Jun 4.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Gastric cancer presents high risk of metastasis and chemotherapy resistance. Hence, it is important to understand the mechanisms of gastric cancer distant metastasis and chemotherapeutic resistance. Our previous study has revealed Four and a Half LIM Domains 3 (FHL3) plays as a binding partner of Glycogen Synthase Kinase 3 Beta (GSK3), promoted tumor metastasis in pancreatic cancer. Read More

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Primary Clear Cell Carcinoma of the Pancreas: A Systematic Review.

Cureus 2021 Jun 15;13(6):e15668. Epub 2021 Jun 15.

Hematology and Medical Oncology, University of California Irvine, Irvine, USA.

Over the years, the world has witnessed many advances in diagnosing and treating multiple types of cancers. These breakthroughs have revolutionized the understanding of the molecular drive behind these neoplasms, leading to tangible therapeutic evolution and promising prognostic implications. However, pancreatic cancer remains a highly lethal disease. Read More

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Implementation of Stereotactic MRI-Guided Adaptive Radiotherapy (SMART) for Hepatobiliary and Pancreatic Cancers in the United Kingdom - Fifty in Five.

Cureus 2021 May 17;13(5):e15075. Epub 2021 May 17.

Radiotherapy, Queen Elizabeth Hospital, Birmingham, GBR.

The first MRIdian® MR linear accelerator (MR-Linac; ViewRay, Oakwood Village, Ohio) in the United Kingdom went live in December 2019 following a record installation time. Stereotactic MRI-guided Adaptive Radiotherapy (SMART) has since been implemented and has advantages of excellent soft tissue definition of both target and organs at risk (OARs), real-time target and OAR visualisation on cine-MRI, daily recontouring of target and critical OARs with live online plan adaptation/re-optimisation, and automatic respiratory-gated treatment delivery. We present a multi-disciplinary narrative and technical description of how this innovative technique was implemented for hepatobiliary (HPB) cancers. Read More

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Integrated analysis identifies S100A16 as a potential prognostic marker for pancreatic cancer.

Am J Transl Res 2021 15;13(5):5720-5730. Epub 2021 May 15.

Department of Laboratory Diagnostics, Changhai Hospital, Navy Medical University Shanghai, China.

Background: The new S100 protein family member S100A16 is functionally expressed in various cancers. This study explored the prognostic value and potential role of S100A16 in pancreatic cancer (PC).

Methods: RNA-seq and clinical data were obtained from The Cancer Genome Atlas-Pancreatic Adenocarcinoma (TCGA-PAAD) dataset to compare the expression level of S100A16 between groups. Read More

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The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action.

Am J Transl Res 2021 15;13(5):5240-5247. Epub 2021 May 15.

Department of Gynecology, Gansu Provincial Maternity and Child-care Hospital Lanzhou 730050, Gansu Province, P. R. China.

Objective: This study aimed to explore the effect of quercetin on cervical cancer cells by inducing tumor endoplasmic reticulum stress (ERS) and apoptosis and its mechanism of action.

Methods: HeLa cells were treated with different concentrations of quercetin, and the cell viability was measured using methyl thiazolyl tetrazolium (MTT) colorimetric assays. The apoptosis rate was measured using flow cytometry. Read More

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Circular RNAs as novel potential biomarkers for pancreatic cancer.

J Cancer 2021 1;12(15):4604-4615. Epub 2021 Jun 1.

Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China.

Pancreatic cancer (PaCa) is the fourth leading cause of cancer-related deaths in the United States, and the vast majority of these malignancies are pancreatic ductal adenocarcinomas (PDAC), but there is still a lack of early detection biomarkers for PaCa. Unlike linear RNAs, circRNAs form covalently closed continuous loops and can act as mammalian gene regulators. They may be diagnostic or predictive biomarkers for some tumors, also be novel potential therapeutic targets in different diseases. Read More

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Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.

J Cancer 2021 1;12(15):4542-4551. Epub 2021 Jun 1.

Department of Gastroenterology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R.China.

