879,868 results match your criteria pain


Analysis of motor unit spike trains estimated from high-density surface electromyography is highly reliable across operators.

J Electromyogr Kinesiol 2021 Mar 30;58:102548. Epub 2021 Mar 30.

Department of Bioengineering, Faculty of Engineering, Imperial College London, UK.

There is a growing interest in decomposing high-density surface electromyography (HDsEMG) into motor unit spike trains to improve knowledge on the neural control of muscle contraction. However, the reliability of decomposition approaches is sometimes questioned, especially because they require manual editing of the outputs. We aimed to assess the inter-operator reliability of the identification of motor unit spike trains. Read More

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Predictors and moderators of quality of life in patients with major depressive disorder: An AGTs-MDD study report.

J Psychiatr Res 2021 Apr 1;138:96-102. Epub 2021 Apr 1.

Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 201108, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, 510515, China. Electronic address:

Effective and targeted interventions for improving quality of life (QOL) in addition to achieving 'clinical remission' are imperatives for patients with major depressive disorder (MDD). This study aimed to examine potential predictors and moderators of QOL in depression. Data were obtained from the Algorithm Guided Treatment Strategies for Major Depressive Disorder (AGTs-MDD) study, a multisite, randomized controlled trial composed of 980 depressed patients. Read More

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A multicenter survey on access to care in Multiple Sclerosis-related trigeminal neuralgia.

J Neurol Sci 2021 Mar 27;424:117430. Epub 2021 Mar 27.

Rehabilitation Department, Mons. L. Novarese, Moncrivello, Vercelli, Italy.

The prevalence of trigeminal neuralgia (TN) in patients with Multiple Sclerosis (MS) is higher than in the general population and its management can be particularly challenging due to a number of reasons including high recurrence rates, lack of MS-specific treatment guidelines and uncertainties about pain pathophysiology. Aim of this cross-sectional, multicentre survey was to gather information on the current treatment modalities and options of MS-related TN across 23 Italian MS centres. Initial medical management (carbamazepine or oxcarbazepine) of MS-related TN was fairly homogeneous throughout Italian centres. Read More

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Ultrasound-guided erector spinae plane block for postoperative analgesia in patients undergoing open radical prostatectomy: A randomized, placebo-controlled trial.

J Clin Anesth 2021 Apr 7;72:110277. Epub 2021 Apr 7.

Department of Urology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Study Objective: The aim of this study was to evaluate the effect of ultrasound-guided erector spinae plane (ESP) block on postoperative pain in radical prostatectomy, which leads to both visceral and somatic pain.

Design: Prospective, randomized, placebo controlled, double-blinded.

Setting: University hospital. Read More

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Construction of a predictive model of post-intubation hypotension in critically ill patients using multiple machine learning classifiers.

J Clin Anesth 2021 Apr 7;72:110279. Epub 2021 Apr 7.

Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. Electronic address:

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Perioperative high inspired oxygen fraction induces atelectasis in patients undergoing abdominal surgery: A randomized controlled trial.

J Clin Anesth 2021 Apr 7;72:110285. Epub 2021 Apr 7.

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine in Seoul, South Korea. Electronic address:

Study Objective: We evaluated the feasibility of use and effects on postoperative atelectasis and complications of lower inspired oxygen fraction (FIO) compared to conventional oxygen therapy.

Design: Single center, randomized clinical trial.

Setting: University hospital, operating room and postoperative recovery area. Read More

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Early-onset complete spontaneous migration of contraceptive intrauterine device to the bladder in a post C-section patient: A case report.

Int J Surg Case Rep 2021 Apr 1;82:105850. Epub 2021 Apr 1.

Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta 10430, Indonesia.

Introduction And Importance: Spontaneous migration of a contraceptive intrauterine device (IUD) to the bladder is very rare. It usually takes years for the IUD to migrate completely from the uterine cavity to the bladder. We report a case of early-onset complete spontaneous migration of contraceptive IUD to the bladder in a post C-section patient. Read More

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Environmental heat-related health symptoms among community in a tropical city.

Sci Total Environ 2021 Mar 30;782:146611. Epub 2021 Mar 30.

Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Due to the changing climate, more frequent and prolonged heatwaves are expected to have a catastrophic consequence on urban human settlement. In tropical cities such as Kuala Lumpur (KL), the quality of the urban environment is made worse by urban heat island (UHI) phenomena due to poor urban planning practices. The prolonged exposure to urban heat is hypothesized to influence human health and well-being, especially in tropical urban areas with high population density. Read More

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A Brief History of Carbon Monoxide and Its Therapeutic Origins.

