19,861 results match your criteria pain consistent

Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint.

Vet Rec 2021 Jun 12:e516. Epub 2021 Jun 12.

Translational Research in Pain (TRiP), Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

Background: This study aimed to define the rate of progression of radiographic osteoarthritis (OA) of the canine hip joint and to describe factors affecting this progression.

Methods: Dogs that underwent unilateral total hip replacement (THR) were reviewed for the evaluation of radiographic appearance of the non-operated hip joint over time. Standard extended ventrodorsal hip radiographs were taken preoperatively and postoperatively. Read More

View Article and Full-Text PDF

Reappearance of Neurological Deficits in Pathologic Brain: Are Sedatives and Opioids Culprits? A Systematic Review.

J Neurosurg Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Medicine, University of Ottawa Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, Toronto, ON Section Intervention Neuroradiology, Department of Radiology, University of Manitoba, Winnipeg, MB, Canada Department of Pathology, Institute of Cardiovascular Physiopathology, University of Buenos Aires, Buenos Aires, Argentina.

Following a brain insult, focal neurological deficits may develop. Despite resolution of these deficits with time, the subsequent administration of sedative medications and opioids may lead to recrudescence of previous neurological deficits. Therefore, the present systematic review aims to explore the role of different sedatives and opioid analgesics at reproducing focal neurological deficits in patients with previous brain insults undergoing surgery. Read More

View Article and Full-Text PDF

Endometrial injury in women undergoing in vitro fertilisation (IVF).

Cochrane Database Syst Rev 2021 Jun 10;6:CD009517. Epub 2021 Jun 10.

SEMEAR Fertilidade, Reproductive Medicine, Ribeirao Preto, Brazil.

Background: Implantation of an embryo within the endometrial cavity is a critical step in the process of in vitro fertilisation (IVF). Previous research has suggested that endometrial injury (also known as endometrial scratching), defined as intentional damage to the endometrium, can increase the chance of pregnancy in women undergoing IVF.

Objectives: To assess the effectiveness and safety of endometrial injury performed before embryo transfer in women undergoing in vitro fertilisation (IVF) including intracytoplasmic sperm injection (ICSI) and frozen embryo transfer. Read More

View Article and Full-Text PDF

A taxonomy for consistent handling of conditions not related to the spinal cord injury (SCI) in the International Standards for Neurological Classification of SCI (ISNCSCI).

Spinal Cord 2021 Jun 9. Epub 2021 Jun 9.

Kessler Institute for Rehabilitation, West Orange, NJ, USA.

Study Design: Committee consensus process including additional structured feedback from spinal cord injury (SCI) experts attending a focus group workshop.

Objectives: To define a taxonomy for standardized documentation of non-SCI-related conditions in the International Standards for Neurological Classification of SCI (ISNCSCI).

Setting: Americal Spinal Injury Association (ASIA) International Standards Committee with 16 international ISNCSCI experts. Read More

View Article and Full-Text PDF

The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema - a systematic review and meta-analysis.

J Orthop Surg Res 2021 Jun 9;16(1):369. Epub 2021 Jun 9.

LANS Medicum Hamburg - Center for Sports and Regenerative Medicine, Stephansplatz 5, 20354, Hamburg, Germany.

Background: Extracorporeal shock wave therapy (ESWT) has been used for various pathologies associated with bone marrow oedema (BME). However, it is still not clear whether ESWT may be favourable in the treatment of BME. Therefore, the aim of this systematic review was to assess the efficacy of ESWT for the treatment of BME. Read More

View Article and Full-Text PDF

Popliteal Artery Entrapment Syndrome: A Diagnostic and Treatment Enigma for Orthopaedic Surgeons.

J Am Acad Orthop Surg 2021 Jun 9. Epub 2021 Jun 9.

From the Departments of Orthopaedics and Vascular Surgery, Sports Medicine Reseach Institute, The Ohio State University Wexner Medical Center, Columbus, OH.

