55,864 results match your criteria palmoplantar pustulosis


Cost-Effectiveness Analysis of Durvalumab Plus Chemotherapy in the First-Line Treatment of Extensive-Stage Small Cell Lung Cancer.

J Natl Compr Canc Netw 2021 Aug 4. Epub 2021 Aug 4.

1Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan.

Background: In the CASPIAN trial, durvalumab + chemotherapy demonstrated significant improvements in overall survival compared with chemotherapy alone in patients with extensive-stage small cell lung cancer (SCLC). We aimed to assess the cost-effectiveness of durvalumab in patients with extensive-stage SCLC from the US healthcare system perspective.

Patients And Methods: A comprehensive Markov model was adapted to evaluate cost and effectiveness of durvalumab combination versus platinum/etoposide alone in the first-line therapy of extensive-stage SCLC based on data from the CASPIAN study. Read More

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Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis.

J Ethnopharmacol 2021 Aug 1:114485. Epub 2021 Aug 1.

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Department of Dermatology, Shanxi TCM Hospital, Xian, 710003, China. Electronic address:

Ethnopharmacological Relevance: Taodan granules (TDG) have been observed to decrease interleukins, or psoriasis area and severity index (PASI) score for psoriasis vulgaris, without significant adverse events. However, the regulatory network remains elucidated.

Aim Of The Study: The objective is to identify critical genes and kernel pathways of TDG treated psoriasis. Read More

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Dietary Inflammatory Index in Relation to Psoriasis Risk, Cardiovascular Risk Factors and Clinical Outcomes; A Result from Case-Control Study in Psoriasis Patients.

Appl Physiol Nutr Metab 2021 Aug 4. Epub 2021 Aug 4.

Thapar Institute of Engineering & Technology, Department of Biotechnology, Delhi , India;

Psoriasis is an inflammatory skin disease. Despite the understanding of the disease pathogenesis, the link between diet-induced inflammation and the risk of psoriasis remains underexplored. Therefore, we have examined the capability of literature-derived Energy-adjusted Dietary Inflammatory Index (E-DII) as a predictive tool for inflammation, incidence, and severity of psoriasis (as indexed by The Psoriasis Area Severity Index (PASI)). Read More

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Racial Representation in Clinical Trials for Dermatologic New Molecular Entities.

Authors:
M V Ha C Wong

Clin Exp Dermatol 2021 Aug 4. Epub 2021 Aug 4.

Case Western Reserve University School of Medicine, Department of Dermatology, Cleveland, OH, USA.

Underrepresentation of minorities in clinical research has major implications for equality of access to current treatments in the field of dermatology. To determine whether there has been equitable representation of Black individuals in the clinical trials for dermatologic new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analyzed data from the FDA Drug Trials Snapshots program from January 2015 to the present. During this period, there was significant underrepresentation of Black people in the clinical trials for NMEs treating acne vulgaris, plaque psoriasis, actinic keratosis, and squamous cell carcinoma. Read More

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Interleukin 36 Expression in Psoriasis Variants and Other Dermatologic Diseases with Psoriasis-Like Histopathologic Features.

J Cutan Pathol 2021 Aug 4. Epub 2021 Aug 4.

University of California San Francisco, San Francisco, CA, 94115.

Background: Elevated epidermal interleukin (IL)-36 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PD) have not been thoroughly investigated for IL-36 expression. In this study, we assess the IL-36 staining pattern (IL36-SP) in psoriasis variants and other PD including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo (IMP) and syphilis (SY).

Methods: IL-36 immunostaining was performed on 307 cases of psoriasis and various PD. Read More

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High serum level of interleukin-6 is linked with dyslipidemia in oral lichen planus.

Exp Ther Med 2021 Sep 13;22(3):987. Epub 2021 Jul 13.

Department of Pathophysiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8 T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. Read More

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September 2021

Psoriasis beyond the skin: Ophthalmological changes (Review).

Exp Ther Med 2021 Sep 12;22(3):981. Epub 2021 Jul 12.

Third Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Read More

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September 2021

Experimental Pharmacological Management of Psoriasis.

J Exp Pharmacol 2021 26;13:725-737. Epub 2021 Jul 26.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.

