19,927 results match your criteria pain elevated


A pediatric case of Bartonella henselae and Epstein Barr virus disease with bone and hepatosplenic involvement.

Bol Med Hosp Infant Mex 2021 ;78(5):467-473

Hospital Francisco Grande Covián, Parres. Asturias, Spain.

Background: Cat scratch disease (CSD) is an infectious disorder caused by Bartonella henselae. The infection usually presents as local lymphadenopathy, fever, and mild constitutional symptoms. Systemic or severe disease is reported in 5-20% of patients with CSD. Read More

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January 2021

CXCR3 signalling partially contributes to the pathogenesis of neuropathic pain in male rodents.

J Oral Rehabil 2021 Sep 27. Epub 2021 Sep 27.

Center for TMD & Orofacial Pain, Peking University School & Hospital of Stomatology, Beijing, China.

Background: Currently, there is a lack of effective therapy for chronic pain. Increasing evidence has shown that chemokines and their correlative receptors involved in the neuron-glial cell cross-talk could contribute to the pathogenesis of neuropathic pain. Our previous studies suggested that CXCR3 expression was elevated in the spinal dorsal horn after nerve injury. Read More

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September 2021

Individual- and Community-Level Factors Associated With Detectable and Elevated Blood Lead Levels in US Children: Results From a National Clinical Laboratory.

JAMA Pediatr 2021 Sep 27. Epub 2021 Sep 27.

Quest Diagnostics, Secaucus, New Jersey.

Importance: No safe level of exposure to lead has been identified.

Objective: To evaluate individual- and community-level factors associated with detectable and elevated blood lead levels (BLLs) in children.

Design, Setting, And Participants: This cross-sectional, retrospective study analyzed deidentified results from blood lead tests performed at a large clinical laboratory from October 1, 2018, to February 29, 2020. Read More

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September 2021

Non-Bleeding Colonic Ulcer as Initial Manifestation of Disseminated Cryptococcosis in a Patient With Human Immunodeficiency Virus.

Cureus 2021 Aug 19;13(8):e17298. Epub 2021 Aug 19.

Pathology, Metropolitan Hospital Center, New York, USA.

Cryptococcosis is an invasive mycosis caused by Cryptococcus sp. Its presence is described closely with immunosuppressive states. Once it has reached the body, it has shown a predilection for two sites: the lungs and the central nervous system. Read More

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An evaluation of factors affecting pain during transrectal ultrasonographic prostate biopsy: a real-life scenario in a retrospective cohort study.

PeerJ 2021 6;9:e12144. Epub 2021 Sep 6.

Department of Urology, Acıbadem Kocaeli Hospital, Kocaeli, Turkey.

Background: Periprostatic infiltration anesthesia (PPIA) and intrarectal topical anesthesia (IRTA) are recommended methods to control pain in transrectal ultrasonographic prostate biopsy (TRUS-Bx). This study evaluates the factors affecting pain during TRUS-Bx, considering the pathologies involved in anorectal pain etiology and comparing the effectiveness of local anesthesia techniques in providing patient comfort.

Material And Methods: We retrospectively evaluated 477 consecutive patients with TRUS-Bx for elevated Prostate Specific Antigen (PSA), abnormal rectal examination findings, or both. Read More

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September 2021

Renal-function change after transjugular intra-hepatic portosystemic shunt placement and its relationship with survival: a single-center experience.

Gastroenterol Rep (Oxf) 2021 Aug 3;9(4):306-312. Epub 2020 Dec 3.

Division of Vascular and Interventional Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The effect of transjugular intra-hepatic portosystemic shunt (TIPS) placement on renal function and the correlation of post-TIPS Cr with mortality remain unclear. This study aimed to assess the effect of TIPS placement on renal function and to examine the relationship between post-TIPS Cr and mortality risk.

Methods: A total of 593 patients who underwent TIPS placement between 2004 and 2017 at a single institution were included in the study. Read More

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Clinical features of lupus enteritis: a single-center retrospective study.

Orphanet J Rare Dis 2021 Sep 26;16(1):396. Epub 2021 Sep 26.

Department of Rheumatology and Immunology, Suining Central Hospital, No.127, West Desheng Rd., Chuanshan District, Suining, Sichuan Province, China.

Background: Lupus enteritis (LEn) is a rare complication of systemic lupus erythematosus (SLE). Timely diagnosis and treatment of LEn are necessary to prevent the most serious consequences - intestinal perforation, gastrointestinal bleeding, and death. We compared the clinical features of SLE patients with and without LEn. Read More

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September 2021

Tolerability of MenACWY-TT vaccination in adolescents in the Netherlands; a cross-sectional study.