Nitric Oxide 2021 Apr 7. Epub 2021 Apr 7.

Department of Anesthesiology and Critical Care, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide (CO) [1]. Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric oxide (NO), and hydrogen sulfide (HS), for which all of life has co-evolved with [2]. Speculation for extraterrestrial life in harsh environments is similarly based on harnessing atmospheric CO as a primary energy source [3]. Read More

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IMAGING OF VASCULAR MALFORMATIONS WITH A HIGH-INTENSITY FOCUSED ULTRASOUND PROBE FOR TREATMENT PLANNING.

J Vasc Surg Venous Lymphat Disord 2021 Apr 7. Epub 2021 Apr 7.

Division of Vascular and Endovascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT; Vascular Malformations Program, Yale New Haven Hospital, New Haven, CT. Electronic address:

Objective: We aimed to investigate whether a current commercially available High-Intensity Focused Ultrasound (HIFU) probe can adequately image targeted vascular malformations in anticipation of HIFU treatment planning and delivery.

Methods: We enrolled 10 consecutive patients scheduled to undergo treatment of their symptomatic peripheral vascular malformations (VM) confirmed on routine preoperative contrast enhanced magnetic resonance imaging (MRI) and soft tissue duplex ultrasound (DUS). Lesions were situated no more than 6 cm from the skin. Read More

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Anti-inflammatory activity of the Tongmai Yangxin Pill in the treatment of Coronary Heart Disease is associated with Estrogen Receptor and NF-κB signaling pathway.

J Ethnopharmacol 2021 Apr 7:114106. Epub 2021 Apr 7.

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address:

Ethnopharmacological Relevance: The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic prescriptions, Zhigancao Decoction and Shenmai Yin, which composed of 11 Chinese medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Spatholobus suberectus Dunn, Ophiopogon japonicus (Thunb. Read More

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True aneurysms of foot arteries: A case report of a young patient.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

The Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Japan.

Background: Reports of true aneurysms of the lower leg are rare. Among them, cases involving young patients are all the more rare, and there are many unexplored aspects to this pathological condition.

Case Presentation: This is a case of a 30-year-old woman who was referred by an orthopedic surgeon with a chief complaint of severe pain during walking and landing. Read More

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Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish.

Behav Brain Res 2021 Apr 7:113293. Epub 2021 Apr 7.

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address:

Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most commonly used drugs globally. Read More

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The Effect of a Psychologically-Informed Intervention to Treat Adolescents with Patellofemoral Pain: A Randomized Controlled Trial.

Arch Phys Med Rehabil 2021 Apr 7. Epub 2021 Apr 7.

Department of Pediatric Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, Ohio, United States.

Objective: To determine if the addition of a brief psychologically-informed video to traditional physical therapy influenced function (primary aim), pain, and psychological beliefs (secondary aims) among adolescents with patellofemoral pain (PFP).

Design: Double-blind randomized controlled trial.

Setting: Outpatient physical therapy clinics of a single pediatric hospital. Read More

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Analytical assessment and performance of the 0/3h algorithm with novel high sensitivity cardiac troponin I.

Clin Chim Acta 2021 Apr 7. Epub 2021 Apr 7.

Laboratoire de Biochimie et Hormonologie, PhyMedExp, Université de Montpellier, INSERM, CNRS, CHU de Montpellier, France. Electronic address:

Background: Recently, Ortho Clinical Diagnostics have launched a high sensitivity cardiac troponin I assay adapted on Vitros3600 / 5600.We aimed at evaluating the analytical and clinical performances using the 0/3-hour algorithm, of the Ortho hs-cTnI assay on the Vitros 3600® (Ortho Clinical Diagnostics, Illkirch, France) analyzer with comparison to Roche hs-cTnT assay on the Cobas8000/e801® module (Roche diagnostics, Meylan, France) and the Abbott STAT hs-cTnI assay on the Alinity i® (Abbott, Rungis, France) analyzer.

Methods: Imprecision studies, linearity, limit of detection, and the interference to hemolysis were performed for Ortho hs-cTnI assay. Read More

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Does the Surgical Intervention for Trigeminal Neuralgia Refractory to Pharmacotherapy Improve Quality-of-Life? - A Systematic Review.

