51,271 results match your criteria pain relief


Coblation Discoplasty Alleviates Cervical Chest Pain after Positive Ultrasound-Guided Nerve Root Block: A Retrospective Study.

World Neurosurg 2021 May 12. Epub 2021 May 12.

Department of Pain Management, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.

Objective: The cervical chest pain (CCP), as one atypical symptom associated with cervical spondylosis, often overlaps with other chest-related diseases. If CCP obviously relieved after ultrasound-guided cervical nerve root block nearby herniated disc, which should be considered as a potential pathological source. The purpose of this study is to investigate whether coblation discoplasty can alleviate CCP after positive ultrasound-guided nerve root block. Read More

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Phase 2 randomized placebo-controlled study of lasmiditan for the acute treatment of migraine in Japanese patients.

Headache 2021 May 15. Epub 2021 May 15.

Eli Lilly Japan K.K., Kobe, Japan.

Objective: To evaluate the efficacy and safety of lasmiditan in Japanese adults with migraine.

Background: Global clinical studies have demonstrated the efficacy and safety of lasmiditan in the acute treatment of migraine.

Methods: This was a multicenter, randomized, double-blind, placebo-controlled, phase 2 study in Japan (NCT03962738), which enrolled adults with migraine with or without aura. Read More

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High flow nasal therapy in the management of hypoxemic dyspnea at the end of life.

Support Care Cancer 2021 May 15. Epub 2021 May 15.

Main Regional Center for Pain Relief & Supportive/Palliative Care, La Maddalena Cancer Center, Palermo, Italy.

Refractory dyspnea is challenging for physicians treating patients near to the end of life. High-flow nasal therapy (HFNT). We report a case in which HFNS was effective in a patient in the last days of life to mitigate dyspnea allowing a minimal quality of life for some days before dying. Read More

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A qualitative investigation of a prenatal yoga intervention to prevent excessive gestational weight gain: A thematic analysis of interviews.

Complement Ther Clin Pract 2021 May 6;44:101414. Epub 2021 May 6.

Arizona State University, College of Health Solutions, 500 N 3rd St., Mail Code 3020, Phoenix, AZ, 85004, USA. Electronic address:

Purpose: To describe pregnant women's experiences and perceived facilitators/barriers of a prenatal yoga intervention to prevent excessive gestational weight gain (EGWG).

Methods: Pregnant women (N = 13) were interviewed after participation in a 12-week prenatal yoga intervention to prevent EGWG. Interviews were summarized using thematic analysis. Read More

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Treatment planning factors associated with long-term outcomes of Gamma Knife surgery in patients with trigeminal neuralgia.

World Neurosurg 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; GammaKnife Radiosurgery Center, Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Gamma Knife surgery (GKS) is an established treatment option for trigeminal neuralgia (TN). However, the long-term efficacy of GKS for patients with TN has not been well-studied. The aim of the study is to evaluate the sequential course of pain control after GKS and analyze the factors associated with the long-term analgesic effect, focusing on radiation dosimetry and neurovascular conflict (NVC) factors. Read More

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Subchondral Bone Changes Following Sacroiliac Joint Arthrodesis - A Morpho-mechanical Assessment of Surgical Treatment of the Painful Joint.

Pain Physician 2021 May;24(3):E317-E326

Department of Anatomy, University of Otago, Dunedin, New Zealand; Department of Orthopaedic and Trauma Surgery, University of Leipzig, Leipzig, Germany; Fraunhofer IWU, Dresden, Germany.

Background: Sacroiliac joint arthrodesis is an ultima ratio treatment option for sacroiliac joint dysfunction. Fusion drastically reduces sacroiliac joint movement providing long-lasting pain-relief associated with tension-relief to the innervated sacroiliac joint structures involved in force closure.

Objectives: To display the bone mineralization distribution patterns of the subchondral bone plate in 3 distinct regions (superior, anterior, and inferior) of the sacral and iliac counterparts of the sacroiliac joint pre- and post-sacroiliac joint arthrodesis and compare patterns of sacroiliac joint dysfunction post-sacroiliac joint fusion with sacroiliac joint dysfunction pre- arthrodesis patterns and those from healthy controls. Read More

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High Attention-Deficit/Hyperactivity Disorder Scale Scores Among Patients with Persistent Chronic Nonspecific Low Back Pain.

