906,080 results match your criteria pain pain


Pain and mortality among older adults in Korea.

Epidemiol Health 2021 Sep 7:e2021058. Epub 2021 Sep 7.

Graduated School of Public Health, Seoul National University, Seoul, Korea.

Objectives: With the rising elderly population subject to chronic disease, pain becomes crucial to understand and design an appropriate approach to it. While pain is a noted mortality risk factor, limited studies exists due to various causes of pain and subjectivity of pain expression. This study aims to examine the relationship between pain and mortality, controlling for other disease and socio-cultural factors. Read More

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September 2021

Thrombus formation and ischemic necrosis of the uterus and adnexa due to purpura fulminans: A case report.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.

Purpura fulminans (PF) is a syndrome characterized by the sudden onset of progressive skin hemorrhage, necrosis of the extremities, and thrombotic occlusion. Although the cause is believed to be protein C deficiency, many aspects of this syndrome have yet to be clarified. A 45-year-old Japanese woman, G2P2 (vaginal delivery), developed fever and lower abdominal pain. Read More

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September 2021

Muscle Activation in the Shoulder Girdle and Lumbopelvic-Hip Complex During Common Therapeutic Exercises.

J Sport Rehabil 2021 Sep 15:1-7. Epub 2021 Sep 15.

Context: Lumbopelvic-hip complex (LPHC) exercises are used to increase stabilization within the human body. Torso-elevated side support (TESS), foot-elevated side support (FESS), prone bridge plank (PBP), and V-sit are common LPHC exercises.

Objective: To evaluate muscle activation in the shoulder girdle and LPHC during 4 LPHC exercises and evaluate the reasoning for termination. Read More

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September 2021

SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy.

Authors:
Josef Finsterer

J Neuroimmunol 2021 Aug 28;360:577703. Epub 2021 Aug 28.

Klinik Landstrasse, Messerli Institute, Vienna, Austria. Electronic address:

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Methodological challenges for living systematic reviews conducted during the COVID-19 pandemic: a concept paper.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

Background: A living systematic review (LSR) is an emerging review type that makes use of continual updating. In the COVID-19 pandemic, we were confronted with a shifting epidemiological landscape, clinical uncertainties and evolving evidence. These unexpected challenges compelled us to amend standard LSR methodology. Read More

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September 2021

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

N Engl J Med 2021 09;385(12):e35

From the Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania (P.T.), and Wistar Institute (K.M., E.L.R., S.B.K., F.I.Z., H.C., D.B.W.), Philadelphia, and Inovio Pharmaceuticals, Plymouth Meeting (S.W., A.S.K., J.B., M.B.) - all in Pennsylvania; GeneOne Life Science, Seoul, South Korea (C.C.R., Y.K.P., C.R., S.E.S., J.N.M.); Infectious Diseases Research Centre-Université Laval, Quebec, QC, Canada (T.R., S.T., G.P.K.); QPS-Miami Research Associates, Miami, (D.K.); and the Department of Medicine, Morristown Medical Center, Morristown, NJ (J.N.M.).

Background: Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection.

Methods: In this phase 1, open-label clinical trial, we evaluated the safety and immunogenicity of a synthetic, consensus DNA vaccine (GLS-5700) encoding the ZIKV premembrane and envelope proteins in two groups of 20 participants each. Read More

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September 2021

Pharmacological blockade of neurokinin1 receptor restricts morphine-induced tolerance and hyperalgesia in the rat.

Scand J Pain 2021 Sep 16. Epub 2021 Sep 16.

Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: The most notable adverse side effects of chronic morphine administration include tolerance and hyperalgesia. This study investigated the involvement of dorsal root ganglion (DRG) protein kinase Cɛ (PKCɛ) expression during chronic morphine administration and also considered the relationship between DRG PKCɛ expression and the substance P- neurokinin1 receptor SP- NK1R) activity.

Methods: Thirty-six animals were divided into six groups (n=6) in this study. Read More

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September 2021

The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomized clinical trial.

Int J Clin Pract 2021 Sep 15:e14872. Epub 2021 Sep 15.

University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, The Department of Anesthesiology and Reanimation, Istanbul, Turkey.

Aims: In this study, we aimed to investigate the anti-inflammatory and antioxidant effects of intravenous ibuprofen by using the C-reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker.

