158,380 results match your criteria palsy


IgG4-related hypophysitis.

Endocrine 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Hypophysitis is a rare pituitary inflammatory disorder classified in different ways. Immunoglobulin G4-related disease (IgG4-RD), also a rare disease is a systemic fibro-inflammatory condition characterized by infiltration of tissue with IgG4-positive plasma cells; however prevalence of both of them probably is underestimated. In this paper, we present an Iranian patient with biopsy-proven IgG4-related hypophysitis and then review the clinical characteristics, laboratory, imaging, pathologic findings and therapeutic management as well as prognosis of 115 published cases of hypophysitis secondary to IgG4-related disease. Read More

View Article and Full-Text PDF

Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations.

Eur J Hum Genet 2021 Apr 9. Epub 2021 Apr 9.

Pediatric Neurology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Genetic alterations in COL4A2 are less common than those of COL4A1 and their fetal phenotype has not been described to date. We describe a three-generation family with an intragenic deletion in COL4A2 associated with a prenatal diagnosis of recurrent fetal intracerebral hemorrhage (ICH), and a myriad of cerebrovascular manifestations. Exome sequencing, co-segregation analysis, and imaging studies were conducted on eight family members including two fetuses with antenatal ICH. Read More

View Article and Full-Text PDF

Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay.

Sci Rep 2021 Apr 9;11(1):7832. Epub 2021 Apr 9.

Neurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.

Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into neuronal cells is mediated by its binding domain (H/A), which binds to gangliosides, including GT1b, and protein cell surface receptors, including SV2. Previously, recombinant H/A was also shown to bind to FGFR3. Read More

View Article and Full-Text PDF

Early Moves: a protocol for a population-based prospective cohort study to establish general movements as an early biomarker of cognitive impairment in infants.

BMJ Open 2021 Apr 9;11(4):e041695. Epub 2021 Apr 9.

Perth Children's Hospital, Perth, Western Australia, Australia

Introduction: The current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes for these children and support them to reach their full life potential. Early Moves aims to identify early biomarkers, including general movements (GMs), for babies at risk of cognitive impairment, allowing early intervention within critical developmental windows to enable these children to have the best possible start to life. Read More

View Article and Full-Text PDF

Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group.

Br J Sports Med 2021 Apr 9. Epub 2021 Apr 9.

Para Football Foundation, Arnhem, The Netherlands.

Concussion is a frequent injury in many sports and is also common in para athletes. However, there is a paucity of concussion research related to para sport, and prior International Concussion in Sport (CIS) consensus papers have not substantively addressed this population. To remedy this and to improve concussion care provided to para athletes, the concussion in para sport (CIPS) multidisciplinary expert group was created. Read More

View Article and Full-Text PDF

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.

J Gen Physiol 2021 May;153(5)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated sodium channels (Navs), which have been implicated in many conditions. We investigated the effects of CBD on Nav1. Read More

View Article and Full-Text PDF

Biocidal efficacy of tutin and its influence on immune cells and expression of growth-blocking and neuroglian peptides in Mythimna separata (Lepidoptera: Noctuidae).

Arch Insect Biochem Physiol 2021 Apr 9:e21767. Epub 2021 Apr 9.

College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.

Mythimna separata Walker (Lepidoptera: Noctuidae) is one of the major pests that can cause severe damage to grain crops. The development of low-toxicity and high-performance botanical insecticides is becoming the focus of new pesticide research to control M. separata. Read More

View Article and Full-Text PDF

Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight.

FASEB J 2021 May;35(5):e21578

Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Bone loss is a major health concern for astronauts during long-term spaceflight and for patients during prolonged bed rest or paralysis. Growing evidence suggests that osteocytes, the most abundant cells in the mineralized bone matrix, play a key role in sensing mechanical forces applied to the skeleton and integrating the orchestrated response into subcellular biochemical signals to modulate bone homeostasis. However, the precise molecular mechanisms underlying both mechanosensation and mechanotransduction in late-osteoblast-to-osteocyte cells under microgravity (µG) have yet to be elucidated. Read More

View Article and Full-Text PDF

Buprenorphine may be effective for treatment of paramyotonia congenita.

Muscle Nerve 2021 Apr 9. Epub 2021 Apr 9.

IRCCS Mondino Foundation, Pavia, Italy.