Pain Physician 2021 May;24(3):E299-E307

International University of Health and Welfare, Mita Hospital, Tokyo, Japan.

Background: Associations between attention-deficit/hyperactivity disorder (ADHD) and chronic pain disorders, such as fibromyalgia, have been reported. However, associations between persistent chronic nonspecific low back pain (CNLBP) and ADHD have not yet been investigated.

Objectives: This study aimed to investigate the positive rates of possible ADHD, as assessed by self-reported ADHD scales, in patients with persistent CNLBP, using data from self-reported questionnaires completed by patients and their families. Read More

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Can Additional Facet Joint Block Improve the Clinical Outcome of Kyphoplasty for Acute Osteoporotic Vertebral Compression Fractures?

Pain Physician 2021 May;24(3):283-291

Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Geriatric Clinical Research Center of Chongqing, Chongqing, China.

Background: Percutaneous kyphoplasty (PKP) has been reported to provide a favorable analgesic effect for pain caused by osteoporotic vertebral compression fractures (OVCFs). However, a systematic review demonstrated that pain relief was only reported for approximately 86% of kyphoplasty treatments.

Objectives: To explore whether an additional facet joint block (FJB) can minimize pain and improve the clinical outcome of PKP in patients with acute OVCFs. Read More

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The Effect of Acupuncture and Physiotherapy on Patients with Knee Osteoarthritis: A Randomized Controlled Study.

Pain Physician 2021 May;24(3):E269-E278

Ankara City Hospital, Physical Therapy and Rehabilitation Clinic, Ankara, Turkey.

Background: Osteoarthritis is the most prevalent form of joint disease, and the most common location is the knee.

Objectives: The aim of this study was to determine the effect of acupuncture treatment and physiotherapy on pain, physical function, and quality of life (QOL) in patients with knee osteoarthritis (KOA).

Study Design: This study was a prospective, randomized, controlled clinical trial. Read More

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Efficacy of Pulsed Radiofrequency or Short-Term Spinal Cord Stimulation for Acute/Subacute Zoster-Related Pain: A Randomized, Double-Blinded, Controlled Trial.

Pain Physician 2021 May;24(3):215-222

Department of Pain Medicine, The First Affiliated Hospital of China Medical University, Shenyang City, China.

Background: Postherpetic neuralgia (PHN) is the final stage of varicella zoster infection and a severe refractory neuropathic pain. Hence preventing transition of herpes zoster-related pain to PHN is a very important therapeutic principle for patients at an early stage, especially for older patients.Both pulsed radiofrequency (PRF) and short-term spinal cord stimulation (stSCS) have been proven to be effective to relieve acute/subacute zoster-related pain. Read More

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Efficacy and safety of radiofrequency in the treatment of trigeminal neuralgia: a systematic review and meta-analysis.

Acta Neurol Belg 2021 May 14. Epub 2021 May 14.

Department of Pain and Interventional Radiology, Huai'an Hospital of Huai'an City, No. 161, Zhenhuailou East Road, Huai'an, China.

To assess the effectiveness of radiofrequency (RF) versus other percutaneous strategies (balloon compression, glycerol rhizotomy [GR], and microvascular decompression [MVD]) in patients with trigeminal neuralgia. We systematically searched the electronic databases of PubMed, Embase, and the Cochrane Library to identify eligible studies throughout October 2020. The odds ratio (OR) with 95% confidence interval (CI) was applied to assess effect estimates using the random-effects model. Read More

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Risk factors for severe opioid-induced respiratory depression in hospitalized adults: A case-control study.

Can J Pain 2020 May 21;4(1):103-110. Epub 2020 May 21.

Ingram School of Nursing, McGill University, Montreal, Quebec, Canada.

: Opioids are commonly prescribed to hospitalized adults to promote adequate pain relief, yet they can cause potentially fatal respiratory depression. : The aim of this study was to examine the risk factors for the development of severe opioid-induced respiratory depression (OIRD) in hospitalized adults to ensure adequate monitoring of high-risk patients. : A retrospective case-control study was conducted using data from the medical records of a university-affiliated hospital in Canada. Read More

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State of the Art in Parent-Delivered Pain-Relieving Interventions in Neonatal Care: A Scoping Review.

