5,586 results match your criteria p63

Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63.

Genetics 2020 Jun;215(2):373-378

Department of Biomedical Sciences and Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850.

Unrepaired DNA damage in mouse oocytes leads to apoptosis, in part via CHK2 signaling to TRP53 and TRP63. Here, Rinaldi, Bloom, and Schimenti provide evidence that CHK1 can also be involved, especially.. Read More

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Phase-Controlled Synthesis of Pd-Sn Nanocrystal Catalysts of Defined Size and Shape.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.

Bimetallic Pd-based nanoparticles (NPs) are of interest as electrocatalysts for formic acid electrooxidation (FAEO) because of their higher initial catalytic activity and CO tolerance when compared to Pt. Intermetallic NPs (-NPs) with specific geometric and electronic structures generally exhibit superior catalytic activity, selectivity, and durability when compared to their disordered (random alloy) counterparts; however, the colloidal synthesis of -NPs remains a challenge. Here, a one-pot method was demonstrated as a facile route to obtain monodisperse Pd-Sn NPs with phase control, including intermetallic hexagonal PdSn (6/), intermetallic orthorhombic PdSn (), and alloy cubic PdSn (FCC, 3) as size-controlled NPs with quasi-spherical shapes. Read More

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Inhibitor of apoptosis stimulating p53 protein (iASPP) protects against inflammatory bowel disease (IBD) in mice models by inhibiting the NF-κB signaling.

Clin Exp Immunol 2021 May 3. Epub 2021 May 3.

Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Drugs and therapies available for the treatment of inflammatory bowel disease (IBD) are not satisfactory. Our previous study has established the inhibitor of apoptosis stimulating p53 protein (iASPP) as an oncogenic regulator in colorectal cancer by forming a regulatory axis or feedback loop with miR-124, p53, or p63. Since iASPP could target and inhibit NF-κB activation, in this study, the role and mechanism of iASPP in IBD was investigated. Read More

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Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia.

Iran J Pathol 2021 26;16(2):181-189. Epub 2020 Dec 26.

Department of Pathology, Pathology and Stem Cell Research Center, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background & Objective: Cervical intraepithelial neoplasia (CIN) is a dysmaturation process in squamous cells in epithelial layer, which highly increases the risk of developing cervical cancer. The aim of this study was to compare the expression of three biomarkers, p16, p63, and CK17 in patients with CIN and in those with atypical squamous metaplasia (ASM).

Methods: In this study, 100 patients underwent a colposcopy-guided cervix biopsy. Read More

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December 2020

[Nodular fasciitis of the breast: a clinicopathological and genetic analysis of seven cases].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):476-481

Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

To investigate the clinicopathological and genetic features of nodular fasciitis of the breast (NFB). The clinical and histologic features of seven NFBs were retrospectively reviewed. Immunohistochemistry, fluorescence in situ hybridization (FISH) and reverse transcription-polymerase chain reaction (RT-PCR) were performed. Read More

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GATA3-Positive Adnexal Adenocarcinoma: Report of a Confusing Case with a Potential Pitfall of Leading to a Misdiagnosis of Urothelial Carcinoma and a Review of Published Work.

Ann Dermatol 2020 Oct 29;32(5):417-421. Epub 2020 Sep 29.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Read More

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October 2020

Intron 4-5 hTERT DNA Hypermethylation in Merkel Cell Carcinoma: Frequency, Association with Other Clinico-pathological Features and Prognostic Relevance.

Endocr Pathol 2021 Apr 28. Epub 2021 Apr 28.

Department of Biomedical and Neuromotor Sciences (DIBINEM) Surgical Pathology Section- Alma Mater Studiorum , University of Bologna , Bologna, Italy.

Merkel cell carcinoma (MCC) is an aggressive skin tumor with neuroendocrine differentiation, mainly affecting elderly population or immunocompromised individuals. As methylation of the human telomerase reverse transcriptase (mhTERT) has been shown to be a prognostic factor in different tumors, we investigated its role in MCC, in particular in intron 4-5 where rs10069690 has been mapped and recognized as a cancer susceptibility locus. DNA methylation analysis of hTERT gene was assessed retrospectively in a cohort of 69 MCC patients from the University of Bologna, University of Turin and University of Insubria. Read More

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Research and Clinical Significance of the Differentially Expressed Genes TP63 and LMO4 in Human Immunodeficiency Virus-Related Penile Squamous Cell Carcinoma.

Am J Mens Health 2021 Mar-Apr;15(2):15579883211011380

Beijing Youan Hospital of Capital Medical University, Fengtai District, Beijing China.

