1,016,599 results match your criteria pa175t severe

Ethanolic extract of C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.

Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. Read More

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Acute hemolytic transfusion reaction caused by anti-Yt.

Immunohematology 2021 Mar;37(1):13-17

Department of Transfusion Medicine and Transplantation Biology, University Clinical Hospital Zagreb , Zagreb , Croatia .

Many patients with anti-Yt receive multiple transfusions of Yt(a+) red blood cells (RBCs) with no ill effects. However, anti-Yt has been implicated in hemolytic transfusion reactions. Antibody identification typically determines specificity of antibodies and their clinical significance to justify blood requirements for antigen-negative blood when clinically significant antibodies are involved. Read More

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COVID-19 and atrial fibrillation in older patients. Does oral anticoagulant therapy provide a survival benefit? An insight from the GeroCovid Registry.

Thromb Haemost 2021 May 7. Epub 2021 May 7.

Department of Medicine, Campus Bio-Medico University, Roma, Italy.

Introduction: Atrial fibrillation (AF), the most frequent arrhythmia of older patients, associates with serious thrombo-embolic complications and high mortality. COVID-19 severely affects aged subjects, determining an important prothrombotic status. Aim of this study was to evaluate mortality-related factors in older AF patients with COVID-19. Read More

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Social Media Use in COPD Patients in Germany and Switzerland.

Pneumologie 2021 May 7. Epub 2021 May 7.

Pforzheim University, School of Engineering, Pforzheim, Germany.

Use of social media and the Internet has changed the information-seeking behaviour and exchange of experience and information by patients. Passive observation of such online interaction between patients (social media listening) is conducted in order to understand the burden of the disease, symptom perception, and expectations from a patient perspective. For most conditions, it remains to be established how representative the social media user community is for the overall patient population. Read More

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Contralateral Masking in the Measurement of Auditory Brainstem Responses with Air-Conducted Tone Burst Stimuli in Individuals with Unilateral Hearing Loss.

J Am Acad Audiol 2021 May 7. Epub 2021 May 7.

Department of Audiology and Speech Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Background:  Contralateral noise masking is an important aspect of auditory brainstem response (ABR) measurements.

Purpose:  The primary aim of this study is to determine how contralateral white noise (WN) masking influences the amplitude and the latency of V wave generated during ABR measurements, using tone burst (TB), in adult ears with normal hearing (NH). The secondary aim of this study is to ascertain the need of contralateral masking in ABR measurements with the TB stimuli using a 3A insertion earphone, and to propose the applicability of WN masking in unilateral sensorineural hearing loss (USNHL). Read More

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Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection.

Aging (Albany NY) 2021 May 6;13. Epub 2021 May 6.

Department of Cardiology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, China.

Patients with pre-existing chronic diseases are more susceptible to coronavirus disease 2019 (COVID-19), yet the underlying causes of increased risk are of infection remain unclear. Angiotensin-converting- enzyme 2 (ACE2), the cell surface receptor that recognizes the coronavirus spike protein has protective effects against inflammation and chronic hyperglycemia in animal models. The roles of ACE2 in severe SARS-CoV-2 infections remains ambiguous due to contradictory findings. Read More

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Increased hypospadias risk by rs3743104[G] in the southern Han Chinese population.

Aging (Albany NY) 2021 May 7;13. Epub 2021 May 7.

Department of Pediatric Urology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.

Hypospadias is a common congenital genitourinary malformation characterized by ventral opening of the urethral meatus. As a member of the bone morphogenic protein antagonist family, has been identified as associated with susceptibility to hypospadias in the European population. The present study was designed to elaborate on the mutual relationship between replicated single-nucleotide polymorphisms (SNPs) and hypospadias in Asia's largest case-control study in the Southern Han Chinese population involving 577 patients and 654 controls. Read More

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Identifying patients at risk for nonroutine discharge after surgery for cervical myelopathy: an analysis from the Quality Outcomes Database.

J Neurosurg Spine 2021 May 7:1-9. Epub 2021 May 7.

15Department of Neurological Surgery, University of Utah, Salt Lake City, Utah.

Objective: Optimizing patient discharge after surgery has been shown to impact patient recovery and hospital/physician workflow and to reduce healthcare costs. In the current study, the authors sought to identify risk factors for nonroutine discharge after surgery for cervical myelopathy by using a national spine registry.

Methods: The Quality Outcomes Database cervical module was queried for patients who had undergone surgery for cervical myelopathy between 2016 and 2018. Read More

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Assessment of speech perception in deaf or hard of hearing children who received auditory-verbal therapy with hearing aids or cochlear implants.

Int J Pediatr Otorhinolaryngol 2021 Apr 27;146:110739. Epub 2021 Apr 27.