Introduction/aims: Paramyotonia congenita (PMC) is a skeletal muscle sodium channelopathy characterized by paradoxical myotonia, cold sensitivity, exercise/cold induced paralysis. Treatment with sodium channel-blocking anti-arrhythmics may expose the patients to a risk of arrhythmia or may be poorly tolerated or ineffective. We explored the effectiveness of non-anti-arrhythmic sodium channel blockers in two patients with PMC. Read More

View Article and Full-Text PDF

Unraveling a cephalalgic quagmire from a cavern to a cave.

J Postgrad Med 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurosurgery, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India.

Headache in women in their late forties can be primary or secondary. We report a 48-year-old female with chronic slowly progressive left temporal headache for 1 year. She also had ipsilateral eye pain and facial numbness for 1 month, with restricted abduction in the left eye and diplopia. Read More

View Article and Full-Text PDF

Positive perception of stem cells for neurological conditions: results from an Australian public forum.

Regen Med 2021 Apr 9. Epub 2021 Apr 9.

Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.

Stem cells offer great hope and promise as a potential treatment for human diseases. The aim of this study was to gain insight into the public perception of stem cells for neurological conditions. A paper-based questionnaire was administered to all attendees of a free, public stem cell forum. Read More

View Article and Full-Text PDF

[Progressive supranuclear paralysis with levodopa-induced dyskinesia].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):110-115

Bashkir State Medical University, Ufa, Russia.

Progressive supranuclear palsy (PNP) is a neurodegenerative disease characterized by a combination of progressive akinetic-rigid syndrome, postural instability with frequent falls, supranuclear ophthalmoplegia, pseudobulbar syndrome and frontal dementia. The disease usually develops after the sixth decade of life, and has a progressive course. An own description of the clinical case of progressive supranuclear palsy in a 79-year-old patient with oromandibular hyperkinesis while taking levodopa is presented. Read More

View Article and Full-Text PDF
January 2021

Transitional milestones and developmental challenges for adults with cerebral palsy.

Authors:
Reuben Escorpizo

Dev Med Child Neurol 2021 Apr 8. Epub 2021 Apr 8.

Department of Rehabilitation and Movement Science, University of Vermont, Burlington, VT, USA.

View Article and Full-Text PDF

The Whitney Comorbidity Index for adults with cerebral palsy: a challenge for practice.

Dev Med Child Neurol 2021 Apr 8. Epub 2021 Apr 8.

Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands.

View Article and Full-Text PDF

Hammersmith Infant Neurological Examination and long-term cognitive outcome in children born very preterm.

Dev Med Child Neurol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatric Neurology, University of Turku, Turku, Finland.

Aim: To study the association between the Hammersmith Infant Neurological Examination (HINE) at age 2 years and neurocognition at age 11 years in children born very preterm. We hypothesized that the HINE at 2 years would be associated with neurocognition, that is, neurological, motor, and cognitive outcomes at 11 years.

Method: A total of 174 children (mean gestational age 29. Read More

View Article and Full-Text PDF

Evaluation of the effects of the COVID-19 pandemic on children with cerebral palsy, caregivers' quality of life, and caregivers' fear of COVID-19 with telemedicine.

Ir J Med Sci 2021 Apr 9. Epub 2021 Apr 9.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Background: The sudden and unexpected pandemic changed the daily routine of the children with cerebral palsy (CP) and their caregivers.

Aims: This study aimed to investigate the impact of the novel coronavirus (COVID-19) pandemic on the utilization of health and rehabilitation services and the general health and physical status of children with CP. In addition, the second aim of the study was to examine the effects of the COVID-19 pandemic on caregivers' quality of life (QOL) and their fear of COVID-19. Read More

View Article and Full-Text PDF

Unusual mechanical failures of intrathecal baclofen pump systems: symptoms, signs, and trouble shooting.

Childs Nerv Syst 2021 Apr 8. Epub 2021 Apr 8.

Division of Neuropediatrics, Hospital for Children and Adolescents, University Hospital Leipzig, Leipzig, Germany.

Introduction: Although intrathecal baclofen (ITB) therapy is an effective treatment for spasticity, it has several disadvantages and a risk of complications.

Methods: We present six pediatric patients who suffered from unusual mechanical failures of intrathecal baclofen pump systems.

Results: With these case-vignettes, we provide a systematic approach on how to interpret the symptoms of ITB complications and an advice which further diagnostic and therapeutic steps to follow. Read More

View Article and Full-Text PDF

Management of facial nerve schwannoma: when is the timing for surgery.