Popliteal artery entrapment syndrome (PAES) is an uncommon condition that causes recurrent posterior leg pain and foot paresthesia in running athletes. This condition occurs most commonly due to an accessory or abnormal implant of the medial head of the gastrocnemius muscle. It may mimic or coincide with other chronic conditions of the lower extremity including chronic exertional compartment syndrome but is most consistent with vascular claudication. Read More

View Article and Full-Text PDF

[Early clinical efficacy analysis of personalized three-dimensional printing talus prosthesis in the treatment of collapse talus necrosis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):470-476

Orthopaedic Sports Medicine Center, the First Affiliated Hospital to Army Medical University, Chongqing 400038, China.

To examine the preliminary clinical efficacy of custom-made three-dimensional(3D) printed talus prosthesis in the treatment of collapse talus necrosis. The clinical data of 8 patients who received 3D printed custom-made talus prostheses replacement for severe collapsed necrosis of the talus at the Orthopaedic Sports Medical Center, the First Affiliated Hospital to Army Medical University were analyzed retrospectively.All patients were male,with an average age of 38. Read More

View Article and Full-Text PDF

Reframing how we care for people with persistent non-traumatic musculoskeletal pain. Suggestions for the rehabilitation community.

Physiotherapy 2021 Apr 20;112:143-149. Epub 2021 Apr 20.

School of Physiotherapy and Exercise Science, Health Sciences Division, Curtin University, Western Australia, Australia; Bodylogic Physiotherapy, Perth, Western Australia, Australia.

There have been repeated calls to re-evaluate how clinicians provide care for people presenting with persistent non-traumatic musculoskeletal conditions. One suggestion is to move away from the 'we can fix and cure you' model to adopting an approach that is more consistent with approaches used when managing other persistent non-communicable diseases; education, advice, a major focus on self-management including lifestyle behavioural change, physical activity and medications as required. Currently the global delivery of musculoskeletal care has many of the elements of a 'super wicked problem', namely conflict of interest from stake-holders due to the consequences of change, prevailing expectation of a structural diagnosis and concomitant fix for musculoskeletal pain, persistent funding of high risk, more expensive care when low risk more economic viable options that don't impact on the quality of outcome exist, and an unquestionable need to find a solution now with the failure resulting in a growing social and economic burden for future generations. Read More

View Article and Full-Text PDF

Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters.

PLoS Comput Biol 2021 Jun 8;17(6):e1009097. Epub 2021 Jun 8.

Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, Texas, United States of America.

The amygdala is a brain area involved in emotional regulation and pain. Over the course of the last 20 years, multiple researchers have studied sensory and motor connections within the amygdala in trying to understand the ultimate role of this structure in pain perception and descending control of pain. A number of investigators have been using cell-type specific manipulations to probe the underlying circuitry of the amygdala. Read More

View Article and Full-Text PDF

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.

Lancet 2021 Jun 4;397(10291):2253-2263. Epub 2021 Jun 4.

Brazilian Research in Intensive Care Network, São Paulo, Brazil; BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Background: COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised with COVID-19 is unknown. We aimed to compare the efficacy and safety of therapeutic versus prophylactic anticoagulation in this population. Read More

View Article and Full-Text PDF

A case of immunoglobulin G4-related sclerosing mesenteritis without other organ involvement.

Clin J Gastroenterol 2021 Jun 7. Epub 2021 Jun 7.

Department of Human and Environmental Sciences, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

A 64-year-old man presented to our hospital with abdominal pain and 4-5 episodes of watery diarrhea per day for 2 months. Abdominal ultrasound examination revealed a mass in the peritoneal cavity, and computed tomography showed a 13.4 cm mass in the mesentery and a 3 cm mass in the mesocolon. Read More

View Article and Full-Text PDF

Treatment-resistant hypertension in a post-transplant patient with cystic fibrosis: a rare case of phaeochromocytoma.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of EndocrinologyMater Misericordiae University Hospital, Dublin, Ireland.

Summary: Phaeochromocytoma is a rare catecholamine-producing tumour. We present the case of phaeochromocytoma in a young man with a background history of a double-lung transplant for cystic fibrosis (CF). Clinical case: A 25-year-old man, with a background history of CF, CF-related diabetes (CFRD) and a double-lung transplant in 2012 was presented to the emergency department with crampy abdominal pain, nausea and vomiting. Read More

View Article and Full-Text PDF

Hormone Receptor Positive/HER2 Negative Breast Cancer With Isolated Bladder Metastasis: A Rare Case.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211022186

Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.

