56 results match your criteria pakistani medicinal

Biochemical Profiling for Antioxidant and Therapeutic Potential of Pakistani Chickpea ( L.) Genetic Resource.

Front Plant Sci 2021 13;12:663623. Epub 2021 Apr 13.

Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences, Faisalabad, Pakistan.

In Pakistan, chickpeas ( L.) are the largest grown legume crops, especially in desert areas. Along with an excellent source of nutrition, chickpea seeds have discernible medicinal and antioxidant characteristics. Read More

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Antihyaluronidase and Alkaline Phosphatase (ALP) Activities of Medicinal Plants to Combat Venom-Induced Toxicities.

Biomed Res Int 2021 16;2021:6618349. Epub 2021 Mar 16.

Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060 KPK, Pakistan.

Snakebite is one of the most neglected diseases of developing countries. Deaths due to snakebite envenoming are quite high in Pakistan, and many deaths are caused by envenomation. Traditional use of medicinal plants against snakebites is a common practice in Pakistan due to countless benefits. Read More

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Anti-5'-Nucleotidases (5'-ND) and Acetylcholinesterase (AChE) Activities of Medicinal Plants to Combat Venom-Induced Toxicities.

Biomed Res Int 2021 4;2021:6631042. Epub 2021 Feb 4.

Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus 22060, KPK, Pakistan.

is one of the highly venomous snakes of Pakistan that is responsible for numerous cases of envenomation and deaths. In Pakistan, medicinal plants are commonly used traditionally for snakebite treatment because of their low cost and easy availability in comparison with antivenom. The current research is aimed at evaluating the inhibitory activity of Pakistani medicinal plants against acetylcholinesterase and 5'-nucleotidases present in venom. Read More

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The genus Nepeta: Traditional uses, phytochemicals and pharmacological properties.

J Ethnopharmacol 2021 Mar 8;268:113679. Epub 2020 Dec 8.

Department of Chemistry, Sant Longowal Institute of Engineering and Technology, Longowal, Sangrur, Punjab, 148106, India. Electronic address:

Ethnopharmacological Relevance: Nepeta is a multiregional genus of the "Lamiaceae" (Labiatae or Mint) family. Species of Nepeta are a valuable part of traditional medicine and used extensively, particularly in the Himalayan region of India (Uttarakhand, Himachal Pradesh, Jammu and Kashmir, Leh-Ladakh), Pakistan (Khyber Pakhtunkhwaand Pakistani Kashmir), Nepal (Baglund district), also in China and hilly regions of Turkey and Iran. Nepeta species are extensively used as a remedy against a variety of ailments and conditions like chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. Read More

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The first bioactivity studies of from high altitude Karakoram-Himalayan desert.

Saudi J Biol Sci 2020 Oct 14;27(10):2514-2520. Epub 2020 Apr 14.

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Couple of ethnopharmacological surveys in the Indian Ladakh and Pakistani Shigar valleys has reported the medicinal use of against cardiac and gastric disorders that however, remains without scientific rationale or experimental validations. Here, we assess the bio/therapeutic activities of extracts as well as chloroform, ethyl acetate, n-butanol and aqueous fractions. The β-carotene-linoleic acid bleaching and DPPH radical scavenging methods demonstrated a very high anti-oxidative property of chloroform and ethyl acetate fractions compared to others. Read More

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October 2020

Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations.

Immunol Invest 2021 May 16;50(4):416-426. Epub 2020 Jun 16.

Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.

Resorption of bones and cartilage coupled with structural changes in the inflamed joints are the major hallmark of rheumatoid arthritis (RA). Genetic polymorphisms in pro-inflammatory interleukins (ILs) appear to play an important role in the susceptibility towards progressive RA. We therefore aimed to investigate the association of single nucleotide polymorphisms (SNP), present in the hotspot coding/promoter regions of IL-6, -17 and -18, with RA susceptibility or severity in a larger study cohort from Pakistan together with finding clues as to how a functional SNP impacts the predisposition towards RA. Read More

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Evaluation of different Pakistani medicinal plants for inhibitory potential against Echis carinatus induced Phospholipase A2 toxicity.

Pak J Pharm Sci 2019 Sep;32(5(Supplementary)):2269-2277

Department of Pharmacy, COMSATS University, Abbottabad Campus, Islamabad, Pakistan.

Medicinal plants of Pakistan are known for their curative properties against snake bite as rural people have been using natural herbs for such injuries for hundreds to thousands of years. People of rural areas of Pakistan are prone to snakebite, and on the whole death due to snakebite has been increasing worldwide. The objective of this study was to test the neutralizing potential of 17 Pakistani medicinal plant extracts against phospholipase A2 activity in Echis carinatus venom. Read More

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September 2019

A novel pathogenic missense variant in CNNM4 underlying Jalili syndrome: Insights from molecular dynamics simulations.

