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Exp Clin Endocrinol Diabetes 2020 Jun 25;128(6-07):401-413. Epub 2020 May 25.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany Institut für Experimentelle Endokrinologie, Berlin, Germany.

Thyroid hormone metabolites (THM) with few or no iodine substituents such as 3,5-T2, the thyronamines 3-T1AM and T0AM, and their oxidation products, the thyroacetic acids (TA) formed by monoamine oxidases, have recently attracted major interest due to their metabolic actions which are in part distinct from those of the classical thyromimetic hormone T3, the major ligand of T3 receptors. This review compiles and discusses effects of 3,5-T2, TAM and TA reported for thyrocytes, pancreatic islets and hepatocytes as well as findings from studies in mouse models after single or repeated administration of pharmacological doses of these agents. Comparison of the 3,5-T2 effects on the transcriptome with not yet published proteome data in livers of obese mice on high fat diet indicate a distinct anti-steatotic effect of this THM. Read More

Endocr Pract 2020 Mar 4;26(3):299-304. Epub 2019 Nov 4.

To assess the evolving standards of care for hyperparathyroidism in kidney transplant candidates. An 11-question, Institutional Review Board-approved survey was designed and reviewed by multiple institutions. The questionnaire was made available to the American Society of Transplantation's Kidney Pancreas Community of Practice membership via their online hub from April through July 2019. Read More

Vojnosanit Pregl 2016 Nov;73(11):1064-7

Introduction: One of the more uncommon etiological factors responsible for the development of acute pancreatitis (AP) is hypercalcemia. Hyperparathyroidism (HPT), as a cause of hypercalcemia, is responsible for 1.5–13% of AP according to a number of studies. Read More

Mediators Inflamm 2015 22;2015:281985. Epub 2015 Mar 22.

Department of General Surgery, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610020, China.

Purpose: This study aimed to investigate the therapeutic potential of hydrogen-rich saline on pancreatic ischemia/reperfusion (I/R) injury in rats.

Methods: Eighty heterotopic pancreas transplantations (HPT) were performed in syngenic rats. The receptors were randomized blindly into the following three groups: the HPT group and two groups that underwent transplantation and administration of hydrogen-rich saline (HS, >0. Read More

J Proteome Res 2014 Apr 10;13(4):1873-84. Epub 2014 Mar 10.

Department of Surgery, University of Michigan , Ann Arbor, Michigan 48109, United States.

Pancreatic cancer is a lethal disease where specific early detection biomarkers would be very valuable to improve outcomes in patients. Many previous studies have compared biosamples from pancreatic cancer patients with healthy controls to find potential biomarkers. However, a range of related disease conditions can influence the performance of these putative biomarkers, including pancreatitis and diabetes. Read More

Diabetologia 2012 Jul 31;55(7):1877-89. Epub 2012 Mar 31.

Institute of Molecular Systems Biology, HPT E73, ETH Zurich, Wolfgang-Pauli-Str 16, 8093 Zurich, Switzerland.

The pancreatic beta cell is responsible for maintaining normoglycaemia by secreting an appropriate amount of insulin according to blood glucose levels. The accurate sensing of the beta cell extracellular environment is therefore crucial to this endocrine function and is transmitted via its cell surface proteome. Various surface proteins that mediate or affect beta cell endocrine function have been identified, including growth factor and cytokine receptors, transporters, ion channels and proteases, attributing important roles to surface proteins in the adaptive behaviour of beta cells in response to acute and chronic environmental changes. Read More

Fetal Pediatr Pathol 2011 ;30(2):106-10

Inpatient Pediatric Services, Mercy Children's Hospital, Toledo, Ohio 43608, USA.

Intussusception is the leading cause of intestinal obstruction in children and is almost invariably idiopathic. Occasionally, there is a lead point for the intussusception. Intussusception caused by heterotopic pancreas (HPT) as the lead point is exceedingly rare. Read More

Regul Pept 2007 Jul 8;142(1-2):60-7. Epub 2007 Feb 8.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan.

Two glycoprotein hormone subunits, glycoprotein hormone subunit alpha (GPA) 2 and glycoprotein hormone subunit beta (GPB) 5, have recently been discovered. When expressed as recombinant proteins, they heterodimerize to form a novel thyrotrophic hormone, thyrostimulin. Recently, we have shown that GPA2 is expressed in both human pancreas and anterior pituitary. Read More

Eur J Clin Invest 2000 Apr;30(4):325-9

Heinrich-Heine-University, Düsseldorf; Institute for Hormone and Fertility Research at the University of Hamburg, Hamburg, Germany.

Background: Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant familial cancer syndrome characterized by tumours of the parathyroids, anterior pituitary gland and endocrine pancreas. Since the cloning of the MEN1 gene (encoding menin) on chromosome 11q13 by Chandrasekharappa et al. in 1997, it has become possible to identify mutations that are responsible. Read More

Horm Res 1997 ;47(4-6):211-20

Service d'Endocrinologie, CHU Bicêtre, Le Kremlin-Bicêtre, France.

Multiple endocrine neoplasia type 1 (MEN 1) is characterized by the combined occurrence, to variable degree, of hyperparathyroidism (HPT) (85.7% of cases according to the French Registry of GENEM 1), tumors of the endocrine pancreas (49.6%), pituitary adenomas (38. Read More

J Okla State Med Assoc 1990 Jun;83(6):255-7

Department of Surgery, University of Oklahoma College of Medicine-Tulsa 74129.

Acute thrombosis in human pancreatic transplantation (HPT) remains a serious problem occurring in 10% to 30% of many reported series. Thrombosis may result from a number of causes including technical error, acute rejection, or low-flow states secondary to conditions within the host or in the transplanted organ. Evidence accumulates suggesting cyclosporine (CSA) acts as a potent vasoconstricting agent and that antihypertensive medications such as calcium channel blocking agents may offer protection from this effect. Read More

Acta Med Scand 1985 ;217(2):205-11

In vitro studies have demonstrated that secretin can stimulate the release of parathyroid hormone (PTH), but reports concerning its effects on PTH and calcium in vivo are contradictory. To examine this question further, a bolus injection of secretin (75 IU) was given to 12 normal subjects and 10 patients with primary hyperparathyroidism (HPT). Six of the patients had multiple endocrine neoplasia and five had endocrine pancreatic tumours (EPT). Read More