Front Pediatr 2021 27;9:651846. Epub 2021 Apr 27.

Faculty of Medicine and Health, School of Health Sciences, Örebro University, Örebro, Sweden.

Parents' active involvement during painful procedures is considered a critical first step in improving neonatal pain practices. Of the non-pharmacological approaches in use, the biopsychosocial perspective supports parent-delivered interventions, in which parents themselves mediate pain relief, consistent with modern family-integrated care. This scoping review synthesizes the available research to provide an overview of the state of the art in parent-delivered pain-relieving interventions. Read More

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Single-Stage Combined Anterior Corpectomy and Posterior Instrumented Fusion in Tuberculous Spondylitis With Varying Degrees of Neurological Deficit.

Int J Spine Surg 2021 May 13. Epub 2021 May 13.

Metro Hospital, New Delhi, India.

Background: A combined anterior decompression and stabilization followed by posterior instrumented fusion promotes fusion of the affected segment of spine and prevents further progression of deformity. The objective of this study is to report on outcome of patients with tuberculous spondylitis, progressive neurologic deficit, and kyphotic deformity who underwent single-stage anterior corpectomy and fusion and posterior decompression with instrumented fusion.

Methods: A total of 49 patients (29 males, 20 females) with varying grades of neurological deficit due to tuberculosis of the spine (thoracic, thoracolumbar, and lumbar) were included in this prospective study. Read More

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Recommendations in the rehabilitation of patients undergoing hip abductor tendon repair: a systematic literature search and evidence based rehabilitation protocol.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Perth Orthopaedic and Sports Medicine Centre, 31 Outram Street, West Perth, WA, 6005, Australia.

Introduction: Advanced hip imaging and surgical findings have demonstrated that a common cause of greater trochanteric pain syndrome (GTPS) is hip abductor tendon (HAT) tears. Traditionally, these patients have been managed non-operatively, often with temporary pain relief. More recently, there has been an increase in published work presenting the results of surgical intervention. Read More

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Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain.

Pain Rep 2021 9;6(1):e867. Epub 2021 Mar 9.

Department of Anesthesiology, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA.

Many common cancers such as breast, prostate, and lung cancer metastasize to bones at advanced stages, producing severe pain and functional impairment. At present, the current pharmacotherapies available for bone cancer pain are insufficient to provide safe and efficacious pain relief. In this narrative review, we discuss the mechanisms used by cancer cells within the bone tumor microenvironment (TME) to drive bone cancer pain. Read More

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Efficacy of Antibiotic-Loaded Cement Augmentation for Correcting Low Grade Pedicle Screw Loosening.

Korean J Neurotrauma 2021 Apr 18;17(1):41-47. Epub 2021 Mar 18.

Department of Neurosurgery, College of Medicine, Chosun University, Gwangju, Korea.

Objective: Altered biomechanics and bone fragility can contribute to pedicle screw loosening. This study aimed to evaluate the efficacy of antibiotic-loaded cement augmentation for correcting symptomatic screw loosening as a minimally invasive alternative to open revision surgery.

Methods: Ten consecutive patients who underwent percutaneous cement augmentation for pedicle screw loosening were included in this study. Read More

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Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients.

Front Psychiatry 2021 26;12:641430. Epub 2021 Apr 26.

Université Clermont Auvergne, CHU Clermont-Ferrand, Inserm, Neuro-Dol, Service de Pharmacologie médicale, Centres Addictovigilance et Pharmacovigilance, Centre Evaluation et Traitement de la Douleur, Service Psychiatrie-Addictologie, Clermont-Ferrand, France.

Chronic pain and substance use disorders frequently co-occur. Indeed, chronic pain is highly prevalent, affecting 23-68% of patients receiving opioid agonist treatments (OAT) worldwide. The majority of available estimates come from American studies, but data are still lacking in Europe. Read More

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Repeat Epidural Injections of SP-102 (Dexamethasone Sodium Phosphate Injectable Gel) in Subjects with Lumbosacral Radiculopathy.