BMC Public Health 2021 Sep 26;21(1):1752. Epub 2021 Sep 26.

Center for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands.

Background: In 2018, meningococcal ACWY-TT vaccine (MenACWY-TT) was offered to adolescents in the Netherlands within the National Immunization Programme at 14 years of age. A questionnaire study assessed the tolerability of this vaccine.

Methods: Five thousand adolescents were invited to participate and to fill in two questionnaires about systemic events in the week before vaccination and local reactions and systemic events in the week after vaccination. Read More

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September 2021

Imaging features of skeletal muscle lymphoma: a case report and literature review.

BMC Med Imaging 2021 Sep 26;21(1):136. Epub 2021 Sep 26.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning Province, Republic of China.

Background: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), occurring predominantly in older people. Skeletal muscle lymphoma is a rare form of DLBCL, most frequently affecting the thigh, upper extremities, calf, and pelvis.

Case Presentation: We report a case of skeletal muscle DLBCL that was diagnosed using ultrasound (US)-guided biopsy. Read More

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September 2021

Silicone gel sheeting for treating hypertrophic scars.

Cochrane Database Syst Rev 2021 Sep 26;9:CD013357. Epub 2021 Sep 26.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Background: Each year, in high-income countries alone, approximately 100 million people develop scars. Excessive scarring can cause pruritus, pain, contractures, and cosmetic disfigurement, and can dramatically affect people's quality of life, both physically and psychologically. Hypertrophic scars are visible and elevated scars that do not spread into surrounding tissues and that often regress spontaneously. Read More

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September 2021

Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT receptors.

Neuropsychopharmacology 2021 Sep 25. Epub 2021 Sep 25.

Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, 98195, USA.

Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. In male mice, we found that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced potentiation of cocaine conditioned place preference (CPP). Within the dorsal raphe nucleus (DRN), two overlapping populations of KOR-expressing neurons: Slc17a8 (VGluT3) and SERT, were distinguished functionally and anatomically. Read More

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September 2021

Disposable and cost-effective label-free electrochemical immunosensor for prolactin based on bismuth sulfide nanorods with polypyrrole.

Bioelectrochemistry 2021 Sep 8;143:107948. Epub 2021 Sep 8.

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan. Electronic address:

Prolactin (PRL) is produced by the pituitary gland and plays a vital role in the production of milk after a baby is born. PRL levels are normally elevated in pregnant and nursing women, and high levels of PRL in the human body cause hyperprolactinemia, infertility, galactorrhea, infrequent or irregular periods, amenorrhea, breast pain, and loss of libido. Accordingly, herein, a novel label-free immunosensor using a bismuth sulfide/polypyrrole (BiS/PPy)-modified screen-printed electrode (SPE) for the fast and facile detection of the peptide hormone PRL. Read More

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September 2021

Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts.

J Lipid Res 2021 Sep 23:100122. Epub 2021 Sep 23.

Institute of Clinical Chemistry, University Hospital Zürich, Switzerland. Electronic address:

Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain and wound healing defects. HSAN1 is caused by several missense mutations in the SPTLC1 and SPTLC2 subunit of the enzyme serine-palmitoyltransferase (SPT) -the key enzyme for the synthesis of sphingolipids. The mutations change the substrate specificity of SPT, which then forms an atypical class of 1-deoxy-sphinglipids (1-deoxySL). Read More

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September 2021

Essential thrombocythaemia first presenting as myocardial infarction in a 36-year-old male.

BMJ Case Rep 2021 Sep 24;14(9). Epub 2021 Sep 24.

Cardiology Department, Bolton NHS Foundation Trust, Bolton, UK.

Essential thrombocythaemia (ET) is a myeloproliferative neoplasm where there is a clonal proliferation of thrombocytes. Whilst most often diagnosed incidentally, it can uncommonly present with arterial thrombosis. This is a case presentation of a 36-year-old male who was diagnosed with ET following myocardial infarction caused by multiple thrombotic emboli. Read More

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September 2021

The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats.

Peptides 2021 Sep 21;146:170651. Epub 2021 Sep 21.

Department of Biology, Faculty of Sciences, Lorestan University, Khorramabad, Iran. Electronic address:

Orexin 1 receptors (Orx1R) and cannabinoid 1 receptors (CB1R) are implicated in migraine pathophysiology. This study evaluated the potential involvement of Orx1R and CB1R within the ventrolateral periaqueductal gray matter (vlPAG) in the modulation of anxiety-like behavior and social interaction of migraineurs rats. A rat model of migraine induced by recurrent administration of nitroglycerin (NTG) (5 mg/kg/i. Read More

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September 2021

IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch.