Materials And Methods: This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either preemptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). Read More

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September 2021

How to manage irritable bowel syndrome in children.

Acta Paediatr 2021 Sep 15. Epub 2021 Sep 15.

KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Aim: This paper discusses the risk factors and management of paediatric irritable bowel syndrome (IBS), with a focus on the role of the gastro-intestinal microbiome.

Methods: English articles of interest published in PubMed and Google Scholar were searched using subject heading and key words of interest.

Results: Only few randomized controlled trials on the management of IBS in children have been published. Read More

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September 2021

Sleep in children and adolescents with juvenile idiopathic arthritis: a systematic review and meta-analysis of case-control studies.

Sleep 2021 Sep 15. Epub 2021 Sep 15.

Université de Toulon, Laboratoire IAPS, Toulon, France.

Study Objectives: Juvenile idiopathic arthritis (JIA) is one of the most common pediatric rheumatic disease. However, sleep alteration associated with this auto-immune disease remain unclear. We aimed in this systematic review and meta-analysis to compare sleep duration, quality, and architecture in JIA subjects with those in their healthy peers. Read More

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September 2021

Identifying risk factors that increase analgesic requirements at discharge among patients with burn injuries.

J Burn Care Res 2021 Sep 15. Epub 2021 Sep 15.

Division of Plastic and Reconstructive Surgery, University of Toronto, Toronto, Ontario, Canada.

Patients with burn injuries require large doses of opioids and gabapentinoids to achieve pain control and are often discharged from hospital with similar amounts. This study aimed to identify patient risk factors that increase analgesic requirements among patients with burn injuries and to determine the relationship between opioid and gabapentinoid use. Patient charts from July 1, 2015 - 2018 were reviewed retrospectively to determine analgesic requirements 24 hours before discharge. Read More

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September 2021

Update: Gender differences in CABG outcomes-Have we bridged the gap?

PLoS One 2021 15;16(9):e0255170. Epub 2021 Sep 15.

Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.

Background: Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. Read More

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September 2021

One Affectionate Puppy: A Case of Septic Arthritis Due to Staphylococcus Pseudintermedius.

Pediatr Infect Dis J 2021 Oct;40(10):e381-e383

Division of Infectious Diseases, Department of Pediatrics, Stony Brook Children's Hospital, Stony Brook, NY.

We describe a case of septic arthritis caused by Staphylococcus pseudintermedius, a common colonizer of dogs that has emerged as a rare human pathogen. Our patient presented with ankle pain and swelling and was treated adequately with cefazolin/cephalexin and arthrotomy. S. Read More

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October 2021

Reliability and Validity of the Spanish Version of the Medical Outcomes Study Pain Severity Scale in Mexican Patients With Rheumatic Diseases.

J Clin Rheumatol 2021 Sep;27(6S):S308-S315

From the Servicio de Reumatología, Hospital General Regional número 1, Delegación Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán; and Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Doctorado en Ciencias Médicas, Universidad Nacional Autónoma de Mexico, Ciudad de México, México.

Objective: To evaluate the reliability and validity of the Spanish version of the Medical Outcomes Study Pain Severity Scale (MOS-PSS) in patients with rheumatic diseases.

Methods: A cross-sectional study was carried out from January 2019 to March 2020 using a nonprobabilistic sampling of consecutive cases. The internal consistency of the scale was evaluated through the Cronbach α coefficient and by the item response theory reliability coefficient. Read More

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September 2021

In Response.

Anesth Analg 2021 Oct;133(4):e52-e53

Department of Anesthesiology and Pain Management, Office of the Executive Vice President for Health System Affairs, Office of the Executive Vice President for Academic Affairs, University of Texas Southwestern Medical Center, Dallas, Texas.

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October 2021

Resources for Optimal Care of Emergency Surgery.

Anesth Analg 2021 Oct;133(4):e48

Department for Anesthesia, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland,

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October 2021

Pick a Nice Dream.

Authors:
William Camann

Anesth Analg 2021 Oct;133(4):1071

From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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October 2021

Perspectives on Pain: A Visual Interpretation of Chronic Headaches.

Anesth Analg 2021 Oct;133(4):1070

From the Stanford Medical School, Stanford, California.

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October 2021

The International Anesthesia Research Society Coronavirus Disease 2019 Pandemic Scientific Advisory Board: Supporting a Pandemic of Positivity.