Breast cancer is the most common cancer diagnosed in women in North America. Hormone receptor positive (HR+) and HER2 negative (HER2-) breast cancers account for at least 60% to 70% of all breast cancer cases. They usually metastasize to lymph nodes, bones, liver, lungs, and brain. Read More

View Article and Full-Text PDF

Differentiating Primary Pancreatic Lymphoma Versus Primary Splenic Lymphoma: A Case Report.

J Pancreat Cancer 2021 29;7(1):20-22. Epub 2021 Mar 29.

Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Both primary pancreatic lymphoma (PPL) and primary splenic lymphoma (PSL) represent rare entities. PPL typically arises in the head of the pancreas but may arise in other locations also. PSL usually presents with nonspecific symptoms, including left upper quadrant pain, weight loss, and fever. Read More

View Article and Full-Text PDF

Review: Mesenchymal Stem Cell Therapy in Canine Osteoarthritis Research: "Experientia Docet" (Experience Will Teach Us).

Front Vet Sci 2021 19;8:668881. Epub 2021 May 19.

Department of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Osteoarthritis (OA) is currently an incurable and progressive condition in dogs causing chronic joint pain and possibly increasing disability. Due to the poor healing capacity of cartilage lesions that occur with OA, development of effective therapeutics is difficult. For this reason, current OA therapy is mostly limited to the management of pain and inflammation, but not directed ad disease modification. Read More

View Article and Full-Text PDF

Paraganglioma with highly malignant potential involving the rib - Case report and review of the literature.

Radiol Case Rep 2021 Jul 21;16(7):1845-1850. Epub 2021 May 21.

Department of Diagnostic Radiology, University of Manitoba, Room O2055, St Boniface General Hospital, 409 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.

Paragangliomas are rare neuroendocrine tumors arising from paraganglion cells in sympathetic or parasympathetic chains, which may develop in the abdomen, chest, skull base, and neck. As paragangliomas have a wide range of imaging features, the diagnosis often requires tissue sampling. We present a unique case of a paraganglioma which originally presented as a rib tumor. Read More

View Article and Full-Text PDF

Safety, Tolerability, and Effect of Nusinersen Treatment in Ambulatory Adults With 5q-SMA.

Front Neurol 2021 20;12:650535. Epub 2021 May 20.

Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

To determine the safety and tolerability of nusinersen treatment in ambulatory adults with spinal muscular atrophy (SMA) and investigate the treatment effect on muscle strength, physical function, and motor unit physiology. Individuals aged 18 years or older with genetically confirmed 5q SMA, three or more copies of the SMN2 gene, and the ability to ambulate 30 feet were enrolled. Safety outcomes included the number of adverse events and serious adverse events, clinically significant vital sign or laboratory parameter abnormalities. Read More

View Article and Full-Text PDF

Predicting cervical spine compression and shear in helicopter helmeted conditions using artificial neural networks.

IISE Trans Occup Ergon Hum Factors 2021 Jun 7:1-15. Epub 2021 Jun 7.

University of Waterloo, Kinesiology, Waterloo, Ontario, Canada.

Occupational ApplicationsMilitary helicopter pilots around the globe are at high risk of neck pain related to their use of helmet-mounted night vision goggles. Unfortunately, it is difficult to design alternative helmet configurations that reduce the biomechanical exposures on the cervical spine during flight because the time and resource costs associated with assessing these exposures are prohibitive. Instead, we developed artificial neural networks (ANNs) to predict cervical spine compression and shear given head-trunk kinematics and joint moments in the lower neck, data readily available from digital human models. Read More

View Article and Full-Text PDF

Facilitating communication for critically ill patients and their family members: Study protocol for two randomized trials implemented in the U.S. and France.

Contemp Clin Trials 2021 Jun 3;107:106465. Epub 2021 Jun 3.

