5,120 results match your criteria pairwise comparison

Sequence similarity in 3D for comparison of protein families.

J Mol Graph Model 2021 Mar 23;106:107906. Epub 2021 Mar 23.

Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil. Electronic address:

Homologous proteins are often compared by pairwise sequence alignment, and structure superposition if the atomic coordinates are available. Unification of sequence and structure data is an important task in structural biology. Here, we present the Sequence Similarity 3D (SS3D) method of integrating sequence and structure information. Read More

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Diagnostic Accuracy of MRI for Differentiation of Benign and Malignant Pancreatic Cystic Lesions Compared to CT and Endoscopic Ultrasound: Systematic Review and Meta-analysis.

J Magn Reson Imaging 2021 Apr 13. Epub 2021 Apr 13.

Department of Diagnostic Imaging, Juravinski Hospital and Cancer Centre, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Differentiation of benign and malignant pancreatic cystic lesions on MRI, computed tomography (CT), and endoscopic ultrasound (EUS) is critical for determining management.

Purpose: To perform a systematic review evaluating the diagnostic accuracy of MRI for diagnosing malignant pancreatic cystic lesions, and to compare the accuracy of MRI to CT and EUS.

Study Type: Systematic review and meta-analysis. Read More

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Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: a structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Apr 12;22(1):270. Epub 2021 Apr 12.

Imperial College, London and Imperial NHS Trust, London, UK.

Objectives: The primary objective of MATIS is to determine the efficacy of ruxolitinib (RUX) or fostamatinib (FOS) compared to standard of care (SOC) with respect to reducing the proportion of hospitalised patients progressing from mild or moderate to severe COVID-19 pneumonia. Secondary objectives, at 14 and 28 days, are to: Determine the efficacy of RUX or FOS to reduce mortality Determine the efficacy of RUX or FOS to reduce the need for invasive ventilation or ECMO Determine the efficacy of RUX or FOS to reduce the need for non-invasive ventilation Determine the efficacy of RUX or FOS to reduce the proportion of participants suffering significant oxygen desaturation Determine the efficacy of RUX or FOS to reduce the need for renal replacement therapy Determine the efficacy of RUX and FOS to reduce the incidence of venous thromboembolism Determine the efficacy of RUX and FOS to reduce the severity of COVID-19 pneumonia [graded by a 9-point modified WHO Ordinal Scale* Determine the efficacy of RUX or FOS to reduce systemic inflammation Determine the efficacy of RUX or FOS to the incidence of renal impairment Determine the efficacy of RUX or FOS to reduce duration of hospital stay Evaluate the safety of RUX and FOS for treatment of COVID-19 pneumonia.

Trial Design: A multi-arm, multi-stage (3-arm parallel-group, 2-stage) randomised controlled trial that allocates participants 1:1:1 and tests for superiority in experimental arms versus standard of care. Read More

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Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study.

Neurotherapeutics 2021 Apr 12. Epub 2021 Apr 12.

Department "G.F. Ingrassia", MS Center, Organization University of Catania, Catania, Italy.

The main aim of the study is to evaluate the efficacy and safety profile of ocrelizumab (OCR), rituximab (RTX), and cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing-remitting multiple sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML). This is a multicentre, retrospective, real-world study on consecutive RRMS patients from eleven tertiary Italian MS centres, who switched from NTZ to OCR, RTX, and CLA from January 1st, 2019, to December 31st, 2019. The primary study outcomes were the annualized relapse rate (ARR) and magnetic resonance imaging (MRI) outcome. Read More

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Double plating is associated with higher fixation strength than single plating in osteoporotic fractures of the scapular spine: a biomechanical study.

Arch Orthop Trauma Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Waldeyer Str. 1, 48149, Muenster, Germany.

Introduction: The number of atraumatic stress fractures of the scapular spine associated with reverse shoulder arthroplasty is increasing. At present, there is no consensus regarding the optimal treatment strategy. Due to the already weakened bone, fractures of the scapular spine require a high fixation stability. Read More

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Dynamic Thiol/Disulphide Homeostasis as Oxidative Stress Marker in Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy.

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases, characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of diseases such as rheumatologic diseases including SpA. This prospective case-control study was designed to compare the thiol-disulfide levels as a marker of oxidative stress in SpA patients with healthy controls. Read More

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Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla.