National Hospital Organization Tokyo Medical Center, National Institute of Sensory Organs, Tokyo, Japan.

Objectives: To reframe the criteria for pediatric cochlear implants (CIs) in Japan, we investigated monosyllabic and word speech perception at the time of school entry in deaf or hard of hearing (D/HH) children who underwent auditory-verbal therapy (AVT) with hearing aids (HAs) or CIs in early childhood.

Methods: D/HH children who started AVT at Fujimidai Auditory Center for Hearing-Impaired Children before the age of 1 year and who underwent auditory assessment in the previous year of schooling (at the age of 5 or 6) from 2010 to 2020 were enrolled in this study. The results of hearing level tests with or without amplification and monosyllabic and word speech discrimination were assessed. Read More

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Loneliness, social relationships, and mental health in adolescents during the COVID-19 pandemic.

J Affect Disord 2021 Apr 24;289:98-104. Epub 2021 Apr 24.

Department of Psychology, University of Bath, UK; Bristol Medical School, University of Bristol, UK.

Loneliness is a common experience in adolescence and is related to a range of mental health problems. Such feelings may have been increased by social distancing measures introduced during the COVID-19 pandemic. We aimed to investigate the effect of loneliness, social contact, and parent relationships on adolescent mental health during lockdown in the UK. Read More

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School performance and behavioral functioning in children after intrauterine transfusions for hemolytic disease of the fetus and newborn.

Early Hum Dev 2021 May 4;157:105381. Epub 2021 May 4.

Department of Medical Psychology, Leiden University Medical Center, the Netherlands.

Aim: To investigate the school performance and behavioral difficulties in children with hemolytic disease of the fetus and newborn (HDFN) treated with intrauterine transfusion (IUT) compared to Dutch norm data.

Study Design: Cros-sectional cohort study.

Subjects: Children who received one or multiple IUTs for severe Rh- or K (Kell)-mediated HDFN between January 2008 and January 2015 at the LUMC. Read More

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Proposal of novel natural inhibitors of severe acute respiratory syndrome coronavirus 2 main protease: Molecular docking and ab initio fragment molecular orbital calculations.

Biophys Chem 2021 Apr 29;275:106608. Epub 2021 Apr 29.

Department of Computer Science and Engineering, Toyohashi University of Technology, Tempaku-cho, Toyohashi, Aichi 441-8580, Japan. Electronic address:

This paper proposes natural drug candidate compounds for the treatment of coronavirus disease 2019 (COVID-19). We investigated the binding properties between the compounds in the Moringa oleifera plant and the main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 using molecular docking and ab initio fragment molecular orbital calculations. Among the 12 compounds, niaziminin was found to bind the strongest to Mpro. Read More

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Asymptomatic acute ischemic lesions in intracerebral hemorrhage: Its frequency, MRI features, and risk factors.

J Neurol Sci 2021 Apr 29;426:117472. Epub 2021 Apr 29.

Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Asymptomatic acute ischemic lesions (AIL) may be coincidentally found on brain magnetic resonance imaging (MRI) obtained during the acute phase of intracerebral hemorrhage, but its clinical significance has yet to be determined. The objective of this study is to determine the frequency of asymptomatic AIL, its characteristic features of brain MRI and risk factors in patients with acute intracerebral hemorrhage.

Methods: We retrospectively reviewed the clinical information of 108 patients with intracerebral hemorrhage who underwent brain MRIs within 30 days of hospitalization between April 2013 and January 2018. Read More

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PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model.

Ecotoxicol Environ Saf 2021 May 4;218:112272. Epub 2021 May 4.

Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, the Third People's Hospital of Chengdu, Chengdu 610031, China; Department of Pulmonary and Critical Care Medicine, Chengdu third people's hospital branch of National Clinical Research Center for Respiratory Disease, Affiliated Hospital of ChongQing Medical University, Chengdu 610031, China. Electronic address:

Background: Particulate matter of 2.5 µm or less in diameter (PM2.5) is one of the most complex pollutants in the atmospheric environment and harmful to human health. Read More

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A case report and literature review of heterotopic mesenteric ossification.

Int J Surg Case Rep 2021 Apr 27;82:105905. Epub 2021 Apr 27.

Department of General Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.

Introduction And Importance: Heterotopic mesenteric ossification is a benign bony tissue growth in the mesentery that mostly follows repetitive or severe abdominal injuries leading to reactive bone formation in the mesentery. There are only 73 cases (51 publications) identified in the literature up to the beginning of 2020.

Case Presentation: 45-year-old Saudi male underwent multiple laparotomies to manage complicated appendicitis which ended with a diverting ileostomy and a colostomy as a mucus fistula. Read More

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Horseshoe kidney leading to ERCP failure; innovative use of guide wire during laparoscopic CBD exploration: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105927. Epub 2021 Apr 29.