J Allergy Clin Immunol 2021 Sep 21. Epub 2021 Sep 21.

Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Background: Chronic pruritus, or itch, is common and debilitating, but the neuro-immune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary for chronic itch remains poorly understood. Read More

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September 2021

MRP8/14 serum levels as diagnostic markers for systemic juvenile idiopathic arthritis in children with prolonged fever.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Department of Pediatric Hematology-Oncology University of Duisburg-Essen, Essen, Germany.

Objectives: Differential diagnosis in children with prolonged fever is challenging. In particular, differentiating systemic-onset juvenile idiopathic arthritis (SJIA) from infectious diseases is difficult. Biomarkers are needed supporting the diagnostic work-up. Read More

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September 2021

Peritoneal dialysis resulting in discontinuance of recurring attacks of acute intermittent porphyria: A case report.

Semin Dial 2021 Sep 24. Epub 2021 Sep 24.

Department of Internal Medicine, Viborg Regional Hospital, Viborg, Denmark.

Acute intermittent porphyria is one of eight disorders arising from disturbances in heme biosynthesis where the precursors, 5-aminolevulinate and porphobilinogen, are elevated in plasma and urine. Attacks are characterized by severe abdominal pain, vomiting and/or obstipation, neurological manifestations, and psychological disturbances. The mainstay of treatment is hemin infusion to induce the negative feedback of heme synthesis. Read More

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September 2021

Side effects of immune-checkpoint inhibitors: Can multiple side effects be seen in a patient?

J Oncol Pharm Pract 2021 Sep 24:10781552211038136. Epub 2021 Sep 24.

Department of Medical Oncology, 147021University of Health Sciences Ümraniye Training and Research Hospital, Turkey.

Introduction: Nivolumab is a human immunoglobulin G4 monoclonal antibody that inhibits programmed cell death-1 activity by binding to the programmed cell death-1 receptors. Cancer cells express increased number of programmed cell death-1 ligands and this allows them to escape the cytotoxic effects of the T cells. Therefore, the negative programmed cell death-1 receptor signal regulates T-cell proliferation and activation is disrupted. Read More

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September 2021

Decreased Autonomic Reactivity and Psychiatric Comorbidities in Neurological Patients With Medically Unexplained Sensory Symptoms: A Case-Control Study.

Front Neurol 2021 7;12:713391. Epub 2021 Sep 7.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany.

Up to 48% of patients with medically unexplained symptoms seen in neurological practice suffer from sensory symptoms, which could be of functional nature or secondary to psychiatric disorders. These patients show high medical care utilization causing elevated healthcare costs. Despite the high prevalence, little is known about clinical characteristics and pathophysiological mechanisms. Read More

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September 2021

Psoas Major and Iliopsoas Hematomas without Anticoagulant Therapy as a Complication of Carbon Monoxide Poisoning: A Case Report.

Am J Case Rep 2021 Sep 24;22:e933322. Epub 2021 Sep 24.

Department of Emergency, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).

BACKGROUND Carbon monoxide poisoning is a common reason for Emergency Department admissions worldwide. The symptoms of carbon monoxide poisoning vary from headache and dizziness to severe neuropsychological and cardiac impairment. However, psoas major and iliopsoas hematomas are a rare complication of carbon monoxide poisoning. Read More

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September 2021

Social norms of college students engaging in non-medical prescription drug use to get high: What's sex got to do with it?

J Am Coll Health 2021 Sep 23:1-8. Epub 2021 Sep 23.

Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Relationships exist between perceived peer and own use of alcohol, cannabis, and tobacco, particularly when peers and participants are sex-matched. We investigated sex influences on social norms effects for college students' non-medical prescription drug use (NMPDU).  = 1986 college students reported on their perceptions of male and female peers' NMPDU frequency and their own past-month NMPDU. Read More

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September 2021

A crawling case of benign acute childhood myositis.

SAGE Open Med Case Rep 2021 17;9:2050313X211047321. Epub 2021 Sep 17.

Penn State College of Medicine, Hershey, PA, USA.

Benign acute childhood myositis is a relatively uncommon complication of viral illness, particularly influenza A and B infections. In this abstract, we present a case report of benign acute childhood myositis secondary to influenza. On presentation, he was ill-appearing, febrile and had significant calf pain that limited mobility. Read More

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September 2021

A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.