Mol Genet Genomic Med 2019 09 25;7(9):e902. Epub 2019 Jul 25.

Institute of Molecular Biology and Biotechnology (IMBB), Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan.

Background: Jalili syndrome (JS) is a rare cone-rod dystrophy (CRD) associated with amelogenesis imperfecta (AI). The first clinical presentation of JS patients was published in 1988 by Jalili and Smith. Pathogenic mutations in the Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 4 (CNNM4) magnesium transporter protein have been reported as the leading cause of this anomaly. Read More

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September 2019

Comparison of Anti-HCV Activity of Multiple Punica granatum Extracts and Fractions in Virus-infected Human Hepatocytes.

Curr Pharm Biotechnol 2018 ;19(15):1221-1231

Dean Post Graduate Study, Allama Iqbal Medical College, Lahore, Pakistan.

Background: Plants extracts and their bioactive constituents can provide an alternative approach for new treatment. Pakistani flora reveals a huge, largely untapped source of potential antiviral constituents.

Objective: High-cost concerns of direct-acting anti-HCV drugs limit their employment specifically in developing countries like Pakistan. Read More

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Chemical and toxicological studies on different brands of Asmad (Antimony sulphide) available in Pakistan and Saudi Arabia.

Pak J Pharm Sci 2018 Nov;31(6 (Supplementary):2591-2595

Department of Biological Sciences, University of Western Sydney, Sydney, Australia.

Eye is the most beautiful, important and sensitive organ of human body. It is not only linked with visionary complex optical system also has the ability to differentiate among the millions of colors. The apparent human personality is also associated with it. Read More

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November 2018

A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anticancer Medicinal Plants of Pakistan.

Curr Cancer Drug Targets 2019 ;19(2):120-151

Department of Pharmacology, College of Pharmacy, The University of Punjab, Lahore, Pakistan.

The widespread emergence of cancer and development of resistance to chemotherapeutic agents is increasing the interest of scientists in the use of ethnomedicinal preparations and isolated phytochemicals in the treatment and prevention of disease. Medicinal plants have been used in Pakistan since prehistoric times. The present review was designed to identify anticancer plants of ethnomedicinal significance and to summarize the anticancer activities carried out on these medicinal plants to establish the pharmacological and phytochemical basis of their use. Read More

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Anti-hepatitis C virus activity and synergistic effect of Nymphaea alba extracts and bioactive constituents in liver infected cells.

Microb Pathog 2018 Aug 31;121:198-209. Epub 2018 May 31.

Dean Post Graduate Study, Allama Iqbal Medical College, Lahore, Pakistan. Electronic address:

Background: Without an effective vaccine, hepatitis C virus (HCV) remains a global threat, inflicting 170-300 million carriers worldwide at risk of cirrhosis and hepatocellular carcinoma (HCC). Though various direct acting antivirals have been redeemed the hepatitis C treatment, a few restraints persist including possible side effects, viral resistance emergence, excessive cost which restricts its availability to a common person.

Hypothesis: There is no preventive HCV vaccine available today so the discovery of potent antiviral natural flora and their bioactive constituents may help to develop preventive cures against HCV infection. Read More

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Quantitative study of medicinal plants used by the communities residing in Koh-e-Safaid Range, northern Pakistani-Afghan borders.

J Ethnobiol Ethnomed 2018 Apr 25;14(1):30. Epub 2018 Apr 25.

Institute of Biological Sciences, Sarhad University of Science and Information Technology, Peshawar, Pakistan.

Background: The residents of remote areas mostly depend on folk knowledge of medicinal plants to cure different ailments. The present study was carried out to document and analyze traditional use regarding the medicinal plants among communities residing in Koh-e-Safaid Range northern Pakistani-Afghan border.

Methods: A purposive sampling method was used for the selection of informants, and information regarding the ethnomedicinal use of plants was collected through semi-structured interviews. Read More

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Identification of novel L2HGDH mutation in a large consanguineous Pakistani family- a case report.

BMC Med Genet 2018 02 20;19(1):25. Epub 2018 Feb 20.

RILD Wellcome Wolfson Centre - Level 4, Royal Devon and Exeter NHS Foundation Trust, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.

Background: L-2-hydroxyglutaric aciduria (L2HGA) is a progressive neurometabolic disease of brain caused by mutations of in L-2-hydroxyglutarate dehydrogenase (L2HGDH) gene. Cardinal clinical features include cerebellar ataxia, epilepsy, neurodevelopmental delay, intellectual disability, and other clinical neurological deficits.