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

Introduction: Horseshoe kidneys are the most common fusion defect of the kidneys, which amounts to about 0.25% of the population. They are usually asymptomatic and are often identified incidentally. Read More

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A case report of necrotizing soft tissue infection of the chest wall: Effective management with serial debridement.

Int J Surg Case Rep 2021 Apr 27;82:105908. Epub 2021 Apr 27.

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Hokkaido, Japan.

Introduction: Necrotizing soft tissue infection (NSTI) of the chest wall is a rare, rapidly spreading, highly lethal surgical disease. Radical debridement interferes with the important anatomical function of the chest wall. We report a case of chest wall NSTI that was successfully managed with early diagnosis and serial debridement. Read More

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Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory.

Psychoneuroendocrinology 2021 Apr 29;129:105248. Epub 2021 Apr 29.

Djavad Mowafaghian Centre for Brain Health and Department of Psychology, University of British Columbia, Vancouver, BC, Canada; Women's Health Research Institute of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health and Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.

Alzheimer's disease (AD) is characterized by severe cognitive decline and pathological changes in the brain (brain atrophy, hyperphosphorylation of tau, and deposition of amyloid-beta protein). Females have greater neuropathology (AD biomarkers and brain atrophy rates) and cognitive decline than males, however these effects can depend on diagnosis (amnestic mild cognitive impairment (aMCI) or AD) and APOE genotype (presence of ε4 alleles). Using the ADNI database (N = 630 females, N = 830 males), we analyzed the effect of sex, APOE genotype (non-carriers or carriers of APOEε4 alleles), and diagnosis (cognitively normal (CN), early aMCI (EMCI), late aMCI (LMCI), probable AD) on cognition (memory and executive function), hippocampal volume, and AD biomarkers (CSF levels of amyloid beta, tau, and ptau). Read More

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Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment.

Water Res 2021 Apr 22;198:117183. Epub 2021 Apr 22.

Eau de Paris, R&D and Water quality department, 33 avenue Jean Jaurès, F-94200 Ivry sur Seine, France.

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a public health emergency of international concern. Although SARS-CoV-2 is considered to be mainly transmitted by inhalation of contaminated droplets and aerosols, SARS-CoV-2 is also detected in human feces and to a less extent in urine, and in raw wastewaters (to date viral RNA only) suggesting that other routes of infection may exist. Monitoring SARS-CoV-2 genomes in wastewaters has been proposed as a complementary approach for tracing the dynamics of virus transmission within human population connected to wastewater network. Read More

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Evaluating the elimination status of medications used for COVID-19 during hemoperfusion and therapeutic plasma exchange: A review.

Int Immunopharmacol 2021 Apr 21;97:107707. Epub 2021 Apr 21.

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran; Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 133362544, Iran. Electronic address:

Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, better known as COVID-19) has rapidly spread worldwide. The primary pathophysiology by which COVID-19 leads to severe lung damage is cytokine releasing syndrome (CRS), which can cause death. Therefore, removing cytokines via therapeutic plasma exchange or hemoperfusion could be a therapeutic approach to treat CRS. Read More

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Increased internal cerebral vein diameter is associated with age.

Clin Imaging 2021 Mar 31;78:187-193. Epub 2021 Mar 31.

Department of Radiology, Longyan First Hospital, Fujian Medical University, No. 105 North 91 Road, Xinluo District, Fujian 364000, China.

Objective: A recent study described the relationship between cerebral venous diameter and white matter hyperintensity (WMH) volume. However, the adults were not further grouped; therefore, we aimed to compare across age groups and use susceptibility-weighted imaging (SWI) to explore whether there is also a relationship between a larger cerebral draining venous diameter and age, which could provide evidence of a temporal relationship.

Methods: We retrospectively analysed data collected from 405 subjects (90 youths, 166 middle-aged participants, and 149 elderly subjects) and respectively used T2-weighted fluid-attenuated inversion recovery (FLAIR) and SWI to assess WMHs and venous diameter. Read More

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Evolutionary algorithms and decision trees for predicting poor outcome after endovascular treatment for acute ischemic stroke.

Comput Biol Med 2021 Apr 21;133:104414. Epub 2021 Apr 21.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Despite the large overall beneficial effects of endovascular treatment in patients with acute ischemic stroke, severe disability or death still occurs in almost one-third of patients. These patients, who might not benefit from treatment, have been previously identified with traditional logistic regression models, which may oversimplify relations between characteristics and outcome, or machine learning techniques, which may be difficult to interpret. We developed and evaluated a novel evolutionary algorithm for fuzzy decision trees to accurately identify patients with poor outcome after endovascular treatment, which was defined as having a modified Rankin Scale score (mRS) higher or equal to 5. Read More

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Long term outcomes of idiopathic intracranial hypertension: Observational study and literature review.