Tumor distant metastasis is the primary cause of death in colorectal cancer (CRC) patients. GL-V9 is a newly synthesized flavonoid derivative with several beneficial biological functions including anti-tumor and anti-inflammation. However, the anti-metastatic effect of GL-V9 and related mechanisms in CRC remains unknown. Read More

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Safety and efficacy of drug-eluting bead transarterial chemoembolization with CalliSpheres® microsphere for hepatocellular carcinoma with portal vein tumor thrombus: a preliminary study.

J Cancer 2021 1;12(15):4522-4529. Epub 2021 Jun 1.

Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

: To prospectively evaluate the safety and therapeutic effectiveness of drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) with CalliSpheres® microsphere (CSM) for the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), and to analyze the prognostic factors. : Between November 2015 and November 2017, consecutive 58 HCC patients with PVTT who received DEB-TACE with CSM treatment were prospectively enrolled in this study. The demographic characteristics, adverse events (AEs) and treatment response were collected. Read More

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Positive Impact of Intraoperative Epidural Ropivacaine Infusion on Oncologic Outcomes in Pancreatic Cancer Patients Undergoing Pancreatectomy: A Retrospective Cohort Study.

J Cancer 2021 27;12(15):4513-4521. Epub 2021 May 27.

Department of Anesthesiology, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, China.

Previous literatures have demonstrated that regional anesthesia such as epidural anesthesia may affect long-term survival of cancer patients. In the present study, we conducted a retrospective cohort study to investigate the survival impact of intraoperatively epidural ropivacaine infusion on pancreatic ductal adenocarcinoma (PDAC) patients. PDAC patients who underwent pancreatic surgery in Zhongshan Hospital Fudan University from January, 2015 to June, 2018 were included. Read More

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C1GALT1 in health and disease.

Oncol Lett 2021 Aug 6;22(2):589. Epub 2021 Jun 6.

Department of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

O-linked glycosylation (-glycosylation) and N-linked glycosylation (-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important. Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 () serves an important role in the regulation of -glycosylation and is an essential enzyme for synthesizing the core 1 structure of mucin-type O-glycans. Read More

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Threshold Analysis of the Cost-effectiveness of Endoscopic Ultrasound in Patients at High Risk for Pancreatic Ductal Adenocarcinoma.

Pancreas 2021 Jun 19. Epub 2021 Jun 19.

From the Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY Division of Gastroenterology, St Luke's University Health Network, Allentown, PA Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA Division of Gastroenterology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: Data from the International Cancer of the Pancreas Screening Consortium studies have demonstrated that screening for pancreatic ductal adenocarcinoma can be effective and that surveillance improves survival in high-risk individuals. Endoscopic ultrasound (EUS) and cross-sectional imaging are both used, although there is some suggestion that EUS is superior. Demonstration of the cost-effectiveness of screening is important to implement screening in high-risk groups. Read More

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Role of standardized reporting and novel imaging markers in chronic pancreatitis.

Curr Opin Gastroenterol 2021 Jun 18. Epub 2021 Jun 18.

Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Radiology, Ohio State University Wexner Medical Center, Columbus, Ohio Lehman, Bucksot and Sherman Section of Pancreatobiliary Endoscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose Of Review: This article reviews recent efforts about standardized imaging features and reporting of chronic pancreatitis and recently published or ongoing imaging studies, which aim to establish novel imaging biomarkers for detection of parenchymal changes seen in chronic pancreatitis.

Recent Findings: New novel MRI techniques are being developed to increase the diagnostic yield of chronic pancreatitis specifically in the early stage. T1 relaxation time, T1 signal intensity ratio and extracellular volume fraction offer potential advantages over conventional cross-sectional imaging, including simplicity of analysis and more objective interpretation of observations allowing population-based comparisons. Read More

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The faith of non-surveilled pancreatic cysts: a bicentric retrospective study.

Eur J Surg Oncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Surgery, Medical University of Vienna, General Hospital, Vienna, Austria.

Background: Incidental discovery of pancreatic cystic neoplasms (PCLs) is a common and steadily increasing occurrence. The aim of this study was to investigate a cohort of patients presenting with incidentally detected PCLs which were not included in a surveillance protocol, and to compare their risk of malignant evolution with that of systematically surveilled lesions.

Materials And Methods: A population of PCLs which did not receive surveillance over a period >10 years (population A) was selected at the Medical University of Vienna. Read More

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