Eur Arch Otorhinolaryngol 2021 Apr 8. Epub 2021 Apr 8.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Purpose: Although the estimated prevalence is extremely low, facial nerve schwannoma (FNS) is the most common primary tumor of the facial nerve (FN). In the present study, the outcome of surgical management in 18 patients with FNS was analyzed and an appropriate time for surgery was proposed.

Materials And Methods: A total of 18 patients with FNS who underwent surgical management by a single surgeon from 1999 to 2018 were retrospectively analyzed. Read More

View Article and Full-Text PDF

Outcomes of Vertical Expandable Prosthetic Titanium Ribs in Children With Early-Onset Scoliosis Secondary to Cerebral Palsy.

Cureus 2021 Mar 4;13(3):e13690. Epub 2021 Mar 4.

Pediatric Orthopaedic Surgery, Children's Hospital of Mississippi, Jackson, USA.

Purpose Patients who have neuromuscular scoliosis, such as cerebral palsy (CP), often develop spinal deformities that negatively impact quality of life. The vertical expandable prosthetic titanium rib (VEPTR) was designed for thoracic insufficiency syndrome (TIS), but it has also been utilized in patients with CP with restrictive lung disease and spine deformity. Few studies report on VEPTRs in neuromuscular scoliosis; however, none reports on their utilization specifically in patients with CP. Read More

View Article and Full-Text PDF

Accidental anterior longitudinal ligament rupture during lateral lumbar interbody fusion disclosed after posterior corrective fusion surgery resulting in local hyper-lordosis.

J Rural Med 2021 Apr 1;16(2):111-114. Epub 2021 Apr 1.

Department of Orthopeadic Surgery, Faculty of Medicine, University of Tsukuba, Japan.

To report a case of anterior longitudinal ligament (ALL) injury that was not noticeable during lateral lumbar interbody fusion and was disclosed after posterior corrective fusion surgery. After performing lateral lumbar interbody fusion followed by posterior corrective fusion surgery, we observed an anterior longitudinal ligament rupture that required additional surgery. Postoperative pain in the left lower limb and muscle weakness due to nerve traction appeared, but this was improved by stabilization between the vertebral bodies. Read More

View Article and Full-Text PDF

A New Neurorehabilitative Postsurgery Intervention for Facial Palsy Based on Smile Observation and Hand-Mouth Motor Synergies.

Neural Plast 2021 24;2021:8890541. Epub 2021 Mar 24.

Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Italy.

Objective: To perform a preliminary test of a new rehabilitation treatment (FIT-SAT), based on mirror mechanisms, for gracile muscles after smile surgery.

Method: A pre- and postsurgery longitudinal design was adopted to study the efficacy of FIT-SAT. Four patients with bilateral facial nerve paralysis (Moebius syndrome) were included. Read More

View Article and Full-Text PDF

The Current Practice of Spinal Anesthesia in Anesthetists at a Comprehensive Specialized Hospital: A Single Center Observational Study.

Local Reg Anesth 2021 31;14:51-56. Epub 2021 Mar 31.

Department of Anesthesia, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Background: Spinal anesthesia block is the most widely practiced anesthesia technique due to its safety margin. It is an invasive procedure that could be associated with a variety of complications like total spinal, cardiovascular collapse, meningitis, paralysis, and even death. The aim of this study to assess the current practice of spinal anesthesia. Read More

View Article and Full-Text PDF

Pattern of comorbidities in school-aged children with cerebral palsy in Cross River State, Nigeria.

BMC Pediatr 2021 Apr 8;21(1):165. Epub 2021 Apr 8.

London School of Hygiene & Tropical Medicine, International Centre for Eye Health, London, UK.

Background: To describe the pattern of comorbidities in school-aged children with cerebral palsy (CP) and to identify which, if any, were associated with poor school attendance. A cross-sectional study, using the key informant methodology, between December 2017 and July 2018 was conducted in Cross River State, Nigeria. Assessments, confirmation of CP and identification of systemic comorbidities using standard tools and questionnaires were performed. Read More

View Article and Full-Text PDF

Acupuncture for drooling in children with cerebral palsy: A protocol for systematic review.

Medicine (Baltimore) 2021 Apr;100(14):e25393

Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.