To study the differential gene expression and clinical significance in human immunodeficiency virus-infected individuals (HIVIIs) with penile squamous cell carcinoma. At our hospital from 2019 to 2020, we selected six samples of HIV-related penile squamous cell carcinoma for the experimental group and six samples of non-HIV-related penile squamous cell carcinoma for the control group. Transcriptome sequencing of sample mRNAs was performed by high-throughput sequencing. Read More

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ALK-Negative Anaplastic Large Cell Lymphoma (ALCL): Prognostic Implications of Molecular Subtyping and JAK-STAT Pathway.

Appl Immunohistochem Mol Morphol 2021 Apr 23. Epub 2021 Apr 23.

Departments of Histopathology and Internal Medicine Post Graduate Institute of Medical Education & Research (PGIMER), Sector-12, Chandigarh, India.

The anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a clinically distinct but heterogeneous entity and lacks the specific immunophenotypic or genetic features compared with the ALK-positive ALCL. Recent molecular studies have provided genetic landscapes of ALK-negative ALCL that have prognostic significance. In this study, we subtyped ALK-negative ALCL based on DUSP22 rearrangements and TP63 expression and also looked for mutations in JAK-STAT pathway. Read More

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The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate.

Oncoscience 2021 24;8:14-30. Epub 2021 Mar 24.

Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.

Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. In this study we investigated the effect of loss of Id4 () on mouse prostate development. Histological analysis was performed on prostates from 25 days, 3 months and 6 months old mice. Read More

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Vaginal Squamous Cell Carcinoma Develops in Mice with Conditional Arid1a Loss and Gain of Oncogenic Kras Driven by Progesterone Receptor Cre.

Am J Pathol 2021 Apr 18. Epub 2021 Apr 18.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Recent sequencing studies have found that loss-of-function mutations in ARID1A were enriched in gynecologic malignant tumors, and oncogenic KRAS mutations are a common finding in endometrial cancers. However, neither of these genetic insults alone was sufficient to develop gynecologic cancer. To determine the role of the combined effects of deletion of Arid1a and oncogenic Kras, Arid1a mice were crossed to Kras mice using progesterone receptor Cre (Pgr). Read More

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Clinical and pathological risk factors for worse stage and mortality of eyelid and periocular squamous cell carcinoma.

Br J Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

Background: The clinical and pathological risk factors for worse T stage and prognosis in eyelid and periocular squamous cell carcinomas (SCCs) remain unclear. P63 was reported to predict a worse prognosis in other SCCs; however, this correlation was not validated in eyelid and periocular SCCs.

Methods: We reported on a retrospective case series of 85 consecutive patients with eyelid and periocular SCCs from 1995 to 2019. Read More

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Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI.

Prostate 2021 Apr 20. Epub 2021 Apr 20.

Medical Artificial Intelligence Laboratory Program, The University of Hong Kong, Hong Kong, Hong Kong SAR.

Background: Tissue clearing technologies have enabled remarkable advancements for in situ characterization of tissues and exploration of the three-dimensional (3D) relationships between cells, however, these studies have predominantly been performed in non-human tissues and correlative assessment with clinical imaging has yet to be explored. We sought to evaluate the feasibility of tissue clearing technologies for 3D imaging of intact human prostate and the mapping of structurally and molecularly preserved pathology data with multi-parametric volumetric MR imaging (mpMRI).

Methods: Whole-mount prostates were processed with either hydrogel-based CLARITY or solvent-based iDISCO. Read More

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The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73.

Biochim Biophys Acta Gen Subj 2021 Apr 17;1865(7):129914. Epub 2021 Apr 17.

Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Joint Units IQFR-CSIC-BIFI, GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain; Fundacion ARAID, Government of Aragon, 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.

Background: Plakophilin 1 (PKP1) is a component of desmosomes, which are key structural components for cell-cell adhesion, and can also be found in other cell locations. The p53, p63 and p73 proteins belong to the p53 family of transcription factors, playing crucial roles in tumour suppression. The α-splice variant of p73 (p73α) has at its C terminus a sterile alpha motif (SAM); such domain, SAMp73, is involved in the interaction with other macromolecules. Read More

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ALK Rearrangements Characterize 2 Distinct Types of Salivary Gland Carcinomas: Clinicopathologic and Molecular Analysis of 4 Cases and Literature Review.

Am J Surg Pathol 2021 Mar 22. Epub 2021 Mar 22.

*Institute of Pathology ¶Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen §DERMPATH Muenchen ∥Institute of Pathology, Ludwig Maximilians University, Munich, Germany †Department of Pathology, Charles University, Faculty of Medicine in Plzen ‡Bioptic Laboratory Ltd, Plzen, Czech Republic #Department of Translational Research, University of Pisa, School of Medicine, Pisa, Italy.