Psoriasis is a chronic, relapsing, immune-mediated systemic disease. Its pathogenesis is complex and not fully understood yet. Genetic and epigenetic factors interact with molecular pathways involving TNF-α, IL-23/IL-17 axis, and peculiar cytokines, as IL-36 or phosphodiesterase 4. Read More

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Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.

Appl Clin Genet 2021 26;14:331-339. Epub 2021 Jul 26.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin Elkom City, Egypt.

Background: Psoriasis is a complex autoimmune multifactorial disease induced by interaction of environmental and genetic factors. This research aimed to clarify the association of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) polymorphisms with susceptibility to psoriasis.

Methods: This case-control study involved 150 patients diagnosed with psoriasis and 100 age- and gender-matched apparently healthy individuals. Read More

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Importance of lymphocyte-stromal cell interactions in autoimmune and inflammatory rheumatic diseases.

Nat Rev Rheumatol 2021 Aug 3. Epub 2021 Aug 3.

Immunogenomics and Inflammation Research Unit, University of Lyon, Department of Immunology and Rheumatology, Hospital Edouard Herriot, Lyon, France.

Interactions between lymphocytes and stromal cells have an important role in immune cell development and responses. During inflammation, stromal cells contribute to inflammation, from induction to chronicity or resolution, through direct cell interactions and through the secretion of pro-inflammatory and anti-inflammatory mediators. Stromal cells are imprinted with tissue-specific phenotypes and contribute to site-specific lymphocyte recruitment. Read More

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Subtypes of atopic dermatitis: From phenotype to endotype.

Allergol Int 2021 Jul 31. Epub 2021 Jul 31.

Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa, Japan; Department of Pediatrics, Chutoen General Medical Center, Kakegawa, Japan.

Atopic dermatitis (AD) is a heterogenous disorder and can be classified into different types. Stratification of subtypes may enable personalized medicine approaches. AD can be categorized into the IgE-high, extrinsic subtype and the IgE-normal, intrinsic subtype. Read More

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Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study.

J Transl Med 2021 08 3;19(1):331. Epub 2021 Aug 3.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Biomarkers for distinguishing psoriatic arthritis (PsA) from psoriasis without arthritis (PsO) are still lacking.

Methods: We applied isobaric tags for relative and absolute quantification (iTRAQ) and LC-MS/MS to analyze the proteome profile of peripheral blood mononuclear cells (PBMCs) collected from patients with PsO, patients with PsA, and healthy controls. Bioinformatics analysis and western blotting were performed to identify and validate differentially expressed proteins. Read More

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Burden of Disease for Psoriasis in Argentina, Brazil, Colombia, and Mexico.

Value Health Reg Issues 2021 Jul 31;26:126-134. Epub 2021 Jul 31.

Eli Lilly and Company, Indianapolis, IN, USA; Division of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, OH, USA.

Objectives: Psoriasis (PsO) is a chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations. The disease is also associated with lower quality of life, lower work productivity, and higher healthcare costs. The objective of this study was to conduct a systematic literature review of the disease burden for PsO in Argentina, Brazil, Colombia, and Mexico. Read More

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Cellular nanovesicles with bioorthogonal targeting enhance photodynamic/photothermal therapy in psoriasis.

Acta Biomater 2021 Jul 31. Epub 2021 Jul 31.

XuZhou Central Hospital, Xuzhou, 221009, PR China; Xuzhou Central Hospital Affiliated to Medical School of Southeast University, Xuzhou, 221009, PR China; XuZhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, PR China. Electronic address:

The interaction between over-proliferating keratinocytes and excessive activated immune cells contributes to the development and progression of psoriasis. Photodynamic therapy (PDT)/photothermal therapy (PTT) is a promising method to treat skin diseases due to their synergistic effect and low side effect. Cell membrane is an ideal cell-mediated drug delivery platform with inherent biocompatibility, but lacks of specific targeting properties to increase drug accumulation in the psoriatic site. Read More

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EFFICACY AND SAFETY OF APREMILAST IN PATIENTS WITH MILD TO MODERATE PLAQUE PSORIASIS: RESULTS OF A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL.