Case Presentation: We describe an index case of the family presented with generalised tonic-clonic seizure, developmental delay, intellectual disability, and ataxia. Read More

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February 2018

Review: Ethnomedicinal, phytochemical and antibacterial activities of medicinal flora of Pakistan used against Pseudomonas aeruginosa-A Review.

Pak J Pharm Sci 2017 Nov;30(6):2285-2300

Department of Botany, Kohat University of Science and Technology, Kohat, Pakistan.

Medicinal plants have been used from ancient time against different infectious diseases caused by microorganisms across the globe. The present review represents different medicinal plants of Pakistan used traditionally for the treatment of variety of ailments caused by Pseudomonas aeruginosa, their in-vitro activities against P. aeruginosa and phytochemistry. Read More

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November 2017

Acute and sub-acute toxicity study of a Pakistani polyherbal formulation.

BMC Complement Altern Med 2017 Aug 4;17(1):387. Epub 2017 Aug 4.

Lahore College of Pharmaceutical Sciences, Lahore, Pakistan.

Background: Herbology is the prevailing system among the nationally-accepted alternative or complementary systems of medicine. The system is due to its general and patient-oriented methodology, is widely used in the general population exposing them to the risk of the side effects of the herbal medicines.

Method: The aim of study was to assess the acute and sub-acute toxicity of the polyherbal formulation Hab-e-Kabad Noshadri tablets. Read More

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Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line.

BMC Complement Altern Med 2017 May 15;17(1):265. Epub 2017 May 15.

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.

Background: Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infections around the world. The medical potentials of a lot of Pakistani local herbs and herbal combinations is relatively unknown, hence attempted to explore. Read More

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Traditional medicine among people of Pakistani descent in the capital region of Copenhagen.

J Ethnopharmacol 2017 Jan 6;196:267-280. Epub 2016 Dec 6.

Section for Social and Clinical Pharmacy, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Ethnopharmacological Relevance: Studies show that ethnic minorities continue to use their cultural traditional medicines also after migration to the West. Research in this field is necessary, given that little is known about traditional medicines' impact on health-related problems. This study sheds light on the issue through a qualitative study among ethnic Pakistanis residing in Denmark. Read More

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January 2017

Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites.

Ann Clin Microbiol Antimicrob 2016 Sep 20;15(1):52. Epub 2016 Sep 20.

Department of Biotechnology, Quaid-i-Azam University Islamabad, Islamabad, 44000, Pakistan.

Background: Leishmaniasis and malaria are the two most common parasitic diseases and responsible for large number of deaths per year particularly in developing countries like Pakistan. Majority of Pakistan population rely on medicinal plants due to their low socio-economic status. The present review was designed to gather utmost fragmented published data on traditionally used medicinal plants against leishmaniasis and malaria in Pakistan and their scientific validation. Read More

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September 2016

Ethnobotany of the Balti community, Tormik valley, Karakorum range, Baltistan, Pakistan.

J Ethnobiol Ethnomed 2016 Sep 9;12(1):38. Epub 2016 Sep 9.

Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Background: Limited health facilities and malnutrition are major problems in the Karakorum Range of Northern Pakistan, often resulting in various human disorders. Since centuries, however, local communities in these areas have developed traditional methods for treating various ailments and local foods capes that can be significant for devising public health and nutritional policies. This study was intended to document the ethnobotanical knowledge of the local peoples in the Tormik Valley, especially in the medical and food domains. Read More

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September 2016

Antitumor evaluation of two selected Pakistani plant extracts on human bone and breast cancer cell lines.

BMC Complement Altern Med 2016 Jul 26;16:244. Epub 2016 Jul 26.

HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi, 75270, Pakistan.

Background: The medicinal plants Vincetoxicum arnottianum (VSM), Berberis orthobotrys (BORM), Onosma hispida (OHRM and OHAM) and Caccinia macranthera (CMM) are used traditionally in Pakistan and around the world for the treatment of various diseases including cancer, dermal infections, uterine tumor, wounds etc. The present study focuses on the investigation of the selected Pakistani plants for their potential as anticancer agents on human bone and breast cancer cell lines in comparison with non-tumorigenic control cells.

Methods: The antitumor evaluation was carried out on human bone (MG-63, Saos-2) and breast cancer cell lines (MCF-7, BT-20) in contrast to non-tumorigenic control cells (POB, MCF-12A) via cell viability measurements, cell cycle analysis, Annexin V/PI staining, microscopy based methods as well as migration/invasion determination, metabolic live cell monitoring and western blotting. Read More

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A review on the elemental contents of Pakistani medicinal plants: Implications for folk medicines.

J Ethnopharmacol 2016 Jul 10;188:177-92. Epub 2016 May 10.