Front Neurosci 2021 24;15:609485. Epub 2021 Mar 24.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine's immediate psychomimetic side-effects were linked to glutamate changes, proton MRS (H-MRS) showed an association between the ratio of glutamate and glutamine and delayed antidepressant effect emerging ∼2 h after ketamine administration. While most H-MRS studies focused on anterior cingulate, recent functional MRI connectivity studies revealed an association between ketamine's antidepressant effect and disturbed connectivity patterns to the posterior cingulate cortex (PCC), and related PCC dysfunction to rumination and memory impairment involved in depressive pathophysiology. Read More

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An International Comparison of EQ-5D-5L and EQ-5D-3L for Use in Cost-Effectiveness Analysis.

Value Health 2021 Apr 6;24(4):568-574. Epub 2021 Jan 6.

University of Leeds, UK.

Objectives: To estimate the impact of using EQ5D-5L (5L) compared with EQ5D-3L (3L) in cost-effectiveness analyses in 6 countries with 3L and 5L values: Germany, Japan, Korea, The Netherlands, China, and Spain.

Methods: Eight cost-effectiveness analyses based on clinical studies with 3L provided 11 pairwise comparisons. We estimated cost-effectiveness by applying the appropriate country values for 3L to observed responses. Read More

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What type of physical exercise should be recommended for improving arterial stiffness on adult population? A network meta-analysis.

Eur J Cardiovasc Nurs 2021 Apr 9. Epub 2021 Apr 9.

Universidad de Castilla-La Mancha, Health and Social Research Center, Santa Teresa Jornet s/n, 16171 Cuenca, Spain.

Aims: Physical exercise has been associated with a reduction in arterial stiffness, a subclinical process underlying cardiovascular disease. However, the effect of different types of exercise (aerobic, resistance, combined, interval training, stretching, or mind-body modalities) on arterial stiffness is unclear. This network meta-analysis aimed to examine the effectiveness of different types of exercise on arterial stiffness as measured by pulse wave velocity in adults. Read More

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Using RNentropy to Detect Significant Variation in Gene Expression Across Multiple RNA-Seq or Single-Cell RNA-Seq Samples.

Methods Mol Biol 2021 ;2284:77-96

Dipartimento di Bioscienze, Università di Milano, Milan, Italy.

RNA-Seq has become the de facto standard technique for characterization and quantification of transcriptomes, and a large number of methods and tools have been proposed to model and detect differential gene expression based on the comparison of transcript abundances across different samples. However, state-of-the-art methods for this task are usually designed for pairwise comparisons, that is, can identify significant variation of expression only between two conditions or samples. We describe the use of RNentropy, a methodology based on information theory, devised to overcome this limitation. Read More

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January 2021

Comparative evaluation of microleakage of metallic copings luted with three different commercially available luting cements: An study.

J Indian Prosthodont Soc 2021 Jan-Mar;21(1):57-65

Department of Prosthodontics, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.

Aim: To evaluate the microleakage of metallic copings luted with three different commercially available luting cements.

Setting And Design: Comparative evaluation in vitro study.

Materials And Methods: Thirty replicas of abutment analog were milled and divided into 3 groups. Read More

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Optimization of the Radiation Dose of Digital Breast Tomosynthesis in Opportunistic Screening by Studying the Effect of Different Combinations of FFDM and DBT Views.

Int J Gen Med 2021 30;14:1147-1154. Epub 2021 Mar 30.

Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, 226019, Jiangsu, People's Republic of China.

Background: Full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) are used separately or in combination to identify small breast lesions. The dose of the examination depends on the density of the breast and the imaging (FFDM or DBT) performed. We have performed a retrospective review of FFDM and DBT in women with denser breasts in order to demonstrate how varying the combination of FFDM and DBT in CC and MLO views affects lesion detection and the average gland dose. Read More

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A comparison of 71 binary similarity coefficients: The effect of base rates.

PLoS One 2021 7;16(4):e0247751. Epub 2021 Apr 7.

Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America.

There are many psychological applications that require collapsing the information in a two-mode (e.g., respondents-by-attributes) binary matrix into a one-mode (e. Read More

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Interface analysis after fatigue loading of adhesively luted bundled fiber posts to human root canal dentin.

J Mech Behav Biomed Mater 2021 Mar 27;119:104385. Epub 2021 Mar 27.

Dept. of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Aßmannshauserstraße 4-6, 14197, Berlin, Germany.

Objectives: The aim of this study was to assess the fatigue loading behavior and fracture resistance of endodontically treated teeth restored with adhesively luted bundled fiber posts in comparison to solid fiber posts. Image analysis (2D and 3D) was applied to evaluate modes of failure and to characterize susceptible parts of the post-and-core interface.