J Am Acad Dermatol 2021 Jul 31. Epub 2021 Jul 31.

University of Utah, Salt Lake City, UT, USA.

Background: Patients with mild-to-moderate psoriasis may have substantial quality-of-life impairment.

Objective: To evaluate apremilast 30 mg BID for mild-to-moderate psoriasis.

Methods: Phase 3, double-blind, placebo-controlled study in adults with mild-to-moderate psoriasis inadequately controlled or intolerant to ≥1 topical psoriasis therapy (NCT03721172). Read More

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Cytokine responses in non-lesional psoriatic skin as clinical predictor to anti-TNF agents.

J Allergy Clin Immunol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

Background: A major issue with the current management of psoriasis is our inability to predict treatment response.

Objective: Our aim was to evaluate the ability to use baseline molecular expression profiling to assess treatment outcome for psoriatic patients.

Methods: We conducted a longitudinal study of 46 patients with chronic plaque psoriasis treated with anti-TNF agent etanercept, and molecular profiles were assessed in over 200 RNA-seq samples. Read More

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Changes in the expression pattern of DUSP1-7 and miRNA regulating their expression in the keratinocytes treated with LPS and adalimumab.

Curr Pharm Biotechnol 2021 Aug 1. Epub 2021 Aug 1.

Department of Histology, Cytophysiology, and Embryology in Zabrze, Faculty of Medicine in Zabrze, The University of Technology in Katowice, 41-800 Zabrze. Poland.

Background: Increased levels of phosphorylated ERK and p38 MAPK proteins have been observed in psoriatic skin biopsies compared to controls, which may be associated with an impaired expression pattern of dual activity protein phosphatase (DUSP).

Objective: The purpose of this study was to assess changes in the expression profile of mRNA DUSP 1-7 and miRNA regulating their expression in human keratinocyte cells (HaCaT) had exposed to the liposaccharide A (LPS).

Methods: HaCaT was exposed to 1 µg/ml LPS and next adalimumab by 2,8,24h compared to untreated cells. Read More

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Potential Role of Cytosolic RNA Sensor as an Inhibitor for Keratinocyte Differentiation in the Pathogenesis of Psoriasis.

Ann Dermatol 2021 Aug 1;33(4):339-344. Epub 2021 Jul 1.

Department of Dermatology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Background: Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date, many psoriasis-related genes have been discovered, but the role of many important genes has not been well understood. Read More

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The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris.

J Am Acad Dermatol 2021 Jul 30. Epub 2021 Jul 30.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA. Electronic address:

Background: While hidradenitis suppurativa (HS) shares some transcriptomic and cellular infiltrate features with psoriasis, their skin proteome remains unknown.

Objective: To define and compare inflammatory protein biomarkers of HS and psoriasis skin.

Methods: We assessed 92 inflammatory biomarkers in HS (n=13), psoriasis (n=11) and control skin (n=11) using Olink high-throughput proteomics. Read More

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A Retrospective Study to Assess the Efficacy, Safety and Drug Survival of Secukinumab in Plaque Psoriasis Patients in China.

Dermatol Ther 2021 Aug 2. Epub 2021 Aug 2.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Secukinumab, a full human immunoglobulinG1κ(IgG1κ) monoclonal antibody that targets interleukin-17A, has demonstrated remarkable efficacy and appreciable tolerance in patients with moderate-to-severe psoriasis. However, data on its real-life performance, particularly on drug survival in China are limited. To investigate the efficacy, safety, and drug survival of secukinumab in Chinese patients with psoriasis, we conducted a monocentric retrospective study of 66 patients with moderate-to-severe psoriasis to followed-up for 52 weeks. Read More

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Rapid response to secukinumab in a 5-year-old with deficiency of the interleukin-36 receptor antagonist (DITRA) with severe scalp and nail involvement.

Pediatr Dermatol 2021 Aug 2. Epub 2021 Aug 2.

Department of Dermatology, University of Hong Kong Shenzhen Hospital, Shenzhen, China.

Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of the IL36RN gene. DITRA is characterized by acute generalized pustular psoriasis (GPP), fever, systemic inflammation, and leukocytosis. We report the case of a 5-year-old girl with severe scalp and nail involvement with a rapid response to secukinumab. Read More

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The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.