Am J Respir Crit Care Med 2021 Sep 22. Epub 2021 Sep 22.

Brigham and Women's Hospital, 1861, Pulmonary and Critical Care Medicine, Boston, Massachusetts, United States;

Mechanical signaling through cell-matrix interactions plays a major role in progressive vascular remodeling in pulmonary arterial hypertension (PAH). Matrix metalloproteinase-8 (MMP-8) is an interstitial collagenase involved in regulating inflammation and fibrosis of the lung and systemic vasculature, but its role in PAH pathogenesis remains unexplored. To evaluate MMP-8 as a modulator of pathogenic mechanical signaling in PAH. Read More

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September 2021

Human Herpes Virus 6 Encephalitis Presenting as Fatal Refractory Status Epilepticus: a Case Report and Systematic Review.

Acta Neurol Taiwan 2021 Mar;30(1):21-26

Department of 1Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines.

Purpose: Encephalitis secondary to human herpesvirus 6 (HHV-6) infection is frequently encountered in immunocompromised patients; in contrast, HHV-6 encephalitis in immunocompetent patients is rare. There are only 3 reports of status epilepticus due to HHV-6 encephalitis in immunocompetent adults. In the present study, a case of refractory status epilepticus secondary to HHV-6 encephalitis was reported in an immunocompetent female. Read More

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Hemophagocytic Lymphohistiocytosis in a Patient With Familial Mediterrean Fever and Miliary Tuberculosis: A Case Report.

Mod Rheumatol Case Rep 2021 Sep 22. Epub 2021 Sep 22.

Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.

Hemophagocytic Lymphohistiocytosis (HLH) is a lethal complication of several infections especially viral origin. M.Tuberculosis infection can also lead HLH, yet it is an uncommon trigger. Read More

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September 2021

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain.

Spine J 2021 Sep 18. Epub 2021 Sep 18.

NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. Electronic address:

Background Context: Individual characteristics can influence outcomes after injury. Our previous work in individuals with early-acute low back pain (LBP) identified subgroups (clusters) with specific biopsychosocial features that recovered poorly or well by 6 months.

Purpose: This study extends on that work by revealing the short- and long-term trajectories of recovery and systemic inflammation of these participant clusters: (1) "inflammatory & poor sleep" (Cluster 1), "high TNF & depression" (Cluster 2), "high pain & high pain-related fear" (Cluster 3), and "low pain & low pain-related fear" (Cluster 4). Read More

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September 2021

A Clinical Prediction Tool for MRI in Emergency Department Patients with Spinal Infection.

West J Emerg Med 2021 Aug 30;22(5):1156-1166. Epub 2021 Aug 30.

Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts.

Introduction: Patients with pyogenic spinal Infection (PSI) are often not diagnosed at their initial presentation, and diagnostic delay is associated with increased morbidity and medical-legal risk. We derived a decision tool to estimate the risk of spinal infection and inform magnetic resonance imaging (MRI) decisions.

Methods: We conducted a two-part prospective observational cohort study that collected variables from spine pain patients over a six-year derivation phase. Read More

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Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia.

PLoS Negl Trop Dis 2021 Sep 20;15(9):e0009749. Epub 2021 Sep 20.

Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis, Ministry of Education, School of Public Health, Jilin University, Changchun, China.

Background: Brucellosis is a critical zoonotic disease in the world, it is the non-specific arthralgia that make brucellosis patients easily misdiagnosed as rheumatoid arthritis (RA) in endemic regions. Elevated rheumatoid factor (RF) is an essential indicator of RA, and the RF in brucellosis patients is significantly higher than healthy people. Therefore, this study further explored the distribution of RF and the relevant factors of the RF positivity in brucellosis patients with arthralgia, in order to strengthen the recognition of physicians for brucellosis patients with RF positivity, especially in brucellosis-endemic areas, so as to avoid misdiagnosis and untimely treatment that may lead to malignant outcomes. Read More

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September 2021

Case 298.

Radiology 2021 10;301(1):239-241

From the Departments of Radiology (M.J.M., J.S.S.), Neurosurgery (J.A.G.), and Endocrinology (J.L.S.), Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226.

History A 37-year-old man from the United States presented with a 1-year history of neck pain and stiffness that had been unsuccessfully treated with manipulative therapy by a chiropractor at another institution. Past medical history was remarkable only for marijuana and air duster abuse. He denied use of any prescription medications. Read More

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October 2021