Cambia Palliative Care Center of Excellence and Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA, United States.

Background: Critically-ill patients and their families suffer a high burden of psychological symptoms due, in part, to many transitions among clinicians and settings during and after critical illness, resulting in fragmented care. Communication facilitators may help.

Design And Intervention: We are conducting two cluster-randomized trials, one in the U. Read More

View Article and Full-Text PDF

Preemptive Intravenous Nalbuphine for the Treatment of Post-Operative Visceral Pain: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

Pain Ther 2021 Jun 4. Epub 2021 Jun 4.

Department of Anaesthesiology and Perioperative Medicine, and The Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, The Second Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui Province, China.

Introduction: Post-operative visceral pain is common in early postoperative period after laparoscopic surgery. As a kappa opioid receptor agonist, the antinociceptive effects of nalbuphine in visceral pain are consistent across a multitude of experimental conditions irrespective of species. We hypothesized that preemptive nalbuphine can decrease the visceral pain for patients with incisional infiltration of ropivacaine after laparoscopic cholecystectomy. Read More

View Article and Full-Text PDF

Reactivation-induced motor skill learning.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel;

Learning motor skills commonly requires repeated execution to achieve gains in performance. Motivated by memory reactivation frameworks predominantly originating from fear-conditioning studies in rodents, which have extended to humans, we asked the following: Could motor skill learning be achieved by brief memory reactivations? To address this question, we had participants encode a motor sequence task in an initial test session, followed by brief task reactivations of only 30 s each, conducted on separate days. Learning was evaluated in a final retest session. Read More

View Article and Full-Text PDF

Vasculitic neuropathy associated with IgG4-related kidney disease: A case report and literature review.

Clin Nephrol 2021 Jun 4. Epub 2021 Jun 4.

IgG4-related disease is an immune-mediated systemic inflammatory condition characterized by tissue infiltration of IgG4-positive plasma cells and elevated serum IgG4 concentrations. Peripheral neuropathy is an atypical manifestation of this disease. We describe an unusual case of vasculitic neuropathy in a patient with IgG4-related kidney disease. Read More

View Article and Full-Text PDF

Idiopathic Myointimal Hyperplasia of Mesenteric Veins (IMHMV) with two spontaneous bowel perforations: A case report and literature review.

Int J Surg Case Rep 2021 May 26;83:106022. Epub 2021 May 26.

Royal Commission Jubail and Yanbu, Saudi Arabia.

Introduction And Importance: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a poorly understood disorder which poses a diagnostic challenge to clinicians and pathologists. Here we have described the case of a male patient with IMHMV along with a presumed history of ulcerative colitis for 1 year.

Case Presentation: A 55-year-old male presented to the OPD with history of chronic abdominal pain. Read More

View Article and Full-Text PDF

Health-related quality of life in youth with abdominal pain: An examination of optimism and pain self-efficacy.

J Psychosom Res 2021 May 24;147:110531. Epub 2021 May 24.

Department of Psychology, University of Guelph, Pediatric Chronic Pain Program, McMaster Children's Hospital, Department of Paediatrics, Western University, Children's Health Research Institute, Canada. Electronic address:

Objectives: Abdominal pain adversely impacts children with functional gastrointestinal disorders (FGIDs) or organic gastrointestinal disorders (OGIDs); findings are inconsistent regarding diagnosis and health-related quality of life (HRQoL). This study utilizes a positive psychology framework to understand the experience of youth with abdominal pain (i.e. Read More

View Article and Full-Text PDF

The role of affect in chronic pain: A systematic review of within-person symptom dynamics.

J Psychosom Res 2021 May 24;147:110527. Epub 2021 May 24.

Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, United States.

Objective: Chronic pain is conceptualized as a biopsychosocial phenomenon that involves both physical and emotional processes. The vast majority of research regarding these facets of chronic pain characterizes differences between individuals. In this review, we describe problems with assuming that differences between persons accurately characterize within-person processes. Read More

View Article and Full-Text PDF

Open-Label Dose Optimization of Methylphenidate Extended-Release Orally Disintegrating Tablet in a Laboratory Classroom Study of Children with Attention-Deficit/Hyperactivity Disorder.