Method: Crowns of 72 human similar-sized central upper incisors were removed and roots received a conventional root canal filling prior to establishing 4 groups of core build-up: No Post group (nP) received a 4 mm deep filling made of composite inside the canal with no dental post, fiber post group (FP) received a conventional solid post, and two experimental groups received bundles of 6 (FB6) or 12 (FB12) 0. Read More

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Characterization and Comparative Transcriptomic Analysis of Skeletal Muscle in Pekin Duck at Different Growth Stages Using RNA-Seq.

Animals (Basel) 2021 Mar 16;11(3). Epub 2021 Mar 16.

College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China.

Skeletal muscle, accounting for approximately 50% of body weight, is the largest and most important tissue. In this study, the gene expression profiles and pathways in skeletal muscle of Pekin duck were investigated and compared at embryonic day 17, 21, and 27 and postnatally at 6 months of age. An average of 49,555,936 reads in each sample was obtained from the transcriptome libraries. Read More

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Intermuscular Coordination in the Power Clean Exercise: Comparison between Olympic Weightlifters and Untrained Individuals-A Preliminary Study.

Sensors (Basel) 2021 Mar 9;21(5). Epub 2021 Mar 9.

Neuromuscular Research Lab, Faculty of Human Kinetics, Lisbon University, 1499-002 Cruz Quebrada-Dafundo, Portugal.

Muscle coordination in human movement has been assessed through muscle synergy analysis. In sports science, this procedure has been mainly applied to the comparison between highly trained and unexperienced participants. However, the lack of knowledge regarding strength training exercises led us to study the differences in neural strategies to perform the power clean between weightlifters and untrained individuals. Read More

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Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens.

Int J Mol Sci 2021 Mar 21;22(6). Epub 2021 Mar 21.

Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland.

Several human tissues are investigated in studies of molecular biomarkers associated with diseases development. Special attention is focused on the blood and its components due to combining abundant information about systemic responses to pathological processes as well as high accessibility. In the current study, transcriptome profiles of peripheral blood mononuclear cells (PBMCs) were used to compare differentially expressed genes between patients with lower extremities arterial disease (LEAD), abdominal aortic aneurysm (AAA) and chronic venous disease (CVD). Read More

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First report of bacterial leaf streak caused by pv. on cultivated wild rice () in Minnesota.

Plant Dis 2021 Apr 2. Epub 2021 Apr 2.

Univeristy of Minnesota, Plant Pathology, 495 Borlaug Hall, 1991 Upper Buford Circle, Saint Paul, Minnesota, United States, 55108;

Known by the indigenous peoples of the Great Lakes region of North America as Manoomin, wild rice () is a native aquatic grass that is honored and central to Anishinaabe culture. Cultivated wild rice, the domesticated form of this cereal bred primarily for resistance to shattering, is grown commercially in paddies. In this study we examined four isolates (CIX303, CIX306, Xt-8, and Xt-22) of , the causative agent of bacterial leaf streak (BLS) on cereals and weedy grasses, in molecular and host range studies to confirm the pathovar identity of strains associated with cultivated wild rice. Read More

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Longitudinal Profiling of Antibody Response in Patients With COVID-19 in a Tertiary Care Hospital in Beijing, China.

Front Immunol 2021 15;12:614436. Epub 2021 Mar 15.

Beijing Youan Hospital, Capital Medical University, Beijing, China.

The novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic of the coronavirus disease 2019 (COVID-19), which elicits a wide variety of symptoms, ranging from mild to severe, with the potential to lead to death. Although used as the standard method to screen patients for SARS-CoV-2 infection, real-time PCR has challenges in dealing with asymptomatic patients and those with an undetectable viral load. Serological tests are therefore considered potent diagnostic tools to complement real-time PCR-based diagnosis and are used for surveillance of seroprevalence in populations. Read More

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Comparative Genomics and Environmental Distribution of Large dsDNA Viruses in the Family .

Front Microbiol 2021 15;12:657471. Epub 2021 Mar 15.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.

The family is a group of nucleo-cytoplasmic large DNA viruses (NCLDVs) of which African swine fever virus (ASFV) is well-characterized. Recently the discovery of several members other than ASFV has suggested that this family represents a diverse and cosmopolitan group of viruses, but the genomics and distribution of this family have not been studied in detail. To this end we analyzed five complete genomes and 35 metagenome-assembled genomes (MAGs) of viruses from this family to shed light on their evolutionary relationships and environmental distribution. Read More

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Effect of dentifrice slurry abrasivity and erosive challenge on simulated non-carious cervical lesions development in vitro.

J Oral Sci 2021 ;63(2):191-194

Department of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, Oral Health Research Institute.