Anesth Analg 2021 Oct;133(4):903-905

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

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October 2021

Pediatric Airway Anatomy and Tracheal Tubes: It Is Not All About the Cuff.

Anesth Analg 2021 Oct;133(4):891-893

Harvard Medical School, Boston, Massachusetts.

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October 2021

The Association of Delayed Care With Depression Among US Middle-Aged and Older Adults During the COVID-19 Pandemic: Cross-sectional Analysis.

Authors:
Yan Luo

JMIR Aging 2021 Jul 31. Epub 2021 Jul 31.

The University of Alabama, 2106 Forest Lake Dr., Tuscaloosa, US.

Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the depression level among US adults has significantly increased. Age disparity in depression during the pandemic was also reported in recent studies. Delay or avoidance of medical care is one of the collateral damages caused by the COVID-19 pandemic and it can lead to increased morbidity and mortality. Read More

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Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study.

AIDS Patient Care STDS 2021 Sep;35(9):342-353

Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. Read More

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September 2021

Biological resurfacing in a canine model of hip osteoarthritis.

Sci Adv 2021 Sep 15;7(38):eabi5918. Epub 2021 Sep 15.

Translational Research in Pain Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

[Figure: see text]. Read More

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September 2021

Hip Range of Motion and Strength Predict 12-Month Physical Function Outcomes in Older Adults With Chronic Low Back Pain: The Delaware Spine Studies.

ACR Open Rheumatol 2021 Sep 15. Epub 2021 Sep 15.

University of Delaware, Newark.

Objective: The objective of this study was to investigate whether poor hip range of motion (ROM) and strength predict 12-month physical function decline among older adults with chronic low back pain (LBP) and whether hip osteoarthritis modifies those relationships.

Methods: At baseline, passive ROM and strength measurements were taken for hip flexion, extension, abduction, adduction, internal rotation, and external rotation; ultrasound images and self-reported symptoms were used to evaluate hip osteoarthritis presence (eg, osteophytes and hip pain). At baseline and 12 months, performance-based (repeated chair rise, self-selected gait speed, 6-minute walk test [6MWT]) and self-reported (Quebec LBP Disability Questionnaire, Late-Life Function & Disability Instrument [LLFDI] basic and advanced lower extremity scales) physical function outcomes were assessed. Read More

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September 2021

Patients with Ehlers-Danlos syndrome on the diagnostic odyssey: Rethinking complexity and difficulty as a hero's journey.

Am J Med Genet C Semin Med Genet 2021 Sep 15. Epub 2021 Sep 15.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Patients with hypermobile Ehlers-Danlos syndrome, an hereditary disorder of the connective tissue, often face a long and difficult diagnostic odyssey in pursuit of a name for their condition. Clinicians may dismiss subjective symptoms of chronic pain, thus prolonging patients' odysseys and worsening their care and satisfaction and creating antagonisms in the patient-provider relationship. A greater understanding of patient experiences is necessary in order to decrease burdens of this relationship and to improve care. Read More

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September 2021

Neural mechanisms of pain processing differ between endurance athletes and nonathletes: A functional connectivity magnetic resonance imaging study.

Hum Brain Mapp 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Psychology, Friedrich-Schiller-University Jena, Jena, Germany.

Pain perception and the ability to modulate arising pain vary tremendously between individuals. It has been shown that endurance athletes possess higher pain tolerance thresholds and a greater effect of conditioned pain modulation than nonathletes, both indicating a more efficient system of endogenous pain inhibition. The aim of the present study was to focus on the neural mechanisms of pain processing in endurance athletes that have not been investigated yet. Read More

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September 2021

Cost-Effectiveness Analysis of Tapentadol Versus Oxycodone/Naloxone in both Branded and Generic Formulations in Patients with Musculoskeletal Pain.

Clin Drug Investig 2021 Sep 15. Epub 2021 Sep 15.

Università di Roma "La Sapienza", Rome, Italy.

Background And Objectives: Current evidence shows that tapentadol hydrochloride prolonged-release is more cost effective than other opioids. However, the introduction into the market of generic formulations of traditional comparators, leading to potential savings due to their lower price, creates space for further research. The objective of this study is to evaluate and compare the efficacy of tapentadol versus oxycodone/naloxone and the economic impact of the two alternatives in both branded and generic formulations. Read More

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September 2021