Department of Environmental Sciences, Fatima Jinnah Women University, The Mall Rawalpindi 46000, Pakistan.

Ethnopharmacological Relevance: Substantially, plants produce chemicals such as primary and secondary metabolites, which have significant applications in modern therapy. Indigenous people mostly rely on traditional medicines derived from medicinal plants. These plants have the capacity to absorb a variety of toxic elements. Read More

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Antinociceptive, antioxidant and phytochemical studies of Pakistani medicinal plants.

Pak J Pharm Sci 2016 May;29(3):929-33

Department of Botany Islamia College University, Peshawar, Pakistan.

The aim of the current study was to evaluate the antinociceptive activity of the selected Pakistani medicinal plants (Chenopodium botrys, Micromeria biflora and Teucrium stocksianum) in-vivo followed by their antioxidant potential against 1,1-diphenyl-2-picrylhidrazyl (DPPH) in-vitro. The results demonstrated profound antinociceptive effect of both the crude methanolic extract of Chenopodium botrys (CBM) and subsequent aqueous fraction (CBW) of C. botrys with 80. Read More

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Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds.

Phytother Res 2016 Mar 21;30(3):447-53. Epub 2015 Dec 21.

Depatrment of Biochemistry, Qauid I Azam University, Islamabad, Pakistan.

Traditional medicinal plants are often used for both the prevention and the treatment of local diseases. Taking into consideration the medicinal importance of Hedera nepalensis within local Pakistani traditions, the present study was undertaken to analyze the in vitro cancer chemopreventive and cytotoxic properties of the plant. The in vitro cancer chemopreventive testing was performed using nitrite assay, NFκB assay, aromatase assay, and quinone reductase 1 (QR1) assay. Read More

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Acta Pol Pharm 2015 May-Jun;72(3):607-14

The aim of the work was to examine the influence of gender on pharmacokinetics of silymarin; a basic constituent of medicinal herb "milk thistle" (Silybum marianum). The presented work is the extension of published work of Usman et al. (16). Read More

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January 2016

Determination of heavy metal contents by atomic absorption spectroscopy (AAS) in some medicinal plants from Pakistani and Malaysian origin.

Pak J Pharm Sci 2015 Sep;28(5):1781-7

School of Pharmacy, Taylor's University, Malaysia.

This study depicts a profile of existence of heavy metals (Cu, Ni, Zn, Cd, Hg, Mn, Fe, Na, Ca, and Mg) in some important herbal plants like (H. Integrifolia, D. regia, R. Read More

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September 2015

Exploring Natural Products from the Biodiversity of Pakistan for Computational Drug Discovery Studies: Collection, Optimization, Design and Development of A Chemical Database (ChemDP).

Curr Comput Aided Drug Des 2015 ;11(2):102-9

Department of Biosciences, COMSATS Institute of Information Technology, Park Road, Chak Shahzad, Islamabad, Pakistan.

Pakistan possesses a rich and vast source of natural products (NPs). Some of these secondary metabolites have been identified as potent therapeutic agents. However, the medicinal usage of most of these compounds has not yet been fully explored. Read More

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Economic benefits of high value medicinal plants to Pakistani communities: an analysis of current practice and potential.

J Ethnobiol Ethnomed 2014 Oct 10;10:71. Epub 2014 Oct 10.

Center for Plant Sciences and Biodiversity, University of Swat, Saidu Sharif, Pakistan.

Background: Poverty is pervasive in the Swat Valley, Pakistan. Most of the people survive by farming small landholdings. Many earn additional income by collecting and selling plant material for use in herbal medicine. Read More

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October 2014

Potential for Pakistani traditional medicinal plants to combat diabetes.

J Tradit Chin Med 2014 Aug;34(4):488-90

Objective: To investigate the potential of medicinal plants used in traditional healing in Pakistan to inhibit the glycation process. This may be useful in combatting diabetes mellitus and its complications.

Methods: The in vitro antiglycation activity of 10 medicinal plants was examined by testing the ability of the extracts to inhibit the methyl-glyoxal-mediated development of fluorescence of bovine serum albumin. Read More

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Ethnomedicinal and phytochemical review of Pakistani medicinal plants used as antibacterial agents against Escherichia coli.

Ann Clin Microbiol Antimicrob 2014 Aug 19;13:40. Epub 2014 Aug 19.

Department of Botany, Kohat University of Science and Technology, Kohat 26000, Pakistan.

Medicinal plants have always been part of human culture and have the potential to cure different diseases caused by microorganisms. In Pakistan, biologists are mainly focusing on plants' antimicrobial activities against Escherichia coli due to its increasing resistance to antibiotics. In total, extracts from 34 ethnomedicinally valuable Pakistani plants were reported for in-vitro anti-E. Read More

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