The majority of salivary gland carcinomas are characterized by recurrent gene fusions that proved highly valuable diagnostically, but only rarely of therapeutic impact. Most of these fusion-positive carcinomas belong to the low-grade or intermediate-grade biological category. To date, only 5 cases of salivary gland carcinomas carrying an oncogenic ALK fusion have been reported in 4 recent studies, but their phenotypic spectrum and their nosological classification remain uncharacterized. Read More

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Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma.

Front Oncol 2021 31;11:632638. Epub 2021 Mar 31.

Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Non-small-cell lung carcinoma (NSCLC) is the major type of lung cancer, which is among the leading causes of cancer-related deaths worldwide. LIMD1 was previously identified as a tumor suppressor in lung cancer, but their detailed interaction in this setting remains unclear. In this study, we have carried out multiple genome-wide bioinformatic analyses for a comprehensive understanding of LIMD1 in NSCLC, using various online algorithm platforms that have been built for mega databases derived from both clinical and cell line samples. Read More

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ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling.

Epigenetics Chromatin 2021 Apr 17;14(1):20. Epub 2021 Apr 17.

Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY, 14203, USA.

Background: ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its binding sites within inaccessible chromatin and induce chromatin remodeling.

Methods: In order to examine if ΔNp63 can bind to inaccessible chromatin and to determine if specific histone modifications are required for binding, we induced ΔNp63 expression in two p63-naïve cell lines. Read More

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Phase relations and thermoelasticity of magnesium silicide at high pressure and temperature.

J Chem Phys 2021 Apr;154(14):144701

Department of Materials Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

Within the exploration of sustainable and functional materials, narrow bandgap magnesium silicide semiconductors have gained growing interest. Intriguingly, squeezing silicides to extreme pressures and exposing them to non-ambient temperatures proves fruitful to study the structural behavior, tune the electronic structure, or discover novel phases. Herein, structural changes and thermoelastic characteristics of magnesium silicides were probed with synchrotron x-ray diffraction techniques using the laser-heated diamond anvil cell and large volume press at high pressure and temperature and temperature-dependent synchrotron powder diffraction. Read More

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Clinicopathologic features and treatment of thymic lymphoepithelioma-like carcinoma: two case reports and literature review.

Am J Transl Res 2021 15;13(3):1896-1903. Epub 2021 Mar 15.

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning, China.

Lymphoepithelioma-like carcinoma (LELC) is rare in the thymus, and easily misdiagnosed. To improve its clinicopathologic knowledge, we describe two cases of thymic LELC, and investigate their microscopic and immunohistochemical features, treatment, and follow-up with a review of previously published cases. Two patients in the First Affiliated Hospital of China Medical University underwent complete surgical resection for thymic LELC. Read More

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Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development.

Head Neck Pathol 2021 Apr 11. Epub 2021 Apr 11.

Departamento de Patologia, Programa de Pós-Graduação Em Biotecnologia, Centro de Ciências da Saúde - Universidade Federal do Espírito santo, Av. Marechal Campos, 1468 Maruípe, Vitoria, Espírito Santo, 29.043-900, Brazil.

To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0. Read More

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E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma.

Cell Death Dis 2021 Apr 8;12(4):381. Epub 2021 Apr 8.

Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.

Targeted therapy has greatly improved both survival and prognosis of cancer patients. However, while therapeutic treatment of adenocarcinoma has been advanced greatly, progress in treatment of squamous cell carcinoma (SCC) has been slow and ineffective. Therefore, it is of great importance to decipher mechanisms and identify new drug targets involved in squamous cell carcinoma development. Read More

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Cation Substitution of Hexagonal Triple Perovskites: A Case in Trimetallic Tellurates AA'BTeO.

Inorg Chem 2021 Apr 6;60(8):6099-6106. Epub 2021 Apr 6.

CAS Key Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics & Chemistry, Xinjiang Key Laboratory of Electronic Information Materials and Devices, 40-1 South Beijing Road, Urumqi 830011, China.

Three new tellurates, namely, KBaPbBaTeO (), RbBaPbBaTeO (), and BaKLiTeO (), with hexagonal triple-perovskite structures have been designed a cation substitution strategy. All three centrosymmetric compounds crystallize in the same hexagonal space group 6/. In their structures, the [BTeO] (B = Pb/Ba for and and Li for ) groups construct the final three-dimensional framework using face-sharing [TeO] dimmers and vertex-linked [BO] linkages. Read More

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Crystal structure refinements of stoichiometric NiSe and NiSe.

Acta Crystallogr C Struct Chem 2021 Apr 9;77(Pt 4):169-175. Epub 2021 Mar 9.

Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube, Yamaguchi 755-8611, Japan.

Single crystals of NiSe (trinickel diselenide) and NiSe (nickel selenide) with stoichiometric chemical compositions were grown in evacuated silica-glass tubes. The chemical compositions of the single crystals of NiSe and NiSe were determined by scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM/EDS). The crystal structures of NiSe [rhombohedral, space group R32, a = 6. Read More

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Mediastinal basaloid carcinoma arising from thymic cysts in two dogs.

J Vet Med Sci 2021 Apr 5. Epub 2021 Apr 5.

Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University.

Mediastinal masses in dogs were diagnosed as basaloid carcinoma associated with multiple thymic cysts (MTCs). The masses were composed of MTCs and proliferating intracystic neoplastic basaloid cells, which immunohistochemically diffusely expressed p63 and cytokeratin 19. A gradual transition from the basal cell layers lining the cysts walls to the neoplastic cells was seen, and it was indicated that the neoplastic cells had originated from the basal cell layers of the cysts. Read More

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Performance comparison of anti-p504s (SP116) Rabbit Monoclonal Primary Antibody vs. Monoclonal Rabbit Anti-Human AMACR clone 13H4 when duplexed with VENTANA Basal Cell Cocktail (34βE12+p63) as a diagnostic aid for prostatic adenocarcinoma using immunohistochemistry.

Virchows Arch 2021 Apr 3. Epub 2021 Apr 3.

Roche Tissue Diagnostics, Tucson, AZ, USA.

Alpha-methylacyl-coenzyme A-racemase (AMACR), also known as p504s, is overexpressed in prostatic adenocarcinoma and is frequently used in combination with basal cell markers to aid in diagnosing difficult prostate adenocarcinoma cases. In this retrospective method comparison study, we examined the sensitivity and specificity of the ready-to-use anti-p504s (SP116) Rabbit Monoclonal Primary Antibody compared to the monoclonal rabbit anti-human AMACR clone 13H4 in prostatic adenocarcinoma samples. De-identified prostatic adenocarcinoma tissue samples were stained with either the SP116 or 13H4 antibody clone in combination with the VENTANA Basal Cell Cocktail (34βE12+p63) and scored as positive or negative for prostatic adenocarcinoma. Read More

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Molecular Mechanisms of Canine Osteosarcoma Metastasis.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.

Osteosarcoma (OSA) represents the most common bone tumor in dogs. The malignancy is highly aggressive, and most of the dogs die due to metastasis, especially to the lungs. The metastatic process is complex and consists of several main steps. Read More

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Structural and Ultrastructural Morphological Evaluation of Giant Anteater () Prostate Gland.

Biology (Basel) 2021 Mar 17;10(3). Epub 2021 Mar 17.

Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18618-81, Brazil.

The giant anteater () is a vulnerable species from Central and South America, and is considered possibly extinct in Belize, Guatemala, El Salvador, and Uruguay. Due to the species' conservation and reproductive importance, this research aimed to characterize the morphology, histochemical, immunohistochemical, and ultrastructural feature of the giant anteater prostate gland. For this, we collected 11 giant anteater prostate glands and performed macroscopic, morphological, histochemical, immunohistochemical, and ultrastructural analysis. Read More

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Predicting the radiosensitivity of HPV-negative oropharyngeal squamous cell carcinoma using miR-130b.

Acta Otolaryngol 2021 Apr 1:1-6. Epub 2021 Apr 1.

Department of Head and Neck Surgery, Division of Otolaryngology, Saitama Medical University International Medical Center, Hidaka, Japan.

Background: Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma shows a higher rate of radiation resistance than HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). Radioresistant HPV-negative OPSCC is associated with unfavourable outcomes, but validated prognostic biomarkers remain lacking.

Aims/objectives: This study investigated biomarkers for radioresistant HPV-negative OPSCC. Read More

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Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway.

Stem Cell Res Ther 2021 Mar 29;12(1):216. Epub 2021 Mar 29.

Department of Pulmonary and Critical Care Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may reportedly contribute to tissue repair in ALI and ARDS. However, applications of MSCs have been restricted due to safety considerations and limitations in terms of large-scale production and industrial delivery. Read More

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A Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature.

Onco Targets Ther 2021 18;14:1997-2002. Epub 2021 Mar 18.

Department of Pathology, Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.

Introduction: Primary tracheal adenoid cystic carcinoma (ACC) is a rare and heterogeneous group of neoplasms arising from the respiratory tract. The solid variant of ACC is a histologically distinct subtype with an unfavorable clinical course. We report on a case of tracheal ACC with immunohistochemical and molecular analysis together with a review of the literature. Read More

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