J Oral Maxillofac Surg 2021 Mar 10. Epub 2021 Mar 10.

Senior Resident, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Purpose: Trigeminal neuralgia (TN) refractory to pharmacotherapy requires surgical interventions which vary from percutaneous procedure to microvascular decompression (MVD). The aim of the systematic review is to find evidence for the surgical treatment for TN with high success rate and low complications which improves the quality-of-life (QOL).

Methods: A systematic literature search was made on published studies from MEDLINE, SCOPUS, science direct, and Cochrane Library databases that report the available surgical treatment for TN up to March 2020 and studies referred in the selected papers. Read More

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Sleep disturbance in patients attending specialized chronic pain clinics in Denmark: a longitudinal study examining the relationship between sleep and pain outcomes.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Department of Clinical Medicine, Interacting Minds Center, Aarhus University, Aarhus, Denmark.

Objectives: Sleep disturbances are highly prevalent in patients with chronic pain. However, the majority of studies to date examining sleep disturbances in patients with chronic pain have been population-based cross-sectional studies. The aims of this study were to 1) examine the frequency of sleep disturbances in patients referred to two interdisciplinary chronic pain clinics in Denmark, 2) explore associations between sleep disturbances and pain intensity, disability and quality of life at baseline and follow-up, and 3) explore whether changes in sleep quality mediated the relationships between pain outcomes at baseline and pain outcomes at follow-up. Read More

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Prevalence of musculoskeletal chest pain in the emergency department: a systematic review and meta-analysis.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Department of Biostatistics, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India.

Objectives: Our objective was to systematically review and meta-analyse relevant studies to determine the prevalence of musculoskeletal chest pain in the emergency department.

Methods: This review was constructed while confirming to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. PubMed, Cochrane Library, SCOPUS, Science Direct, and OVID were systematically searched from their inception to January 19, 2020, to identify observational studies, where the prevalence of musculoskeletal causes of chest pain was reported in isolation or in combination with other causes or could be calculated from the available data. Read More

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Long-term postoperative opioid prescription after cholecystectomy or gastric by-pass surgery: a retrospective observational study.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Objectives: Opioids are commonly prescribed post-surgery. We investigated the proportion of patients who were prescribed any opioids 6-12 months after two common surgeries - laparoscopic cholecystectomy and gastric by-pass (GBP) surgery. A secondary aim was to examine risk factors prior to surgery associated with the prescription of any opioids after surgery. Read More

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Neural activity during cognitive reappraisal in chronic low back pain: a preliminary study.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University, Melbourne, VIC3004, Australia.

Objectives: Chronic pain patients often report higher levels of negative emotions, suggesting reduced ability to regulate emotions effectively, however, little is known of the underlying neural cognitive mechanisms. Therefore, the aim of this study was to explore brain activity and connectivity during cognitive reappraisal in chronic low back pain (CLBP).

Methods: This study recruited 24 female participants; 12 with CLBP and 12 healthy controls. Read More

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Complementary and alternative medicine therapies and COVID-19: a systematic review.

Rev Environ Health 2021 Apr 12. Epub 2021 Apr 12.

Internal Medicine and Nephrology, Clinical Immunology Research Center, Ali-Ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Objectives: Despite the high prevalence of coronavirus and various treatment approaches, including complementary and alternative medicine (CAM), there is still no definitive treatment for coronavirus. The present study aimed to evaluate the effect of CAM interventions on COVID-19 patients.

Content: Four databases (Web of Science, PubMed, Scopus, and EMBASE) were searched from the inception of databases until July 16, 2020. Read More

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The challenge of recognizing severe pain and autonomic abnormalities for early diagnosis of CRPS.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Objectives: Complex regional pain syndrome (CRPS) is a disabling usually post-traumatic pain condition. International guidelines emphasize early diagnosis for treatment and improved outcome. Early intense and persistent pain along with features of autonomic dysfunction in the first week's post-injury are early warning signs for development of CRPS. Read More

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Evaluation of an opioid restrictive pain management initiative in adult kidney transplant recipients.

Clin Transplant 2021 Apr 10:e14313. Epub 2021 Apr 10.

Department of Pharmacy, Michigan Medicine, Ann Arbor, MI, U.S.

Purpose: Evidence to guide opioid utilization following kidney transplantation is lacking. The purpose of this study is to evaluate the implementation of an opioid restrictive post-operative pain management protocol in adult kidney transplant recipients.