J Pain Res 2021 5;14:1231-1239. Epub 2021 May 5.

Global Research and Development, Scilex Pharmaceuticals Inc, Palo Alto, CA, USA.

Purpose: SP-102 is a novel epidural steroid injection (ESI) formulation of 10 mg dexamethasone sodium phosphate in a viscous gel solution. Repeat dosing of ESIs is possible if required for pain relief, but with consideration of hypothalamic-pituitary-adrenal (HPA) axis suppression from prolonged systemic exposure. This phase I/II study investigated the effect of initial and repeat SP-102 injections on HPA suppression and analgesia. Read More

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Laparoscopic Cholecystectomy for Gallbladder Dysfunction and Polyps: Incidence and Follow up.

JSLS 2021 Apr-Jun;25(2)

University Hospital Hairmyres, Lanarkshire, Scotland, UK.

Aim: This study aims to evaluate the incidence, indications, management, and long term follow up of cholecystectomy in patients with no gallstones, other than acalculous acute cholecystitis.

Methods: Prospectively collected data of 5675 patients undergoing laparoscopic cholecystectomy (LC) over 28 years was extracted and analyzed. Patients with biliary symptoms, no stones on ultrasound scans and abnormal hepatobiliary iminodiacetic acid scans, and those with confirmed gallbladder polyps (GBP) were included. Read More

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Slipping rib syndrome: case report of an iatrogenic result following video-assisted thoracic surgery and chest tube placement.

Pain Manag 2021 May 13. Epub 2021 May 13.

Anesthesiology & Pain Medicine, Henry Ford Health Systems, Detroit, MI 48202, USA.

The aim of this case report is to shed light on slipping rib syndrome (SRS), a painful and overlooked condition. A 62-year old man reported intermittent, self-resolving sharp rib pain that began after a video-assisted thoracic surgery and chest tube placement 4 years prior to presentation. The patient's pain was associated with a rigid protrusion in the right upper quadrant, and home use of acetaminophen provided no relief. Read More

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Inferior Articular Process Fracture in a Collegiate Athlete Causing Back Pain: A Case Report of Surgical Treatment.

JBJS Case Connect 2021 04 19;11(2). Epub 2021 Apr 19.

Hospital for Special Surgery, New York, New York.

Case: A 20-year-old male athlete presented with 8 months of low back pain. Conservative management had been unsuccessful. He noted lumbar spine pain with extension, and imaging showed features of an L4-5 inferior articular facet tip fracture. Read More

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Medial thalamotomy using stereotactic radiosurgery for intractable pain: a systematic review.

Neurosurg Rev 2021 May 12. Epub 2021 May 12.

Department of Neurosurgery, Humanitas Research Hospital IRCCS, via Manzoni 56, 20089, Rozzano, MI, Italy.

Medial thalamotomy using stereotactic radiosurgery (SRS) is a potential treatment for intractable pain. However, the ideal treatment parameters and expected outcomes from this procedure remain unclear. The aim of this systematic review is to provide further insights on medial thalamotomy using SRS, specifically for intractable pain. Read More

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Repetitive Transcranial Magnetic Stimulation for Treating Chronic Neuropathic Pain: a Systematic Review.

Curr Pain Headache Rep 2021 May 12;25(7):48. Epub 2021 May 12.

Department of Anaesthesia and Pain Medicine, Manchester University Foundation Trust, Manchester, UK.

Given pharmacological interventions' limited efficacy and abundance of its adverse effects, the repetitive transcranial magnetic stimulation (rTMS) is considered a viable non-invasive option for managing chronic neuropathic pain of different origins with promising outcomes. PURPOSE OF REVIEW: The provision of a systematic review of current literature on rTMS for managing chronic neuropathic pain of different origins, and assess its efficacy and outcomes, highlighting the need for standard protocols for utilizing rTMS. RECENT FINDINGS: Variable stimulation modalities were trialed targeting the M1, DLPFC, and somatosensory cortices S1 and S2. Read More

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Exponential correlations among neuropathic components, pain intensity, and catastrophic thoughts in patients with musculoskeletal pain disorder.

