Sci Rep 2021 Apr 9;11(1):7832. Epub 2021 Apr 9.
Neurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.
Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into neuronal cells is mediated by its binding domain (H/A), which binds to gangliosides, including GT1b, and protein cell surface receptors, including SV2. Previously, recombinant H/A was also shown to bind to FGFR3. Read More