J Child Adolesc Psychopharmacol 2021 Jun 2. Epub 2021 Jun 2.

Neos Therapeutics, Inc., Grand Prairie, Texas, USA.

To examine the efficacy, safety, and tolerability of methylphenidate extended-release orally disintegrating tablets (MPH XR-ODT) for the treatment of attention-deficit/hyperactivity disorder (ADHD) during the open-label dose-optimization/stabilization period of a phase 3 laboratory classroom study. Children (6-12 years) diagnosed with ADHD were enrolled. Treatment was initiated with MPH XR-ODT 20 mg daily. Read More

View Article and Full-Text PDF

Patient-centered behavioral services for women veterans with mental health conditions.

Transl Behav Med 2021 Jun 3. Epub 2021 Jun 3.

Geriatric Research, Education, and Clinical Center, Durham Veterans Affairs Healthcare System, Durham, NC, USA.

The Veterans Health Administration (VHA) is undergoing a transformational shift from disease-focused care to a Whole Health model that emphasizes physical, mental, emotional, and spiritual health and well-being. As this shift is occurring, women veterans using VHA services face challenges navigating a system that has historically served a primarily male demographic, without consistent consensus on which services require specialization by gender. A quality improvement project was conducted to solicit feedback on VHA behavioral and wellness programs from women veterans enrolled in VHA mental healthcare services. Read More

View Article and Full-Text PDF

Ophthalmic Solution Safety Profile: Active Surveillance of a Sodium Hyaluronate/Chondroitin Sulfate Combination in Peruvian Population.

Drug Healthc Patient Saf 2021 27;13:117-123. Epub 2021 May 27.

Pharmacovigilance Department, Laboratorios Sophia, S.A. de C.V., Guadalajara, Jalisco, Mexico.

Background: Sodium hyaluronate/chondroitin sulfate fixed combination plays an essential role in the treatment of keratoconjunctivitis sicca, a multifactorial disease accompanied by ocular symptoms like alteration of the tear film. Despite low or no absorption of such drugs, these can cause secondary effects. An essential tool in the study of medication behavior is active pharmacovigilance. Read More

View Article and Full-Text PDF

Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for the treatment of chronic pain: a single-blind randomized controlled trial.

Pain 2021 Jun 1. Epub 2021 Jun 1.

Department of Psychiatry and Behavioral Sciences, Rush University Medical Center Department of Rehabilitation Medicine, University of Washington Department of Psychology, The University of Alabama Professor of Medicine and Population Health Sciences, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School University of Washington, Department of Rehabilitation Medicine Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine.

Abstract: Trials of Cognitive Therapy (CT), Mindfulness-Based Stress Reduction (MBSR), and Behavior Therapy (BT) suggest that all three treatments produce reductions in pain and improvements in physical function, mood and sleep disturbance in people with chronic pain conditions. Fewer studies have compared the relative efficacies of these treatments. In this randomized controlled study, we compared CT, MBSR, BT and treatment as usual (TAU) in a sample of people with chronic low back pain (N = 521). Read More

View Article and Full-Text PDF

The Great Gut Mimicker: A case report of MIS-C and appendicitis clinical presentation overlap in a teenage patient.

BMC Pediatr 2021 06 1;21(1):258. Epub 2021 Jun 1.

Department of Pediatrics, Medical College of Wisconsin, Children's Corporate Center Suite 560, 999 North 92nd Street, Wisconsin, 53226, Milwaukee, USA.

Background: Abdominal pain and other gastrointestinal symptoms are common presenting features of multisystem inflammatory syndrome in children (MIS-C) and can overlap with infectious or inflammatory abdominal conditions, making accurate diagnosis challenging.

Case Presentation: We describe the case of a 16-year-old female who presented with clinical symptoms suggestive of appendicitis and an abdominal computed tomography (CT) that revealed features concerning for appendicitis. After laparoscopic appendectomy, histopathology of the appendix demonstrated only mild serosal inflammation and was not consistent with acute appendicitis. Read More

View Article and Full-Text PDF