Curr Med Res Opin 2021 May 12. Epub 2021 May 12.

Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.

Background: Neuropathic components and catastrophic thoughts contribute to quality of life impairments in patients with chronic pain. This retrospective cross-sectional observational study examined the extent to which neuropathic components affect pain intensity and catastrophic thoughts using a mathematical model.

Methods: Participants with chronic pain with spinal or joint disorders were rated for pain intensity using a numerical rating scale (NRS), painDETECT questionnaire (PDQ), and pain catastrophizing scale (PCS). Read More

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The role of positive nerve root sedimentation sign in the treatment of patients undergoing lumbar disc herniation.

Br J Neurosurg 2021 May 12:1-6. Epub 2021 May 12.

Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China.

Background: To investigate the efficacy of percutaneous transforaminal endoscopic discectomy (PTED) in the treatment of patients who were diagnosed with lumbar disc herniation (LDH) with positive nerve root sedimentation sign (NRSS).

Methods: A total of 86 patients who underwent LDH were recruited and divided into NRSS-positive group ( = 49) and NRSS-negative group ( = 37). The visual analog scale (VAS), Japanese Orthopaedic Association (JOA), and Oswestry disability index (ODI) were used to evaluate the low back pain and functional recovery and were compared between the two groups. Read More

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Effectiveness of exercise therapy versus occlusal splint therapy for the treatment of painful temporomandibular disorders: a systematic review and meta-analysis.

Ann Palliat Med 2021 May 10. Epub 2021 May 10.

Department of Rehabilitation, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Background: This systematic review of the literature was to compare the effects of exercise therapy and occlusal splint therapy on pain and mobility in individuals with painful temporomandibular disorders (TMD).

Methods: PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched for English publications from database root to March 1, 2020. Search terms were [("temporomandibular joint disorders" or "temporomandibular disorders" or "craniomandibular disorders" or "orofacial pain" or "myofascial pain" or "myofascial pain" or "facial pain") AND (exercise or "physical therapy modalities" or physiotherapy or "exercise therapy") AND ("splints" or "occlusal splints" or "stabilization splint" or "occlusal appliance" or "occlusal splint therapy")]. Read More

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[Treatment of patients with metastatic lesions of the long bones].

Khirurgiia (Mosk) 2021 (5):89-94

Herzen Moscow Research Cancer Institute, Moscow, Russia.

Objective: To optimize orthopedic care in patients with complicated course of metastatic lesions of the long bones.

Material And Methods: There were 201 patients (72 men and 129 women) who underwent orthopedic care for metastatic lesions of the long bones for the period from 2006 to 2019. Breast cancer metastases were diagnosed in 71 (35%) cases, kidney cancer - 56 (28%) patients, prostate cancer - 19 (9%) cases, metastases without a primary identified focus - 15 (8%) patients. Read More

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[Effect of morphological state of pancreatic parenchyma on the long-term outcome of surgery for chronic pancreatitis].

Khirurgiia (Mosk) 2021 (5):42-49

Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Objective: To determine the effect of baseline morphological state of the pancreas on the long-term outcomes of duodenum-preserving pancreatic head resection (DPPHR).

Material And Methods: The study included 104 patients with chronic pancreatitis (CP), who underwent DPPHR in 2014-2019. Pain syndrome, exocrine and endocrine pancreatic insufficiency and quality of life (QoL) were assessed in long-term postoperative period. Read More

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Gamma Knife radiosurgery and refractory glossopharyngeal neuralgia: a single-center series with long-term follow-up.

Neurosurg Rev 2021 May 11. Epub 2021 May 11.

Department of Functional Neurosurgery and Gamma Knife Radiosurgery, Ruber Internacional Hospital, C/ La Masó, 38, CP 28034, Madrid, Spain.

We present our experience with Gamma Knife surgery (GKS) and refractory glossopharyngeal neuralgia (GPN), analyzing its usefulness and safety in patients with or without previous surgeries, another concomitant neuralgia, or retreats. In addition, we study some factors that could condition the outcome of this technique. According to our review, our follow-up is the longest in the literature. Read More

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