PLoS One 2021 2;16(8):e0255492. Epub 2021 Aug 2.

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Objective: To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.

Methods: In Taiwan's national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. Read More

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Serological Evidence of in Patients with Morphea from West-Central Poland: An Original Paper and Review of Literature.

Vector Borne Zoonotic Dis 2021 Jul 30. Epub 2021 Jul 30.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Morphea (localized scleroderma) is an inflammatory connective tissue disease. , as a causative factor, has been discussed controversially. The aim of this original study was to evaluate the frequency of IgM and IgG classes of anti-Borrelia antibodies in groups of morphea and psoriasis patients using the traditional ELISA method. Read More

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Long-Term Proactive Treatment of Plaque Psoriasis with Calcipotriene/Betamethasone Dipropionate Foam Prolongs Remission and Reduces Relapses Irrespective of Patient Baseline Characteristics.

Dermatol Ther (Heidelb) 2021 Aug 2. Epub 2021 Aug 2.

The Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR Biomedical Research Centre, The University of Manchester, Manchester, M6 8HD, UK.

Introduction: The phase 3 PSO LONG study (NCT02899962) demonstrated superior efficacy of proactive (PM) versus reactive management (RM) using calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam in adults with psoriasis. Read More

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Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress.

Immunopharmacol Immunotoxicol 2021 Aug 2:1-13. Epub 2021 Aug 2.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel condition considered by oxido-nitrosative stress and the release of pro-inflammatory cytokines that affects the mucosal lining of the colon. Sarsasapogenin (SG), as an active component, has been found in many plants, and it exhibits potential protective effects, such as anti-inflammatory, antioxidant, anti-psoriasis, anti-arthritis, anti-asthma, anti-depressant and anti-cancer. However, the effects of SG on UC remain unknown. Read More

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Data-driven prediction of biologic treatment responses in psoriasis: steps towards precision medicine.

Br J Dermatol 2021 Aug 1. Epub 2021 Aug 1.

Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.

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Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis.

Front Med (Lausanne) 2021 16;8:712511. Epub 2021 Jul 16.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Ablative fractional laser treatment facilitates epidermal drug delivery, which might be an interesting option to increase the topical efficacy of biological drugs in a variety of dermatological diseases. This work aims at investigating safety and tolerability of this new treatment approach in patients with plaque-type psoriasis. Eight patients with plaque-type psoriasis were enrolled in this study. Read More

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Safety and Efficacy of Risankizumab and Infliximab in the Treatment of Plaque Psoriasis: Results From a Direct and Indirect Meta-Analysis.

Cureus 2021 Jun 27;13(6):e15963. Epub 2021 Jun 27.

Dermatology, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.

The objective of our study was to compare a potent drug of the anti-TNF class family, infliximab, with a potent drug of the IL-inhibitors family, risankizumab, in terms of efficacy and safety endpoints. Online databases were searched for relevant placebo-controlled, randomized trials. The following efficacy outcomes were included: PASI-75, PASI-90, and sPGA, as well as the incidence of any adverse events and serious adverse events. Read More

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New-onset guttate psoriasis secondary to COVID-19.

Clin Case Rep 2021 Jul 28;9(7):e04542. Epub 2021 Jul 28.

Department of Dermatology The Military Hospital of Tunis Tunis Tunisia.

SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is associated with flares of psoriasis in patients with well-documented disease. Both viral infection and medications used for treatment, like hydroxychloroquine, were incriminated. Herein, we report the case of a 25-year-old male patient who presented a first-onset guttate psoriasis following a COVID-19 infection. Read More

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Experimental research in topical psoriasis therapy (Review).

Exp Ther Med 2021 Sep 8;22(3):971. Epub 2021 Jul 8.

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Psoriasis, one of the most prevalent inflammatory diseases in dermatologic pathology, remains a challenge in regards to the therapeutic approach. Topical therapy for psoriasis is a current trending subject as it implies good compliance for the patient, few adverse systemic reactions and a targeted effect. Numerous substances are now being tested, from natural to synthetic compounds and already known substances in improved formulas such as vesicular systems. Read More

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September 2021