Clin Neurol Neurosurg 2021 Jan 5;205:106463. Epub 2021 Jan 5.

Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is an unexplained increase in intracranial pressure often associated with obesity. The aim of this study was to conduct a retrospective observational study of the long term clinical, visual, and treatment outcomes in IIH patients.

Methods: A retrospective observational study of patients diagnosed with IIH over a 12-year period at a single centre was completed via database review. Read More

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January 2021

Low Dose Aspirin in high-risk pregnancies: The volatile effect of acetylsalicylic acid on the inhibition of platelets uncovered by G. Born's light transmission aggregometry.

J Reprod Immunol 2021 Apr 8;145:103320. Epub 2021 Apr 8.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Electronic address:

Preeclampsia still represents a life-threatening pregnancy complication, associated with severe maternal and neonatal morbidity and mortality. Low-dose Aspirin is advised to avoid preeclampsia in high-risk pregnancies worldwide. As Aspirin does not cover all women at risk, the prescription raises questions concerning optimal target population, dosage, and onset of therapy. Read More

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Extracorporeal support for trauma: A trauma quality improvement project (TQIP) analysis in patients with acute respiratory distress syndrome.

Am J Emerg Med 2021 Apr 30;48:170-176. Epub 2021 Apr 30.

Division of Acute Care Surgery, University of Southern California, Los Angeles, CA, United States of America.

Introduction: The use of extracorporeal membrane oxygenation (ECMO) in trauma patients with severe acute respiratory distress syndrome (ARDS) continues to evolve. The objective of this study was to perform a comparative analysis of trauma patients with ARDS who received ECMO to a propensity matched cohort of patients who underwent conventional management.

Methods: The Trauma Quality Improvement Program (TQIP) database was queried from 2013 to 2016 for all patients with ARDS and those who received ECMO. Read More

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A Systematic Review Of Primary Ankle Arthrodesis In The Treatment Of Pilon Fractures.

Foot (Edinb) 2021 Jan 21;47:101780. Epub 2021 Jan 21.

Division of foot, ankle and limb reconstruction surgery, Department of Trauma and Orthopaedics, The Queen Elizabeth University Hospital, Glasgow, United Kingdom.

Background: Pilon fractures are severe, intra-articular and comminuted fractures to the distal tibia. They are uncommon injuries and are often associated with fibular fractures. The optimal management of these fractures is widely debated. Read More

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January 2021

Online singing groups for people with dementia: scoping review.

Public Health 2021 May 4;194:196-201. Epub 2021 May 4.

Institute of Mental Health & School of Sociology and Social Policy, University of Nottingham, Nottingham, UK.

Objectives: In the face of the SARS-CoV-2 pandemic, people with dementia and their carers are contending with serious challenges to their health and wellbeing, due to risk of severe illness, limiting of social contact and disruption to usual activities. Many forms of support for people with dementia and their carers, including singing groups, have moved online using videoconferencing. Previous research has demonstrated the benefits of group singing, which include cognitive stimulation, meaningful activity and peer support. Read More

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Clinical course of alopecia after severe acute respiratory syndrome coronavirus 2 infection.

Int J Infect Dis 2021 May 4. Epub 2021 May 4.

Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; Emerging and Re-emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan.

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Bone quality, as measured by trabecular bone score in normocalcaemic primary hyperparathyroidism.

Endocr Pract 2021 May 4. Epub 2021 May 4.

Unit of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy. Electronic address:

Background: The impact of normocalcemic hyperparathyroidism (NHPT) on bone quality remains largely unexplored. We aimed to investigate the usefulness of trabecular bone score (TBS) assessment in NHPT and the accuracy of TBS in predicting vertebral fractures (VFs) in NHPT.

Methods: In this multicentric cross-sectional study, we assessed the TBS in 47 subjects with NHPT, 41 with primary hyperparathyroidism (PHPT) and 39 age- and sex-matched control subjects. Read More

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TAK1 is a novel target in Hepatocellular Carcinoma and contributes to sorafenib resistance.

Cell Mol Gastroenterol Hepatol 2021 May 4. Epub 2021 May 4.

Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, 310016, Hangzhou, China; Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment 310016, Hangzhou, China; Zhejiang University Cancer Center, 310058, Hangzhou, China; Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China. Electronic address:

Background & Aims: Identifying novel and actional targets in hepatocellular carcinoma (HCC) remains an unmet medical need. TAK1 was originally identified as a TGF-β-activated kinase and was further proved to phosphorylate and activate numerous downstream targets and promote cancer progression. However, the role of TAK1 in developed HCC progression and targeted therapy resistance is poorly understood. Read More

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