Purpose: To investigate the effect of slurry abrasive levels and acidic challenges on the development of non-carious cervical lesions.

Methods: Ninety-six extracted upper premolars were affixed in pairs to acrylic blocks and had their root surfaces covered by acrylic resin except for 2 mm from the cemento-enamel junction. The specimens were distributed into six groups (n = 8 pairs) based on two experimental factors: (1) slurry abrasivity level [low/medium/high] and (2) citric acid challenge [yes/no]. Read More

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Private health care market shaping and changes in inequities in childhood diarrhoea treatment coverage: evidence from the analysis of baseline and endline surveys of an ORS and zinc scale-up program in Nigeria.

Int J Equity Health 2021 Mar 31;20(1):88. Epub 2021 Mar 31.

Clinton Health Access Initiative, Boston, MA, USA.

Background: Nearly 90,000 under-five children die from diarrhoea annually in Nigeria. Over 90% of the deaths can be prevented with oral rehydration salt (ORS) and zinc treatment but coverage nationally was less than 34% for ORS and 3% for zinc with wide inequities. A program was implemented in eight states to address critical barriers to the optimal functioning of the health care market to deliver these treatments. Read More

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Genetic diversity and selection signatures in maize landraces compared across 50 years of in situ and ex situ conservation.

Heredity (Edinb) 2021 Mar 30. Epub 2021 Mar 30.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.

Genomics-based, longitudinal comparisons between ex situ and in situ agrobiodiversity conservation strategies can contribute to a better understanding of their underlying effects. However, landrace designations, ambiguous common names, and gaps in sampling information complicate the identification of matching ex situ and in situ seed lots. Here we report a 50-year longitudinal comparison of the genetic diversity of a set of 13 accessions from the state of Morelos, Mexico, conserved ex situ since 1967 and retrieved in situ from the same donor families in 2017. Read More

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Mortality in adolescent trauma: a comparison of children's, mixed and adult major trauma centres.

Emerg Med J 2021 Mar 30. Epub 2021 Mar 30.

Paediatric Emergency Department, Royal Belfast Hospital for Sick Children, Belfast, UK

Objective: We aimed to compare adolescent mortality rates between different types of major trauma centre (MTC or level 1; adult, children's and mixed).

Methods: Data were obtained from TARN (Trauma Audit Research Network) from English sites over a 6-year period (2012-2018), with adolescence defined as 10-24.99 years. Read More

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Biomechanical Effects of Unidirectional Expansion Using Anisotropic Expanders in Horse Skin Tissue.

J Equine Vet Sci 2021 Apr 3;99:103399. Epub 2021 Feb 3.

Department of Materials, University of Oxford, Parks Road, OX1 3PH, United Kingdom.

The use of a self-inflating tissue expander is a technique to stretch cutaneous tissues for potential use in reconstructive skin surgeries. This study investigates the mechanical properties of horse skin stretched by the subcutaneous implantation of anisotropic tissue expanders at the forehead, right shoulder, and dorsomedial part of the cannon region of the right forelimb in six (n = 6) horses. After 14 days of skin expansion, expanded and normal (control) skin samples were harvested and their mechanical properties of elastic modulus (EM), maximum force (MF), maximum stress (MSs) and maximum strain (MSr) were evaluated using uniaxial tension test. Read More

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The Relationship between %BML, Urine Color, Thirst Level and Urine Indices of Hydration Status.

Ann Nutr Metab 2020 29;76 Suppl 1:65-66. Epub 2021 Mar 29.

Department of Kinesiology, Status Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.

Introduction: Dehydration is known to impair health, quality of daily life, and exercise performance [1]. While several methods are utilized to assess fluid balance, there is no gold standard to assess hydration status [2]. Cheuvront and Kenefick [3] suggested the use of a Venn diagram, which consists of % body mass weight (BML), urine color, and thirst level (WUT) to measure hydration status and fluid needs. Read More

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Spectral Independent Component Analysis with noise modeling for M/EEG source separation.

J Neurosci Methods 2021 May 23;356:109144. Epub 2021 Mar 23.

Inria Saclay, Université Paris-Saclay, Palaiseau, France.

Background: Independent Component Analysis (ICA) is a widespread tool for exploration and denoising of electroencephalography (EEG) or magnetoencephalography (MEG) signals. In its most common formulation, ICA assumes that the signal matrix is a noiseless linear mixture of independent sources that are assumed non-Gaussian. A limitation is that it enforces to estimate as many sources as sensors or to rely on a detrimental PCA step. Read More

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