Methods: We analyzed patients who underwent kidney transplant between 1/1/2017 to 8/15/2018. Read More

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Dental Students' Experience of Conscious Sedation: A Qualitative Review of Student Reflections.

Eur J Dent Educ 2021 Apr 10. Epub 2021 Apr 10.

School of Dentistry, University Hospital Wales, Heath Park, Cardiff, CF14 4XY, UK.

Introduction: The UK General Dental Council (GDC), require dental graduates to competently identify, manage and refer patients with dental pain and anxiety. This study aimed to explore sedation training experience quantitatively and qualitatively through individual reflective logs.

Methodology: A single-centre mixed-methods evaluation of teaching within a UK university conscious sedation department. Read More

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Hypokalemia-Induced Rhabdomyolysis Caused by Adrenal Tumor-Related Primary Aldosteronism: A Report of 2 Cases.

Am J Case Rep 2021 Apr 10;22:e929758. Epub 2021 Apr 10.

Division of Urology, Department of Surgery, Cathay General Hospital, Taipei, Taiwan.

BACKGROUND Primary aldosteronism, also known as Conn's syndrome, is a clinical condition caused by excessive production of aldosterone. The classic presenting signs of primary aldosteronism are hypertension and hypokalemia. However, rhabdomyolysis induced by severe hypokalemia is a rare manifestation of primary aldosteronism. Read More

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Mucosal eosinophils, mast cells, and intraepithelial lymphocytes in youth with rumination syndrome.

Neurogastroenterol Motil 2021 Apr 10:e14155. Epub 2021 Apr 10.

Division of Gastroenterology, Hepatology, & Nutrition, Children's Mercy, Kansas City, MO, USA.

Background: Rumination syndrome has been associated with increased duodenal eosinophils and intraepithelial lymphocytes in adults. The aims of the current study were to assess densities of antroduodenal eosinophils and mast cells and duodenal intraepithelial lymphocytes in youth with rumination syndrome and to compare cell densities in those with and without abdominal pain or early satiety.

Methods: Twenty-eight youth fulfilling Rome IV criteria for rumination syndrome who had undergone endoscopy were identified and compared to 10 controls. Read More

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Single-port robotic-assisted simple prostatectomy is associated with decreased post-operative narcotic use in a propensity score matched analysis.

J Robot Surg 2021 Apr 10. Epub 2021 Apr 10.

Department of Urology, University of Texas Southwestern, 2001 Inwood Dr., WCB3, Suite 4.878, Dallas, TX, 75390 MC 9110, USA.

Robotic-assisted simple prostatectomy (RASP) has proven to be an effective minimally invasive option for benign prostatic enlargement (BPE) in recent years. Single-site surgery is theorized to reduce post-operative pain beyond traditional minimally invasive approaches. We sought to assess whether use of a single-port robotic platform decreases post-operative opioid use in patients undergoing robotic-assisted simple prostatectomy (RASP). Read More

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Inferior mesenteric arteriovenous fistula with colonic ischemia: a case report and review of the literature.

Clin J Gastroenterol 2021 Apr 10. Epub 2021 Apr 10.

Department of Radiology, Saint-Eloi University Hospital, 80 Av. Augustin Fliche, 34000, Montpellier, France.

Inferior mesenteric arteriovenous fistula is a rare abnormal high flow communication with only 40 primary and secondary cases reported in literature. Shunting of arterial flow through the inferior mesenteric vein to the portal system can cause a variety of nonspecific clinical signs and symptoms usually associated with the diagnosis of arteriovenous malformation. Symptom intensities are flow-dependent and can range from minimal abdominal symptoms to severe heart failure due to left to right shunt. Read More

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Does Inhaled Methoxyflurane Implement Fast and Efficient Pain Management in Trauma Patients? A Systematic Review and Meta-Analysis.

Pain Ther 2021 Apr 10. Epub 2021 Apr 10.

Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, China.

Introduction: Evidence on the use of inhaled methoxyflurane in the management of trauma pain is conflicting and obfuscated. This study aimed to determine the efficacy and safety of inhaled methoxyflurane for trauma pain on the basis of published randomized controlled trials (RCTs).

Methods: RCTs assessing the efficacy of methoxyflurane in adults or adolescents with acute trauma pain published in PubMed, Web of Science, Embase, Cochrane Library, and Google Scholar were searched. Read More

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