Background: The aim of this study is to provide the methods used to evaluate the effectiveness and safety of acupuncture therapy for treating drooling in children with cerebral palsy.

Methods And Analysis: A comprehensive search of Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, 4 Chinese databases (China National Knowledge Infrastructure, Chinese Biomedical Literatures database, Wan-Fang Database and Chinese Science and Technology Periodicals will be conducted to identify randomized controlled trials of acupuncture for treating children with cerebral palsy salivation with no restriction on time or language. The primary outcome of this systematic review will be the effective rate. Read More

View Article and Full-Text PDF

[Thoracic Endovascular Aortic Repair for Idiopathic Aortic Rupture].

Kyobu Geka 2021 Mar;74(3):202-205

Department of Cardiovascular Surgery, Yamanashi Prefectural Central Hospital, Kofu, Japan.

Idiopathic aortic rupture is a rare but often fatal condition that requires urgent attention and repair. I have performed thoracic endovascular aortic repair ( TEVAR) in two cases of idiopathic aortic rupture and have achieved positive results. It can be difficult to identify the site of rupture in these cases. Read More

View Article and Full-Text PDF

Generation of GPAM knockout human embryonic stem cell line SYSUe-008-A using CRISPR/Cas9.

Stem Cell Res 2021 Mar 19;53:102303. Epub 2021 Mar 19.

Laboratory of Medical Systems Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China; Third Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China. Electronic address:

GPAM (glycerol-3-phosphateacyltransferase1) is a mitochondrial enzyme that catalyze an essential step in glycerolphospholipids and triacylglycerol biosynthesis process. Loss-of-function mutation of GPAM has been shown to lead to hypomyelination of corticospinal tract in cerebral palsy patient. To model this rare disease with human brain organoid, we generated a GPAM knockout human embryonic stem cell line SYSUe-008-A by CRISPR/cas9. Read More

View Article and Full-Text PDF

Intrapartum opioid analgesia and childhood neurodevelopmental outcomes among infants born preterm.

Am J Obstet Gynecol MFM 2021 Apr 5:100372. Epub 2021 Apr 5.

Center for Women's Reproductive Health, University of Alabama at Birmingham; Department of Obstetrics and Gynecology, University of Alabama at Birmingham.

Background: There are concerns regarding neurobehavioral changes in infants exposed to parenteral opioids during labor, yet long-term neurodevelopment remains unstudied.

Objective: We aimed to examine the association between parenteral opioids for labor analgesia and perinatal outcomes and childhood neurodevelopment until two years of age among infants born preterm. We hypothesized that intrapartum exposure to parenteral opioids is associated with impaired neurodevelopment and adverse perinatal outcomes. Read More

View Article and Full-Text PDF

Nerve transfers to restore femoral nerve function following oncologic nerve resection.

J Surg Oncol 2021 Apr 8. Epub 2021 Apr 8.

Department of Plastic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Introduction: Advances in the care of soft-tissue tumors, including imaging capabilities and adjuvant radiation therapy, have broadened the indications and opportunities to pursue surgical limb salvage. However, peripheral nerve involvement and femoral nerve resection can still result in devastating functional outcomes. Nerve transfers offer a versatile solution to restore nerve function following tumor resection. Read More

View Article and Full-Text PDF

Endoscopic Left Central Lymph Node Dissection of Thyroid Cancer: Safe, Feasible, and Relatively Easy.

Surg Innov 2021 Apr 8:1553350620983640. Epub 2021 Apr 8.

Department of General Surgery, 162698Jinan University First Affiliated Hospital, Guangzhou, China.

. The purpose of this study was to explore the feasibility of left central lymph node dissection (CLND) in endoscopic thyroidectomy via chest-breast approach (ETCB). Retrospective analysis of 57 cases of left CLND (group A) via ETCB, 35 cases of open left CLND (group B), and 90 cases of right CLND via ETCB (Group C) were performed from October 2014 to October 2019. Read More

View Article and Full-Text PDF

Tau strains shape disease.

Acta Neuropathol 2021 Apr 8. Epub 2021 Apr 8.

Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease (PiD). Tauopathies are defined by brain accumulation of microtubule-associated protein tau in fibrillar aggregates, whose prevalence strongly correlates with dementia. Dominant mutations in tau cause neurodegenerative diseases, and most increase its aggregation propensity. Read More

View Article and Full-Text PDF